Expression patterns of odorant receptors and response properties of olfactory sensory neurons in aged mice.

Abstract:

:The sense of smell deteriorates in normal aging, but the underling mechanisms are still elusive. Here we investigated age-related alterations in expression patterns of odorant receptor (OR) genes and functional properties of olfactory sensory neurons (OSNs)-2 critical factors that define the odor detection threshold in the olfactory epithelium. Using in situ hybridization for 9 representative OR genes, we compared the cell densities of each OR in coronal nose sections at different ages (3-27 months). The cell density for different ORs peaked at different time points and a decline was observed for 6 of 9 ORs at advanced ages. Using patch clamp recordings, we then examined the odorant responses of individual OSNs coexpressing a defined OR (MOR23) and green fluorescent protein. The MOR23 neurons recorded from aged animals maintained a similar sensitivity and dynamic range in response to the cognate odorant (lyral) as those from younger mice. The results indicate that although the cell densities of OSNs expressing certain types of ORs decline at advanced ages, individual OSNs can retain their sensitivity. The implications of these findings in age-related olfactory deterioration are discussed.

journal_name

Chem Senses

journal_title

Chemical senses

authors

Lee AC,Tian H,Grosmaitre X,Ma M

doi

10.1093/chemse/bjp056

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

695-703

issue

8

eissn

0379-864X

issn

1464-3553

pii

bjp056

journal_volume

34

pub_type

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