Presynaptic inhibition of olfactory sensory neurons: new mechanisms and potential functions.

abstract：:The G protein subunit alpha-gustducin is expressed in a subset of light (Type II) but not in dark (Type I) cells in rat vallate taste buds. The thymidine analogue 5-bromo-2'-deoxyuridine (BrdU) is incorporated into DNA during the S-phase of the cell cycle and can be used to determine the time of origin of a cell. In t...

journal_title：Chemical senses

authors： Cho YK,Farbman AI,Smith DV

更新日期：1998-12-01 00:00:00

abstract：:Identifications of 5 odorants selected to be nontrigeminal stimuli were compared using retronasal and oral-cavity-only (OCO) air-phase presentations, with OCO produced by both exhalation through the mouth and a nose clip that closed the nostrils. Nine identifiers were available on each trial; 1 or 2 were correct for e...

journal_title：Chemical senses

authors： Chen V,Halpern BP

更新日期：2008-02-01 00:00:00

abstract：:In rodents, the vomeronasal system controls social and sexual behavior. However, several mechanistic aspects of sensory signaling in the vomeronasal organ remain unclear. Here, we investigate the biophysical basis of a recently proposed vomeronasal signal transduction component-a Ca(2+)-activated Cl(-) current. As the...

journal_title：Chemical senses

authors： Untiet V,Moeller LM,Ibarra-Soria X,Sánchez-Andrade G,Stricker M,Neuhaus EM,Logan DW,Gensch T,Spehr M

更新日期：2016-10-01 00:00:00

abstract：:A list of 147 tetralin- and indan-like compounds was compiled from the literature for investigating the relationship between molecular structure and musk odor. Each compound in the data set was represented by 374 CODESSA and 970 TAE descriptors. A genetic algorithm (GA) for pattern recognition analysis was used to id...

journal_title：Chemical senses

authors： Lavine BK,White C,Mirjankar N,Sundling CM,Breneman CM

更新日期：2012-10-01 00:00:00

abstract：:Laboratory rats and mice prefer some concentrations of tri- and tetrasodium pyrophosphate (Na3HP2O7 and Na4P2O7) to water, but how they detect pyrophosphates is unknown. Here, we assessed whether T1R3 is involved. We found that relative to wild-type littermate controls, Tas1r3 knockout mice had stronger preferences fo...

journal_title：Chemical senses

authors： Tordoff MG,Aleman TR,McCaughey SA

更新日期：2015-01-01 00:00:00

abstract：:Glutathione, a natural substance, acts on calcium receptors on the tongue and is known to enhance basic taste sensations. However, the effects of glutathione on brain activity associated with taste sensation on the tongue have not been determined under standardized taste delivery conditions. In this study, we investig...

journal_title：Chemical senses

authors： Goto TK,Yeung AW,Tanabe HC,Ito Y,Jung HS,Ninomiya Y

更新日期：2016-09-01 00:00:00

abstract：:The effect of soluble starch (acid-modified starch) on taste intensity was investigated in human subjects. Different concentrations of sucrose (Suc), six sweeteners, NaCl, quinine-HCl (QHCl) and citric acid (Cit) were dissolved in either distilled water (DW; standard) or starch solution (test solution). The solutions ...

journal_title：Chemical senses

authors： Kanemaru N,Harada S,Kasahara Y

更新日期：2002-01-01 00:00:00

abstract：:Chemical signals are common in most crustacean social interactions and are often perceived via chemosensory (olfactory) organs on the first antenna. Intermolt courtship behaviors and mating were investigated in size-matched pairs of intermolt European lobsters (Homarus gammarus) where the olfactory receptors of either...

journal_title：Chemical senses

authors： Skog M

更新日期：2009-02-01 00:00:00

abstract：:Lectin binding patterns in the olfactory bulb of the mouse were investigated using 12 biotinylated lectins. Three, with specificities for galactose, N-acetylgalactosamine and L-fucose, stained only the nervous and glomerular layers of the accessory olfactory bulb; four, with specificities for galactose or N-acetylgluc...

journal_title：Chemical senses

authors： Salazar I,Sánchez Quinteiro P,Lombardero M,Cifuentes JM

更新日期：2001-07-01 00:00:00

abstract：:Chemosensory receptors, including odor, taste, and vomeronasal receptors, comprise the largest group of G protein-coupled receptors (GPCRs) in the mammalian genome. However, little is known about the molecular determinants that are critical for the detection and discrimination of ligands by most of these receptors. Th...

journal_title：Chemical senses

authors： Nie Y,Hobbs JR,Vigues S,Olson WJ,Conn GL,Munger SD

更新日期：2006-07-01 00:00:00

abstract：:To date, most studies on the relationship between chemosensory performance and quality of life have focused on orthonasal measures of olfactory function. In the current investigation, we examined the predictive value of orthonasal and flavor identification indices of olfactory function on a wide spectrum of health and...

journal_title：Chemical senses

authors： Oleszkiewicz A,Park D,Resler K,Draf J,Schulze A,Zang Y,Hähner A,Hummel T

更新日期：2019-07-17 00:00:00

abstract：:The adult olfactory system undergoes experience-dependent plasticity to adapt to the olfactory environment. This plasticity may be accompanied by perceptual changes, including improved olfactory discrimination. Here, we assessed experience-dependent changes in the perception of a homologous aldehyde pair by testing mi...

journal_title：Chemical senses

authors： Kass MD,Guang SA,Moberly AH,McGann JP

更新日期：2016-02-01 00:00:00

abstract：:The septal organ of Masera (SO) is a small, isolated patch of olfactory epithelium, located in the ventral part of the nasal septum. We investigated in this systematic study the postnatal development of the SO in histological sections of rats at various ages from the day of birth (P1) to P666. The SO-area increases to...

journal_title：Chemical senses

authors： Weiler E,Farbman AI

更新日期：2003-09-01 00:00:00

abstract：:We report 2 experiments designed to investigate the effect of people's prior beliefs concerning specific color-flavor associations on their ability to discriminate the flavor of colored sugar-coated chocolate sweets. The participants in our study judged whether pairs of Smarties had the same flavor or not. In our firs...

journal_title：Chemical senses

authors： Levitan CA,Zampini M,Li R,Spence C

更新日期：2008-06-01 00:00:00

abstract：:Cigarettes are an often-used consumer product, and flavor is an important determinant of their product appeal. Cigarettes with strong nontobacco flavors are popular among young people, and may facilitate smoking initiation. Discriminating flavors in tobacco is important for regulation purposes, for instance to set upp...

journal_title：Chemical senses

authors： Krüsemann EJ,Cremers JW,Visser WF,Punter PH,Talhout R

更新日期：2017-03-01 00:00:00

abstract：:Insect odorant receptors (ORs) function as heteromeric odorant-gated ion channels consisting of a conserved coreceptor, Orco, and an odorant-sensitive tuning subunit. Although some OR modulators have been identified, an extended library of pharmacological tools is currently lacking and would aid in furthering our unde...

journal_title：Chemical senses

authors： Pask GM,Bobkov YV,Corey EA,Ache BW,Zwiebel LJ

更新日期：2013-03-01 00:00:00

abstract：:The embryonic origins of taste receptor cells have not been established experimentally. Although related receptor cells (e.g. hair cells of the inner ear, lateral line receptors) are known to arise from neurogenic ectoderm (e.g. neural crest or placodes), taste buds are described as arising from local epithelial cells...

journal_title：Chemical senses

authors： Stone LM,Finger TE

更新日期：1994-12-01 00:00:00

abstract：:Taste sensitivity plays a major role in controlling feeding behavior, and alterations in feeding habit induced by changes in taste sensitivity can drive speciation. We investigated variability in taste preferences in wild-derived inbred lines from the Drosophila melanogaster Genetic Reference Panel. Preferences for di...

journal_title：Chemical senses

authors： Uchizono S,Tanimura T

更新日期：2017-05-01 00:00:00

abstract：:To analyze the mechanisms of perception and processing of pheromonal signals in vitro, we previously developed a new culture system for vomeronasal receptor neurons (VRNs), referred to as the vomeronasal pocket (VN pocket). However, very few VRNs were found to express the olfactory marker protein (OMP) and to have pro...

journal_title：Chemical senses

authors： Moriya-Ito K,Osada T,Ishimatsu Y,Muramoto K,Kobayashi T,Ichikawa M

更新日期：2005-02-01 00:00:00

abstract：:An odor emitted by an object signals the presence of that object and may draw attention to it. Can odors that are not actually emitted by an object also function as a signal? We investigated whether the degree of thematic congruency between an ambient odor and a magazine affected magazine sales in a retail store. We s...

journal_title：Chemical senses

authors： Schifferstein HN,Blok ST

更新日期：2002-07-01 00:00:00

abstract：:Anosmia and hyposmia, the inability or decreased ability to smell, is estimated to afflict 3-20% of the population. Risk of olfactory dysfunction increases with old age and may also result from chronic sinonasal diseases, severe head trauma, and upper respiratory infections, or neurodegenerative diseases. These disord...

journal_title：Chemical senses

authors： Boesveldt S,Postma EM,Boak D,Welge-Luessen A,Schöpf V,Mainland JD,Martens J,Ngai J,Duffy VB

更新日期：2017-09-01 00:00:00

abstract：:The distribution of NADPH-diaphroase activity was examined in the accessory olfactory bulb of the rat using a direct histochemical technique. Labeled fibers and somata were found in all layers of the accessory olfactory bulb. The entire vomeronasal nerve and all vomeronasal glomeruli were strongly labeled, contrary to...

journal_title：Chemical senses

authors： Porteros A,Alonso JR,Arévalo R,García-Ojeda E,Crespo C,Aijón J

更新日期：1994-10-01 00:00:00

abstract：:Three experiments assessed potential changes in the rat's perception of sodium chloride (NaCl) during a state of sodium appetite. In Experiment 1, sodium-sufficient rats licking a range of NaCl concentrations (0.028-0.89M) in 15s trials showed an inverted U-shaped concentration response function peaking at 0.281M. Dep...

journal_title：Chemical senses

authors： St John SJ

更新日期：2017-02-01 00:00:00

abstract：:Restriction of dietary sodium during gestation has major effects on taste function and anatomy in the offspring. The chorda tympani nerve of offspring that are maintained on sodium-reduced chow throughout life (NaDep) has reduced neurophysiological responses to sodium and altered morphology of its terminal field in th...

journal_title：Chemical senses

authors： Sollars SI,Hill DL

更新日期：2000-12-01 00:00:00

abstract：:Experiments were performed to determine which bundles of the olfactory tracts were essential for mediating alarm reaction in crucian carp (Carassius carassius L.). The fish were maintained in physiological saline after surgery to preserve the remaining tracts and postoperative inspections revealed the functionality of...

journal_title：Chemical senses

authors： Hamdani EH,Stabell OB,Alexander G,Døving KB

更新日期：2000-02-01 00:00:00

abstract：:Ten SW.B6 SOA nontaster strains congenic with the SWR/J SOA taster inbred strain were bred via repeated backcross-intercross cycles, with selection for nontasting in each cycle. Preference ratio distributions and phenotypic proportions across cycles at 0.1 mM SOA were consistent with monogenic predictions. The SW.B6 m...

journal_title：Chemical senses

authors： Harder DB,Gannon KS,Whitney G

更新日期：1996-10-01 00:00:00

abstract：:Social behaviors of most mammals are affected by chemical signals, pheromones, exchanged between conspecifics. Previous experiments have shown that behavioral responses to the same pheromone differ depending on the sex and endocrine status of the respondent. Although the exact mechanism of this dimorphism is not known...

journal_title：Chemical senses

authors： Thompson RN,Robertson BK,Napier A,Wekesa KS

更新日期：2004-11-01 00:00:00

abstract：:Single carbon to 18 carbon n-aliphatic carboxylic acids were tested for their attractive effects on female Aedes aegypti in a Y-tube olfactometer. Each acid was tested over a wide range of concentrations together with L-(+)-lactic acid, the indispensable synergist for other attractive components emitted from human hos...

journal_title：Chemical senses

authors： Bosch OJ,Geier M,Boeckh J

更新日期：2000-06-01 00:00:00

abstract：:The effects of the membrane-permeable dibutyryl guanosine 3', 5'-cyclic monophosphate (db-cGMP) on the bombykol-elicited receptor current and nerve impulse activity were studied using the open sensillum recording technique. db-cGMP was applied to the outer dendritic membrane of the olfactory receptor neuron of the mot...

journal_title：Chemical senses

authors： Redkozubov A

更新日期：2000-08-01 00:00:00

abstract：:Current ambiguity concerning the related issues of optimal means for measurement of odor sensitivity and the functional properties of the olfactory system hinders progress in basic and applied research on the human sense of smell. To address these needs, we selected n-amyl acetate (nAA) as a test odorant and developed...

journal_title：Chemical senses

authors： Walker JC,Hall SB,Walker DB,Kendal-Reed MS,Hood AF,Niu XF

更新日期：2003-11-01 00:00:00