Abstract:
:We have previously modeled the interaction of the sweet protein brazzein with the extracellular domains of the sweet taste receptor. Here, we describe the application of that model to the design of 12 new highly potent analogs of brazzein. Eight of the 12 analogs have higher sweetness potency than wild-type brazzein. Results are consistent with our brazzein-receptor interaction model. The model predicts binding of brazzein to the open form of T1R2 in the T1R2-T1R3 heterodimer.
journal_name
Chem Sensesjournal_title
Chemical sensesauthors
Walters DE,Cragin T,Jin Z,Rumbley JN,Hellekant Gdoi
10.1093/chemse/bjp048subject
Has Abstractpub_date
2009-10-01 00:00:00pages
679-83issue
8eissn
0379-864Xissn
1464-3553pii
bjp048journal_volume
34pub_type
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