Activation and inhibition of the transduction process in silkmoth olfactory receptor neurons.


:Electrophysiological responses of olfactory receptor neurons in both male and female silkmoths (Bombyx mori) were investigated. In both sexes, the G-protein activator sodium fluoride and 1,2-dioctanoyl-sn-glycerol, a membrane-permeable analog of the protein kinase C activator diacylglycerol, elicited nerve impulse responses similar to those elicited by weak continuous stimulation with odorants. Therefore, G(q)-proteins and diacylglycerol-activated ion channels seem to be involved in the transduction process in both pheromone-sensitive neurons in males and general odorant-sensitive neurons in females. Decyl-thio-trifluoro-propanone is known to inhibit electrophysiological responses of male moths to pheromones, but has no effect in females. Application of this inhibitor reduced the frequency, but not the amplitude of elementary receptor potentials. It had no inhibitory effect on nerve impulse responses elicited by sodium fluoride or 1,2-dioctanoyl-sn-glycerol. This supports the idea that decyl-thio-trifluoro-propanone acts on a prior step of the transduction cascade, e.g. on the pheromone receptor molecules. General odorants, such as (+/-)-linalool and 1-heptanol, excite olfactory receptor neurons in females, but inhibit the pheromone-sensitive neurons in males. Both (+/-)-linalool and 1-heptanol inhibited the responses of male neurons elicited by sodium fluoride or 1,2-dioctanoyl-sn-glycerol. (+/-)-Linalool reduced the amplitude of elementary receptor potentials. In contrast to decyl-thio-trifluoro-propanone, (+/-)-linalool and 1-heptanol seem to interfere with later processes of the transduction cascade, possibly the opening of ion channels.


Chem Senses


Chemical senses


Pophof B,Van der Goes van Naters W





Has Abstract


2002-06-01 00:00:00












  • The septal organ of the rat during postnatal development.

    abstract::The septal organ of Masera (SO) is a small, isolated patch of olfactory epithelium, located in the ventral part of the nasal septum. We investigated in this systematic study the postnatal development of the SO in histological sections of rats at various ages from the day of birth (P1) to P666. The SO-area increases to...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Weiler E,Farbman AI

    更新日期:2003-09-01 00:00:00

  • A candidate pheromone receptor and two odorant receptors of the hawkmoth Manduca sexta.

    abstract::In this study, we cloned and characterized three Manduca sexta odorant receptors (ORs). One receptor is a putative pheromone receptor expressed exclusively in a cell associated with male-specific type-I trichoid sensilla. We describe the results of real-time PCR (RT-PCR) and quantitative real-time PCR (qRT-PCR) experi...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Patch HM,Velarde RA,Walden KK,Robertson HM

    更新日期:2009-05-01 00:00:00

  • Analysis of slow depolarizing potential in frog taste cell induced by parasympathetic efferent stimulation under hypoxia.

    abstract::Strong electrical stimulation (ES) of the frog glossopharyngeal (GP) efferent nerve induced slow depolarizing potentials (DPs) in taste cells under hypoxia. This study aimed to elucidate whether the slow DPs were postsynaptically induced in taste cells. After a block of parasympathetic nerve (PSN) ganglia by tubocurar...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Sato T,Nishishita K,Okada Y,Toda K

    更新日期:2007-05-01 00:00:00

  • Expression and purification of functional ligand-binding domains of T1R3 taste receptors.

    abstract::Chemosensory receptors, including odor, taste, and vomeronasal receptors, comprise the largest group of G protein-coupled receptors (GPCRs) in the mammalian genome. However, little is known about the molecular determinants that are critical for the detection and discrimination of ligands by most of these receptors. Th...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Nie Y,Hobbs JR,Vigues S,Olson WJ,Conn GL,Munger SD

    更新日期:2006-07-01 00:00:00

  • Chemosensory cross-modal stroop effects: congruent odors facilitate taste identification.

    abstract::In order to explore the cross-modal cognitive associations between smell and taste, a chemosensory analogue of the Stroop task (Stroop 1935) was developed. Fourteen participants were presented with an odorant and a tastant and asked to identify the tastant as "sweet" or "sour" by pressing 1 of 2 buttons as quickly as ...

    journal_title:Chemical senses

    pub_type: 杂志文章,随机对照试验


    authors: White TL,Prescott J

    更新日期:2007-05-01 00:00:00

  • Activity-Dependent Gene Expression in the Mammalian Olfactory Epithelium.

    abstract::Activity-dependent processes are important to olfactory sensory neurons (OSNs) in several ways, such as cell survival and the specificity of axonal convergence. The identification of activity-dependent mRNAs has contributed to our understanding of OSN axon convergence, but has revealed surprisingly little about other ...

    journal_title:Chemical senses

    pub_type: 杂志文章,评审


    authors: Wang Q,Titlow WB,McClintock DA,Stromberg AJ,McClintock TS

    更新日期:2017-10-01 00:00:00

  • The influence of sodium salts on binary mixtures of bitter-tasting compounds.

    abstract::In order to study potential mixture interactions among bitter compounds, selected sodium salts were added to five compounds presented either alone or as binary bitter-compound mixtures. Each compound was tested at a concentration that elicited 'weak' perceived bitterness. The bitter compounds were mixed at these conce...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Keast RS,Canty TM,Breslin PA

    更新日期:2004-06-01 00:00:00

  • Changes in Olfactory Sensory Neuron Physiology and Olfactory Perceptual Learning After Odorant Exposure in Adult Mice.

    abstract::The adult olfactory system undergoes experience-dependent plasticity to adapt to the olfactory environment. This plasticity may be accompanied by perceptual changes, including improved olfactory discrimination. Here, we assessed experience-dependent changes in the perception of a homologous aldehyde pair by testing mi...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Kass MD,Guang SA,Moberly AH,McGann JP

    更新日期:2016-02-01 00:00:00

  • Perception of everyday odors--correlation between intensity, familiarity and strength of hedonic judgement.

    abstract::In this study, 40 Japanese, 44 German and 39 Mexican women were presented with 18 everyday odorants. They were asked to rate them for intensity on a six-point scale from not detectable to very strong, for pleasantness on an 11-point scale from -5, to neutral at 0, to +5, and for familiarity on a six-point scale from c...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Distel H,Ayabe-Kanamura S,Martínez-Gómez M,Schicker I,Kobayakawa T,Saito S,Hudson R

    更新日期:1999-04-01 00:00:00

  • Olfactory fMRI: Implications of Stimulation Length and Repetition Time.

    abstract::Studying olfaction with functional magnetic resonance imaging (fMRI) poses various methodological challenges. This study aimed to investigate the effects of stimulation length and repetition time (TR) on the activation pattern of 4 olfactory brain regions: the anterior and the posterior piriform cortex, the orbitofron...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Georgiopoulos C,Witt ST,Haller S,Dizdar N,Zachrisson H,Engström M,Larsson EM

    更新日期:2018-07-05 00:00:00

  • Understanding the regulation and function of adult neurogenesis: contribution from an insect model, the house cricket.

    abstract::Since the discovery of adult neurogenesis, a major issue is the role of newborn neurons and the function-dependent regulation of adult neurogenesis. We decided to use an animal model with a relatively simple brain to address these questions. In the adult cricket brain as in mammals, new neurons are produced throughout...

    journal_title:Chemical senses

    pub_type: 杂志文章,评审


    authors: Cayre M,Scotto-Lomassese S,Malaterre J,Strambi C,Strambi A

    更新日期:2007-05-01 00:00:00

  • Histochemical localization of NADPH-diaphorase in the rat accessory olfactory bulb.

    abstract::The distribution of NADPH-diaphroase activity was examined in the accessory olfactory bulb of the rat using a direct histochemical technique. Labeled fibers and somata were found in all layers of the accessory olfactory bulb. The entire vomeronasal nerve and all vomeronasal glomeruli were strongly labeled, contrary to...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Porteros A,Alonso JR,Arévalo R,García-Ojeda E,Crespo C,Aijón J

    更新日期:1994-10-01 00:00:00

  • Distortion of olfactory perception: diagnosis and treatment.

    abstract::Clinically, olfaction can fail in any of three ways: (i) decreased sensitivity (hyposmia, anosmia) and two types of distortion (dysosmia); (ii) distorted quality of an odorant stimulation (troposmia); (iii) perceived odor when no odorant is present (phantosmia, hallucination). The distortions are usually much more ups...

    journal_title:Chemical senses

    pub_type: 杂志文章,评审


    authors: Leopold D

    更新日期:2002-09-01 00:00:00

  • Human responses to propionic acid. II. Quantification of breathing responses and their relationship to perception.

    abstract::In 20 normal and four anosmic participants, instantaneous inhalation and exhalation flow rates were recorded in response to 15 s stimulations with clean air or propionic acid concentrations (0.16, 1.14, 8.22 and 59.15 p.p.m., v/v) that ranged from peri-threshold for normals to clearly supra-threshold for anosmics. Eac...

    journal_title:Chemical senses

    pub_type: 临床试验,杂志文章


    authors: Walker JC,Kendal-Reed M,Hall SB,Morgan WT,Polyakov VV,Lutz RW

    更新日期:2001-05-01 00:00:00

  • Infant Acceptance of Primary Tastes and Fat Emulsion: Developmental Changes and Links with Maternal and Infant Characteristics.

    abstract::Previous studies on taste acceptance have been conducted taste-by-taste and with a cross-sectional design. The aim of this study was to longitudinally evaluate the acceptance of sweet, salty, bitter, sour and umami solutions, and a fat emulsion comparatively in a birth cohort from 3 to 20 months old. The acceptance of...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Schwartz C,Chabanet C,Szleper E,Feyen V,Issanchou S,Nicklaus S

    更新日期:2017-09-01 00:00:00

  • Methyl salicylate, identified as primary odorant of a specific receptor neuron type, inhibits oviposition by the moth Mamestra brassicae L. (Lepidoptera, noctuidae).

    abstract::The cabbage moth, Mamestra brassicae L. (Lepidoptera, Noctuidae), is a polyphagous species that is often choosing plants of Brassica as hosts for oviposition. In the search for biologically relevant odorants used by these moths, gas chromatography linked to electrophysiological recordings from single receptor neurons ...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Ulland S,Ian E,Mozuraitis R,Borg-Karlson AK,Meadow R,Mustaparta H

    更新日期:2008-01-01 00:00:00

  • Histochemical identification of carbohydrate moieties in the accessory olfactory bulb of the mouse using a panel of lectins.

    abstract::Lectin binding patterns in the olfactory bulb of the mouse were investigated using 12 biotinylated lectins. Three, with specificities for galactose, N-acetylgalactosamine and L-fucose, stained only the nervous and glomerular layers of the accessory olfactory bulb; four, with specificities for galactose or N-acetylgluc...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Salazar I,Sánchez Quinteiro P,Lombardero M,Cifuentes JM

    更新日期:2001-07-01 00:00:00

  • Making scents: dynamic olfactometry for threshold measurement.

    abstract::Data on human odor thresholds show disparities huge enough to marginalize olfactory psychophysics and delegitimize importation of its data into other areas. Variation of orders of magnitude from study to study, much of it systematic, threatens meaningful comparisons with animal species, comparison between in vivo with...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Schmidt R,Cain WS

    更新日期:2010-02-01 00:00:00

  • SW.B6-Soa(b) nontaster congenic strains completed and a sucrose octaacetate congenic quartet tested with other bitters.

    abstract::Ten SW.B6 SOA nontaster strains congenic with the SWR/J SOA taster inbred strain were bred via repeated backcross-intercross cycles, with selection for nontasting in each cycle. Preference ratio distributions and phenotypic proportions across cycles at 0.1 mM SOA were consistent with monogenic predictions. The SW.B6 m...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Harder DB,Gannon KS,Whitney G

    更新日期:1996-10-01 00:00:00

  • Temporally staggered glomerulus development in the moth Manduca sexta.

    abstract::Glomeruli, neuropilar structures composed of olfactory receptor neuron (ORN) axon terminals and central neuron dendrites, are a common feature of olfactory systems. Typically, ORN axons segregate into glomeruli based on odor specificity, making glomeruli the basic unit for initial processing of odorant information. De...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Lipscomb BW,Tolbert LP

    更新日期:2006-03-01 00:00:00

  • The Perceptual Characteristics of Sodium Chloride to Sodium-Depleted Rats.

    abstract::Three experiments assessed potential changes in the rat's perception of sodium chloride (NaCl) during a state of sodium appetite. In Experiment 1, sodium-sufficient rats licking a range of NaCl concentrations (0.028-0.89M) in 15s trials showed an inverted U-shaped concentration response function peaking at 0.281M. Dep...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: St John SJ

    更新日期:2017-02-01 00:00:00

  • Color enhances orthonasal olfactory intensity and reduces retronasal olfactory intensity.

    abstract::The effect of color on orthonasal and retronasal odor intensities was investigated. When odorants were smelled orthonasally (i.e., through the nostrils), color enhanced odor intensity ratings, consistent with previous reports. However, when odorants were smelled retronasally (i.e., the odorous solution was put in the ...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Koza BJ,Cilmi A,Dolese M,Zellner DA

    更新日期:2005-10-01 00:00:00

  • Responses of cultured rat trigeminal ganglion neurons to bitter tastants.

    abstract::The initial steps in taste and olfaction result from the activation by chemical stimuli of taste receptor cells (TRCs) and olfactory receptor neurons (ORNs). In parallel with these two pathways is the chemosensitive trigeminal pathway whose neurons terminate in the oral and nasal cavities and which are activated by ma...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Liu L,Simon SA

    更新日期:1998-04-01 00:00:00

  • Mosaic analysis of the embryonic origin of taste buds.

    abstract::The embryonic origins of taste receptor cells have not been established experimentally. Although related receptor cells (e.g. hair cells of the inner ear, lateral line receptors) are known to arise from neurogenic ectoderm (e.g. neural crest or placodes), taste buds are described as arising from local epithelial cells...

    journal_title:Chemical senses

    pub_type: 杂志文章,评审


    authors: Stone LM,Finger TE

    更新日期:1994-12-01 00:00:00

  • Assessing the role of color cues and people's beliefs about color-flavor associations on the discrimination of the flavor of sugar-coated chocolates.

    abstract::We report 2 experiments designed to investigate the effect of people's prior beliefs concerning specific color-flavor associations on their ability to discriminate the flavor of colored sugar-coated chocolate sweets. The participants in our study judged whether pairs of Smarties had the same flavor or not. In our firs...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Levitan CA,Zampini M,Li R,Spence C

    更新日期:2008-06-01 00:00:00

  • Calcium signaling in taste cells: regulation required.

    abstract::Peripheral taste receptor cells depend on distinct calcium signals to generate appropriate cellular responses that relay taste information to the central nervous system. Some taste cells have conventional chemical synapses and rely on calcium influx through voltage-gated calcium channels. Other taste cells lack these ...

    journal_title:Chemical senses

    pub_type: 杂志文章,评审


    authors: Medler KF

    更新日期:2010-11-01 00:00:00

  • Oral amiloride treatment decreases taste sensitivity to sodium salts in C57BL/6J and DBA/2J mice.

    abstract::Sodium taste transduction is thought to occur via an amiloride-sensitive, sodium-selective pathway and an amiloride-insensitive, cation nonselective, anion-dependent pathway(s). It has been shown by others that amiloride, an epithelial sodium channel (ENaC) blocker, significantly reduces the chorda tympani nerve respo...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Eylam S,Spector AC

    更新日期:2003-06-01 00:00:00

  • The signal function of thematically (In)congruent ambient scents in a retail environment.

    abstract::An odor emitted by an object signals the presence of that object and may draw attention to it. Can odors that are not actually emitted by an object also function as a signal? We investigated whether the degree of thematic congruency between an ambient odor and a magazine affected magazine sales in a retail store. We s...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Schifferstein HN,Blok ST

    更新日期:2002-07-01 00:00:00

  • Porcine VEG proteins and tear prealbumins.

    abstract::Small soluble proteins, belonging to the lipocalin family are secreted in large amounts by tongue von Ebner's glands and lachrymal glands. In humans, the lingual protein, called VEG, and the lachrymal protein, called tear prealbumin, have shown identical cDNA sequences. In the pig, we have purified homodimeric protein...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Garibotti M,Christiansen H,Schmale H,Pelosi P

    更新日期:1995-02-01 00:00:00

  • Subunit contributions to insect olfactory receptor function: channel block and odorant recognition.

    abstract::Insect olfactory receptors are heteromeric ligand-gated ion channels composed of at least one common subunit (Orco) and at least one subunit that confers odorant specificity. Little is known about how individual subunits contribute to the structure and function of the olfactory receptor complex. We expressed insect ol...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Nichols AS,Chen S,Luetje CW

    更新日期:2011-11-01 00:00:00