Guanosine 3',5'-cyclic monophosphate reduces the response of the Moth's olfactory receptor neuron to pheromone.

Abstract:

:The effects of the membrane-permeable dibutyryl guanosine 3', 5'-cyclic monophosphate (db-cGMP) on the bombykol-elicited receptor current and nerve impulse activity were studied using the open sensillum recording technique. db-cGMP was applied to the outer dendritic membrane of the olfactory receptor neuron of the moth Bombyx mori. db-cGMP reduced the amplitude of the overall receptor current activated by a pulse of strong pheromone stimuli as well as diminished the nerve impulse frequency elicited by continuously applied weak pheromone stimuli. The observed inhibition of the response to pheromone was due to size reduction of an elementary receptor current that elicits the nerve impulses and underlies the overall receptor current. It is suggested that cGMP is a factor which may adjust cell sensitivity to odour and play a role in olfactory adaptation.

journal_name

Chem Senses

journal_title

Chemical senses

authors

Redkozubov A

doi

10.1093/chemse/25.4.381

keywords:

subject

Has Abstract

pub_date

2000-08-01 00:00:00

pages

381-5

issue

4

eissn

0379-864X

issn

1464-3553

journal_volume

25

pub_type

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