Abstract:
:Parasympathetic nerve (PSN) innervates taste cells of the frog taste disk, and electrical stimulation of PSN elicited a slow hyperpolarizing potential (HP) in taste cells. Here we report that gustatory receptor potentials in frog taste cells are depressed by PSN-induced slow HPs. When PSN was stimulated at 30 Hz during generation of taste cell responses, the large amplitude of depolarizing receptor potential for 1 M NaCl and 1 mM acetic acid was depressed by approximately 40% by slow HPs, but the small amplitude of the depolarizing receptor potential for 10 mM quinine-HCl (Q-HCl) and 1 M sucrose was completely depressed by slow HPs and furthermore changed to the hyperpolarizing direction. The duration of the depolarizing receptor potentials depressed by slow HPs prolonged with increasing period of PSN stimulation. As tastant-induced depolarizing receptor potentials were increased, the amplitude of PSN-induced slow HPs inhibiting the receptor potentials gradually decreased. The mean reversal potentials of the slow HPs were approximately -1 mV under NaCl and acetic acid stimulations, but approximately -14 mV under Q-HCl and sucrose stimulations. This implies that when a slow HP was evoked on the same amplitude of depolarizing receptor potentials, the depression of the NaCl and acetic acid responses in taste cells was larger than that of Q-HCl and sucrose responses. It is concluded that slow HP-induced depression of gustatory depolarizing receptor potentials derives from the interaction between gustatory receptor current and slow hyperpolarizing current in frog taste cells and that the interaction is stronger for NaCl and acetic acid stimulations than for Q-HCl and sucrose stimulations.
journal_name
Chem Sensesjournal_title
Chemical sensesauthors
Sato T,Nishishita K,Mineda T,Okada Y,Toda Kdoi
10.1093/chemse/bjl028subject
Has Abstractpub_date
2007-01-01 00:00:00pages
3-10issue
1eissn
0379-864Xissn
1464-3553pii
bjl028journal_volume
32pub_type
杂志文章相关文献
CHEMICAL SENSES文献大全abstract::The perception of sweetness and flavour were studied in viscous solutions containing 50 g/l sucrose, 100 p.p.m. iso-amyl acetate and varying concentrations of three hydrocolloid thickeners (guar gum, lambda-carrageenan and hydroxypropylmethyl cellulose). Zero-shear viscosity of the samples ranged from 1 to 5000 mPas. ...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/28.1.11
更新日期:2003-01-01 00:00:00
abstract::A list of 147 tetralin- and indan-like compounds was compiled from the literature for investigating the relationship between molecular structure and musk odor. Each compound in the data set was represented by 374 CODESSA and 970 TAE descriptors. A genetic algorithm (GA) for pattern recognition analysis was used to id...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjs058
更新日期:2012-10-01 00:00:00
abstract::Odors are inherently ambiguous and therefore susceptible to redundant sensory as well as context information. The identification of an odor object relies largely on visual input. Thus far, it is unclear whether visual and olfactory stimuli are indeed integrated at an early perceptual stage and which role the congruenc...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjy018
更新日期:2018-05-23 00:00:00
abstract::Olfactory discrimination of amino acids was investigated in brown bullhead catfish (Ameiurus nebulosus). Based on the magnitude of the observed food search activity of catfish conditioned to single amino acids, the tested compounds were classified as being detected by the catfish as equal to, similar to, or different ...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/25.1.21
更新日期:2000-02-01 00:00:00
abstract::Individual recognition has been studied across a number of taxa and modalities; however, few attempts have been made to combine chemical and biological approaches and arrive at a more complete understanding of the use of secretions as signals. We combined behavioral habituation experiments with gas chromatography-mass...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjr055
更新日期:2011-11-01 00:00:00
abstract::Sodium taste transduction is thought to occur via an amiloride-sensitive, sodium-selective pathway and an amiloride-insensitive, cation nonselective, anion-dependent pathway(s). It has been shown by others that amiloride, an epithelial sodium channel (ENaC) blocker, significantly reduces the chorda tympani nerve respo...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/28.5.447
更新日期:2003-06-01 00:00:00
abstract::When the glossopharyngeal (GP) nerve of the frog was stimulated electrically, electropositive slow potentials were recorded from the tongue surface and depolarizing slow potentials from taste cells in the fungiform papillae. The amplitude of the slow potentials was stimulus strength- and the frequency-dependent. Gener...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/25.5.583
更新日期:2000-10-01 00:00:00
abstract::Recent evidence has suggested that factors related to sensory perception may explain excess weight. The objective of this study was to consider multiple aspects while investigating the phenomenon of obesity. One goal was to compare taste acuity (taste threshold and density of fungiform papillae) in both normal weight ...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjv072
更新日期:2016-02-01 00:00:00
abstract::The central projections of olfactory receptor cells associated with two distinct types of antennal sensilla in the sphinx moth Manduca sexta were revealed by anterograde staining. In both sexes, receptor axons that arise from sexually isomorphic, type-II trichoid sensilla (and possibly some basiconic sensilla) project...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/20.3.313
更新日期:1995-06-01 00:00:00
abstract::Sight is undoubtedly not only important for food identification and selection but also for the modulation of gustatory sensitivity. We can, therefore, assume that taste sensitivity and eating habits are affected by visual deprivation from birth. We measured taste detection and identification thresholds of the 5 basic ...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjt021
更新日期:2013-07-01 00:00:00
abstract::The suitability of Beidler's mixture equation for mixtures of sucrose and maltitol as well as for mixtures of sucrose and aspartame was examined in the presence of an orange aroma. The mean scores for the attribute sweet remained constant for each combination of sucrose and maltitol and for each combination of sucrose...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/23.1.59
更新日期:1998-02-01 00:00:00
abstract::In this review we report data from freely breathing animals in an attempt to show how respiratory dynamics can influence bulbar and cortical activity. Relying on in vivo data as well as in vitro observations, we try to emphasize the multiple mechanisms that underlie this modulation, its multiple origins, and its possi...
journal_title:Chemical senses
pub_type: 杂志文章,评审
doi:10.1093/chemse/bjj010
更新日期:2006-02-01 00:00:00
abstract::Many rodents are now known to exhibit an obligate proteinuria that delivers urine-mediated chemosignals. In this paper, we explore the urinary proteins of the Roborovski hamster (Phodopus roborovskii). Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of urine from individual male and female Roborovsk...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjq060
更新日期:2010-10-01 00:00:00
abstract::Previous studies have reported that the umami taste of monosodium l-glutamate (MSG) and salty-smelling odors (e.g., soy sauce, bacon, sardines) enhance the perception of saltiness. This study aimed to investigate the neural basis of the enhancement of saltiness in human participants using functional near-infrared spec...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjx084
更新日期:2018-02-26 00:00:00
abstract::Olfactory disorders are believed to affect 5% of the general population and have been shown to bear significant psychosocial consequences to sufferers. Although more common than blindness and profound deafness in the United Kingdom, the impact of these disorders has not been assessed to date and the plight of British ...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bju043
更新日期:2014-10-01 00:00:00
abstract::It was recently shown that in some subjects capsaicin can evoke bitterness as well as burning and stinging, particularly in the circumvallate (CV) region of the tongue. Because perception of bitterness from capsaicin is characterized by large individual differences, the main goal of the present study was to learn whet...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjh005
更新日期:2004-01-01 00:00:00
abstract::The sense of smell deteriorates in normal aging, but the underling mechanisms are still elusive. Here we investigated age-related alterations in expression patterns of odorant receptor (OR) genes and functional properties of olfactory sensory neurons (OSNs)-2 critical factors that define the odor detection threshold i...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjp056
更新日期:2009-10-01 00:00:00
abstract::The aim of this investigation was to compare olfactory functions of patients suffering from Parkinson's disease (PD) and Alzheimer's disease (AD). Olfactory threshold, odor identification ability and odor memory performance were assessed in 21 non-demented PD patients and in 22 AD patients. Both patient groups were im...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/22.1.105
更新日期:1997-02-01 00:00:00
abstract::Previous studies on taste acceptance have been conducted taste-by-taste and with a cross-sectional design. The aim of this study was to longitudinally evaluate the acceptance of sweet, salty, bitter, sour and umami solutions, and a fat emulsion comparatively in a birth cohort from 3 to 20 months old. The acceptance of...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjx040
更新日期:2017-09-01 00:00:00
abstract::Evidence suggests that women outperform men in core aspects of odor perception, and sex hormones may play a significant role in moderating this effect. The gender-affirming treatment (GAT) of transgender persons constitutes a powerful natural experiment to study the psychological and behavioral effects of high dosages...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjz069
更新日期:2020-01-01 00:00:00
abstract::We previously reported that stressed male Wistar rats released alarm pheromone from the perianal region, which aggravated stress-induced hyperthermia and increased Fos expression in the mitral/tufted cell layer of the accessory olfactory bulb in recipient rats. In this study, we attempted to obtain this pheromone in w...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bji044
更新日期:2005-07-01 00:00:00
abstract::This study determined taste thresholds for copper as its speciation was varied among free cupric ion, complexed cupric ion, and precipitated cupric particles. The impact of copper chemistry on taste is important as copper is added to many beverages and can be present in drinking water as a natural mineral or due to co...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjl010
更新日期:2006-09-01 00:00:00
abstract::We have developed a strategy for the rapid high-throughput screening of odor responsivity in genetically altered mice (in fact, any experimentally altered animal). Specifically, the report presents the development and validation of a fully automated procedure based on the evaluation of an animal's stimulus-induced ref...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bji017
更新日期:2005-03-01 00:00:00
abstract::Restriction of dietary sodium during gestation has major effects on taste function and anatomy in the offspring. The chorda tympani nerve of offspring that are maintained on sodium-reduced chow throughout life (NaDep) has reduced neurophysiological responses to sodium and altered morphology of its terminal field in th...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/25.6.719
更新日期:2000-12-01 00:00:00
abstract::It is difficult to determine the reason why a patient complains of a bitter taste when their mouth is empty. We examined a new diagnostic test using a bitterness masking substance. The bitterness masking substance, 'Benecoat BMI-60' (hereafter BMI-60), is a masking substance specific to the taste cells' bitterness rec...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/26.1.91
更新日期:2001-01-01 00:00:00
abstract::The septal organ of Masera (SO) is a small, isolated patch of olfactory epithelium, located in the ventral part of the nasal septum. We investigated in this systematic study the postnatal development of the SO in histological sections of rats at various ages from the day of birth (P1) to P666. The SO-area increases to...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjg047
更新日期:2003-09-01 00:00:00
abstract::Cnidarians are the simplest metazoans to exhibit satiety after feeding. When hydra are fed to repletion, they close their mouths and cease to capture prey. As feeding stops, contractions of the tentacles and body column increase. Our earlier experiments showed that a gel chromatographic fraction of prey substances inh...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/21.3.313
更新日期:1996-06-01 00:00:00
abstract::In this study, 40 Japanese, 44 German and 39 Mexican women were presented with 18 everyday odorants. They were asked to rate them for intensity on a six-point scale from not detectable to very strong, for pleasantness on an 11-point scale from -5, to neutral at 0, to +5, and for familiarity on a six-point scale from c...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/24.2.191
更新日期:1999-04-01 00:00:00
abstract::Organotypic cultures of the mouse olfactory epithelium connected to the olfactory bulb were obtained with the roller tube technique from postnatal mice aged between 13 and 66 days. To test the functionality of the cultures, we measured electroolfactograms (EOGs) at different days in vitro (DIV), up to 7 DIV, and we co...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjn007
更新日期:2008-04-01 00:00:00
abstract::The prevalence of obesity and obesity-related disorders such as type 2 diabetes (T2D) and metabolic syndrome has increased significantly in the past decades, reaching epidemic levels and therefore becoming a major health issue worldwide. Chronic overeating of highly palatable foods is one of the main responsible aspec...
journal_title:Chemical senses
pub_type: 杂志文章,评审
doi:10.1093/chemse/bjx062
更新日期:2017-12-25 00:00:00