Olfactory cocainization is not an effective long-term treatment for phantosmia.

Abstract:

:Phantosmia, the perception of an odor when there are no odorants in the environment, can be a very debilitating symptom. In the 1960s, Zilstorff reported olfactory distortions could be treated by the topical application of a cocaine solution to the olfactory epithelium. In evaluating this treatment, we observed no long-term benefit using cocaine on 6 patients with phantosmia. Based on our observations, the patient's olfactory ability was not a determining factor in the initiation or quality of their phantosmia. Following topical cocainization, we observed a remarkable delay of hours to days in the return of olfactory ability, and when cocaine was applied to only 1 nostril, there was a decreased olfactory ability on the noncocainized side. These results may suggest the possibility that phantosmia is related to a central processing problem.

journal_name

Chem Senses

journal_title

Chemical senses

authors

Leopold DA,Hornung DE

doi

10.1093/chemse/bjt047

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

803-6

issue

9

eissn

0379-864X

issn

1464-3553

pii

bjt047

journal_volume

38

pub_type

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