Frequent microsatellite alterations at chromosomes 9p21 and 3p14 in oral premalignant lesions and their value in cancer risk assessment.

abstract：:We investigated whether immunization with recombinant anti-idiotypic antibody fragments mimicking the conformation of the capsular antigen can protect against infection by group B streptococcus, an important neonatal pathogen. Single-chain fragment-variable anti-idiotypes competed with the type III carbohydrate for bi...

journal_title：Nature medicine

authors： Magliani W,Polonelli L,Conti S,Salati A,Rocca PF,Cusumano V,Mancuso G,Teti G

更新日期：1998-06-01 00:00:00

abstract：:The HIV-1-specific cytotoxic T lymphocyte (CTL) response is temporally associated with the decline in viremia during primary HIV-1 infection, but definitive evidence that it is of importance in virus containment has been lacking. Here we show that in a patient whose early CTL response was focused on a highly immunodom...

journal_title：Nature medicine

authors： Borrow P,Lewicki H,Wei X,Horwitz MS,Peffer N,Meyers H,Nelson JA,Gairin JE,Hahn BH,Oldstone MB,Shaw GM

更新日期：1997-02-01 00:00:00

abstract：:Infections are thought to be important in the pathogenesis of many heart diseases. Coxsackievirus B3 (CVB3) has been linked to chronic dilated cardiomyopathy, a common cause of progressive heart disease, heart failure and sudden death. We show here that the sarcoma (Src) family kinase Lck (p56lck) is required for effi...

journal_title：Nature medicine

authors： Liu P,Aitken K,Kong YY,Opavsky MA,Martino T,Dawood F,Wen WH,Kozieradzki I,Bachmaier K,Straus D,Mak TW,Penninger JM

更新日期：2000-04-01 00:00:00

abstract：:Two papers suggest that apoptosis of alloreactive T cells is required for induction of peripheral transplantation tolerance. These findings raise new questions about how lymphocytes reach from beyond the grave to influence the immune response (pages 1298-1302 and 1303-1307). ...

journal_title：Nature medicine

authors： Ferguson TA,Green DR

更新日期：1999-11-01 00:00:00

abstract：:Congenital disorder of glycosylation-Ia (CDG-Ia, also known as PMM2-CDG) is caused by mutations in the gene that encodes phosphomannomutase 2 (PMM2, EC 5.4.2.8) leading to a multisystemic disease with severe psychomotor and mental retardation. In a hypomorphic Pmm2 mouse model, we were able to overcome embryonic letha...

journal_title：Nature medicine

authors： Schneider A,Thiel C,Rindermann J,DeRossi C,Popovici D,Hoffmann GF,Gröne HJ,Körner C

更新日期：2011-12-11 00:00:00

abstract：:Because of their abundance, resistance to proteolysis, rapid aggregation and neurotoxicity, N-terminally truncated and, in particular, pyroglutamate (pE)-modified Abeta peptides have been suggested as being important in the initiation of pathological cascades resulting in the development of Alzheimer's disease. We fou...

journal_title：Nature medicine

authors： Schilling S,Zeitschel U,Hoffmann T,Heiser U,Francke M,Kehlen A,Holzer M,Hutter-Paier B,Prokesch M,Windisch M,Jagla W,Schlenzig D,Lindner C,Rudolph T,Reuter G,Cynis H,Montag D,Demuth HU,Rossner S

更新日期：2008-10-01 00:00:00

abstract：:CD4(+) T cells that express the forkhead box P3 (FOXP3) transcription factor function as regulatory T (Treg) cells and hinder effective immune responses against cancer cells. Abundant Treg cell infiltration into tumors is associated with poor clinical outcomes in various types of cancers. However, the role of Treg cel...

journal_title：Nature medicine

authors： Saito T,Nishikawa H,Wada H,Nagano Y,Sugiyama D,Atarashi K,Maeda Y,Hamaguchi M,Ohkura N,Sato E,Nagase H,Nishimura J,Yamamoto H,Takiguchi S,Tanoue T,Suda W,Morita H,Hattori M,Honda K,Mori M,Doki Y,Sakaguchi S

更新日期：2016-06-01 00:00:00

abstract：:The dorsomedial hypothalamic nucleus harbors leptin sensitive neurons and is intrinsically connected to hypothalamic nuclei involved in feeding behavior. However, it also receives ascending input from the visceroceptive neurons of the brainstem. We have identified a unique glucagon-like-peptide-2 containing neuronal p...

journal_title：Nature medicine

authors： Tang-Christensen M,Larsen PJ,Thulesen J,Rømer J,Vrang N

更新日期：2000-07-01 00:00:00

abstract：:The microbiome of the female reproductive tract has implications for women's reproductive health. We examined the vaginal microbiome in two cohorts of women who experienced normal term births: a cross-sectionally sampled cohort of 613 pregnant and 1,969 non-pregnant women, focusing on 300 pregnant and 300 non-pregnant...

journal_title：Nature medicine

authors： Serrano MG,Parikh HI,Brooks JP,Edwards DJ,Arodz TJ,Edupuganti L,Huang B,Girerd PH,Bokhari YA,Bradley SP,Brooks JL,Dickinson MR,Drake JI,Duckworth RA 3rd,Fong SS,Glascock AL,Jean S,Jimenez NR,Khoury J,Koparde VN,La

更新日期：2019-06-01 00:00:00

abstract：:Overwhelming evidence that relationships between universities, physicians and the medical products industry benefit patients explains the ubiquitous calls to encourage such relationships. Yet accumulating 'conflict of interest' regulations in academic health centers, government and industry have had the opposite effec...

journal_title：Nature medicine

authors： Stossel TP,Stell LK

更新日期：2011-04-01 00:00:00

abstract：:Targeting the mammalian target of rapamycin (mTOR) protein is a promising strategy for cancer therapy. The mTOR kinase functions in two complexes, TORC1 (target of rapamycin complex-1) and TORC2 (target of rapamycin complex-2); however, neither of these complexes is fully inhibited by the allosteric inhibitor rapamyci...

journal_title：Nature medicine

authors： Janes MR,Limon JJ,So L,Chen J,Lim RJ,Chavez MA,Vu C,Lilly MB,Mallya S,Ong ST,Konopleva M,Martin MB,Ren P,Liu Y,Rommel C,Fruman DA

更新日期：2010-02-01 00:00:00

abstract：:CD23 is a low-affinity receptor for immunoglobulin E (IgE) expressed by a variety of haematopoietic cells. Proteolytic cleavage of the transmembrane receptor generates soluble forms, which can be detected in biological fluids. CD23 regulates many functional aspects of immune cells, both in its cell-associated and solu...

journal_title：Nature medicine

authors： Plater-Zyberk C,Bonnefoy JY

更新日期：1995-08-01 00:00:00

abstract：:There has been a rise in the prevalence of nonalcoholic fatty liver disease (NAFLD), paralleling a worldwide increase in diabetes and metabolic syndrome. NAFLD, a continuum of liver abnormalities from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), has a variable course but can lead to cirrhosi...

journal_title：Nature medicine

authors： Friedman SL,Neuschwander-Tetri BA,Rinella M,Sanyal AJ

更新日期：2018-07-01 00:00:00

abstract：:Naturally occurring mutations in HIV-1-infected patients have important implications for therapy and the outcome of clinical studies. However, little is known about the prevalence of mutations that confer resistance to HIV-1 protease inhibitors in isolates derived from patients naive for such inhibitors. In the first ...

journal_title：Nature medicine

authors： Kozal MJ,Shah N,Shen N,Yang R,Fucini R,Merigan TC,Richman DD,Morris D,Hubbell E,Chee M,Gingeras TR

更新日期：1996-07-01 00:00:00

abstract：:The skin protects mammals from insults, infection and dehydration and enables thermoregulation and sensory perception. Various skin-resident cells carry out these diverse functions. Constant turnover of cells and healing upon injury necessitate multiple reservoirs of stem cells. Thus, the skin provides a model for stu...

journal_title：Nature medicine

authors： Hsu YC,Li L,Fuchs E

更新日期：2014-08-01 00:00:00

abstract：:Foxp3(+) regulatory T (T(reg)) cells suppress different types of immune responses to help maintain homeostasis in the body. How T(reg) cells regulate humoral immunity, including germinal center reactions, is unclear. Here we identify a subset of T(reg) cells expressing CXCR5 and Bcl-6 that localize to the germinal cen...

journal_title：Nature medicine

authors： Chung Y,Tanaka S,Chu F,Nurieva RI,Martinez GJ,Rawal S,Wang YH,Lim H,Reynolds JM,Zhou XH,Fan HM,Liu ZM,Neelapu SS,Dong C

更新日期：2011-07-24 00:00:00

abstract：:Noninvasive imaging at the molecular level is an emerging field in biomedical research. This paper introduces a new technology synergizing two leading imaging methodologies: positron emission tomography (PET) and magnetic resonance imaging (MRI). Although the value of PET lies in its high-sensitivity tracking of bioma...

journal_title：Nature medicine

authors： Judenhofer MS,Wehrl HF,Newport DF,Catana C,Siegel SB,Becker M,Thielscher A,Kneilling M,Lichy MP,Eichner M,Klingel K,Reischl G,Widmaier S,Röcken M,Nutt RE,Machulla HJ,Uludag K,Cherry SR,Claussen CD,Pichler BJ

更新日期：2008-04-01 00:00:00

abstract：:A variable region gene of the T-cell receptor, V beta 8.2, is rearranged, and its product is expressed on pathogenic T cells that induce experimental autoimmune encephalomyelitis (EAE) in H-2u mice after immunization with myelin basic protein (MBP). Vaccination of these mice with naked DNA encoding V beta 8.2 protecte...

journal_title：Nature medicine

authors： Waisman A,Ruiz PJ,Hirschberg DL,Gelman A,Oksenberg JR,Brocke S,Mor F,Cohen IR,Steinman L

更新日期：1996-08-01 00:00:00

abstract：:Mesenchymal stem cells can give rise to several cell types, but varying results depending on isolation methods and tissue source have led to controversies about their usefulness in clinical medicine. Here we show that vascular endothelial cells can transform into multipotent stem-like cells by an activin-like kinase-2...

journal_title：Nature medicine

authors： Medici D,Shore EM,Lounev VY,Kaplan FS,Kalluri R,Olsen BR

更新日期：2010-12-01 00:00:00

abstract：:Osteoarthritis is a highly prevalent and debilitating joint disorder. There is no effective medical therapy for the condition because of limited understanding of its pathogenesis. We show that transforming growth factor β1 (TGF-β1) is activated in subchondral bone in response to altered mechanical loading in an anteri...

journal_title：Nature medicine

authors： Zhen G,Wen C,Jia X,Li Y,Crane JL,Mears SC,Askin FB,Frassica FJ,Chang W,Yao J,Carrino JA,Cosgarea A,Artemov D,Chen Q,Zhao Z,Zhou X,Riley L,Sponseller P,Wan M,Lu WW,Cao X

更新日期：2013-06-01 00:00:00

abstract：:Hemophilia B is a severe X-linked bleeding diathesis caused by the absence of functional blood coagulation factor IX, and is an excellent candidate for treatment of a genetic disease by gene therapy. Using an adeno-associated viral vector, we demonstrate sustained expression (>17 months) of factor IX in a large-animal...

journal_title：Nature medicine

authors： Herzog RW,Yang EY,Couto LB,Hagstrom JN,Elwell D,Fields PA,Burton M,Bellinger DA,Read MS,Brinkhous KM,Podsakoff GM,Nichols TC,Kurtzman GJ,High KA

更新日期：1999-01-01 00:00:00

abstract：:The World Health Organization estimates that tobacco will become the largest single health problem by 2020, causing an estimated 8.4 million deaths annually. But the smoking burden will not be distributed evenly across the globe; deaths in developed nations are set to rise 50% to 2.4 million while those in Asia will s...

journal_title：Nature medicine

authors： Raw M

更新日期：2001-01-01 00:00:00

abstract：:The mechanism by which angiogenic factors recruit bone marrow (BM)-derived quiescent endothelial and hematopoietic stem cells (HSCs) is not known. Here, we report that functional vascular endothelial growth factor receptor-1 (VEGFR1) is expressed on human CD34(+) and mouse Lin(-)Sca-1(+)c-Kit(+) BM-repopulating stem c...

journal_title：Nature medicine

authors： Hattori K,Heissig B,Wu Y,Dias S,Tejada R,Ferris B,Hicklin DJ,Zhu Z,Bohlen P,Witte L,Hendrikx J,Hackett NR,Crystal RG,Moore MA,Werb Z,Lyden D,Rafii S

更新日期：2002-08-01 00:00:00

abstract：:Treating KRAS-mutant lung adenocarcinoma (LUAD) remains a major challenge in cancer treatment given the difficulties associated with directly inhibiting the KRAS oncoprotein. One approach to addressing this challenge is to define mutations that frequently co-occur with those in KRAS, which themselves may lead to thera...

journal_title：Nature medicine

authors： Romero R,Sayin VI,Davidson SM,Bauer MR,Singh SX,LeBoeuf SE,Karakousi TR,Ellis DC,Bhutkar A,Sánchez-Rivera FJ,Subbaraj L,Martinez B,Bronson RT,Prigge JR,Schmidt EE,Thomas CJ,Goparaju C,Davies A,Dolgalev I,Heguy A,A

更新日期：2017-11-01 00:00:00

abstract：:Advances in imaging are transforming our understanding of angiogenesis and the evaluation of drugs that stimulate or inhibit angiogenesis in preclinical models and human disease. Vascular imaging makes it possible to quantify the number and spacing of blood vessels, measure blood flow and vascular permeability, and an...

journal_title：Nature medicine

authors： McDonald DM,Choyke PL

更新日期：2003-06-01 00:00:00

abstract：:Much effort has been devoted to the design of vaccines that induce adaptive cellular immunity, in particular CD8+ T cells, which have a central role in the host response to viral infections and cancers. To date, however, the development of effective T cell vaccines remains elusive. This is due, in part, to the lack of...

journal_title：Nature medicine

authors： Appay V,Douek DC,Price DA

更新日期：2008-06-01 00:00:00

abstract：:Mice transgenic for antisense Notch and normal mice treated with inhibitors of the Notch-activating enzyme gamma-secretase showed reduced damage to brain cells and improved functional outcome in a model of focal ischemic stroke. Notch endangers neurons by modulating pathways that increase their vulnerability to apopto...

journal_title：Nature medicine

authors： Arumugam TV,Chan SL,Jo DG,Yilmaz G,Tang SC,Cheng A,Gleichmann M,Okun E,Dixit VD,Chigurupati S,Mughal MR,Ouyang X,Miele L,Magnus T,Poosala S,Granger DN,Mattson MP

更新日期：2006-06-01 00:00:00

abstract：:The TAM receptors Tyro3, Axl and Mertk are receptor tyrosine kinases that dampen host innate immune responses following engagement with their ligands Gas6 and Protein S, which recognize phosphatidylserine on apoptotic cells. In a form of apoptotic mimicry, many enveloped viruses display phosphatidylserine on the outer...

journal_title：Nature medicine

authors： Miner JJ,Daniels BP,Shrestha B,Proenca-Modena JL,Lew ED,Lazear HM,Gorman MJ,Lemke G,Klein RS,Diamond MS

更新日期：2015-12-01 00:00:00

abstract：:Approximately 1-5% of breast cancers are attributed to inherited mutations in BRCA1 or BRCA2 and are selectively sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. In other cancer types, germline and/or somatic mutations in BRCA1 and/or BRCA2 (BRCA1/BRCA2) also confer selective sensitivity to PARP inhibitors....

journal_title：Nature medicine

authors： Davies H,Glodzik D,Morganella S,Yates LR,Staaf J,Zou X,Ramakrishna M,Martin S,Boyault S,Sieuwerts AM,Simpson PT,King TA,Raine K,Eyfjord JE,Kong G,Borg Å,Birney E,Stunnenberg HG,van de Vijver MJ,Børresen-Dale AL,Ma

更新日期：2017-04-01 00:00:00

abstract：:We formulate a two-phase paradigm of autoimmunity associated with systemic lupus erythematosus, the archetypal autoimmune disease. The initial Toll-like receptor (TLR)-independent phase is mediated by dendritic cell uptake of apoptotic cell debris and associated nucleic acids, whereas the subsequent TLR-dependent phas...

journal_title：Nature medicine

authors： Baccala R,Hoebe K,Kono DH,Beutler B,Theofilopoulos AN

更新日期：2007-05-01 00:00:00