The influence of sodium salts on binary mixtures of bitter-tasting compounds.

Abstract:

:In order to study potential mixture interactions among bitter compounds, selected sodium salts were added to five compounds presented either alone or as binary bitter-compound mixtures. Each compound was tested at a concentration that elicited 'weak' perceived bitterness. The bitter compounds were mixed at these concentrations to form a subset of possible binary mixtures. For comparison, the concentration of each solitary compound was doubled to measure bitterness inhibition at the higher intensity level elicited by the mixtures. The following sodium salts were tested for bitterness inhibition: 100 mM sodium chloride (salty), 100 mM sodium gluconate (salty), 100 and 20 mM monosodium glutamate (umami), and 50 mM adenosine monophosphate disodium salt (umami). Sucrose (sweet) was also employed as a bitterness suppressor. The sodium salts differentially suppressed the bitterness of compounds and their binary combinations. Although most bitter compounds were suppressed, the bitterness of tetralone was not suppressed, nor was the bitterness of the binary mixtures that contained it. In general, the percent suppression of binary mixtures of compounds was predicted by the average percent suppression of its two components. Within the constraints of the present study, the bitterness of mixtures was suppressed by sodium salts and sucrose independently, with few bitter interactions. This is consistent with observations that the bitter taste system integrates the bitterness of multi-compound solutions linearly.

journal_name

Chem Senses

journal_title

Chemical senses

authors

Keast RS,Canty TM,Breslin PA

doi

10.1093/chemse/bjh045

keywords:

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

431-9

issue

5

eissn

0379-864X

issn

1464-3553

pii

29/5/431

journal_volume

29

pub_type

杂志文章
  • Switch and bait: probing the discriminative basis of odor identification via recognition memory.

    abstract::When people misidentify everyday odors, as they often do, their errors may conceivably lie in faulty perceptions or in faulty access to the names. Discussions of the matter usually focus on the latter, as if people had no problems with perceptual accuracy. (The problem of faulty access may get attention because its hi...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/21.1.35

    authors: Cain WS,Potts BC

    更新日期:1996-02-01 00:00:00

  • Human odor detectability: new methodology used to determine threshold and variation.

    abstract::Current ambiguity concerning the related issues of optimal means for measurement of odor sensitivity and the functional properties of the olfactory system hinders progress in basic and applied research on the human sense of smell. To address these needs, we selected n-amyl acetate (nAA) as a test odorant and developed...

    journal_title:Chemical senses

    pub_type: 临床试验,杂志文章

    doi:10.1093/chemse/bjg075

    authors: Walker JC,Hall SB,Walker DB,Kendal-Reed MS,Hood AF,Niu XF

    更新日期:2003-11-01 00:00:00

  • Individual Differences in Verbal and Non-Verbal Affective Responses to Smells: Influence of Odor Label Across Cultures.

    abstract::Olfactory perception is highly variable from one person to another, as a function of individual and contextual factors. Here, we investigated the influence of 2 important factors of variation: culture and semantic information. More specifically, we tested whether cultural-specific knowledge and presence versus absence...

    journal_title:Chemical senses

    pub_type: 临床试验,杂志文章

    doi:10.1093/chemse/bjw098

    authors: Ferdenzi C,Joussain P,Digard B,Luneau L,Djordjevic J,Bensafi M

    更新日期:2017-01-01 00:00:00

  • The relationship between fungiform papillae density and detection threshold for sucrose in the young males.

    abstract::The aim of this study was to investigate the relationship of fungiform papillae density with taste detection thresholds for sucrose of young male adults. One hundred and eighty two subjects aged 18-23 years (mean age: 21.9 +/- 1.2 years) were included. The densities of fungiform papillae were recorded with the aid of ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjn059

    authors: Zhang GH,Zhang HY,Wang XF,Zhan YH,Deng SP,Qin YM

    更新日期:2009-01-01 00:00:00

  • Olfactory discrimination: when vision matters?

    abstract::Many previous studies have attempted to investigate the effect of visual cues on olfactory perception in humans. The majority of this research has only looked at the modulatory effect of color, which has typically been explained in terms of multisensory perceptual interactions. However, such crossmodal effects may equ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjn055

    authors: Demattè ML,Sanabria D,Spence C

    更新日期:2009-02-01 00:00:00

  • Individual differences in the perceived intensity and quality of specific odors following self- and cross-adaptation.

    abstract::Adaptation techniques have traditionally been employed in sensory physiology and psychology to characterize afferent pathways and to dissect the quantitative and, to a lesser degree, the qualitative aspects of perception. We continue to explore the individual differences in olfactory capabilities among subjects initia...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/19.3.197

    authors: O'Connell RJ,Stevens DA,Zogby LM

    更新日期:1994-06-01 00:00:00

  • Temporal changes in the neonatal recognition cue of Dohne Merino lambs (Ovis aries).

    abstract::The strong bond that is formed between ewe and lamb after parturition is important for lamb survival. Evidence exists that the ewe mainly employs olfactory recognition cues to distinguish her lamb from other lambs in the flock. We have found that volatile organic compounds in the wool of Merino lambs that presumably c...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjt075

    authors: Viviers MZ,Burger BV,le Roux NJ,Morris J,le Roux M

    更新日期:2014-03-01 00:00:00

  • Lack of functional and morphological susceptibility of the greater superficial petrosal nerve to developmental dietary sodium restriction.

    abstract::Restriction of dietary sodium during gestation has major effects on taste function and anatomy in the offspring. The chorda tympani nerve of offspring that are maintained on sodium-reduced chow throughout life (NaDep) has reduced neurophysiological responses to sodium and altered morphology of its terminal field in th...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/25.6.719

    authors: Sollars SI,Hill DL

    更新日期:2000-12-01 00:00:00

  • Evaluation of the key odorants of foods by dilution experiments, aroma models and omission.

    abstract::The state of the art in aroma analysis is reviewed with emphasis on aroma-recombination studies using synthetic blends of odorants (aroma models) which have been prepared on the basis of analytical data. The model that matches the original aroma is the starting material for omission experiments which are performed to ...

    journal_title:Chemical senses

    pub_type: 杂志文章,评审

    doi:10.1093/chemse/26.5.533

    authors: Grosch W

    更新日期:2001-06-01 00:00:00

  • The influence of taste on swallowing apnea, oral preparation time, and duration and amplitude of submental muscle contraction.

    abstract::Prior research has documented a modulating effect of taste on swallowing. We hypothesized that presentation of tastant stimuli would be a significant variable in swallowing-respiratory coordination, duration of oral bolus preparation, and submental muscle contraction. Twenty-three healthy females were presented with 1...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjl037

    authors: Leow LP,Huckabee ML,Sharma S,Tooley TP

    更新日期:2007-02-01 00:00:00

  • Olfactory cocainization is not an effective long-term treatment for phantosmia.

    abstract::Phantosmia, the perception of an odor when there are no odorants in the environment, can be a very debilitating symptom. In the 1960s, Zilstorff reported olfactory distortions could be treated by the topical application of a cocaine solution to the olfactory epithelium. In evaluating this treatment, we observed no lon...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjt047

    authors: Leopold DA,Hornung DE

    更新日期:2013-11-01 00:00:00

  • Using Errors by Guard Honeybees (Apis mellifera) to Gain New Insights into Nestmate Recognition Signals.

    abstract::Although the honeybee (Apis mellifera) is one of the world most studied insects, the chemical compounds used in nestmate recognition, remains an open question. By exploiting the error prone recognition system of the honeybee, coupled with genotyping, we studied the correlation between cuticular hydrocarbon (CHC) profi...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjv053

    authors: Pradella D,Martin SJ,Dani FR

    更新日期:2015-11-01 00:00:00

  • Female snake sex pheromone induces membrane responses in vomeronasal sensory neurons of male snakes.

    abstract::The vomeronasal organ (VNO) is important for activating accessory olfactory pathways that are involved in sexually dimorphic mating behavior. The VNO of male garter snakes is critically important for detection of, and response to, female sex pheromones. In the present study, under voltage-clamp conditions, male snake ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjj056

    authors: Huang GZ,Zhang JJ,Wang D,Mason RT,Halpern M

    更新日期:2006-07-01 00:00:00

  • Guanosine 3',5'-cyclic monophosphate reduces the response of the Moth's olfactory receptor neuron to pheromone.

    abstract::The effects of the membrane-permeable dibutyryl guanosine 3', 5'-cyclic monophosphate (db-cGMP) on the bombykol-elicited receptor current and nerve impulse activity were studied using the open sensillum recording technique. db-cGMP was applied to the outer dendritic membrane of the olfactory receptor neuron of the mot...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/25.4.381

    authors: Redkozubov A

    更新日期:2000-08-01 00:00:00

  • Analysis of slow hyperpolarizing potentials in frog taste cells induced by glossopharyngeal nerve stimulation.

    abstract::Electrical stimulation of the frog glossopharyngeal (GP) nerve evoked slow hyperpolarizing potentials (HPs) in taste cells. This study aimed to clarify whether slow HPs were postsynaptically induced in taste cells. The slow HPs were recorded intracellularly with a microelectrode. When Ca2+ concentration in the blood p...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjh072

    authors: Sato T,Okada Y,Toda K

    更新日期:2004-10-01 00:00:00

  • Study of the olfactory epithelium in the developing sturgeon. Characterization of the crypt cells.

    abstract::In acipenserids, crypt cells (CCs) have only been observed in juvenile specimens, and it has not been clarified whether they differentiate along with olfactory receptor neurons (ORNs) during the lecithotrophic stage or during later development stages. Furthermore, no detailed optical microscopy (OM) or electron micros...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjp091

    authors: Camacho S,Ostos-Garrido MV,Domezain A,Carmona R

    更新日期:2010-02-01 00:00:00

  • Are odorant-binding proteins involved in odorant discrimination?

    abstract::Pheromone-sensitive sensilla trichodea of nine moth species belonging to six families and three superfamilies of Lepidoptera were immunolabelled with an antiserum against the pheromone-binding protein of Antheraea polyphemus. Strong immunolabelling of the sensillum lymph was observed in all long sensilla trichodea of ...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/21.6.719

    authors: Steinbrecht RA

    更新日期:1996-12-01 00:00:00

  • Derivation and evaluation of a labeled hedonic scale.

    abstract::The objective of this study was to develop a semantically labeled hedonic scale (LHS) that would yield ratio-level data on the magnitude of liking/disliking of sensation equivalent to that produced by magnitude estimation (ME). The LHS was constructed by having 49 subjects who were trained in ME rate the semantic magn...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjp054

    authors: Lim J,Wood A,Green BG

    更新日期:2009-11-01 00:00:00

  • Temporal integration in nasal lateralization and nasal detection of carbon dioxide.

    abstract::Two experiments examined time/concentration trading for the detection of carbon dioxide, an irritant with little or no odor. Experiment 1 employed the nasal lateralization method: subjects attempted to determine which nostril received carbon dioxide and which received pure air when presented simultaneously. Experiment...

    journal_title:Chemical senses

    pub_type: 临床试验,杂志文章

    doi:10.1093/chemse/bjh018

    authors: Wise PM,Radil T,Wysocki CJ

    更新日期:2004-02-01 00:00:00

  • The T cells in peripheral taste tissue of healthy human adults: predominant memory T cells and Th-1 cells.

    abstract::A healthy taste system is important to the maintenance of nutrition and overall quality of life, and taste disorders are associated with many inflammatory states. We previously determined the immune cells in normal human gustatory tissue; they are predominantly dendritic cells and CD4 T cells with a few macrophages an...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjq040

    authors: Feng P,Wang H,Feldman RS,Pribitkin EA,Breslin PA

    更新日期:2010-07-01 00:00:00

  • Understanding the regulation and function of adult neurogenesis: contribution from an insect model, the house cricket.

    abstract::Since the discovery of adult neurogenesis, a major issue is the role of newborn neurons and the function-dependent regulation of adult neurogenesis. We decided to use an animal model with a relatively simple brain to address these questions. In the adult cricket brain as in mammals, new neurons are produced throughout...

    journal_title:Chemical senses

    pub_type: 杂志文章,评审

    doi:10.1093/chemse/bjm010

    authors: Cayre M,Scotto-Lomassese S,Malaterre J,Strambi C,Strambi A

    更新日期:2007-05-01 00:00:00

  • Now you like me, now you don't: impact of labels on odor perception.

    abstract::Past research has shown that odor perception can be affected by how we label odors. The aim of this study was to expand on previous work by investigating the impact of labels on edibility, pleasantness, and intensity ratings as well as on reaction times when detecting labeled odors. We tested 50 subjects. Five odorant...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjt066

    authors: Manescu S,Frasnelli J,Lepore F,Djordjevic J

    更新日期:2014-02-01 00:00:00

  • Anosmia-A Clinical Review.

    abstract::Anosmia and hyposmia, the inability or decreased ability to smell, is estimated to afflict 3-20% of the population. Risk of olfactory dysfunction increases with old age and may also result from chronic sinonasal diseases, severe head trauma, and upper respiratory infections, or neurodegenerative diseases. These disord...

    journal_title:Chemical senses

    pub_type: 杂志文章,评审

    doi:10.1093/chemse/bjx025

    authors: Boesveldt S,Postma EM,Boak D,Welge-Luessen A,Schöpf V,Mainland JD,Martens J,Ngai J,Duffy VB

    更新日期:2017-09-01 00:00:00

  • Depression of gustatory receptor potential in frog taste cell by parasympathetic nerve-induced slow hyperpolarizing potential.

    abstract::Parasympathetic nerve (PSN) innervates taste cells of the frog taste disk, and electrical stimulation of PSN elicited a slow hyperpolarizing potential (HP) in taste cells. Here we report that gustatory receptor potentials in frog taste cells are depressed by PSN-induced slow HPs. When PSN was stimulated at 30 Hz durin...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjl028

    authors: Sato T,Nishishita K,Mineda T,Okada Y,Toda K

    更新日期:2007-01-01 00:00:00

  • Evaluation of copper speciation and water quality factors that affect aqueous copper tasting response.

    abstract::This study determined taste thresholds for copper as its speciation was varied among free cupric ion, complexed cupric ion, and precipitated cupric particles. The impact of copper chemistry on taste is important as copper is added to many beverages and can be present in drinking water as a natural mineral or due to co...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjl010

    authors: Cuppett JD,Duncan SE,Dietrich AM

    更新日期:2006-09-01 00:00:00

  • Retronasal but not oral-cavity-only identification of "purely olfactory" odorants.

    abstract::Identifications of 5 odorants selected to be nontrigeminal stimuli were compared using retronasal and oral-cavity-only (OCO) air-phase presentations, with OCO produced by both exhalation through the mouth and a nose clip that closed the nostrils. Nine identifiers were available on each trial; 1 or 2 were correct for e...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjm069

    authors: Chen V,Halpern BP

    更新日期:2008-02-01 00:00:00

  • Sex-specific responses to urinary chemicals by the mouse vomeronasal organ.

    abstract::Social behaviors of most mammals are affected by chemical signals, pheromones, exchanged between conspecifics. Previous experiments have shown that behavioral responses to the same pheromone differ depending on the sex and endocrine status of the respondent. Although the exact mechanism of this dimorphism is not known...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjh076

    authors: Thompson RN,Robertson BK,Napier A,Wekesa KS

    更新日期:2004-11-01 00:00:00

  • Expression and purification of functional ligand-binding domains of T1R3 taste receptors.

    abstract::Chemosensory receptors, including odor, taste, and vomeronasal receptors, comprise the largest group of G protein-coupled receptors (GPCRs) in the mammalian genome. However, little is known about the molecular determinants that are critical for the detection and discrimination of ligands by most of these receptors. Th...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjj053

    authors: Nie Y,Hobbs JR,Vigues S,Olson WJ,Conn GL,Munger SD

    更新日期:2006-07-01 00:00:00

  • Odor-evoked autobiographical memories: age and gender differences along the life span.

    abstract::Odors are powerful in bringing back old and vivid memories bearing emotional content. This inherent hedonic property of olfactory stimuli makes this sensory modality particularly suitable for studying autobiographical memory. In the present work, adolescents (first experiment), young adults (second experiment), and el...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjr089

    authors: Zucco GM,Aiello L,Turuani L,Köster E

    更新日期:2012-02-01 00:00:00

  • Elevated Cytosolic Cl- Concentrations in Dendritic Knobs of Mouse Vomeronasal Sensory Neurons.

    abstract::In rodents, the vomeronasal system controls social and sexual behavior. However, several mechanistic aspects of sensory signaling in the vomeronasal organ remain unclear. Here, we investigate the biophysical basis of a recently proposed vomeronasal signal transduction component-a Ca(2+)-activated Cl(-) current. As the...

    journal_title:Chemical senses

    pub_type: 杂志文章

    doi:10.1093/chemse/bjw077

    authors: Untiet V,Moeller LM,Ibarra-Soria X,Sánchez-Andrade G,Stricker M,Neuhaus EM,Logan DW,Gensch T,Spehr M

    更新日期:2016-10-01 00:00:00