Current status of antisense DNA methods in behavioral studies.

Abstract:

:The antisense DNA method has been used successfully to block the expression of specific genes in vivo in neuronal systems. An increasing number of studies in the last few years have shown that antisense DNA administered directly into the brain can modify various kinds of behaviors. These findings strongly suggest that the antisense DNA method can be used as a powerful tool to study causal relationships between molecular processes in the brain and behavior. In this article we review the current status of the antisense method in behavioral studies and discuss its potentials and problems by focusing on the following four aspects; (i) optimal application paradigms of antisense DNA methods in behavioral studies; (ii) efficiencies of different administration methods of antisense DNA used in behavioral studies; (iii) determination of specificity of behavioral effects of antisense DNA; and (iv) discrepancies between antisense DNA effects on behaviors and those on protein levels of the targeted gene.

journal_name

Chem Senses

journal_title

Chemical senses

authors

Ogawa S,Pfaff DW

doi

10.1093/chemse/23.2.249

subject

Has Abstract

pub_date

1998-04-01 00:00:00

pages

249-55

issue

2

eissn

0379-864X

issn

1464-3553

journal_volume

23

pub_type

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