Abstract:
:Phantosmia, the perception of an odor when there are no odorants in the environment, can be a very debilitating symptom. In the 1960s, Zilstorff reported olfactory distortions could be treated by the topical application of a cocaine solution to the olfactory epithelium. In evaluating this treatment, we observed no long-term benefit using cocaine on 6 patients with phantosmia. Based on our observations, the patient's olfactory ability was not a determining factor in the initiation or quality of their phantosmia. Following topical cocainization, we observed a remarkable delay of hours to days in the return of olfactory ability, and when cocaine was applied to only 1 nostril, there was a decreased olfactory ability on the noncocainized side. These results may suggest the possibility that phantosmia is related to a central processing problem.
journal_name
Chem Sensesjournal_title
Chemical sensesauthors
Leopold DA,Hornung DEdoi
10.1093/chemse/bjt047subject
Has Abstractpub_date
2013-11-01 00:00:00pages
803-6issue
9eissn
0379-864Xissn
1464-3553pii
bjt047journal_volume
38pub_type
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