Heritability and genetic covariation of sensitivity to PROP, SOA, quinine HCl, and caffeine.

Abstract:

:The perceived bitterness intensity for bitter solutions of propylthiouracil (PROP), sucrose octa-acetate (SOA), quinine HCl and caffeine were examined in a genetically informative sample of 392 females and 313 males (mean age of 17.8 +/- 3.1 years), including 62 monozygotic and 131 dizygotic twin pairs and 237 sib pairs. Broad-sense heritabilities were estimated at 0.72, 0.28, 0.34, and 0.30 for PROP, SOA, quinine, and caffeine, respectively, for perceived intensity measures. Modeling showed 1) a group factor which explained a large amount of the genetic variation in SOA, quinine, and caffeine (22-28% phenotypic variation), 2) a factor responsible for all the genetic variation in PROP (72% phenotypic variation), which only accounted for 1% and 2% of the phenotypic variation in SOA and caffeine, respectively, and 3) a modest specific genetic factor for quinine (12% phenotypic variation). Unique environmental influences for all four compounds were due to a single factor responsible for 7-22% of phenotypic variation. The results suggest that the perception of PROP and the perception of SOA, quinine, and caffeine are influenced by two distinct sets of genes.

journal_name

Chem Senses

journal_title

Chemical senses

authors

Hansen JL,Reed DR,Wright MJ,Martin NG,Breslin PA

doi

10.1093/chemse/bjj044

keywords:

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

403-13

issue

5

eissn

0379-864X

issn

1464-3553

pii

bjj044

journal_volume

31

pub_type

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