Expression and purification of functional ligand-binding domains of T1R3 taste receptors.

abstract：:In working and practical contexts, dogs rely upon their ability to discriminate a target odor from distracting odors and other sensory stimuli. Using awake functional magnetic resonance imaging (fMRI) in 18 dogs, we examined the neural mechanisms underlying odor discrimination between 2 odors and a mixture of the odor...

journal_title：Chemical senses

authors： Prichard A,Chhibber R,King J,Athanassiades K,Spivak M,Berns GS

更新日期：2020-12-05 00:00:00

abstract：:Olfactory lamellae of teleosts contain two morphologically different types of olfactory receptor neurons (ORNs): ciliated ORNs (cORNs) and microvillous ORNs (mORNs). However, little is known about the functional difference between these two types of ORNs in fish olfaction. We isolated cORNs and mORNs using a Ca(2+)-fr...

journal_title：Chemical senses

authors： Sato K,Suzuki N

更新日期：2001-11-01 00:00:00

abstract：:When one taste (masker) is strong enough, it can completely mask another task (target) of different quality. How strong the masker must be to do this depends on how strong the target is. As the target concentration is increased, the masking concentration must be increased, too, but in ever-increasing proportion. To qu...

journal_title：Chemical senses

authors： Stevens JC

更新日期：1996-04-01 00:00:00

abstract：:Ten SW.B6 SOA nontaster strains congenic with the SWR/J SOA taster inbred strain were bred via repeated backcross-intercross cycles, with selection for nontasting in each cycle. Preference ratio distributions and phenotypic proportions across cycles at 0.1 mM SOA were consistent with monogenic predictions. The SW.B6 m...

journal_title：Chemical senses

authors： Harder DB,Gannon KS,Whitney G

更新日期：1996-10-01 00:00:00

abstract：:Experience is an essential factor informing food choice. Eating food generates enduring odor-taste associations that link an odor with a taste's quality and hedonic value (pleasantness/unpleasantness) and creates the perception of a congruent odor-taste combination. Previous human psychophysical experiments demonstrat...

journal_title：Chemical senses

authors： McQueen KA,Fredericksen KE,Samuelsen CL

更新日期：2020-05-29 00:00:00

abstract：:To examine whether age influences taste solution preferences, we measured taste preferences of C57BL/6J and 129X1/SvJ mice given a series of 48-h 2-bottle tests with a choice between water and one of the following taste solutions: 2 mM saccharin, 5 mM citric acid, 30 microM quinine hydrochloride, 75 mM sodium chloride...

journal_title：Chemical senses

authors： Tordoff MG

更新日期：2007-09-01 00:00:00

abstract：:Natural odors occur as turbulent plumes resulting in spatially and temporally variable odor signals at the chemoreceptor cells. Concentrations can fluctuate widely within discrete packets of odor and individual packets are very intermittent and unpredictable. Chemoreceptor cells display the temporally dynamic properti...

journal_title：Chemical senses

authors： Moore PA

更新日期：1994-02-01 00:00:00

abstract：:Suppression of the saltiness of NaCl solutions by amiloride, a sodium channel blocker, has previously been reported a number of times in humans. This suppression was seen with techniques that involved stimulation of small areas of the tongue. It was not certain, however, whether amiloride would suppress saltiness with...

journal_title：Chemical senses

authors： Tennissen AM,McCutcheon NB

更新日期：1996-04-01 00:00:00

abstract：:Our study was designed to examine how components of complex mixtures can inhibit the binding of other components to receptor sites in the olfactory system of the spiny lobster Panulirus argus. Biochemical binding assays were used to study how two- to six-component mixtures inhibit binding of the radiolabeled odorants ...

journal_title：Chemical senses

authors： Gentilcore LR,Derby CD

更新日期：1998-06-01 00:00:00

abstract：:Glucose is a universal phagostimulant in many animal species, including the cockroach Blattella germanica. However, some natural populations of B. germanica have been found that are behaviorally deterred from eating glucose. In dose-response studies, glucose was a powerful phagostimulant for wild-type cockroaches, but...

journal_title：Chemical senses

authors： Wada-Katsumata A,Silverman J,Schal C

更新日期：2011-09-01 00:00:00

abstract：:Laboratory rats and mice prefer some concentrations of tri- and tetrasodium pyrophosphate (Na3HP2O7 and Na4P2O7) to water, but how they detect pyrophosphates is unknown. Here, we assessed whether T1R3 is involved. We found that relative to wild-type littermate controls, Tas1r3 knockout mice had stronger preferences fo...

journal_title：Chemical senses

authors： Tordoff MG,Aleman TR,McCaughey SA

更新日期：2015-01-01 00:00:00

abstract：:Taste perception is important for animals to take adequate nutrients and avoid toxins for their survival. Appetitive and aversive behaviors are produced by value evaluation of taste and taste expectation caused by other sensations. The value evaluation, coupled with a cue presentation, produces outcome expectation and...

journal_title：Chemical senses

authors： Takei K,Fujita K,Kashimori Y

更新日期：2020-01-01 00:00:00

abstract：:Electrical stimulation of the frog glossopharyngeal (GP) nerve evoked slow hyperpolarizing potentials (HPs) in taste cells. This study aimed to clarify whether slow HPs were postsynaptically induced in taste cells. The slow HPs were recorded intracellularly with a microelectrode. When Ca2+ concentration in the blood p...

journal_title：Chemical senses

authors： Sato T,Okada Y,Toda K

更新日期：2004-10-01 00:00:00

abstract：:To assess the feasibility of using odors as a potential mechanism for treating sleep apnea, we set out to test the hypothesis that odorants delivered during sleep would modify respiratory patterns without inducing arousal or wake in healthy sleepers. We used 2 mildly trigeminal odorants: the pleasant lavender and unpl...

journal_title：Chemical senses

authors： Arzi A,Sela L,Green A,Givaty G,Dagan Y,Sobel N

更新日期：2010-01-01 00:00:00

abstract：:Anosmia affects the western world population, mostly the elderly, reaching to 5% in subjects over the age of 45 years and strongly lowering their quality of life. A smaller minority (about 0.01%) is born without a sense of smell, afflicted with congenital general anosmia (CGA). No causative genes for human CGA have be...

journal_title：Chemical senses

authors： Feldmesser E,Bercovich D,Avidan N,Halbertal S,Haim L,Gross-Isseroff R,Goshen S,Lancet D

更新日期：2007-01-01 00:00:00

abstract：:Studying olfaction with functional magnetic resonance imaging (fMRI) poses various methodological challenges. This study aimed to investigate the effects of stimulation length and repetition time (TR) on the activation pattern of 4 olfactory brain regions: the anterior and the posterior piriform cortex, the orbitofron...

journal_title：Chemical senses

authors： Georgiopoulos C,Witt ST,Haller S,Dizdar N,Zachrisson H,Engström M,Larsson EM

更新日期：2018-07-05 00:00:00

abstract：:Aiming to unravel interspecific differences in olfactory preferences, we performed comparative studies of odor valence in flies, mice, and humans. Our analysis suggests a model where flies and mice share similar olfactory preferences, but neither species share odor preferences with humans. This model contrasts with a ...

journal_title：Chemical senses

authors： Manoel D,Makhlouf M,Scialdone A,Saraiva LR

更新日期：2019-01-01 00:00:00

abstract：:Olfactory discrimination of amino acids was investigated in brown bullhead catfish (Ameiurus nebulosus). Based on the magnitude of the observed food search activity of catfish conditioned to single amino acids, the tested compounds were classified as being detected by the catfish as equal to, similar to, or different ...

journal_title：Chemical senses

authors： Valentincic T,Metelko J,Ota D,Pirc V,Blejec A

更新日期：2000-02-01 00:00:00

abstract：:When people misidentify everyday odors, as they often do, their errors may conceivably lie in faulty perceptions or in faulty access to the names. Discussions of the matter usually focus on the latter, as if people had no problems with perceptual accuracy. (The problem of faulty access may get attention because its hi...

journal_title：Chemical senses

authors： Cain WS,Potts BC

更新日期：1996-02-01 00:00:00

abstract：:Odor and lateralization (irritation) thresholds (LTs) for ammonia vapor were measured using static and dynamic olfactometry. The purpose of the study was to explore the test-retest reliability and comparability of dynamic olfactometry methodology, generally used to determine odor thresholds following European Committe...

journal_title：Chemical senses

authors： Smeets MA,Bulsing PJ,van Rooden S,Steinmann R,de Ru JA,Ogink NW,van Thriel C,Dalton PH

更新日期：2007-01-01 00:00:00

abstract：:Brazzein, a 54 residue sweet-tasting protein, is thought to participate in a multipoint binding interaction with the sweet taste receptor. Proposed sites for interaction with the receptor include 2 surface loops and the disulfide bond that connects the N- and C-termini. However, the importance of each site is not well...

journal_title：Chemical senses

authors： Dittli SM,Rao H,Tonelli M,Quijada J,Markley JL,Max M,Assadi-Porter F,Maillet E

更新日期：2011-11-01 00:00:00

abstract：:Glutathione, a natural substance, acts on calcium receptors on the tongue and is known to enhance basic taste sensations. However, the effects of glutathione on brain activity associated with taste sensation on the tongue have not been determined under standardized taste delivery conditions. In this study, we investig...

journal_title：Chemical senses

authors： Goto TK,Yeung AW,Tanabe HC,Ito Y,Jung HS,Ninomiya Y

更新日期：2016-09-01 00:00:00

abstract：:Strong electrical stimulation (ES) of the frog glossopharyngeal (GP) efferent nerve induced slow depolarizing potentials (DPs) in taste cells under hypoxia. This study aimed to elucidate whether the slow DPs were postsynaptically induced in taste cells. After a block of parasympathetic nerve (PSN) ganglia by tubocurar...

journal_title：Chemical senses

authors： Sato T,Nishishita K,Okada Y,Toda K

更新日期：2007-05-01 00:00:00

abstract：:Individual recognition has been studied across a number of taxa and modalities; however, few attempts have been made to combine chemical and biological approaches and arrive at a more complete understanding of the use of secretions as signals. We combined behavioral habituation experiments with gas chromatography-mass...

journal_title：Chemical senses

authors： Liu D,Huang KJ,Zhang JX

更新日期：2011-11-01 00:00:00

abstract：:Feeding behavior of adult rainbow trout (Oncorhynchus mykiss) is released by visual and/or chemical stimuli. Detection of either a conditioned visual or a conditioned chemical stimulus creates an excitatory feeding state within the central nervous system which turns on feeding behavior composed of swimming, turning an...

journal_title：Chemical senses

authors： Valentincic T,Caprio J

更新日期：1997-08-01 00:00:00

abstract：:Anosmia and hyposmia, the inability or decreased ability to smell, is estimated to afflict 3-20% of the population. Risk of olfactory dysfunction increases with old age and may also result from chronic sinonasal diseases, severe head trauma, and upper respiratory infections, or neurodegenerative diseases. These disord...

journal_title：Chemical senses

authors： Boesveldt S,Postma EM,Boak D,Welge-Luessen A,Schöpf V,Mainland JD,Martens J,Ngai J,Duffy VB

更新日期：2017-09-01 00:00:00

abstract：:The suitability of Beidler's mixture equation for mixtures of sucrose and maltitol as well as for mixtures of sucrose and aspartame was examined in the presence of an orange aroma. The mean scores for the attribute sweet remained constant for each combination of sucrose and maltitol and for each combination of sucrose...

journal_title：Chemical senses

authors： Nahon DF,Roozen JP,de Graaf C

更新日期：1998-02-01 00:00:00

abstract：:The role of odors in the long-distance navigation of birds has elicited intense debate for more than half a century. Failure to resolve many of the issues fueling this debate is due at least in part to the absence of controls for a variety of non-specific effects that odors have on the navigational process. The presen...

journal_title：Chemical senses

authors： Jorge PE,Marques PAM,Pinto BV,Phillips JB

更新日期：2016-11-01 00:00:00

abstract：:To analyze the mechanisms of perception and processing of pheromonal signals in vitro, we previously developed a new culture system for vomeronasal receptor neurons (VRNs), referred to as the vomeronasal pocket (VN pocket). However, very few VRNs were found to express the olfactory marker protein (OMP) and to have pro...

journal_title：Chemical senses

authors： Moriya-Ito K,Osada T,Ishimatsu Y,Muramoto K,Kobayashi T,Ichikawa M

更新日期：2005-02-01 00:00:00

abstract：:It was recently shown that in some subjects capsaicin can evoke bitterness as well as burning and stinging, particularly in the circumvallate (CV) region of the tongue. Because perception of bitterness from capsaicin is characterized by large individual differences, the main goal of the present study was to learn whet...

journal_title：Chemical senses

authors： Green BG,Hayes JE

更新日期：2004-01-01 00:00:00