Abstract:
:Laboratory rats and mice prefer some concentrations of tri- and tetrasodium pyrophosphate (Na3HP2O7 and Na4P2O7) to water, but how they detect pyrophosphates is unknown. Here, we assessed whether T1R3 is involved. We found that relative to wild-type littermate controls, Tas1r3 knockout mice had stronger preferences for 5.6-56mM Na3HP2O7 in 2-bottle choice tests, and they licked more 17.8-56mM Na3HP2O7 in brief-access tests. We hypothesize that pyrophosphate taste in the intact mouse involves 2 receptors: T1R3 to produce a hedonically negative signal and an unknown G protein-coupled receptor to produce a hedonically positive signal; in Tas1r3 knockout mice, the hedonically negative signal produced by T1R3 is absent, leading to a heightened avidity for pyrophosphate.
journal_name
Chem Sensesjournal_title
Chemical sensesauthors
Tordoff MG,Aleman TR,McCaughey SAdoi
10.1093/chemse/bju059subject
Has Abstractpub_date
2015-01-01 00:00:00pages
53-9issue
1eissn
0379-864Xissn
1464-3553pii
bju059journal_volume
40pub_type
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