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Neonatal mouse immunity against group B streptococcal infection by maternal vaccination with recombinant anti-idiotypes.

Abstract：

:We investigated whether immunization with recombinant anti-idiotypic antibody fragments mimicking the conformation of the capsular antigen can protect against infection by group B streptococcus, an important neonatal pathogen. Single-chain fragment-variable anti-idiotypes competed with the type III carbohydrate for binding to type-specific antibodies and elicited, in mice, the production of protective immunoglobulins reacting against the type III polysaccharide. Moreover, maternal immunization with soluble or phage-displayed fragments protected neonatal mice against streptococcal infection. These data indicate that recombinant anti-idiotypic antibodies may be useful in developing protein images of relevant carbohydrate epitopes and, ultimately, in preventing infections by encapsulated bacteria.

journal_name

Nat Med

journal_title

Nature medicine

authors

Magliani W,Polonelli L,Conti S,Salati A,Rocca PF,Cusumano V,Mancuso G,Teti G

doi

10.1038/nm0698-705

subject

Has Abstract

pub_date

1998-06-01 00:00:00

pages

705-9

issue

6

eissn

1078-8956

issn

1546-170X

journal_volume

4

pub_type

杂志文章

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