Comparison of Olfactory Identification Patterns among Parkinson's Disease Patients from Different Countries.

Abstract:

:Olfactory function assessment is an important screening tool and also may differentiate Parkinson's disease (PD) patients from other parkinsonisms, including nondegenerative ones, such as, normal pressure hydrocephalus, vascular, drug induced, or infectious parkinsonism. Several authors in different countries have reported various sets of odors that best differentiate between these conditions. It is debated if distinctive patterns of "restrictive" or "selective" hyposmia in PD may be affected by cultural aspects. To compare the olfactory identification function in PD across different countries, we analyzed Sniffin' Sticks identification task results between 112 PD patients from Argentina and previously reported data of PD patients from Brazil (106 patients), the Netherlands (400 patients), Germany (40 patients), China (110 patients), and Sri Lanka (89 patients). Categorical principal component analysis (CATPCA) was performed to find components reflecting groups of odors similarly perceived across subjects. CATPCA analysis found 2 components for each group which shared 10 out of 16 odors amongst each other. We found that only the shared items of component 2 (orange, mint, banana, garlic, coffee, cloves, and fish) showed uniform results across all of the included countries, whereas variations in component 1 (licorice, turpentine, and apple) were attributed mostly to differences across control groups.

journal_name

Chem Senses

journal_title

Chemical senses

authors

Millar Vernetti P,Rossi M,Cerquetti D,Perez Lloret S,Merello M

doi

10.1093/chemse/bjv062

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

77-83

issue

1

eissn

0379-864X

issn

1464-3553

pii

bjv062

journal_volume

41

pub_type

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