Abstract:
:The effects of the membrane-permeable dibutyryl guanosine 3', 5'-cyclic monophosphate (db-cGMP) on the bombykol-elicited receptor current and nerve impulse activity were studied using the open sensillum recording technique. db-cGMP was applied to the outer dendritic membrane of the olfactory receptor neuron of the moth Bombyx mori. db-cGMP reduced the amplitude of the overall receptor current activated by a pulse of strong pheromone stimuli as well as diminished the nerve impulse frequency elicited by continuously applied weak pheromone stimuli. The observed inhibition of the response to pheromone was due to size reduction of an elementary receptor current that elicits the nerve impulses and underlies the overall receptor current. It is suggested that cGMP is a factor which may adjust cell sensitivity to odour and play a role in olfactory adaptation.
journal_name
Chem Sensesjournal_title
Chemical sensesauthors
Redkozubov Adoi
10.1093/chemse/25.4.381keywords:
subject
Has Abstractpub_date
2000-08-01 00:00:00pages
381-5issue
4eissn
0379-864Xissn
1464-3553journal_volume
25pub_type
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