Probing the Impact of Gender-Affirming Hormone Treatment on Odor Perception.

Abstract:

:Evidence suggests that women outperform men in core aspects of odor perception, and sex hormones may play a significant role in moderating this effect. The gender-affirming treatment (GAT) of transgender persons constitutes a powerful natural experiment to study the psychological and behavioral effects of high dosages of cross-sex hormone applications. Therefore, our aim was to investigate the effects of GAT on odor perception in a sample of 131 participants including female and male controls, as well as transmen and transwomen over their first 4 months of gender transition. The Sniffin' Sticks test battery was used to measure odor detection, discrimination, and identification at baseline, as well as 1 and 4 months after the start of GAT. Plasma levels of estradiol, testosterone, and sex hormone-binding globulin were analyzed for each assessment point. Results revealed no significant change of olfactory performance in the two transgender groups compared with female and male controls. There was no significant difference between groups at baseline or any other time point. Neither biological sex, nor gender identity had an influence on odor perception. Moreover, there was no significant correlation between sex hormones and odor perception and between GAT-induced changes in sex hormones and changes in odor perception. Our results indicate that the effects of sex hormones on olfactory performance are subtle, if present at all. However, our results do not preclude hormonal effects on odors not included in the Sniffin' Sticks test battery, such as body odors or odors associated with sex.

journal_name

Chem Senses

journal_title

Chemical senses

authors

Kranz GS,Kaufmann U,Lanzenberger R

doi

10.1093/chemse/bjz069

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

37-44

issue

1

eissn

0379-864X

issn

1464-3553

pii

5602474

journal_volume

45

pub_type

杂志文章
  • Electrophysiological properties of frog olfactory supporting cells.

    abstract::Cells, identified as supporting cells by Lucifer Yellow injection, were recorded from slices of frog olfactory epithelium using patch-clamp recordings. Cell-attached single-channel recordings indicated that the intracellular potential (IP) was -68 +/- 7 mV (n = 22) with 4 mM K+ in the bath ([K+]o). IP was -67 +/- 4 mV...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/23.3.363

    authors: Trotier D

    更新日期:1998-06-01 00:00:00

  • Changes in Olfactory Sensory Neuron Physiology and Olfactory Perceptual Learning After Odorant Exposure in Adult Mice.

    abstract::The adult olfactory system undergoes experience-dependent plasticity to adapt to the olfactory environment. This plasticity may be accompanied by perceptual changes, including improved olfactory discrimination. Here, we assessed experience-dependent changes in the perception of a homologous aldehyde pair by testing mi...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjv065

    authors: Kass MD,Guang SA,Moberly AH,McGann JP

    更新日期:2016-02-01 00:00:00

  • Olfactory cocainization is not an effective long-term treatment for phantosmia.

    abstract::Phantosmia, the perception of an odor when there are no odorants in the environment, can be a very debilitating symptom. In the 1960s, Zilstorff reported olfactory distortions could be treated by the topical application of a cocaine solution to the olfactory epithelium. In evaluating this treatment, we observed no lon...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjt047

    authors: Leopold DA,Hornung DE

    更新日期:2013-11-01 00:00:00

  • Structural role of the terminal disulfide bond in the sweetness of brazzein.

    abstract::Brazzein, a 54 residue sweet-tasting protein, is thought to participate in a multipoint binding interaction with the sweet taste receptor. Proposed sites for interaction with the receptor include 2 surface loops and the disulfide bond that connects the N- and C-termini. However, the importance of each site is not well...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjr057

    authors: Dittli SM,Rao H,Tonelli M,Quijada J,Markley JL,Max M,Assadi-Porter F,Maillet E

    更新日期:2011-11-01 00:00:00

  • Chemoreceptive control of feeding processes in hydra.

    abstract::Cnidarians are the simplest metazoans to exhibit satiety after feeding. When hydra are fed to repletion, they close their mouths and cease to capture prey. As feeding stops, contractions of the tentacles and body column increase. Our earlier experiments showed that a gel chromatographic fraction of prey substances inh...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/21.3.313

    authors: Grosvenor W,Rhoads DE,Kass-Simon G

    更新日期:1996-06-01 00:00:00

  • Asymmetrical Processing of Olfactory Input in the Piriform Cortex Mediates "Activation" of the Avian Navigation Circuitry.

    abstract::The role of odors in the long-distance navigation of birds has elicited intense debate for more than half a century. Failure to resolve many of the issues fueling this debate is due at least in part to the absence of controls for a variety of non-specific effects that odors have on the navigational process. The presen...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjw084

    authors: Jorge PE,Marques PAM,Pinto BV,Phillips JB

    更新日期:2016-11-01 00:00:00

  • Food perception with age and its relationship to pleasantness.

    abstract::Differences between elderly subjects (n = 46, 61-86 years) and young subjects (n = 36, 18-25 years) in food perception and food liking were investigated. Intensity and liking ratings were assessed for custard dessert, in which flavor enrichment, textural change, and irritant addition were incorporated as strategies to...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjm028

    authors: Kremer S,Bult JH,Mojet J,Kroeze JH

    更新日期:2007-07-01 00:00:00

  • Chemosensory cross-modal stroop effects: congruent odors facilitate taste identification.

    abstract::In order to explore the cross-modal cognitive associations between smell and taste, a chemosensory analogue of the Stroop task (Stroop 1935) was developed. Fourteen participants were presented with an odorant and a tastant and asked to identify the tastant as "sweet" or "sour" by pressing 1 of 2 buttons as quickly as ...

    journal_title:Chemical senses

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/chemse/bjm001

    authors: White TL,Prescott J

    更新日期:2007-05-01 00:00:00

  • Expression of trace amine-associated receptors in the Grueneberg ganglion.

    abstract::The Grueneberg ganglion (GG) in the vestibule of the anterior nasal cavity is considered as an olfactory subcompartment based on expression of the olfactory marker protein (OMP) and axonal projection to the olfactory bulb. Searching for olfactory receptors present in the GG, it has been observed recently that V2r83, a...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjm032

    authors: Fleischer J,Schwarzenbacher K,Breer H

    更新日期:2007-07-01 00:00:00

  • Differential inputs from chemosensory appendages mediate feeding responses to glucose in wild-type and glucose-averse German cockroaches, Blattella germanica.

    abstract::Glucose is a universal phagostimulant in many animal species, including the cockroach Blattella germanica. However, some natural populations of B. germanica have been found that are behaviorally deterred from eating glucose. In dose-response studies, glucose was a powerful phagostimulant for wild-type cockroaches, but...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjr023

    authors: Wada-Katsumata A,Silverman J,Schal C

    更新日期:2011-09-01 00:00:00

  • Taste sensitivity and aging: high incidence of decline revealed by repeated threshold measures.

    abstract::Contrary to what has often been said about the subject, decline in taste sensitivity with aging characterizes virtually everybody and is not the artificial result of averaging large losses of a minority with negligible losses of a majority. This assertion is supported by six repeated measures of sucrose thresholds in ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/20.4.451

    authors: Stevens JC,Cruz LA,Hoffman JM,Patterson MQ

    更新日期:1995-08-01 00:00:00

  • Selective inhibition of sweetness by the sodium salt of +/-2-(4-methoxyphenoxy)propanoic acid.

    abstract::The purpose of this study was to determine the degree to which the sodium salt of +/-2-(4-methoxyphenoxy)propanoic acid (Na-PMP) reduced sweet intensity ratings of 15 sweeteners in mixtures. Na-PMP has been approved for use in confectionary/frostings, soft candy and snack products in the USA at concentrations up to 15...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/24.4.439

    authors: Schiffman SS,Booth BJ,Sattely-Miller EA,Graham BG,Gibes KM

    更新日期:1999-08-01 00:00:00

  • A metamemory perspective on odor naming and identification.

    abstract::A metacognitive perspective is utilized to elucidate why it is so difficult to name common odors and what characterizes the subjective knowledge people have about their actual odor knowledge. Odor-naming failures are often accompanied by strong feelings of knowing (FOK) or feelings of imminent retrieval of what it is ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bji030

    authors: Jönsson FU,Tchekhova A,Lönner P,Olsson MJ

    更新日期:2005-05-01 00:00:00

  • Male but not female olfaction is crucial for intermolt mating in European lobsters (Homarus gammarus L.).

    abstract::Chemical signals are common in most crustacean social interactions and are often perceived via chemosensory (olfactory) organs on the first antenna. Intermolt courtship behaviors and mating were investigated in size-matched pairs of intermolt European lobsters (Homarus gammarus) where the olfactory receptors of either...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjn073

    authors: Skog M

    更新日期:2009-02-01 00:00:00

  • Distracted Sniffing of Food Odors Leads to Diminished Behavioral and Neural Responses.

    abstract::Eating under distracted conditions such as viewing television is associated with overeating and weight gain. Following evidence from earlier findings, in this issue Hoffman-Hensel et al. report a study in which they investigated the influence of distraction on intensity perception of low and high caloric food odors an...

    journal_title:Chemical senses

    pub_type: 评论,杂志文章

    doi:10.1093/chemse/bjx060

    authors: Veldhuizen MG

    更新日期:2017-10-31 00:00:00

  • Detection of tastes in mixture with other tastes: issues of masking and aging.

    abstract::When one taste (masker) is strong enough, it can completely mask another task (target) of different quality. How strong the masker must be to do this depends on how strong the target is. As the target concentration is increased, the masking concentration must be increased, too, but in ever-increasing proportion. To qu...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/21.2.211

    authors: Stevens JC

    更新日期:1996-04-01 00:00:00

  • Taste solution preferences of C57BL/6J and 129X1/SvJ mice: influence of age, sex, and diet.

    abstract::To examine whether age influences taste solution preferences, we measured taste preferences of C57BL/6J and 129X1/SvJ mice given a series of 48-h 2-bottle tests with a choice between water and one of the following taste solutions: 2 mM saccharin, 5 mM citric acid, 30 microM quinine hydrochloride, 75 mM sodium chloride...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjm034

    authors: Tordoff MG

    更新日期:2007-09-01 00:00:00

  • Individual differences in sour and salt sensitivity: detection and quality recognition thresholds for citric acid and sodium chloride.

    abstract::Taste sensitivity is assessed with various techniques, including absolute detection and quality recognition. For any stimulus, one might expect individual differences in sensitivity to be reflected in all measures, but they are often surprisingly independent. Here, we focus on sensitivity to sour and salty taste, in p...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjt003

    authors: Wise PM,Breslin PA

    更新日期:2013-05-01 00:00:00

  • Temporal integration in nasal lateralization and nasal detection of carbon dioxide.

    abstract::Two experiments examined time/concentration trading for the detection of carbon dioxide, an irritant with little or no odor. Experiment 1 employed the nasal lateralization method: subjects attempted to determine which nostril received carbon dioxide and which received pure air when presented simultaneously. Experiment...

    journal_title:Chemical senses

    pub_type: 临床试验,杂志文章

    doi:10.1093/chemse/bjh018

    authors: Wise PM,Radil T,Wysocki CJ

    更新日期:2004-02-01 00:00:00

  • Sensory evaluation of mixtures of maltitol or aspartame, sucrose and an orange aroma.

    abstract::The suitability of Beidler's mixture equation for mixtures of sucrose and maltitol as well as for mixtures of sucrose and aspartame was examined in the presence of an orange aroma. The mean scores for the attribute sweet remained constant for each combination of sucrose and maltitol and for each combination of sucrose...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/23.1.59

    authors: Nahon DF,Roozen JP,de Graaf C

    更新日期:1998-02-01 00:00:00

  • Visual-Olfactory Interactions: Bimodal Facilitation and Impact on the Subjective Experience.

    abstract::Odors are inherently ambiguous and therefore susceptible to redundant sensory as well as context information. The identification of an odor object relies largely on visual input. Thus far, it is unclear whether visual and olfactory stimuli are indeed integrated at an early perceptual stage and which role the congruenc...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjy018

    authors: Amsellem S,Höchenberger R,Ohla K

    更新日期:2018-05-23 00:00:00

  • A model of the role of adaptation and disadaptation in olfactory receptor neurons: implications for the coding of temporal and intensity patterns in odor signals.

    abstract::Natural odors occur as turbulent plumes resulting in spatially and temporally variable odor signals at the chemoreceptor cells. Concentrations can fluctuate widely within discrete packets of odor and individual packets are very intermittent and unpredictable. Chemoreceptor cells display the temporally dynamic properti...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/19.1.71

    authors: Moore PA

    更新日期:1994-02-01 00:00:00

  • Odor-evoked autobiographical memories: age and gender differences along the life span.

    abstract::Odors are powerful in bringing back old and vivid memories bearing emotional content. This inherent hedonic property of olfactory stimuli makes this sensory modality particularly suitable for studying autobiographical memory. In the present work, adolescents (first experiment), young adults (second experiment), and el...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjr089

    authors: Zucco GM,Aiello L,Turuani L,Köster E

    更新日期:2012-02-01 00:00:00

  • Olfactory Coding in Antennal Neurons of the Malaria Mosquito, Anopheles gambiae.

    abstract::Olfactory receptor neurons (ORNs) in the antenna of insects serve to encode odors in action potential activity conducted to the olfactory lobe of the deuterocerebrum. We performed an analysis of the electrophysiological responses of olfactory neurons in the antennae of the female malaria mosquito Anopheles gambiae s.s...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjl027

    authors: Qiu YT,van Loon JJ,Takken W,Meijerink J,Smid HM

    更新日期:2006-11-01 00:00:00

  • Understanding creaminess perception of dairy products using free-choice profiling and genetic responsivity to 6-n-propylthiouracil.

    abstract::Flavor and texture contribute to the perception of creaminess in dairy products, but the nature of this interaction is not well understood. Previous studies on the genetic ability to perceive the bitter compound 6-n-propylthiouracil (PROP) reveal the existence of individual differences in creaminess perception. The ob...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/28.6.527

    authors: Kirkmeyer SV,Tepper BJ

    更新日期:2003-07-01 00:00:00

  • Porcine VEG proteins and tear prealbumins.

    abstract::Small soluble proteins, belonging to the lipocalin family are secreted in large amounts by tongue von Ebner's glands and lachrymal glands. In humans, the lingual protein, called VEG, and the lachrymal protein, called tear prealbumin, have shown identical cDNA sequences. In the pig, we have purified homodimeric protein...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/20.1.69

    authors: Garibotti M,Christiansen H,Schmale H,Pelosi P

    更新日期:1995-02-01 00:00:00

  • Human odor detectability: new methodology used to determine threshold and variation.

    abstract::Current ambiguity concerning the related issues of optimal means for measurement of odor sensitivity and the functional properties of the olfactory system hinders progress in basic and applied research on the human sense of smell. To address these needs, we selected n-amyl acetate (nAA) as a test odorant and developed...

    journal_title:Chemical senses

    pub_type: 临床试验,杂志文章

    doi:10.1093/chemse/bjg075

    authors: Walker JC,Hall SB,Walker DB,Kendal-Reed MS,Hood AF,Niu XF

    更新日期:2003-11-01 00:00:00

  • Metabolic and Sensory Influences on Odor Sensitivity in Humans.

    abstract::Our olfactory sense plays an important role in eating behavior by modulating our food preferences and intake. However, hunger or satiety may also influence how we perceive odors. Albeit speculative, contradictory results found in the past may have resulted from confounding by type of meal that participants ate to indu...

    journal_title:Chemical senses

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/chemse/bjv068

    authors: Ramaekers MG,Verhoef A,Gort G,Luning PA,Boesveldt S

    更新日期:2016-02-01 00:00:00

  • Understanding the regulation and function of adult neurogenesis: contribution from an insect model, the house cricket.

    abstract::Since the discovery of adult neurogenesis, a major issue is the role of newborn neurons and the function-dependent regulation of adult neurogenesis. We decided to use an animal model with a relatively simple brain to address these questions. In the adult cricket brain as in mammals, new neurons are produced throughout...

    journal_title:Chemical senses

    pub_type: 杂志文章,评审

    doi:10.1093/chemse/bjm010

    authors: Cayre M,Scotto-Lomassese S,Malaterre J,Strambi C,Strambi A

    更新日期:2007-05-01 00:00:00

  • Decoding Odor Mixtures in the Dog Brain: An Awake fMRI Study.

    abstract::In working and practical contexts, dogs rely upon their ability to discriminate a target odor from distracting odors and other sensory stimuli. Using awake functional magnetic resonance imaging (fMRI) in 18 dogs, we examined the neural mechanisms underlying odor discrimination between 2 odors and a mixture of the odor...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjaa068

    authors: Prichard A,Chhibber R,King J,Athanassiades K,Spivak M,Berns GS

    更新日期:2020-12-05 00:00:00