Analysis of slow depolarizing potential in frog taste cell induced by parasympathetic efferent stimulation under hypoxia.

Abstract:

:Strong electrical stimulation (ES) of the frog glossopharyngeal (GP) efferent nerve induced slow depolarizing potentials (DPs) in taste cells under hypoxia. This study aimed to elucidate whether the slow DPs were postsynaptically induced in taste cells. After a block of parasympathetic nerve (PSN) ganglia by tubocurarine, ES of GP nerve never induced slow DPs in the taste cells, so slow DPs were induced by PSN. When Ca(2+) in the blood plasma under hypoxia was decreased to approximately 0.5 mM, the slow DPs reduced in amplitude and lengthened in latency. Increasing the normal Ca(2+) to approximately 20 mM increased the amplitude of slow DPs and shortened the latency. Addition of Cd(2+) to the plasma greatly reduced the amplitude of slow DPs and lengthened the latency. These data suggest that the slow DPs depend on Ca(2+) and Cd(2+) concentration at the presynaptic PSN terminals of taste disk. Antagonists, [D-Arg(1), D-Trp(7,9), Leu(11)]-substance P and L-703 606, of neurotransmitter substance P neurokinin(1) receptor completely blocked the slow DPs. Intravenous application of substance P induced a DP of approximately 7 mV and a reduction of membrane resistance of approximately 48% in taste cells. A nonselective cation channel antagonist, flufenamic acid, completely blocked the slow DPs. These findings suggest that the slow DPs are postsynaptically initiated in frog taste cells under hypoxia by opening nonselective cation channels on the postsynaptic membrane after substance P is probably released from the presynaptic PSN axon terminals.

journal_name

Chem Senses

journal_title

Chemical senses

authors

Sato T,Nishishita K,Okada Y,Toda K

doi

10.1093/chemse/bjm003

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

329-36

issue

4

eissn

0379-864X

issn

1464-3553

pii

bjm003

journal_volume

32

pub_type

杂志文章
  • Changes in Olfactory Sensory Neuron Physiology and Olfactory Perceptual Learning After Odorant Exposure in Adult Mice.

    abstract::The adult olfactory system undergoes experience-dependent plasticity to adapt to the olfactory environment. This plasticity may be accompanied by perceptual changes, including improved olfactory discrimination. Here, we assessed experience-dependent changes in the perception of a homologous aldehyde pair by testing mi...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjv065

    authors: Kass MD,Guang SA,Moberly AH,McGann JP

    更新日期:2016-02-01 00:00:00

  • Complex binding interactions between multicomponent mixtures and odorant receptors in the olfactory organ of the Caribbean spiny lobster Panulirus argus.

    abstract::Our study was designed to examine how components of complex mixtures can inhibit the binding of other components to receptor sites in the olfactory system of the spiny lobster Panulirus argus. Biochemical binding assays were used to study how two- to six-component mixtures inhibit binding of the radiolabeled odorants ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/23.3.269

    authors: Gentilcore LR,Derby CD

    更新日期:1998-06-01 00:00:00

  • Elevated Cytosolic Cl- Concentrations in Dendritic Knobs of Mouse Vomeronasal Sensory Neurons.

    abstract::In rodents, the vomeronasal system controls social and sexual behavior. However, several mechanistic aspects of sensory signaling in the vomeronasal organ remain unclear. Here, we investigate the biophysical basis of a recently proposed vomeronasal signal transduction component-a Ca(2+)-activated Cl(-) current. As the...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjw077

    authors: Untiet V,Moeller LM,Ibarra-Soria X,Sánchez-Andrade G,Stricker M,Neuhaus EM,Logan DW,Gensch T,Spehr M

    更新日期:2016-10-01 00:00:00

  • Presynaptic inhibition of olfactory sensory neurons: new mechanisms and potential functions.

    abstract::Presynaptic inhibition is the suppression of neurotransmitter release from a neuron by inhibitory input onto its presynaptic terminal. In the olfactory system, the primary sensory afferents from the olfactory neuroepithelium to the brain's olfactory bulb are strongly modulated by a presynaptic inhibition that has been...

    journal_title:Chemical senses

    pub_type: 杂志文章,评审

    doi:10.1093/chemse/bjt018

    authors: McGann JP

    更新日期:2013-07-01 00:00:00

  • Temperature Affects Human Sweet Taste via At Least Two Mechanisms.

    abstract::The reported effects of temperature on sweet taste in humans have generally been small and inconsistent. Here, we describe 3 experiments that follow up a recent finding that cooling from 37 to 21 °C does not reduce the initial sweetness of sucrose but increases sweet taste adaptation. In experiment 1, subjects rated t...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjv021

    authors: Green BG,Nachtigal D

    更新日期:2015-07-01 00:00:00

  • Olfactory memory: the long and short of it.

    abstract::It has been proposed that memory for odors does not have a short-term (or working) memory system. The distinction between short- and long-term memory in other sensory modalities has been generally supported by three main lines of evidence: capacity differences between the proposed systems, evidence of differential cod...

    journal_title:Chemical senses

    pub_type: 杂志文章,评审

    doi:10.1093/chemse/23.4.433

    authors: White TL

    更新日期:1998-08-01 00:00:00

  • Detecting gustatory-olfactory flavor mixtures: models of probability summation.

    abstract::Odorants and flavorants typically contain many components. It is generally easier to detect multicomponent stimuli than to detect a single component, through either neural integration or probability summation (PS) (or both). PS assumes that the sensory effects of 2 (or more) stimulus components (e.g., gustatory and ol...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjr103

    authors: Marks LE,Veldhuizen MG,Shepard TG,Shavit AY

    更新日期:2012-03-01 00:00:00

  • Adding cocoa to sucrose: the effect on cold pain tolerance.

    abstract::The sweet taste of sucrose acts as an analgesic, whereas the taste of a bitter substance decreases pain tolerance. The present experiment explores the analgesic effect of a complex taste and asks how adding cocoa, a substance often associated with sweet foods but that has a bitter taste, to a sucrose solution affects ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjq016

    authors: Eggleston K,White TL,Sheehe PR

    更新日期:2010-05-01 00:00:00

  • Distracted Sniffing of Food Odors Leads to Diminished Behavioral and Neural Responses.

    abstract::Eating under distracted conditions such as viewing television is associated with overeating and weight gain. Following evidence from earlier findings, in this issue Hoffman-Hensel et al. report a study in which they investigated the influence of distraction on intensity perception of low and high caloric food odors an...

    journal_title:Chemical senses

    pub_type: 评论,杂志文章

    doi:10.1093/chemse/bjx060

    authors: Veldhuizen MG

    更新日期:2017-10-31 00:00:00

  • Metabolic and Sensory Influences on Odor Sensitivity in Humans.

    abstract::Our olfactory sense plays an important role in eating behavior by modulating our food preferences and intake. However, hunger or satiety may also influence how we perceive odors. Albeit speculative, contradictory results found in the past may have resulted from confounding by type of meal that participants ate to indu...

    journal_title:Chemical senses

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/chemse/bjv068

    authors: Ramaekers MG,Verhoef A,Gort G,Luning PA,Boesveldt S

    更新日期:2016-02-01 00:00:00

  • Tastant-Evoked Arc Expression in the Nucleus of the Solitary Tract and Nodose/Petrosal Ganglion of the Mouse Is Specific for Bitter Compounds.

    abstract::Despite long and intense research, some fundamental questions regarding representation of taste information in the brain still remain unanswered. This might in part be due to shortcomings of the established methods that limit the researcher either to thorough characterization of few elements or to analyze the response...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjy017

    authors: Töle J,Stolzenburg A,Tyree SM,Stähler F,Meyerhof W

    更新日期:2018-04-23 00:00:00

  • Revisiting sugar-fat mixtures: sweetness and creaminess vary with phenotypic markers of oral sensation.

    abstract::Genetic variation in oral sensation presumably influences ingestive behaviors through sensations arising from foods and beverages. Here, we investigated the influence of taste phenotype [6-n-propylthiouracil (PROP) bitterness, fungiform papillae (FP) density] on sweet and creamy sensations from sugar/fat mixtures. Sev...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjl050

    authors: Hayes JE,Duffy VB

    更新日期:2007-03-01 00:00:00

  • Alarm reaction in the crucian carp is mediated by the medial bundle of the medial olfactory tract.

    abstract::Experiments were performed to determine which bundles of the olfactory tracts were essential for mediating alarm reaction in crucian carp (Carassius carassius L.). The fish were maintained in physiological saline after surgery to preserve the remaining tracts and postoperative inspections revealed the functionality of...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/25.1.103

    authors: Hamdani EH,Stabell OB,Alexander G,Døving KB

    更新日期:2000-02-01 00:00:00

  • Calcium signaling in taste cells: regulation required.

    abstract::Peripheral taste receptor cells depend on distinct calcium signals to generate appropriate cellular responses that relay taste information to the central nervous system. Some taste cells have conventional chemical synapses and rely on calcium influx through voltage-gated calcium channels. Other taste cells lack these ...

    journal_title:Chemical senses

    pub_type: 杂志文章,评审

    doi:10.1093/chemse/bjq082

    authors: Medler KF

    更新日期:2010-11-01 00:00:00

  • Oral amiloride treatment decreases taste sensitivity to sodium salts in C57BL/6J and DBA/2J mice.

    abstract::Sodium taste transduction is thought to occur via an amiloride-sensitive, sodium-selective pathway and an amiloride-insensitive, cation nonselective, anion-dependent pathway(s). It has been shown by others that amiloride, an epithelial sodium channel (ENaC) blocker, significantly reduces the chorda tympani nerve respo...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/28.5.447

    authors: Eylam S,Spector AC

    更新日期:2003-06-01 00:00:00

  • Enhancement of sucrose sweetness with soluble starch in humans.

    abstract::The effect of soluble starch (acid-modified starch) on taste intensity was investigated in human subjects. Different concentrations of sucrose (Suc), six sweeteners, NaCl, quinine-HCl (QHCl) and citric acid (Cit) were dissolved in either distilled water (DW; standard) or starch solution (test solution). The solutions ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/27.1.67

    authors: Kanemaru N,Harada S,Kasahara Y

    更新日期:2002-01-01 00:00:00

  • Do tastants have a smell?

    abstract::The stimuli used in taste research are usually considered to be odourless. This was tested in two experiments with aqueous solutions of two representative compounds for each of the five taste qualities including umami. In the first experiment elderly and young subjects rated the intensity and pleasantness of three con...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjh251

    authors: Mojet J,Köster EP,Prinz JF

    更新日期:2005-01-01 00:00:00

  • Temporal changes in the neonatal recognition cue of Dohne Merino lambs (Ovis aries).

    abstract::The strong bond that is formed between ewe and lamb after parturition is important for lamb survival. Evidence exists that the ewe mainly employs olfactory recognition cues to distinguish her lamb from other lambs in the flock. We have found that volatile organic compounds in the wool of Merino lambs that presumably c...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjt075

    authors: Viviers MZ,Burger BV,le Roux NJ,Morris J,le Roux M

    更新日期:2014-03-01 00:00:00

  • Temporal integration in nasal lateralization and nasal detection of carbon dioxide.

    abstract::Two experiments examined time/concentration trading for the detection of carbon dioxide, an irritant with little or no odor. Experiment 1 employed the nasal lateralization method: subjects attempted to determine which nostril received carbon dioxide and which received pure air when presented simultaneously. Experiment...

    journal_title:Chemical senses

    pub_type: 临床试验,杂志文章

    doi:10.1093/chemse/bjh018

    authors: Wise PM,Radil T,Wysocki CJ

    更新日期:2004-02-01 00:00:00

  • Electric shock-induced associative olfactory learning in Drosophila larvae.

    abstract::Associative plasticity is a basic essential attribute of nervous systems. As shown by numerous reports, Drosophila is able to establish simple forms of appetitive and aversive olfactory associations at both larval and adult stages. Whereas most adult studies on aversive learning employed electric shock as a negative r...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjq023

    authors: Pauls D,Pfitzenmaier JE,Krebs-Wheaton R,Selcho M,Stocker RF,Thum AS

    更新日期:2010-05-01 00:00:00

  • Heightened avidity for trisodium pyrophosphate in mice lacking Tas1r3.

    abstract::Laboratory rats and mice prefer some concentrations of tri- and tetrasodium pyrophosphate (Na3HP2O7 and Na4P2O7) to water, but how they detect pyrophosphates is unknown. Here, we assessed whether T1R3 is involved. We found that relative to wild-type littermate controls, Tas1r3 knockout mice had stronger preferences fo...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bju059

    authors: Tordoff MG,Aleman TR,McCaughey SA

    更新日期:2015-01-01 00:00:00

  • Experience-induced changes in sugar taste discrimination.

    abstract::An apparent plasticity in glucose sensitivity was first noted while studying human taste variants, but the experimental design did not rule out regression to the mean. Since then, a human taste induction hypothesis that sensitivity for a taste stimulus increases with repeated exposure to it has been supported first by...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjm078

    authors: Gonzalez KM,Peo C,Livdahl T,Kennedy LM

    更新日期:2008-02-01 00:00:00

  • The Sensory Difference Threshold of Menthol Odor in Flavored Tobacco Determined by Combining Sensory and Chemical Analysis.

    abstract::Cigarettes are an often-used consumer product, and flavor is an important determinant of their product appeal. Cigarettes with strong nontobacco flavors are popular among young people, and may facilitate smoking initiation. Discriminating flavors in tobacco is important for regulation purposes, for instance to set upp...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjw123

    authors: Krüsemann EJ,Cremers JW,Visser WF,Punter PH,Talhout R

    更新日期:2017-03-01 00:00:00

  • Chemosensory cross-modal stroop effects: congruent odors facilitate taste identification.

    abstract::In order to explore the cross-modal cognitive associations between smell and taste, a chemosensory analogue of the Stroop task (Stroop 1935) was developed. Fourteen participants were presented with an odorant and a tastant and asked to identify the tastant as "sweet" or "sour" by pressing 1 of 2 buttons as quickly as ...

    journal_title:Chemical senses

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/chemse/bjm001

    authors: White TL,Prescott J

    更新日期:2007-05-01 00:00:00

  • Histochemical identification of carbohydrate moieties in the accessory olfactory bulb of the mouse using a panel of lectins.

    abstract::Lectin binding patterns in the olfactory bulb of the mouse were investigated using 12 biotinylated lectins. Three, with specificities for galactose, N-acetylgalactosamine and L-fucose, stained only the nervous and glomerular layers of the accessory olfactory bulb; four, with specificities for galactose or N-acetylgluc...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/26.6.645

    authors: Salazar I,Sánchez Quinteiro P,Lombardero M,Cifuentes JM

    更新日期:2001-07-01 00:00:00

  • Roborovskin, a lipocalin in the urine of the Roborovski hamster, Phodopus roborovskii.

    abstract::Many rodents are now known to exhibit an obligate proteinuria that delivers urine-mediated chemosignals. In this paper, we explore the urinary proteins of the Roborovski hamster (Phodopus roborovskii). Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of urine from individual male and female Roborovsk...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjq060

    authors: Turton MJ,Robertson DH,Smith JR,Hurst JL,Beynon RJ

    更新日期:2010-10-01 00:00:00

  • Odor-evoked autobiographical memories: age and gender differences along the life span.

    abstract::Odors are powerful in bringing back old and vivid memories bearing emotional content. This inherent hedonic property of olfactory stimuli makes this sensory modality particularly suitable for studying autobiographical memory. In the present work, adolescents (first experiment), young adults (second experiment), and el...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjr089

    authors: Zucco GM,Aiello L,Turuani L,Köster E

    更新日期:2012-02-01 00:00:00

  • CRISPR/Cas 9-Mediated Mutations as a New Tool for Studying Taste in Honeybees.

    abstract::Honeybees rely on nectar as their main source of carbohydrates. Sucrose, glucose, and fructose are the main components of plant nectars. Intriguingly, honeybees express only 3 putative sugar receptors (AmGr1, AmGr2, and AmGr3), which is in stark contrast to many other insects and vertebrates. The sugar receptors are o...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjaa063

    authors: Değirmenci L,Geiger D,Rogé Ferreira FL,Keller A,Krischke B,Beye M,Steffan-Dewenter I,Scheiner R

    更新日期:2020-11-07 00:00:00

  • The impact of olfactory disorders in the United kingdom.

    abstract::Olfactory disorders are believed to affect 5% of the general population and have been shown to bear significant psychosocial consequences to sufferers. Although more common than blindness and profound deafness in the United Kingdom, the impact of these disorders has not been assessed to date and the plight of British ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bju043

    authors: Philpott CM,Boak D

    更新日期:2014-10-01 00:00:00

  • Interactions of odorants with olfactory receptors and other preprocessing mechanisms: how complex and difficult to predict?

    abstract::In this issue of Chemical Senses, Münch et al. present a thorough analysis of how mixtures of odorants interact with olfactory receptors (ORs) borne by olfactory receptor neurons (ORNs). Using fruit fly ORNs expressing the receptor OR22a, they provide a clear example of mixture interaction and confirm that the respons...

    journal_title:Chemical senses

    pub_type: 评论,杂志文章

    doi:10.1093/chemse/bjt004

    authors: Rospars JP

    更新日期:2013-05-01 00:00:00