Comparison of Olfactory Identification Patterns among Parkinson's Disease Patients from Different Countries.


:Olfactory function assessment is an important screening tool and also may differentiate Parkinson's disease (PD) patients from other parkinsonisms, including nondegenerative ones, such as, normal pressure hydrocephalus, vascular, drug induced, or infectious parkinsonism. Several authors in different countries have reported various sets of odors that best differentiate between these conditions. It is debated if distinctive patterns of "restrictive" or "selective" hyposmia in PD may be affected by cultural aspects. To compare the olfactory identification function in PD across different countries, we analyzed Sniffin' Sticks identification task results between 112 PD patients from Argentina and previously reported data of PD patients from Brazil (106 patients), the Netherlands (400 patients), Germany (40 patients), China (110 patients), and Sri Lanka (89 patients). Categorical principal component analysis (CATPCA) was performed to find components reflecting groups of odors similarly perceived across subjects. CATPCA analysis found 2 components for each group which shared 10 out of 16 odors amongst each other. We found that only the shared items of component 2 (orange, mint, banana, garlic, coffee, cloves, and fish) showed uniform results across all of the included countries, whereas variations in component 1 (licorice, turpentine, and apple) were attributed mostly to differences across control groups.


Chem Senses


Chemical senses


Millar Vernetti P,Rossi M,Cerquetti D,Perez Lloret S,Merello M




Has Abstract


2016-01-01 00:00:00














  • Do tastants have a smell?

    abstract::The stimuli used in taste research are usually considered to be odourless. This was tested in two experiments with aqueous solutions of two representative compounds for each of the five taste qualities including umami. In the first experiment elderly and young subjects rated the intensity and pleasantness of three con...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Mojet J,Köster EP,Prinz JF

    更新日期:2005-01-01 00:00:00

  • Color enhances orthonasal olfactory intensity and reduces retronasal olfactory intensity.

    abstract::The effect of color on orthonasal and retronasal odor intensities was investigated. When odorants were smelled orthonasally (i.e., through the nostrils), color enhanced odor intensity ratings, consistent with previous reports. However, when odorants were smelled retronasally (i.e., the odorous solution was put in the ...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Koza BJ,Cilmi A,Dolese M,Zellner DA

    更新日期:2005-10-01 00:00:00

  • Odor discrimination and task duration in young and older adults.

    abstract::The effect of task duration on odor discrimination in aging was studied. Twenty-seven young male adults and 24 young female adults between 18 and 30 years of age, and 17 older male adults between 45 and 65 years of age completed an odor discrimination task. The odor discrimination task consisted of two parts of 16 tri...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Hulshoff Pol HE,Hijman R,Baaré WF,van Eekelen S,van Ree JM

    更新日期:2000-08-01 00:00:00

  • Evaluation of the key odorants of foods by dilution experiments, aroma models and omission.

    abstract::The state of the art in aroma analysis is reviewed with emphasis on aroma-recombination studies using synthetic blends of odorants (aroma models) which have been prepared on the basis of analytical data. The model that matches the original aroma is the starting material for omission experiments which are performed to ...

    journal_title:Chemical senses

    pub_type: 杂志文章,评审


    authors: Grosch W

    更新日期:2001-06-01 00:00:00

  • Distortion of olfactory perception: diagnosis and treatment.

    abstract::Clinically, olfaction can fail in any of three ways: (i) decreased sensitivity (hyposmia, anosmia) and two types of distortion (dysosmia); (ii) distorted quality of an odorant stimulation (troposmia); (iii) perceived odor when no odorant is present (phantosmia, hallucination). The distortions are usually much more ups...

    journal_title:Chemical senses

    pub_type: 杂志文章,评审


    authors: Leopold D

    更新日期:2002-09-01 00:00:00

  • Temporal integration in nasal lateralization and nasal detection of carbon dioxide.

    abstract::Two experiments examined time/concentration trading for the detection of carbon dioxide, an irritant with little or no odor. Experiment 1 employed the nasal lateralization method: subjects attempted to determine which nostril received carbon dioxide and which received pure air when presented simultaneously. Experiment...

    journal_title:Chemical senses

    pub_type: 临床试验,杂志文章


    authors: Wise PM,Radil T,Wysocki CJ

    更新日期:2004-02-01 00:00:00

  • A sexually dimorphic group of atypical glomeruli in the mouse olfactory bulb.

    abstract::Atypical glomeruli (AtG) are clearly distinguishable from typical ones because of their strong cholinergic innervation. AtG are located in defined positions in the caudal half of the main olfactory bulb of rodents. The AtG partially overlap with other specialized olfactory subsystems, such as the modified glomerular c...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Weruaga E,Briñón JG,Porteros A,Arévalo R,Aijón J,Alonso JR

    更新日期:2001-01-01 00:00:00

  • Evaluation of copper speciation and water quality factors that affect aqueous copper tasting response.

    abstract::This study determined taste thresholds for copper as its speciation was varied among free cupric ion, complexed cupric ion, and precipitated cupric particles. The impact of copper chemistry on taste is important as copper is added to many beverages and can be present in drinking water as a natural mineral or due to co...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Cuppett JD,Duncan SE,Dietrich AM

    更新日期:2006-09-01 00:00:00

  • The distribution of sugar chains on the vomeronasal epithelium observed with an atomic force microscope.

    abstract::The distribution of sugar chains on tissue sections of the rat vomeronasal epithelium, and the adhesive force between the sugar and its specific lectin were examined with an atomic force microscope (AFM). AFM tips were modified with a lectin, Vicia villosa agglutinin, which recognizes terminal N-acetyl-D-galactosamine...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Osada T,Takezawa S,Itoh A,Arakawa H,Ichikawa M,Ikai A

    更新日期:1999-02-01 00:00:00

  • Making scents: dynamic olfactometry for threshold measurement.

    abstract::Data on human odor thresholds show disparities huge enough to marginalize olfactory psychophysics and delegitimize importation of its data into other areas. Variation of orders of magnitude from study to study, much of it systematic, threatens meaningful comparisons with animal species, comparison between in vivo with...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Schmidt R,Cain WS

    更新日期:2010-02-01 00:00:00

  • Electroolfactogram responses from organotypic cultures of the olfactory epithelium from postnatal mice.

    abstract::Organotypic cultures of the mouse olfactory epithelium connected to the olfactory bulb were obtained with the roller tube technique from postnatal mice aged between 13 and 66 days. To test the functionality of the cultures, we measured electroolfactograms (EOGs) at different days in vitro (DIV), up to 7 DIV, and we co...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Pinato G,Rievaj J,Pifferi S,Dibattista M,Masten L,Menini A

    更新日期:2008-04-01 00:00:00

  • Changes in Olfactory Sensory Neuron Physiology and Olfactory Perceptual Learning After Odorant Exposure in Adult Mice.

    abstract::The adult olfactory system undergoes experience-dependent plasticity to adapt to the olfactory environment. This plasticity may be accompanied by perceptual changes, including improved olfactory discrimination. Here, we assessed experience-dependent changes in the perception of a homologous aldehyde pair by testing mi...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Kass MD,Guang SA,Moberly AH,McGann JP

    更新日期:2016-02-01 00:00:00

  • The septal organ of the rat during postnatal development.

    abstract::The septal organ of Masera (SO) is a small, isolated patch of olfactory epithelium, located in the ventral part of the nasal septum. We investigated in this systematic study the postnatal development of the SO in histological sections of rats at various ages from the day of birth (P1) to P666. The SO-area increases to...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Weiler E,Farbman AI

    更新日期:2003-09-01 00:00:00

  • Taste sensitivity and aging: high incidence of decline revealed by repeated threshold measures.

    abstract::Contrary to what has often been said about the subject, decline in taste sensitivity with aging characterizes virtually everybody and is not the artificial result of averaging large losses of a minority with negligible losses of a majority. This assertion is supported by six repeated measures of sucrose thresholds in ...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Stevens JC,Cruz LA,Hoffman JM,Patterson MQ

    更新日期:1995-08-01 00:00:00

  • Effects of aromatic compounds on antennal responses and on the pheromone-binding proteins of the gypsy moth (Lymantria dispar).

    abstract::Female gypsy moths emit a pheromone, (+)-disparlure, which the males follow until they locate the emitter. The male moths' antennae are covered with innervated sensory hairs, specialized in detection of the pheromone. The neurons in these sensory hairs are bathed by a solution rich in pheromone-binding protein (PBP). ...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Gong Y,Plettner E

    更新日期:2011-03-01 00:00:00

  • A model of the role of adaptation and disadaptation in olfactory receptor neurons: implications for the coding of temporal and intensity patterns in odor signals.

    abstract::Natural odors occur as turbulent plumes resulting in spatially and temporally variable odor signals at the chemoreceptor cells. Concentrations can fluctuate widely within discrete packets of odor and individual packets are very intermittent and unpredictable. Chemoreceptor cells display the temporally dynamic properti...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Moore PA

    更新日期:1994-02-01 00:00:00

  • Olfactory functions in Parkinson's disease and Alzheimer's disease.

    abstract::The aim of this investigation was to compare olfactory functions of patients suffering from Parkinson's disease (PD) and Alzheimer's disease (AD). Olfactory threshold, odor identification ability and odor memory performance were assessed in 21 non-demented PD patients and in 22 AD patients. Both patient groups were im...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Lehrner JP,Brücke T,Dal-Bianco P,Gatterer G,Kryspin-Exner I

    更新日期:1997-02-01 00:00:00

  • A new method to improve olfactory responses to GC effluents.

    abstract::Biological detectors such as the human nose or an insect antenna represent extremely attractive detectors for gas chromatography (GC) since they are specifically tuned to perceive biologically relevant compounds. However, these detectors are nonlinear, noisy and often perform poorly under standard GC conditions since ...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Gouinguené S,de Cruz I,van der Pers J,Wadhams L,Marion-Poll F

    更新日期:1998-12-01 00:00:00

  • Reduced taste sensitivity in congenital blindness.

    abstract::Sight is undoubtedly not only important for food identification and selection but also for the modulation of gustatory sensitivity. We can, therefore, assume that taste sensitivity and eating habits are affected by visual deprivation from birth. We measured taste detection and identification thresholds of the 5 basic ...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Gagnon L,Kupers R,Ptito M

    更新日期:2013-07-01 00:00:00

  • Female snake sex pheromone induces membrane responses in vomeronasal sensory neurons of male snakes.

    abstract::The vomeronasal organ (VNO) is important for activating accessory olfactory pathways that are involved in sexually dimorphic mating behavior. The VNO of male garter snakes is critically important for detection of, and response to, female sex pheromones. In the present study, under voltage-clamp conditions, male snake ...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Huang GZ,Zhang JJ,Wang D,Mason RT,Halpern M

    更新日期:2006-07-01 00:00:00

  • The Effects of Odor Quality and Temporal Asynchrony on Modulation of Taste Intensity by Retronasal Odor.

    abstract::The experiments had 2 main goals: 1) to add to the sparse literature on how retronasal aromas interact with bitter tastes, and 2) to determine whether modulation of taste intensity by aroma depends on temporal contiguity, as one might expect if flavor interactions depend on cross-modal binding (similar to object perce...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Isogai T,Wise PM

    更新日期:2016-09-01 00:00:00

  • Interactions of odorants with olfactory receptors and other preprocessing mechanisms: how complex and difficult to predict?

    abstract::In this issue of Chemical Senses, Münch et al. present a thorough analysis of how mixtures of odorants interact with olfactory receptors (ORs) borne by olfactory receptor neurons (ORNs). Using fruit fly ORNs expressing the receptor OR22a, they provide a clear example of mixture interaction and confirm that the respons...

    journal_title:Chemical senses

    pub_type: 评论,杂志文章


    authors: Rospars JP

    更新日期:2013-05-01 00:00:00

  • Identification of gustatory-olfactory flavor mixtures: effects of linguistic labeling.

    abstract::Two experiments, using different ranges and numbers of stimuli, examined how linguistic labels affect the identification of flavor mixtures containing different proportions of sucrose (gustatory flavorant) and citral (olfactory flavorant). Both experiments asked subjects to identify each stimulus as having either "mos...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Brewer JM,Shavit AY,Shepard TG,Veldhuizen MG,Parikh R,Marks LE

    更新日期:2013-05-01 00:00:00

  • Visual and chemical release of feeding behavior in adult rainbow trout.

    abstract::Feeding behavior of adult rainbow trout (Oncorhynchus mykiss) is released by visual and/or chemical stimuli. Detection of either a conditioned visual or a conditioned chemical stimulus creates an excitatory feeding state within the central nervous system which turns on feeding behavior composed of swimming, turning an...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Valentincic T,Caprio J

    更新日期:1997-08-01 00:00:00

  • SW.B6-Soa(b) nontaster congenic strains completed and a sucrose octaacetate congenic quartet tested with other bitters.

    abstract::Ten SW.B6 SOA nontaster strains congenic with the SWR/J SOA taster inbred strain were bred via repeated backcross-intercross cycles, with selection for nontasting in each cycle. Preference ratio distributions and phenotypic proportions across cycles at 0.1 mM SOA were consistent with monogenic predictions. The SW.B6 m...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Harder DB,Gannon KS,Whitney G

    更新日期:1996-10-01 00:00:00

  • Individual differences in sour and salt sensitivity: detection and quality recognition thresholds for citric acid and sodium chloride.

    abstract::Taste sensitivity is assessed with various techniques, including absolute detection and quality recognition. For any stimulus, one might expect individual differences in sensitivity to be reflected in all measures, but they are often surprisingly independent. Here, we focus on sensitivity to sour and salty taste, in p...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Wise PM,Breslin PA

    更新日期:2013-05-01 00:00:00

  • Methyl salicylate, identified as primary odorant of a specific receptor neuron type, inhibits oviposition by the moth Mamestra brassicae L. (Lepidoptera, noctuidae).

    abstract::The cabbage moth, Mamestra brassicae L. (Lepidoptera, Noctuidae), is a polyphagous species that is often choosing plants of Brassica as hosts for oviposition. In the search for biologically relevant odorants used by these moths, gas chromatography linked to electrophysiological recordings from single receptor neurons ...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Ulland S,Ian E,Mozuraitis R,Borg-Karlson AK,Meadow R,Mustaparta H

    更新日期:2008-01-01 00:00:00

  • Food perception with age and its relationship to pleasantness.

    abstract::Differences between elderly subjects (n = 46, 61-86 years) and young subjects (n = 36, 18-25 years) in food perception and food liking were investigated. Intensity and liking ratings were assessed for custard dessert, in which flavor enrichment, textural change, and irritant addition were incorporated as strategies to...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Kremer S,Bult JH,Mojet J,Kroeze JH

    更新日期:2007-07-01 00:00:00

  • Individual Differences in Verbal and Non-Verbal Affective Responses to Smells: Influence of Odor Label Across Cultures.

    abstract::Olfactory perception is highly variable from one person to another, as a function of individual and contextual factors. Here, we investigated the influence of 2 important factors of variation: culture and semantic information. More specifically, we tested whether cultural-specific knowledge and presence versus absence...

    journal_title:Chemical senses

    pub_type: 临床试验,杂志文章


    authors: Ferdenzi C,Joussain P,Digard B,Luneau L,Djordjevic J,Bensafi M

    更新日期:2017-01-01 00:00:00

  • Sex-specific responses to urinary chemicals by the mouse vomeronasal organ.

    abstract::Social behaviors of most mammals are affected by chemical signals, pheromones, exchanged between conspecifics. Previous experiments have shown that behavioral responses to the same pheromone differ depending on the sex and endocrine status of the respondent. Although the exact mechanism of this dimorphism is not known...

    journal_title:Chemical senses

    pub_type: 杂志文章


    authors: Thompson RN,Robertson BK,Napier A,Wekesa KS

    更新日期:2004-11-01 00:00:00