The Sensory Difference Threshold of Menthol Odor in Flavored Tobacco Determined by Combining Sensory and Chemical Analysis.

Abstract:

:Cigarettes are an often-used consumer product, and flavor is an important determinant of their product appeal. Cigarettes with strong nontobacco flavors are popular among young people, and may facilitate smoking initiation. Discriminating flavors in tobacco is important for regulation purposes, for instance to set upper limits to the levels of important flavor additives. We provide a simple and fast method to determine the human odor difference threshold for flavor additives in a tobacco matrix, using a combination of chemical and sensory analysis. For an example, the human difference threshold for menthol odor, one of the most frequently used tobacco flavors, was determined. A consumer panel consisting of 20 women compared different concentrations of menthol-flavored tobacco to unflavored cigarette tobacco using the 2-alternative forced choice method. Components contributing to menthol odor were quantified using headspace GC-MS. The sensory difference threshold of menthol odor corresponded to a mixture of 43 (37-50)% menthol-flavored tobacco, containing 1.8 (1.6-2.1) mg menthol, 2.7 (2.3-3.1) µg menthone, and 1.0 (0.9-1.2) µg neomenthyl acetate per gram of tobacco. Such a method is important in the context of the European Tobacco Product Directive, and the US Food and Drug Administration Tobacco Control Act, that both prohibit cigarettes and roll-your-own tobacco with a characterizing flavor other than tobacco. Our method can also be adapted for matrices other than tobacco, such as food.

journal_name

Chem Senses

journal_title

Chemical senses

authors

Krüsemann EJ,Cremers JW,Visser WF,Punter PH,Talhout R

doi

10.1093/chemse/bjw123

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

233-238

issue

3

eissn

0379-864X

issn

1464-3553

pii

bjw123

journal_volume

42

pub_type

杂志文章
  • Psychometrics of odor quality discrimination: method for threshold determination.

    abstract::There is no natural physical continuum for odor quality along which an odor quality discrimination (OQD) threshold can be measured. In an attempt to overcome this problem, the substitution-reciprocity (SURE) method defines a framework for the measurement of an OQD threshold. More specifically, it (i) defines a thresho...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/25.5.493

    authors: Olsson MJ,Cain WS

    更新日期:2000-10-01 00:00:00

  • The influence of taste on swallowing apnea, oral preparation time, and duration and amplitude of submental muscle contraction.

    abstract::Prior research has documented a modulating effect of taste on swallowing. We hypothesized that presentation of tastant stimuli would be a significant variable in swallowing-respiratory coordination, duration of oral bolus preparation, and submental muscle contraction. Twenty-three healthy females were presented with 1...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjl037

    authors: Leow LP,Huckabee ML,Sharma S,Tooley TP

    更新日期:2007-02-01 00:00:00

  • Impact of swallowing on the dynamics of aroma release and perception during the consumption of alcoholic beverages.

    abstract::The consumption protocol used during alcoholic beverage tasting may affect aroma perception. We used an integrated approach combining sensory analysis and physicochemistry to investigate the impact of swallowing on aroma release and perception. A panel of 10 persons evaluated the dynamics of aroma perception during th...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjr038

    authors: Déléris I,Saint-Eve A,Guo Y,Lieben P,Cypriani ML,Jacquet N,Brunerie P,Souchon I

    更新日期:2011-10-01 00:00:00

  • Detection of tastes in mixture with other tastes: issues of masking and aging.

    abstract::When one taste (masker) is strong enough, it can completely mask another task (target) of different quality. How strong the masker must be to do this depends on how strong the target is. As the target concentration is increased, the masking concentration must be increased, too, but in ever-increasing proportion. To qu...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/21.2.211

    authors: Stevens JC

    更新日期:1996-04-01 00:00:00

  • Female marmoset monkeys (Callithrix jacchus) can be identified from the chemical composition of their scent marks.

    abstract::The present study analyzed 42 organic solvent extracts of scent mark pools from five dominant female common marmosets by gas chromatography (GC) and combined GC and mass spectrometry. We determined whether there were qualitative or quantitative differences between the chemical composition of scent marks from individua...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/26.5.449

    authors: Smith TE,Tomlinson AJ,Mlotkiewicz JA,Abbott DH

    更新日期:2001-06-01 00:00:00

  • Bimodal (taste/tactile) fibers innervate the maxillary barbel in the channel catfish.

    abstract::Analysis of single fibers isolated from a branch of the facial/trigeminal complex innervating the maxillary barbel of the channel catfish, Ictalurus punctatus, indicated the existence of bimodal (taste/tactile) fibers. Of the 60 single fibers recorded, 14 (23%) responded to both taste (amino acid) and tactile stimulat...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/22.4.477

    authors: Ogawa K,Marui T,Caprio J

    更新日期:1997-08-01 00:00:00

  • The origin of slow potentials on the tongue surface induced by frog glossopharyngeal efferent fiber stimulation.

    abstract::When the glossopharyngeal (GP) nerve of the frog was stimulated electrically, electropositive slow potentials were recorded from the tongue surface and depolarizing slow potentials from taste cells in the fungiform papillae. The amplitude of the slow potentials was stimulus strength- and the frequency-dependent. Gener...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/25.5.583

    authors: Sato T,Toda K,Miyamoto T,Okada Y,Fujiyama R

    更新日期:2000-10-01 00:00:00

  • Expression and purification of functional ligand-binding domains of T1R3 taste receptors.

    abstract::Chemosensory receptors, including odor, taste, and vomeronasal receptors, comprise the largest group of G protein-coupled receptors (GPCRs) in the mammalian genome. However, little is known about the molecular determinants that are critical for the detection and discrimination of ligands by most of these receptors. Th...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjj053

    authors: Nie Y,Hobbs JR,Vigues S,Olson WJ,Conn GL,Munger SD

    更新日期:2006-07-01 00:00:00

  • Asymmetrical Processing of Olfactory Input in the Piriform Cortex Mediates "Activation" of the Avian Navigation Circuitry.

    abstract::The role of odors in the long-distance navigation of birds has elicited intense debate for more than half a century. Failure to resolve many of the issues fueling this debate is due at least in part to the absence of controls for a variety of non-specific effects that odors have on the navigational process. The presen...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjw084

    authors: Jorge PE,Marques PAM,Pinto BV,Phillips JB

    更新日期:2016-11-01 00:00:00

  • Individual differences in the perceived intensity and quality of specific odors following self- and cross-adaptation.

    abstract::Adaptation techniques have traditionally been employed in sensory physiology and psychology to characterize afferent pathways and to dissect the quantitative and, to a lesser degree, the qualitative aspects of perception. We continue to explore the individual differences in olfactory capabilities among subjects initia...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/19.3.197

    authors: O'Connell RJ,Stevens DA,Zogby LM

    更新日期:1994-06-01 00:00:00

  • Distinct projections of two populations of olfactory receptor axons in the antennal lobe of the sphinx moth Manduca sexta.

    abstract::The central projections of olfactory receptor cells associated with two distinct types of antennal sensilla in the sphinx moth Manduca sexta were revealed by anterograde staining. In both sexes, receptor axons that arise from sexually isomorphic, type-II trichoid sensilla (and possibly some basiconic sensilla) project...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/20.3.313

    authors: Christensen TA,Harrow ID,Cuzzocrea C,Randolph PW,Hildebrand JG

    更新日期:1995-06-01 00:00:00

  • Temporary modification of salivary protein profile and individual responses to repeated phenolic astringent stimuli.

    abstract::The extent of the change in salivary protein characteristics after repeated stimulations was shown to be correlated to differences in perceived astringency. Salivary characteristics of 77 subjects were compared after masticatory (S1) and taste/masticatory (S2) stimulations. The variations (S2 minus S1) of protein conc...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjp084

    authors: Dinnella C,Recchia A,Vincenzi S,Tuorila H,Monteleone E

    更新日期:2010-01-01 00:00:00

  • Anosmia-A Clinical Review.

    abstract::Anosmia and hyposmia, the inability or decreased ability to smell, is estimated to afflict 3-20% of the population. Risk of olfactory dysfunction increases with old age and may also result from chronic sinonasal diseases, severe head trauma, and upper respiratory infections, or neurodegenerative diseases. These disord...

    journal_title:Chemical senses

    pub_type: 杂志文章,评审

    doi:10.1093/chemse/bjx025

    authors: Boesveldt S,Postma EM,Boak D,Welge-Luessen A,Schöpf V,Mainland JD,Martens J,Ngai J,Duffy VB

    更新日期:2017-09-01 00:00:00

  • Design and evaluation of new analogs of the sweet protein brazzein.

    abstract::We have previously modeled the interaction of the sweet protein brazzein with the extracellular domains of the sweet taste receptor. Here, we describe the application of that model to the design of 12 new highly potent analogs of brazzein. Eight of the 12 analogs have higher sweetness potency than wild-type brazzein. ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjp048

    authors: Walters DE,Cragin T,Jin Z,Rumbley JN,Hellekant G

    更新日期:2009-10-01 00:00:00

  • Interspecific variation of olfactory preferences in flies, mice, and humans.

    abstract::Aiming to unravel interspecific differences in olfactory preferences, we performed comparative studies of odor valence in flies, mice, and humans. Our analysis suggests a model where flies and mice share similar olfactory preferences, but neither species share odor preferences with humans. This model contrasts with a ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjy074

    authors: Manoel D,Makhlouf M,Scialdone A,Saraiva LR

    更新日期:2019-01-01 00:00:00

  • Electroolfactogram responses from organotypic cultures of the olfactory epithelium from postnatal mice.

    abstract::Organotypic cultures of the mouse olfactory epithelium connected to the olfactory bulb were obtained with the roller tube technique from postnatal mice aged between 13 and 66 days. To test the functionality of the cultures, we measured electroolfactograms (EOGs) at different days in vitro (DIV), up to 7 DIV, and we co...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjn007

    authors: Pinato G,Rievaj J,Pifferi S,Dibattista M,Masten L,Menini A

    更新日期:2008-04-01 00:00:00

  • Male but not female olfaction is crucial for intermolt mating in European lobsters (Homarus gammarus L.).

    abstract::Chemical signals are common in most crustacean social interactions and are often perceived via chemosensory (olfactory) organs on the first antenna. Intermolt courtship behaviors and mating were investigated in size-matched pairs of intermolt European lobsters (Homarus gammarus) where the olfactory receptors of either...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjn073

    authors: Skog M

    更新日期:2009-02-01 00:00:00

  • Elevated Cytosolic Cl- Concentrations in Dendritic Knobs of Mouse Vomeronasal Sensory Neurons.

    abstract::In rodents, the vomeronasal system controls social and sexual behavior. However, several mechanistic aspects of sensory signaling in the vomeronasal organ remain unclear. Here, we investigate the biophysical basis of a recently proposed vomeronasal signal transduction component-a Ca(2+)-activated Cl(-) current. As the...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjw077

    authors: Untiet V,Moeller LM,Ibarra-Soria X,Sánchez-Andrade G,Stricker M,Neuhaus EM,Logan DW,Gensch T,Spehr M

    更新日期:2016-10-01 00:00:00

  • Evaluation of copper speciation and water quality factors that affect aqueous copper tasting response.

    abstract::This study determined taste thresholds for copper as its speciation was varied among free cupric ion, complexed cupric ion, and precipitated cupric particles. The impact of copper chemistry on taste is important as copper is added to many beverages and can be present in drinking water as a natural mineral or due to co...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjl010

    authors: Cuppett JD,Duncan SE,Dietrich AM

    更新日期:2006-09-01 00:00:00

  • Human responses to propionic acid. II. Quantification of breathing responses and their relationship to perception.

    abstract::In 20 normal and four anosmic participants, instantaneous inhalation and exhalation flow rates were recorded in response to 15 s stimulations with clean air or propionic acid concentrations (0.16, 1.14, 8.22 and 59.15 p.p.m., v/v) that ranged from peri-threshold for normals to clearly supra-threshold for anosmics. Eac...

    journal_title:Chemical senses

    pub_type: 临床试验,杂志文章

    doi:10.1093/chemse/26.4.351

    authors: Walker JC,Kendal-Reed M,Hall SB,Morgan WT,Polyakov VV,Lutz RW

    更新日期:2001-05-01 00:00:00

  • The influence of sodium salts on binary mixtures of bitter-tasting compounds.

    abstract::In order to study potential mixture interactions among bitter compounds, selected sodium salts were added to five compounds presented either alone or as binary bitter-compound mixtures. Each compound was tested at a concentration that elicited 'weak' perceived bitterness. The bitter compounds were mixed at these conce...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjh045

    authors: Keast RS,Canty TM,Breslin PA

    更新日期:2004-06-01 00:00:00

  • Olfactory Responses of Southern House Mosquito, Culex quinquefasciatus, to Human Odorants.

    abstract::Mosquito control is essential to protect humans from mosquito-borne diseases. The host recognition between mosquitoes and humans is achieved by the mosquito olfactory system. Antennal sensilla, which house olfactory receptor neurons, are responsible for detecting chemical cues from hosts. To deepen our understanding o...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjv089

    authors: Ye Z,Liu F,Liu N

    更新日期:2016-06-01 00:00:00

  • Current status of antisense DNA methods in behavioral studies.

    abstract::The antisense DNA method has been used successfully to block the expression of specific genes in vivo in neuronal systems. An increasing number of studies in the last few years have shown that antisense DNA administered directly into the brain can modify various kinds of behaviors. These findings strongly suggest that...

    journal_title:Chemical senses

    pub_type: 杂志文章,评审

    doi:10.1093/chemse/23.2.249

    authors: Ogawa S,Pfaff DW

    更新日期:1998-04-01 00:00:00

  • Structural role of the terminal disulfide bond in the sweetness of brazzein.

    abstract::Brazzein, a 54 residue sweet-tasting protein, is thought to participate in a multipoint binding interaction with the sweet taste receptor. Proposed sites for interaction with the receptor include 2 surface loops and the disulfide bond that connects the N- and C-termini. However, the importance of each site is not well...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjr057

    authors: Dittli SM,Rao H,Tonelli M,Quijada J,Markley JL,Max M,Assadi-Porter F,Maillet E

    更新日期:2011-11-01 00:00:00

  • Temporal synchrony and integration of sub-threshold taste and smell signals.

    abstract::The importance of stimulus timing and location on the perceptual integration of taste and odour was studied based on a sub-threshold methodology. From a panel of 16 people, 12 showed the integration effect previously reported while 4 showed no effect. The experiment was repeated using retronasal and orthonasal deliver...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bji047

    authors: Pfeiffer JC,Hollowood TA,Hort J,Taylor AJ

    更新日期:2005-09-01 00:00:00

  • Enhancement of Combined Umami and Salty Taste by Glutathione in the Human Tongue and Brain.

    abstract::Glutathione, a natural substance, acts on calcium receptors on the tongue and is known to enhance basic taste sensations. However, the effects of glutathione on brain activity associated with taste sensation on the tongue have not been determined under standardized taste delivery conditions. In this study, we investig...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjw066

    authors: Goto TK,Yeung AW,Tanabe HC,Ito Y,Jung HS,Ninomiya Y

    更新日期:2016-09-01 00:00:00

  • Tastant-Evoked Arc Expression in the Nucleus of the Solitary Tract and Nodose/Petrosal Ganglion of the Mouse Is Specific for Bitter Compounds.

    abstract::Despite long and intense research, some fundamental questions regarding representation of taste information in the brain still remain unanswered. This might in part be due to shortcomings of the established methods that limit the researcher either to thorough characterization of few elements or to analyze the response...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjy017

    authors: Töle J,Stolzenburg A,Tyree SM,Stähler F,Meyerhof W

    更新日期:2018-04-23 00:00:00

  • Odor Emotional Quality Predicts Odor Identification.

    abstract::It is commonly agreed upon a strong link between emotion and olfaction. Odor-evoked memories are experienced as more emotional compared with verbal, visual, and tactile stimuli. Moreover, the emotional quality of odor cues increases memory performance, but contrary to this, odors are poor retrieval cues for verbal lab...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjv037

    authors: Bestgen AK,Schulze P,Kuchinke L

    更新日期:2015-09-01 00:00:00

  • Chemical Profiles of Integumentary and Glandular Substrates in Australian Sea Lion Pups (Neophoca cinerea).

    abstract::Recognition of individuals or classes of individuals plays an important role in the communication systems of many mammals. The ability of otariid (i.e., fur seal and sea lion) females to locate and identify their offspring in colonies after returning from regular foraging trips is essential to successful pup rearing. ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjz008

    authors: Wierucka K,Barthes N,Pitcher BJ,Schaal B,Charrier I,Harcourt RG

    更新日期:2019-03-11 00:00:00

  • Clinical bitterness masking test for phantogeusia.

    abstract::It is difficult to determine the reason why a patient complains of a bitter taste when their mouth is empty. We examined a new diagnostic test using a bitterness masking substance. The bitterness masking substance, 'Benecoat BMI-60' (hereafter BMI-60), is a masking substance specific to the taste cells' bitterness rec...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/26.1.91

    authors: Ishimaru T,Hatanaka S,Miwa T,Furukawa M

    更新日期:2001-01-01 00:00:00