Anterior tongue stimulation with amiloride suppresses NaCl saltiness, but not citric acid sourness in humans.

Abstract:

:Suppression of the saltiness of NaCl solutions by amiloride, a sodium channel blocker, has previously been reported a number of times in humans. This suppression was seen with techniques that involved stimulation of small areas of the tongue. It was not certain, however, whether amiloride would suppress saltiness with stimulation of a much larger area of the tongue; one published study, in fact, found negative results with whole mouth stimulation. For this study, eight subjects dipped a large part of the anterior portion of the tongue into a 10-ml sample of NaCl solution, or a NaCl and amiloride solution, and reported its magnitude of saltiness intensity. The results show that amiloride suppressed the saltiness of NaCl when a large area of the anterior tongue was stimulated. Consistent with previous studies, there was individual variability across subjects in this suppressive effect of amiloride. This study also used this method to test the effects of amiloride on the sourness of citric acid, which was not expected to be affected. No suppression of sourness was seen with amiloride.

journal_name

Chem Senses

journal_title

Chemical senses

authors

Tennissen AM,McCutcheon NB

doi

10.1093/chemse/21.2.113

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

113-20

issue

2

eissn

0379-864X

issn

1464-3553

journal_volume

21

pub_type

杂志文章
  • Changes in Olfactory Sensory Neuron Physiology and Olfactory Perceptual Learning After Odorant Exposure in Adult Mice.

    abstract::The adult olfactory system undergoes experience-dependent plasticity to adapt to the olfactory environment. This plasticity may be accompanied by perceptual changes, including improved olfactory discrimination. Here, we assessed experience-dependent changes in the perception of a homologous aldehyde pair by testing mi...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjv065

    authors: Kass MD,Guang SA,Moberly AH,McGann JP

    更新日期:2016-02-01 00:00:00

  • Activation and inhibition of the transduction process in silkmoth olfactory receptor neurons.

    abstract::Electrophysiological responses of olfactory receptor neurons in both male and female silkmoths (Bombyx mori) were investigated. In both sexes, the G-protein activator sodium fluoride and 1,2-dioctanoyl-sn-glycerol, a membrane-permeable analog of the protein kinase C activator diacylglycerol, elicited nerve impulse res...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/27.5.435

    authors: Pophof B,Van der Goes van Naters W

    更新日期:2002-06-01 00:00:00

  • Enhancement of Combined Umami and Salty Taste by Glutathione in the Human Tongue and Brain.

    abstract::Glutathione, a natural substance, acts on calcium receptors on the tongue and is known to enhance basic taste sensations. However, the effects of glutathione on brain activity associated with taste sensation on the tongue have not been determined under standardized taste delivery conditions. In this study, we investig...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjw066

    authors: Goto TK,Yeung AW,Tanabe HC,Ito Y,Jung HS,Ninomiya Y

    更新日期:2016-09-01 00:00:00

  • Taste sensitivity and aging: high incidence of decline revealed by repeated threshold measures.

    abstract::Contrary to what has often been said about the subject, decline in taste sensitivity with aging characterizes virtually everybody and is not the artificial result of averaging large losses of a minority with negligible losses of a majority. This assertion is supported by six repeated measures of sucrose thresholds in ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/20.4.451

    authors: Stevens JC,Cruz LA,Hoffman JM,Patterson MQ

    更新日期:1995-08-01 00:00:00

  • The timing of alpha-gustducin expression during cell renewal in rat vallate taste buds.

    abstract::The G protein subunit alpha-gustducin is expressed in a subset of light (Type II) but not in dark (Type I) cells in rat vallate taste buds. The thymidine analogue 5-bromo-2'-deoxyuridine (BrdU) is incorporated into DNA during the S-phase of the cell cycle and can be used to determine the time of origin of a cell. In t...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/23.6.735

    authors: Cho YK,Farbman AI,Smith DV

    更新日期:1998-12-01 00:00:00

  • The impact of olfactory disorders in the United kingdom.

    abstract::Olfactory disorders are believed to affect 5% of the general population and have been shown to bear significant psychosocial consequences to sufferers. Although more common than blindness and profound deafness in the United Kingdom, the impact of these disorders has not been assessed to date and the plight of British ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bju043

    authors: Philpott CM,Boak D

    更新日期:2014-10-01 00:00:00

  • Alarm pheromone that aggravates stress-induced hyperthermia is soluble in water.

    abstract::We previously reported that stressed male Wistar rats released alarm pheromone from the perianal region, which aggravated stress-induced hyperthermia and increased Fos expression in the mitral/tufted cell layer of the accessory olfactory bulb in recipient rats. In this study, we attempted to obtain this pheromone in w...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bji044

    authors: Kiyokawa Y,Kikusui T,Takeuchi Y,Mori Y

    更新日期:2005-07-01 00:00:00

  • Ontogeny of the solitary chemosensory cells in the zebrafish, Danio rerio.

    abstract::Secondary epidermal solitary chemosensory cells (SCCs) are widespread among the primary aquatic vertebrates. They resemble taste bud sensory cells in fine structure and may be innervated from facial or spinal nerves. According to previous studies, SCCs may constitute a water sampling system in the contexts of predator...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/22.2.111

    authors: Kotrschal K,Krautgartner WD,Hansen A

    更新日期:1997-04-01 00:00:00

  • Visual and chemical release of feeding behavior in adult rainbow trout.

    abstract::Feeding behavior of adult rainbow trout (Oncorhynchus mykiss) is released by visual and/or chemical stimuli. Detection of either a conditioned visual or a conditioned chemical stimulus creates an excitatory feeding state within the central nervous system which turns on feeding behavior composed of swimming, turning an...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/22.4.375

    authors: Valentincic T,Caprio J

    更新日期:1997-08-01 00:00:00

  • Odors: implicit memory and performance effects.

    abstract::In order to assess the influence of odors on human performance and implicit memory for odors, 108 subjects completed a variety of tests in weakly scented (jasmine, lavender or odorless) rooms without having been made aware of the odor. After a 30 min interval the subjects were shown slides of different surroundings, i...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/24.3.317

    authors: Degel J,Köster EP

    更新日期:1999-06-01 00:00:00

  • A sexually dimorphic group of atypical glomeruli in the mouse olfactory bulb.

    abstract::Atypical glomeruli (AtG) are clearly distinguishable from typical ones because of their strong cholinergic innervation. AtG are located in defined positions in the caudal half of the main olfactory bulb of rodents. The AtG partially overlap with other specialized olfactory subsystems, such as the modified glomerular c...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/26.1.7

    authors: Weruaga E,Briñón JG,Porteros A,Arévalo R,Aijón J,Alonso JR

    更新日期:2001-01-01 00:00:00

  • Subunit contributions to insect olfactory receptor function: channel block and odorant recognition.

    abstract::Insect olfactory receptors are heteromeric ligand-gated ion channels composed of at least one common subunit (Orco) and at least one subunit that confers odorant specificity. Little is known about how individual subunits contribute to the structure and function of the olfactory receptor complex. We expressed insect ol...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjr053

    authors: Nichols AS,Chen S,Luetje CW

    更新日期:2011-11-01 00:00:00

  • Enhancement of sucrose sweetness with soluble starch in humans.

    abstract::The effect of soluble starch (acid-modified starch) on taste intensity was investigated in human subjects. Different concentrations of sucrose (Suc), six sweeteners, NaCl, quinine-HCl (QHCl) and citric acid (Cit) were dissolved in either distilled water (DW; standard) or starch solution (test solution). The solutions ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/27.1.67

    authors: Kanemaru N,Harada S,Kasahara Y

    更新日期:2002-01-01 00:00:00

  • Temporary modification of salivary protein profile and individual responses to repeated phenolic astringent stimuli.

    abstract::The extent of the change in salivary protein characteristics after repeated stimulations was shown to be correlated to differences in perceived astringency. Salivary characteristics of 77 subjects were compared after masticatory (S1) and taste/masticatory (S2) stimulations. The variations (S2 minus S1) of protein conc...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjp084

    authors: Dinnella C,Recchia A,Vincenzi S,Tuorila H,Monteleone E

    更新日期:2010-01-01 00:00:00

  • Olfactory discrimination of amino acids in brown bullhead catfish.

    abstract::Olfactory discrimination of amino acids was investigated in brown bullhead catfish (Ameiurus nebulosus). Based on the magnitude of the observed food search activity of catfish conditioned to single amino acids, the tested compounds were classified as being detected by the catfish as equal to, similar to, or different ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/25.1.21

    authors: Valentincic T,Metelko J,Ota D,Pirc V,Blejec A

    更新日期:2000-02-01 00:00:00

  • Individual differences in the perceived intensity and quality of specific odors following self- and cross-adaptation.

    abstract::Adaptation techniques have traditionally been employed in sensory physiology and psychology to characterize afferent pathways and to dissect the quantitative and, to a lesser degree, the qualitative aspects of perception. We continue to explore the individual differences in olfactory capabilities among subjects initia...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/19.3.197

    authors: O'Connell RJ,Stevens DA,Zogby LM

    更新日期:1994-06-01 00:00:00

  • Nestmate recognition cues in the honey bee: differential importance of cuticular alkanes and alkenes.

    abstract::In social insects, recognition of nestmates from aliens is based on olfactory cues, and many studies have demonstrated that such cues are contained within the lipid layer covering the insect cuticle. These lipids are usually a complex mixture of tens of compounds in which aliphatic hydrocarbons are generally the major...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bji040

    authors: Dani FR,Jones GR,Corsi S,Beard R,Pradella D,Turillazzi S

    更新日期:2005-07-01 00:00:00

  • The signal function of thematically (In)congruent ambient scents in a retail environment.

    abstract::An odor emitted by an object signals the presence of that object and may draw attention to it. Can odors that are not actually emitted by an object also function as a signal? We investigated whether the degree of thematic congruency between an ambient odor and a magazine affected magazine sales in a retail store. We s...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/27.6.539

    authors: Schifferstein HN,Blok ST

    更新日期:2002-07-01 00:00:00

  • Roborovskin, a lipocalin in the urine of the Roborovski hamster, Phodopus roborovskii.

    abstract::Many rodents are now known to exhibit an obligate proteinuria that delivers urine-mediated chemosignals. In this paper, we explore the urinary proteins of the Roborovski hamster (Phodopus roborovskii). Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of urine from individual male and female Roborovsk...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjq060

    authors: Turton MJ,Robertson DH,Smith JR,Hurst JL,Beynon RJ

    更新日期:2010-10-01 00:00:00

  • A new method to improve olfactory responses to GC effluents.

    abstract::Biological detectors such as the human nose or an insect antenna represent extremely attractive detectors for gas chromatography (GC) since they are specifically tuned to perceive biologically relevant compounds. However, these detectors are nonlinear, noisy and often perform poorly under standard GC conditions since ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/23.6.647

    authors: Gouinguené S,de Cruz I,van der Pers J,Wadhams L,Marion-Poll F

    更新日期:1998-12-01 00:00:00

  • Now you like me, now you don't: impact of labels on odor perception.

    abstract::Past research has shown that odor perception can be affected by how we label odors. The aim of this study was to expand on previous work by investigating the impact of labels on edibility, pleasantness, and intensity ratings as well as on reaction times when detecting labeled odors. We tested 50 subjects. Five odorant...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjt066

    authors: Manescu S,Frasnelli J,Lepore F,Djordjevic J

    更新日期:2014-02-01 00:00:00

  • Olfactory functions in Parkinson's disease and Alzheimer's disease.

    abstract::The aim of this investigation was to compare olfactory functions of patients suffering from Parkinson's disease (PD) and Alzheimer's disease (AD). Olfactory threshold, odor identification ability and odor memory performance were assessed in 21 non-demented PD patients and in 22 AD patients. Both patient groups were im...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/22.1.105

    authors: Lehrner JP,Brücke T,Dal-Bianco P,Gatterer G,Kryspin-Exner I

    更新日期:1997-02-01 00:00:00

  • Odor Emotional Quality Predicts Odor Identification.

    abstract::It is commonly agreed upon a strong link between emotion and olfaction. Odor-evoked memories are experienced as more emotional compared with verbal, visual, and tactile stimuli. Moreover, the emotional quality of odor cues increases memory performance, but contrary to this, odors are poor retrieval cues for verbal lab...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjv037

    authors: Bestgen AK,Schulze P,Kuchinke L

    更新日期:2015-09-01 00:00:00

  • A candidate pheromone receptor and two odorant receptors of the hawkmoth Manduca sexta.

    abstract::In this study, we cloned and characterized three Manduca sexta odorant receptors (ORs). One receptor is a putative pheromone receptor expressed exclusively in a cell associated with male-specific type-I trichoid sensilla. We describe the results of real-time PCR (RT-PCR) and quantitative real-time PCR (qRT-PCR) experi...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjp002

    authors: Patch HM,Velarde RA,Walden KK,Robertson HM

    更新日期:2009-05-01 00:00:00

  • Perception of everyday odors--correlation between intensity, familiarity and strength of hedonic judgement.

    abstract::In this study, 40 Japanese, 44 German and 39 Mexican women were presented with 18 everyday odorants. They were asked to rate them for intensity on a six-point scale from not detectable to very strong, for pleasantness on an 11-point scale from -5, to neutral at 0, to +5, and for familiarity on a six-point scale from c...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/24.2.191

    authors: Distel H,Ayabe-Kanamura S,Martínez-Gómez M,Schicker I,Kobayakawa T,Saito S,Hudson R

    更新日期:1999-04-01 00:00:00

  • Chemical stimulation of the thalamic reticular nucleus inhibits the neuronal activity of the posterior insular cortex in rats.

    abstract::Extracellular neuronal responses were recorded from the posterior insular cortex following electrical and chemical stimulation of the thalamic reticular nucleus (Rt) regions. In the present study, most neurons (29/32) were first characterized for their responses to electrical stimulation of the superior laryngeal (SL)...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjg064

    authors: Hanamori T

    更新日期:2003-10-01 00:00:00

  • The regeneration of P2 olfactory sensory neurons is selectively impaired following methyl bromide lesion.

    abstract::The capacity of the peripheral olfactory system to recover after injury has not been thoroughly explored. P2-IRES-tauLacZ mice were exposed to methyl bromide, which causes epithelial damage and kills 90% of the P2 neurons. With subsequent neuronal regeneration, P2 neurons recover within their usual territory to equal ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bju033

    authors: Holbrook EH,Iwema CL,Peluso CE,Schwob JE

    更新日期:2014-09-01 00:00:00

  • Emotional Body Odors as Context: Effects on Cardiac and Subjective Responses.

    abstract::Many studies have indicated that the chemical cues from body odors (BOs) of donors experiencing negative emotions can influence the psychophysiological and behavioral response of the observers. However, these olfactory cues have been used mainly as contextual information for processing visual stimuli. Here, for the fi...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjy021

    authors: Ferreira J,Parma V,Alho L,Silva CF,Soares SC

    更新日期:2018-05-23 00:00:00

  • Contribution of fatty acids to olfactory host finding of female Aedes aegypti.

    abstract::Single carbon to 18 carbon n-aliphatic carboxylic acids were tested for their attractive effects on female Aedes aegypti in a Y-tube olfactometer. Each acid was tested over a wide range of concentrations together with L-(+)-lactic acid, the indispensable synergist for other attractive components emitted from human hos...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.chemse.a014042

    authors: Bosch OJ,Geier M,Boeckh J

    更新日期:2000-06-01 00:00:00

  • The septal organ of the rat during postnatal development.

    abstract::The septal organ of Masera (SO) is a small, isolated patch of olfactory epithelium, located in the ventral part of the nasal septum. We investigated in this systematic study the postnatal development of the SO in histological sections of rats at various ages from the day of birth (P1) to P666. The SO-area increases to...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjg047

    authors: Weiler E,Farbman AI

    更新日期:2003-09-01 00:00:00