A flux capacitor for moth pheromones.

abstract：:We have previously modeled the interaction of the sweet protein brazzein with the extracellular domains of the sweet taste receptor. Here, we describe the application of that model to the design of 12 new highly potent analogs of brazzein. Eight of the 12 analogs have higher sweetness potency than wild-type brazzein. ...

journal_title：Chemical senses

authors： Walters DE,Cragin T,Jin Z,Rumbley JN,Hellekant G

更新日期：2009-10-01 00:00:00

abstract：:Parasympathetic nerve (PSN) innervates taste cells of the frog taste disk, and electrical stimulation of PSN elicited a slow hyperpolarizing potential (HP) in taste cells. Here we report that gustatory receptor potentials in frog taste cells are depressed by PSN-induced slow HPs. When PSN was stimulated at 30 Hz durin...

journal_title：Chemical senses

authors： Sato T,Nishishita K,Mineda T,Okada Y,Toda K

更新日期：2007-01-01 00:00:00

abstract：:The prevalence of obesity and obesity-related disorders such as type 2 diabetes (T2D) and metabolic syndrome has increased significantly in the past decades, reaching epidemic levels and therefore becoming a major health issue worldwide. Chronic overeating of highly palatable foods is one of the main responsible aspec...

journal_title：Chemical senses

authors： Tarragon E,Moreno JJ

更新日期：2017-12-25 00:00:00

abstract：:The aim of this investigation was to compare olfactory functions of patients suffering from Parkinson's disease (PD) and Alzheimer's disease (AD). Olfactory threshold, odor identification ability and odor memory performance were assessed in 21 non-demented PD patients and in 22 AD patients. Both patient groups were im...

journal_title：Chemical senses

authors： Lehrner JP,Brücke T,Dal-Bianco P,Gatterer G,Kryspin-Exner I

更新日期：1997-02-01 00:00:00

abstract：:Studies over the last 8 years have identified 3 potential channels that appear to release ATP from Type II cells in response to taste stimuli. These studies have taken different methodological approaches but have all provided data supporting their candidate channel as the ATP release channel. These potential channels ...

journal_title：Chemical senses

authors： Medler KF

更新日期：2015-09-01 00:00:00

abstract：:Identifications of 5 odorants selected to be nontrigeminal stimuli were compared using retronasal and oral-cavity-only (OCO) air-phase presentations, with OCO produced by both exhalation through the mouth and a nose clip that closed the nostrils. Nine identifiers were available on each trial; 1 or 2 were correct for e...

journal_title：Chemical senses

authors： Chen V,Halpern BP

更新日期：2008-02-01 00:00:00

abstract：:The central projections of olfactory receptor cells associated with two distinct types of antennal sensilla in the sphinx moth Manduca sexta were revealed by anterograde staining. In both sexes, receptor axons that arise from sexually isomorphic, type-II trichoid sensilla (and possibly some basiconic sensilla) project...

journal_title：Chemical senses

authors： Christensen TA,Harrow ID,Cuzzocrea C,Randolph PW,Hildebrand JG

更新日期：1995-06-01 00:00:00

abstract：:Olfaction involves a dual sensory process for perceiving odors orthonasally (through the nostrils) and retronasally (through the mouth). This investigation entailed developing a measure of sensitivity to an odor delivered in an orally sampled food (orange flavoring in a sucrose-sweetened gelatin) and examining sensiti...

journal_title：Chemical senses

authors： Duffy VB,Cain WS,Ferris AM

更新日期：1999-12-01 00:00:00

abstract：:An apparent plasticity in glucose sensitivity was first noted while studying human taste variants, but the experimental design did not rule out regression to the mean. Since then, a human taste induction hypothesis that sensitivity for a taste stimulus increases with repeated exposure to it has been supported first by...

journal_title：Chemical senses

authors： Gonzalez KM,Peo C,Livdahl T,Kennedy LM

更新日期：2008-02-01 00:00:00

abstract：:It was recently shown that in some subjects capsaicin can evoke bitterness as well as burning and stinging, particularly in the circumvallate (CV) region of the tongue. Because perception of bitterness from capsaicin is characterized by large individual differences, the main goal of the present study was to learn whet...

journal_title：Chemical senses

authors： Green BG,Hayes JE

更新日期：2004-01-01 00:00:00

abstract：:Regarding the chemotaxis of sperms, new insights have been gained during the last 20 years. Olfactory receptors are expressed on the flagellar midpiece of human spermatogenic cells. One of them, OR1D2, is also expressed in the olfactory epithelium. This receptor has been suggested to play a role in sperm chemotaxis an...

journal_title：Chemical senses

authors： Sinding C,Kemper E,Spornraft-Ragaller P,Hummel T

更新日期：2013-06-01 00:00:00

abstract：:Associative plasticity is a basic essential attribute of nervous systems. As shown by numerous reports, Drosophila is able to establish simple forms of appetitive and aversive olfactory associations at both larval and adult stages. Whereas most adult studies on aversive learning employed electric shock as a negative r...

journal_title：Chemical senses

authors： Pauls D,Pfitzenmaier JE,Krebs-Wheaton R,Selcho M,Stocker RF,Thum AS

更新日期：2010-05-01 00:00:00

abstract：:Contrary to what has often been said about the subject, decline in taste sensitivity with aging characterizes virtually everybody and is not the artificial result of averaging large losses of a minority with negligible losses of a majority. This assertion is supported by six repeated measures of sucrose thresholds in ...

journal_title：Chemical senses

authors： Stevens JC,Cruz LA,Hoffman JM,Patterson MQ

更新日期：1995-08-01 00:00:00

abstract：:Secondary epidermal solitary chemosensory cells (SCCs) are widespread among the primary aquatic vertebrates. They resemble taste bud sensory cells in fine structure and may be innervated from facial or spinal nerves. According to previous studies, SCCs may constitute a water sampling system in the contexts of predator...

journal_title：Chemical senses

authors： Kotrschal K,Krautgartner WD,Hansen A

更新日期：1997-04-01 00:00:00

abstract：:When one taste (masker) is strong enough, it can completely mask another task (target) of different quality. How strong the masker must be to do this depends on how strong the target is. As the target concentration is increased, the masking concentration must be increased, too, but in ever-increasing proportion. To qu...

journal_title：Chemical senses

authors： Stevens JC

更新日期：1996-04-01 00:00:00

abstract：:The vast number of detectable odors makes matching olfactory receptors (ORs) to their ligands a daunting task. Krautwurst and colleagues have hypothesized that this process can be simplified by focusing on those odorants that are perceptually relevant food odors. In this issue of Chemical Senses, they use this framewo...

journal_title：Chemical senses

authors： Trimmer C,Mainland JD

更新日期：2017-03-01 00:00:00

abstract：:Organotypic cultures of the mouse olfactory epithelium connected to the olfactory bulb were obtained with the roller tube technique from postnatal mice aged between 13 and 66 days. To test the functionality of the cultures, we measured electroolfactograms (EOGs) at different days in vitro (DIV), up to 7 DIV, and we co...

journal_title：Chemical senses

authors： Pinato G,Rievaj J,Pifferi S,Dibattista M,Masten L,Menini A

更新日期：2008-04-01 00:00:00

abstract：:The study investigated the potential for facial electromyography (EMG) to be used as a clinical tool for measuring the responses of children to pleasant and unpleasant smell and taste stimuli. Responses in the zygomaticus major and levator labii muscles to 4 odorants and 4 tastants were recorded from 34 children aged ...

journal_title：Chemical senses

authors： Armstrong JE,Hutchinson I,Laing DG,Jinks AL

更新日期：2007-07-01 00:00:00

abstract：:Laboratory rats and mice prefer some concentrations of tri- and tetrasodium pyrophosphate (Na3HP2O7 and Na4P2O7) to water, but how they detect pyrophosphates is unknown. Here, we assessed whether T1R3 is involved. We found that relative to wild-type littermate controls, Tas1r3 knockout mice had stronger preferences fo...

journal_title：Chemical senses

authors： Tordoff MG,Aleman TR,McCaughey SA

更新日期：2015-01-01 00:00:00

abstract：:Lectin binding patterns in the olfactory bulb of the mouse were investigated using 12 biotinylated lectins. Three, with specificities for galactose, N-acetylgalactosamine and L-fucose, stained only the nervous and glomerular layers of the accessory olfactory bulb; four, with specificities for galactose or N-acetylgluc...

journal_title：Chemical senses

authors： Salazar I,Sánchez Quinteiro P,Lombardero M,Cifuentes JM

更新日期：2001-07-01 00:00:00

abstract：:Natural odors occur as turbulent plumes resulting in spatially and temporally variable odor signals at the chemoreceptor cells. Concentrations can fluctuate widely within discrete packets of odor and individual packets are very intermittent and unpredictable. Chemoreceptor cells display the temporally dynamic properti...

journal_title：Chemical senses

authors： Moore PA

更新日期：1994-02-01 00:00:00

abstract：:Electrophysiological responses of olfactory receptor neurons in both male and female silkmoths (Bombyx mori) were investigated. In both sexes, the G-protein activator sodium fluoride and 1,2-dioctanoyl-sn-glycerol, a membrane-permeable analog of the protein kinase C activator diacylglycerol, elicited nerve impulse res...

journal_title：Chemical senses

authors： Pophof B,Van der Goes van Naters W

更新日期：2002-06-01 00:00:00

abstract：:The experiments had 2 main goals: 1) to add to the sparse literature on how retronasal aromas interact with bitter tastes, and 2) to determine whether modulation of taste intensity by aroma depends on temporal contiguity, as one might expect if flavor interactions depend on cross-modal binding (similar to object perce...

journal_title：Chemical senses

authors： Isogai T,Wise PM

更新日期：2016-09-01 00:00:00

abstract：:In 20 normal and four anosmic participants, instantaneous inhalation and exhalation flow rates were recorded in response to 15 s stimulations with clean air or propionic acid concentrations (0.16, 1.14, 8.22 and 59.15 p.p.m., v/v) that ranged from peri-threshold for normals to clearly supra-threshold for anosmics. Eac...

journal_title：Chemical senses

authors： Walker JC,Kendal-Reed M,Hall SB,Morgan WT,Polyakov VV,Lutz RW

更新日期：2001-05-01 00:00:00

abstract：:Strong electrical stimulation (ES) of the frog glossopharyngeal (GP) efferent nerve induced slow depolarizing potentials (DPs) in taste cells under hypoxia. This study aimed to elucidate whether the slow DPs were postsynaptically induced in taste cells. After a block of parasympathetic nerve (PSN) ganglia by tubocurar...

journal_title：Chemical senses

authors： Sato T,Nishishita K,Okada Y,Toda K

更新日期：2007-05-01 00:00:00

abstract：:Experience is an essential factor informing food choice. Eating food generates enduring odor-taste associations that link an odor with a taste's quality and hedonic value (pleasantness/unpleasantness) and creates the perception of a congruent odor-taste combination. Previous human psychophysical experiments demonstrat...

journal_title：Chemical senses

authors： McQueen KA,Fredericksen KE,Samuelsen CL

更新日期：2020-05-29 00:00:00

abstract：:Activity-dependent processes are important to olfactory sensory neurons (OSNs) in several ways, such as cell survival and the specificity of axonal convergence. The identification of activity-dependent mRNAs has contributed to our understanding of OSN axon convergence, but has revealed surprisingly little about other ...

journal_title：Chemical senses

authors： Wang Q,Titlow WB,McClintock DA,Stromberg AJ,McClintock TS

更新日期：2017-10-01 00:00:00

abstract：:Ten SW.B6 SOA nontaster strains congenic with the SWR/J SOA taster inbred strain were bred via repeated backcross-intercross cycles, with selection for nontasting in each cycle. Preference ratio distributions and phenotypic proportions across cycles at 0.1 mM SOA were consistent with monogenic predictions. The SW.B6 m...

journal_title：Chemical senses

authors： Harder DB,Gannon KS,Whitney G

更新日期：1996-10-01 00:00:00

abstract：:Odors are inherently ambiguous and therefore susceptible to redundant sensory as well as context information. The identification of an odor object relies largely on visual input. Thus far, it is unclear whether visual and olfactory stimuli are indeed integrated at an early perceptual stage and which role the congruenc...

journal_title：Chemical senses

authors： Amsellem S,Höchenberger R,Ohla K

更新日期：2018-05-23 00:00:00

abstract：:To analyze the mechanisms of perception and processing of pheromonal signals in vitro, we previously developed a new culture system for vomeronasal receptor neurons (VRNs), referred to as the vomeronasal pocket (VN pocket). However, very few VRNs were found to express the olfactory marker protein (OMP) and to have pro...

journal_title：Chemical senses

authors： Moriya-Ito K,Osada T,Ishimatsu Y,Muramoto K,Kobayashi T,Ichikawa M

更新日期：2005-02-01 00:00:00