Dopamine regulation of transcription factor-target interactions in rat striatum.

Abstract:

:Transcriptional regulation is an important mechanism by which neurons adapt to environmental stimuli. The indirect dopamine agonists, amphetamine and cocaine have been shown to induce expression of immediate early genes, such as c-fos, and neuropeptide genes, such as prodynorphin in the rat striatum. Here we show that phosphorylation of transcription factor CREB is a critical early event coupling dopamine stimulation to gene regulation. CREB interacts with functional regulatory elements in both the c-fos and prodynorphin genes, and is phosphorylated in response to dopamine in a D1 dopamine receptor-dependent manner. In addition, we show by intra-striatal injection of antisense oligonucleotides directed against CREB mRNA, that CREB protein is required for c-fos induction by amphetamine.

journal_name

Chem Senses

journal_title

Chemical senses

authors

Hyman SE,Cole RL,Konradi C,Kosofsky BE

doi

10.1093/chemse/20.2.257

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

257-60

issue

2

eissn

0379-864X

issn

1464-3553

journal_volume

20

pub_type

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