Abstract:
:Transcriptional regulation is an important mechanism by which neurons adapt to environmental stimuli. The indirect dopamine agonists, amphetamine and cocaine have been shown to induce expression of immediate early genes, such as c-fos, and neuropeptide genes, such as prodynorphin in the rat striatum. Here we show that phosphorylation of transcription factor CREB is a critical early event coupling dopamine stimulation to gene regulation. CREB interacts with functional regulatory elements in both the c-fos and prodynorphin genes, and is phosphorylated in response to dopamine in a D1 dopamine receptor-dependent manner. In addition, we show by intra-striatal injection of antisense oligonucleotides directed against CREB mRNA, that CREB protein is required for c-fos induction by amphetamine.
journal_name
Chem Sensesjournal_title
Chemical sensesauthors
Hyman SE,Cole RL,Konradi C,Kosofsky BEdoi
10.1093/chemse/20.2.257subject
Has Abstractpub_date
1995-04-01 00:00:00pages
257-60issue
2eissn
0379-864Xissn
1464-3553journal_volume
20pub_type
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