Honing in on the ATP Release Channel in Taste Cells.

Abstract:

:Studies over the last 8 years have identified 3 potential channels that appear to release ATP from Type II cells in response to taste stimuli. These studies have taken different methodological approaches but have all provided data supporting their candidate channel as the ATP release channel. These potential channels include Pannexin 1, Connexins (30 and/or 43), and most recently, the Calhm1 channel. Two papers in this issue of Chemical Senses provide compelling new evidence that Pannexin 1 is not the ATP release channel. Tordoff et al. did a thorough behavioral analysis of the Pannexin1 knock out mouse and found that these animals have the same behavioral responses as wild type mice for 7 different taste stimuli that were tested. Vandenbeuch et al. presented an equally thorough analysis of the gustatory nerve responses in the Pannexin1 knock out mouse and found no differences compared with controls. Thus when the role of Pannexin 1 is analyzed at the systems level, it is not required for normal taste perception. Further studies are needed to determine the role of this hemichannel in taste cells.

journal_name

Chem Senses

journal_title

Chemical senses

authors

Medler KF

doi

10.1093/chemse/bjv035

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

449-51

issue

7

eissn

0379-864X

issn

1464-3553

pii

bjv035

journal_volume

40

pub_type

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