Heightened avidity for trisodium pyrophosphate in mice lacking Tas1r3.

Abstract:

:Laboratory rats and mice prefer some concentrations of tri- and tetrasodium pyrophosphate (Na3HP2O7 and Na4P2O7) to water, but how they detect pyrophosphates is unknown. Here, we assessed whether T1R3 is involved. We found that relative to wild-type littermate controls, Tas1r3 knockout mice had stronger preferences for 5.6-56mM Na3HP2O7 in 2-bottle choice tests, and they licked more 17.8-56mM Na3HP2O7 in brief-access tests. We hypothesize that pyrophosphate taste in the intact mouse involves 2 receptors: T1R3 to produce a hedonically negative signal and an unknown G protein-coupled receptor to produce a hedonically positive signal; in Tas1r3 knockout mice, the hedonically negative signal produced by T1R3 is absent, leading to a heightened avidity for pyrophosphate.

journal_name

Chem Senses

journal_title

Chemical senses

authors

Tordoff MG,Aleman TR,McCaughey SA

doi

10.1093/chemse/bju059

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

53-9

issue

1

eissn

0379-864X

issn

1464-3553

pii

bju059

journal_volume

40

pub_type

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