Abstract:
:Adaptation techniques have traditionally been employed in sensory physiology and psychology to characterize afferent pathways and to dissect the quantitative and, to a lesser degree, the qualitative aspects of perception. We continue to explore the individual differences in olfactory capabilities among subjects initially classified by their ability to detect and identify the diastereoisomeric ketone, cis-4-(4'-t-butylcyclohexyl)-4-methyl-2-pentanone (pemenone) which shares with 5 alpha-androst-16-en-3-one (androstenone) a pronounced urine-sweaty odor. Our previous studies of these and other compounds for which specific anosmias were said to exist revealed significant relationships between intensity scores and a corresponding clustering of the odor quality descriptors used to characterize these materials by subjects judged to be specifically anosmic for the urinous note. Here, we attempt to dissect the web of interactions which give rise to individual differences in perceived odor quality by evaluating the effects of self- and cross-adaptation on the intensity and quality reports elicited by pemenone, androstenone and four other odors in 18 human subjects including both pemenone-osmic and non-osmic (n = 6) individuals. Intensity and quality ratings for the six compounds were obtained before and after an adaptation sequence in which subjects sniffed a test odorant, pemenone or the diluent. For each odorant, intensity ratings under the different adapting conditions were compared by ANOVA. Self-adaptation was universal but cross-adaptation by pemenone was only found in the intensity ratings of androstenone. The intensity ratings of isovaleric acid, which shares the urinous note with pemenone and androstenone, were unaffected by pemenone adaptation. Most of the subjects judged to be osmic still reported a urinous odor quality for androstenone and isovaleric acid following pemenone adaptation. Except for shifts to the no-odor category, adaptation did not significantly alter the odor quality reports of osmic or non-osmic individuals. This suggests that the odor quality reports engendered by these substances are multidimensional and that compounds which share the same odor quality label may interact with different perceptual channels.
journal_name
Chem Sensesjournal_title
Chemical sensesauthors
O'Connell RJ,Stevens DA,Zogby LMdoi
10.1093/chemse/19.3.197subject
Has Abstractpub_date
1994-06-01 00:00:00pages
197-208issue
3eissn
0379-864Xissn
1464-3553journal_volume
19pub_type
杂志文章相关文献
CHEMICAL SENSES文献大全abstract::The suitability of Beidler's mixture equation for mixtures of sucrose and maltitol as well as for mixtures of sucrose and aspartame was examined in the presence of an orange aroma. The mean scores for the attribute sweet remained constant for each combination of sucrose and maltitol and for each combination of sucrose...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/23.1.59
更新日期:1998-02-01 00:00:00
abstract::Anosmia and hyposmia, the inability or decreased ability to smell, is estimated to afflict 3-20% of the population. Risk of olfactory dysfunction increases with old age and may also result from chronic sinonasal diseases, severe head trauma, and upper respiratory infections, or neurodegenerative diseases. These disord...
journal_title:Chemical senses
pub_type: 杂志文章,评审
doi:10.1093/chemse/bjx025
更新日期:2017-09-01 00:00:00
abstract::In this study, we cloned and characterized three Manduca sexta odorant receptors (ORs). One receptor is a putative pheromone receptor expressed exclusively in a cell associated with male-specific type-I trichoid sensilla. We describe the results of real-time PCR (RT-PCR) and quantitative real-time PCR (qRT-PCR) experi...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjp002
更新日期:2009-05-01 00:00:00
abstract::Anosmia affects the western world population, mostly the elderly, reaching to 5% in subjects over the age of 45 years and strongly lowering their quality of life. A smaller minority (about 0.01%) is born without a sense of smell, afflicted with congenital general anosmia (CGA). No causative genes for human CGA have be...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjl032
更新日期:2007-01-01 00:00:00
abstract::Individual recognition has been studied across a number of taxa and modalities; however, few attempts have been made to combine chemical and biological approaches and arrive at a more complete understanding of the use of secretions as signals. We combined behavioral habituation experiments with gas chromatography-mass...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjr055
更新日期:2011-11-01 00:00:00
abstract::Arecoline, a major alkaloid in areca nuts, is involved in the pathogenesis of oral diseases. Mammalian taste buds are the structural unit for detecting taste stimuli in the oral cavity. The effects of arecoline on taste bud morphology are poorly understood. Arecoline was injected intraperitoneally (IP) into C57BL/6 mi...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjv059
更新日期:2016-01-01 00:00:00
abstract::To assess the feasibility of using odors as a potential mechanism for treating sleep apnea, we set out to test the hypothesis that odorants delivered during sleep would modify respiratory patterns without inducing arousal or wake in healthy sleepers. We used 2 mildly trigeminal odorants: the pleasant lavender and unpl...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjp079
更新日期:2010-01-01 00:00:00
abstract::Two experiments, using different ranges and numbers of stimuli, examined how linguistic labels affect the identification of flavor mixtures containing different proportions of sucrose (gustatory flavorant) and citral (olfactory flavorant). Both experiments asked subjects to identify each stimulus as having either "mos...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjs142
更新日期:2013-05-01 00:00:00
abstract::The objective of this study was to develop a semantically labeled hedonic scale (LHS) that would yield ratio-level data on the magnitude of liking/disliking of sensation equivalent to that produced by magnitude estimation (ME). The LHS was constructed by having 49 subjects who were trained in ME rate the semantic magn...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjp054
更新日期:2009-11-01 00:00:00
abstract::Our study was designed to examine how components of complex mixtures can inhibit the binding of other components to receptor sites in the olfactory system of the spiny lobster Panulirus argus. Biochemical binding assays were used to study how two- to six-component mixtures inhibit binding of the radiolabeled odorants ...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/23.3.269
更新日期:1998-06-01 00:00:00
abstract::Evidence suggests that women outperform men in core aspects of odor perception, and sex hormones may play a significant role in moderating this effect. The gender-affirming treatment (GAT) of transgender persons constitutes a powerful natural experiment to study the psychological and behavioral effects of high dosages...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjz069
更新日期:2020-01-01 00:00:00
abstract::The extent of the change in salivary protein characteristics after repeated stimulations was shown to be correlated to differences in perceived astringency. Salivary characteristics of 77 subjects were compared after masticatory (S1) and taste/masticatory (S2) stimulations. The variations (S2 minus S1) of protein conc...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjp084
更新日期:2010-01-01 00:00:00
abstract::Recognition of individuals or classes of individuals plays an important role in the communication systems of many mammals. The ability of otariid (i.e., fur seal and sea lion) females to locate and identify their offspring in colonies after returning from regular foraging trips is essential to successful pup rearing. ...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjz008
更新日期:2019-03-11 00:00:00
abstract::Regarding the chemotaxis of sperms, new insights have been gained during the last 20 years. Olfactory receptors are expressed on the flagellar midpiece of human spermatogenic cells. One of them, OR1D2, is also expressed in the olfactory epithelium. This receptor has been suggested to play a role in sperm chemotaxis an...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjt009
更新日期:2013-06-01 00:00:00
abstract::The capacity of the peripheral olfactory system to recover after injury has not been thoroughly explored. P2-IRES-tauLacZ mice were exposed to methyl bromide, which causes epithelial damage and kills 90% of the P2 neurons. With subsequent neuronal regeneration, P2 neurons recover within their usual territory to equal ...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bju033
更新日期:2014-09-01 00:00:00
abstract::Despite long and intense research, some fundamental questions regarding representation of taste information in the brain still remain unanswered. This might in part be due to shortcomings of the established methods that limit the researcher either to thorough characterization of few elements or to analyze the response...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjy017
更新日期:2018-04-23 00:00:00
abstract::The distribution of NADPH-diaphroase activity was examined in the accessory olfactory bulb of the rat using a direct histochemical technique. Labeled fibers and somata were found in all layers of the accessory olfactory bulb. The entire vomeronasal nerve and all vomeronasal glomeruli were strongly labeled, contrary to...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/19.5.413
更新日期:1994-10-01 00:00:00
abstract::Although the honeybee (Apis mellifera) is one of the world most studied insects, the chemical compounds used in nestmate recognition, remains an open question. By exploiting the error prone recognition system of the honeybee, coupled with genotyping, we studied the correlation between cuticular hydrocarbon (CHC) profi...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjv053
更新日期:2015-11-01 00:00:00
abstract::Sodium taste transduction is thought to occur via an amiloride-sensitive, sodium-selective pathway and an amiloride-insensitive, cation nonselective, anion-dependent pathway(s). It has been shown by others that amiloride, an epithelial sodium channel (ENaC) blocker, significantly reduces the chorda tympani nerve respo...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/28.5.447
更新日期:2003-06-01 00:00:00
abstract::Electrophysiological responses of olfactory receptor neurons in both male and female silkmoths (Bombyx mori) were investigated. In both sexes, the G-protein activator sodium fluoride and 1,2-dioctanoyl-sn-glycerol, a membrane-permeable analog of the protein kinase C activator diacylglycerol, elicited nerve impulse res...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/27.5.435
更新日期:2002-06-01 00:00:00
abstract::The aim of this investigation was to compare olfactory functions of patients suffering from Parkinson's disease (PD) and Alzheimer's disease (AD). Olfactory threshold, odor identification ability and odor memory performance were assessed in 21 non-demented PD patients and in 22 AD patients. Both patient groups were im...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/22.1.105
更新日期:1997-02-01 00:00:00
abstract::The present study demonstrated that 100 microM amiloride serves as an ineffective conditioned taste stimulus in a taste aversion paradigm. Even if amiloride has a detectable taste, it's unlikely that its behavioral effects in salt mixture experiments are due to its inherent taste quality. ...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/20.5.559
更新日期:1995-10-01 00:00:00
abstract::Suppression of the saltiness of NaCl solutions by amiloride, a sodium channel blocker, has previously been reported a number of times in humans. This suppression was seen with techniques that involved stimulation of small areas of the tongue. It was not certain, however, whether amiloride would suppress saltiness with...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/21.2.113
更新日期:1996-04-01 00:00:00
abstract::Olfactory perception is highly variable from one person to another, as a function of individual and contextual factors. Here, we investigated the influence of 2 important factors of variation: culture and semantic information. More specifically, we tested whether cultural-specific knowledge and presence versus absence...
journal_title:Chemical senses
pub_type: 临床试验,杂志文章
doi:10.1093/chemse/bjw098
更新日期:2017-01-01 00:00:00
abstract::Electrical stimulation of the frog glossopharyngeal (GP) nerve evoked slow hyperpolarizing potentials (HPs) in taste cells. This study aimed to clarify whether slow HPs were postsynaptically induced in taste cells. The slow HPs were recorded intracellularly with a microelectrode. When Ca2+ concentration in the blood p...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjh072
更新日期:2004-10-01 00:00:00
abstract::It is commonly agreed upon a strong link between emotion and olfaction. Odor-evoked memories are experienced as more emotional compared with verbal, visual, and tactile stimuli. Moreover, the emotional quality of odor cues increases memory performance, but contrary to this, odors are poor retrieval cues for verbal lab...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjv037
更新日期:2015-09-01 00:00:00
abstract::Data on human odor thresholds show disparities huge enough to marginalize olfactory psychophysics and delegitimize importation of its data into other areas. Variation of orders of magnitude from study to study, much of it systematic, threatens meaningful comparisons with animal species, comparison between in vivo with...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjp088
更新日期:2010-02-01 00:00:00
abstract::Small soluble proteins, belonging to the lipocalin family are secreted in large amounts by tongue von Ebner's glands and lachrymal glands. In humans, the lingual protein, called VEG, and the lachrymal protein, called tear prealbumin, have shown identical cDNA sequences. In the pig, we have purified homodimeric protein...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/20.1.69
更新日期:1995-02-01 00:00:00
abstract::The embryonic origins of taste receptor cells have not been established experimentally. Although related receptor cells (e.g. hair cells of the inner ear, lateral line receptors) are known to arise from neurogenic ectoderm (e.g. neural crest or placodes), taste buds are described as arising from local epithelial cells...
journal_title:Chemical senses
pub_type: 杂志文章,评审
doi:10.1093/chemse/19.6.725
更新日期:1994-12-01 00:00:00
abstract::Phantosmia, the perception of an odor when there are no odorants in the environment, can be a very debilitating symptom. In the 1960s, Zilstorff reported olfactory distortions could be treated by the topical application of a cocaine solution to the olfactory epithelium. In evaluating this treatment, we observed no lon...
journal_title:Chemical senses
pub_type: 杂志文章
doi:10.1093/chemse/bjt047
更新日期:2013-11-01 00:00:00