Genetic clues to the pathogenesis of Parkinson's disease.

abstract：:Attachment to the plasma membrane by linkage to a glycosylphosphatidylinositol (GPI) anchor is a mode of protein expression highly conserved from protozoa to mammals. As a clinical entity, deficiency of GPI has been recognized as paroxysmal nocturnal hemoglobinuria, an acquired clonal disorder associated with somatic ...

journal_title：Nature medicine

authors： Almeida AM,Murakami Y,Layton DM,Hillmen P,Sellick GS,Maeda Y,Richards S,Patterson S,Kotsianidis I,Mollica L,Crawford DH,Baker A,Ferguson M,Roberts I,Houlston R,Kinoshita T,Karadimitris A

更新日期：2006-07-01 00:00:00

abstract：:Unlike normal melanocytes, primary and metastatic human melanomas express high levels of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 (FGFR-1) messenger RNA, and expression of these genes is essential in sustaining the proliferation of malignant melanomas in vitro. To determine whether...

journal_title：Nature medicine

authors： Wang Y,Becker D

更新日期：1997-08-01 00:00:00

abstract：:Solid organ transplants contain small numbers of leukocytes that can migrate into the host and establish long-lasting microchimerism. Although such microchimerism is often associated with graft acceptance and tolerance, it has been difficult to demonstrate a true causal link. Using skin from mutant mice deficient for ...

journal_title：Nature medicine

authors： Anderson CC,Matzinger P

更新日期：2001-01-01 00:00:00

abstract：:After transplantation of primarily vascularized xenografts (Xgs), T-independent mechanisms may lead to Xg rejection before T-cell activation even takes place. The possibility of achieving T-independent xenotolerance was evaluated in nude rats that normally reject hamster cardiac Xgs within 4 days by non-T cell-mediate...

journal_title：Nature medicine

authors： Lin Y,Goebels J,Xia G,Ji P,Vandeputte M,Waer M

更新日期：1998-02-01 00:00:00

abstract：:Activating mutations in genes encoding G protein α (Gα) subunits occur in 4-5% of all human cancers, but oncogenic alterations in Gβ subunits have not been defined. Here we demonstrate that recurrent mutations in the Gβ proteins GNB1 and GNB2 confer cytokine-independent growth and activate canonical G protein signalin...

journal_title：Nature medicine

authors： Yoda A,Adelmant G,Tamburini J,Chapuy B,Shindoh N,Yoda Y,Weigert O,Kopp N,Wu SC,Kim SS,Liu H,Tivey T,Christie AL,Elpek KG,Card J,Gritsman K,Gotlib J,Deininger MW,Makishima H,Turley SJ,Javidi-Sharifi N,Maciejewski

更新日期：2015-01-01 00:00:00

abstract：:The Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) is expressed in all KSHV-associated tumors, including Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL). We found that beta-catenin is overexpressed in both PEL cells and KS tissue. Introduction of anti-LANA small inte...

journal_title：Nature medicine

authors： Fujimuro M,Wu FY,ApRhys C,Kajumbula H,Young DB,Hayward GS,Hayward SD

更新日期：2003-03-01 00:00:00

abstract：:Huntington's disease (HD) is a fatal dominantly inherited neurodegenerative disorder caused by a CAG repeat expansion leading to an elongated polyglutamine stretch in huntingtin. Mutant huntingtin (mHTT) is ubiquitously expressed in all cells but elicits selective cortical and striatal neurodegeneration in HD. The mec...

journal_title：Nature medicine

authors： Wang N,Gray M,Lu XH,Cantle JP,Holley SM,Greiner E,Gu X,Shirasaki D,Cepeda C,Li Y,Dong H,Levine MS,Yang XW

更新日期：2014-05-01 00:00:00

abstract：:Physical function declines in old age, portending disability, increased health expenditures, and mortality. Cellular senescence, leading to tissue dysfunction, may contribute to these consequences of aging, but whether senescence can directly drive age-related pathology and be therapeutically targeted is still unclear...

journal_title：Nature medicine

authors： Xu M,Pirtskhalava T,Farr JN,Weigand BM,Palmer AK,Weivoda MM,Inman CL,Ogrodnik MB,Hachfeld CM,Fraser DG,Onken JL,Johnson KO,Verzosa GC,Langhi LGP,Weigl M,Giorgadze N,LeBrasseur NK,Miller JD,Jurk D,Singh RJ,Allison

更新日期：2018-08-01 00:00:00

abstract：:Hearing impairment is the most common sensory disorder, with congenital hearing impairment present in approximately 1 in 1,000 newborns. Hereditary deafness is often mediated by the improper development or degeneration of cochlear hair cells. Until now, it was not known whether such congenital failures could be mitiga...

journal_title：Nature medicine

authors： Lentz JJ,Jodelka FM,Hinrich AJ,McCaffrey KE,Farris HE,Spalitta MJ,Bazan NG,Duelli DM,Rigo F,Hastings ML

更新日期：2013-03-01 00:00:00

abstract：:T-cell acute lymphoblastic leukemia (T-ALL), unlike other ALL types, is only infrequently associated with chromosomal aberrations, but it was recently shown that most individuals with T-ALL carry activating mutations in the NOTCH1 gene. However, the signaling pathways and target genes responsible for Notch1-induced ne...

journal_title：Nature medicine

authors： Vilimas T,Mascarenhas J,Palomero T,Mandal M,Buonamici S,Meng F,Thompson B,Spaulding C,Macaroun S,Alegre ML,Kee BL,Ferrando A,Miele L,Aifantis I

更新日期：2007-01-01 00:00:00

abstract：:Recurrent medulloblastoma and ependymoma are universally lethal, with no approved targeted therapies and few candidates presently under clinical evaluation. Nearly all recurrent medulloblastomas and posterior fossa group A (PFA) ependymomas are located adjacent to and bathed by the cerebrospinal fluid, presenting an o...

journal_title：Nature medicine

authors： Donovan LK,Delaidelli A,Joseph SK,Bielamowicz K,Fousek K,Holgado BL,Manno A,Srikanthan D,Gad AZ,Van Ommeren R,Przelicki D,Richman C,Ramaswamy V,Daniels C,Pallota JG,Douglas T,Joynt ACM,Haapasalo J,Nor C,Vladoiu MC,

更新日期：2020-05-01 00:00:00

abstract：:Matrix-producing osteoblasts and bone-resorbing osteoclasts maintain bone homeostasis. Osteoclasts are multinucleated, giant cells of hematopoietic origin formed by the fusion of mononuclear pre-osteoclasts derived from myeloid cells. Fusion-mediated giant cell formation is critical for osteoclast maturation; without ...

journal_title：Nature medicine

authors： Lee SH,Rho J,Jeong D,Sul JY,Kim T,Kim N,Kang JS,Miyamoto T,Suda T,Lee SK,Pignolo RJ,Koczon-Jaremko B,Lorenzo J,Choi Y

更新日期：2006-12-01 00:00:00

abstract：:Molecular targeted therapy has the potential to dramatically improve survival in patients with cancer. However, complete and durable responses to targeted therapy are rare in individuals with advanced-stage solid cancers. Even the most effective targeted therapies generally do not induce a complete tumor response, res...

journal_title：Nature medicine

authors： Bivona TG,Doebele RC

更新日期：2016-05-05 00:00:00

abstract：:Expression of the oncogenic transcription factor MYC is disproportionately elevated in triple-negative breast cancer (TNBC), as compared to estrogen receptor-, progesterone receptor- or human epidermal growth factor 2 receptor-positive (RP) breast cancer. We and others have shown that MYC alters metabolism during tumo...

journal_title：Nature medicine

authors： Camarda R,Zhou AY,Kohnz RA,Balakrishnan S,Mahieu C,Anderton B,Eyob H,Kajimura S,Tward A,Krings G,Nomura DK,Goga A

更新日期：2016-04-01 00:00:00

abstract：:Increased production of very low-density lipoprotein (VLDL) is a critical feature of the metabolic syndrome. Here we report that a selective increase in brain glucose lowered circulating triglycerides (TG) through the inhibition of TG-VLDL secretion by the liver. We found that the effect of glucose required its conver...

journal_title：Nature medicine

authors： Lam TK,Gutierrez-Juarez R,Pocai A,Bhanot S,Tso P,Schwartz GJ,Rossetti L

更新日期：2007-02-01 00:00:00

abstract：:Substantial global effort has been devoted to curtailing the tobacco epidemic over the past two decades, especially after the adoption of the Framework Convention on Tobacco Control1 by the World Health Organization in 2003. In 2015, in recognition of the burden resulting from tobacco use, strengthened tobacco control...

journal_title：Nature medicine

authors： Flor LS,Reitsma MB,Gupta V,Ng M,Gakidou E

更新日期：2021-01-21 00:00:00

abstract：:Angiogenic tumor vessels are promising targets for the activity and the selective delivery of cancer therapeutics. The bone marrow contributes different cell types to the tumor stroma, including hematopoietic cells and, as recently suggested, vascular endothelial cells (ECs). Thus, transplantation of genetically modif...

journal_title：Nature medicine

authors： De Palma M,Venneri MA,Roca C,Naldini L

更新日期：2003-06-01 00:00:00

abstract：:Together with recent advances in the processing and culture of human tissue, bioengineering, xenotransplantation and genome editing, Induced pluripotent stem cells (iPSCs) present a range of new opportunities for the study of human cancer. Here we discuss the main advantages and limitations of iPSC modeling, and how t...

journal_title：Nature medicine

authors： Papapetrou EP

更新日期：2016-12-06 00:00:00

abstract：:Neutrophils have key roles in modulating the immune response. We present a robust methodology for rapidly isolating neutrophils directly from whole blood with 'on-chip' processing for mRNA and protein isolation for genomics and proteomics. We validate this device with an ex vivo stimulation experiment and by compariso...

journal_title：Nature medicine

authors： Kotz KT,Xiao W,Miller-Graziano C,Qian WJ,Russom A,Warner EA,Moldawer LL,De A,Bankey PE,Petritis BO,Camp DG 2nd,Rosenbach AE,Goverman J,Fagan SP,Brownstein BH,Irimia D,Xu W,Wilhelmy J,Mindrinos MN,Smith RD,Davis RW

更新日期：2010-09-01 00:00:00

abstract：:Hepatic insulin resistance is a driving force in the pathogenesis of type 2 diabetes mellitus (T2DM) and is tightly coupled with excessive storage of fat and the ensuing inflammation within the liver. There is compelling evidence that activation of the transcription factor nuclear factor-κB (NF-κB) and downstream infl...

journal_title：Nature medicine

authors： Kiechl S,Wittmann J,Giaccari A,Knoflach M,Willeit P,Bozec A,Moschen AR,Muscogiuri G,Sorice GP,Kireva T,Summerer M,Wirtz S,Luther J,Mielenz D,Billmeier U,Egger G,Mayr A,Oberhollenzer F,Kronenberg F,Orthofer M,Penni

更新日期：2013-03-01 00:00:00

abstract：:Kidney transplantation has been one of the major medical advances of the past 30 years. However, tissue availability remains a major obstacle. This can potentially be overcome by the use of undifferentiated or partially developed kidney precursor cells derived from early embryos and fetal tissue. Here, transplantation...

journal_title：Nature medicine

authors： Dekel B,Burakova T,Arditti FD,Reich-Zeliger S,Milstein O,Aviel-Ronen S,Rechavi G,Friedman N,Kaminski N,Passwell JH,Reisner Y

更新日期：2003-01-01 00:00:00

abstract：:The human CD4 molecule (hCD4) is expressed on T lymphocytes and macrophages and acts as a key component of the cellular receptor for HIV. At baseline, hCD4 transgenic mice expressed hCD4 on microglia, the resident mononuclear phagocytes of the brain, and showed no neuronal damage. Activation of brain microglia by peri...

journal_title：Nature medicine

authors： Buttini M,Westland CE,Masliah E,Yafeh AM,Wyss-Coray T,Mucke L

更新日期：1998-04-01 00:00:00

abstract：:Despite a more than 20-year experience of therapeutic benefit, the relevant molecular and cellular targets of intravenous immunoglobulin (IVIg) in autoimmune disease remain unclear. Contrary to the prevailing theories of IVIg action in autoimmunity, we show that IVIg drives signaling through activating Fc gamma recept...

journal_title：Nature medicine

authors： Siragam V,Crow AR,Brinc D,Song S,Freedman J,Lazarus AH

更新日期：2006-06-01 00:00:00

abstract：:Autophagy, an evolutionarily conserved process for the bulk degradation of cytoplasmic components, serves as a cell survival mechanism in starving cells. Although altered autophagy has been observed in various heart diseases, including cardiac hypertrophy and heart failure, it remains unclear whether autophagy plays a...

journal_title：Nature medicine

authors： Nakai A,Yamaguchi O,Takeda T,Higuchi Y,Hikoso S,Taniike M,Omiya S,Mizote I,Matsumura Y,Asahi M,Nishida K,Hori M,Mizushima N,Otsu K

更新日期：2007-05-01 00:00:00

abstract：:Osteopontin (Opn) is important for T helper type 1 (T(H)1) immunity and autoimmunity. However, the role of this cytokine in T(H)2-mediated allergic disease as well as its effects on primary versus secondary antigenic encounters remain unclear. Here we demonstrate that OPN is expressed in the lungs of asthmatic individ...

journal_title：Nature medicine

authors： Xanthou G,Alissafi T,Semitekolou M,Simoes DC,Economidou E,Gaga M,Lambrecht BN,Lloyd CM,Panoutsakopoulou V

更新日期：2007-05-01 00:00:00

abstract：:Hemophilia B is a severe X-linked bleeding diathesis caused by the absence of functional blood coagulation factor IX, and is an excellent candidate for treatment of a genetic disease by gene therapy. Using an adeno-associated viral vector, we demonstrate sustained expression (>17 months) of factor IX in a large-animal...

journal_title：Nature medicine

authors： Herzog RW,Yang EY,Couto LB,Hagstrom JN,Elwell D,Fields PA,Burton M,Bellinger DA,Read MS,Brinkhous KM,Podsakoff GM,Nichols TC,Kurtzman GJ,High KA

更新日期：1999-01-01 00:00:00

abstract：:The bromodomain and extraterminal (BET) family of proteins comprises four members-BRD2, BRD3, BRD4 and the testis-specific isoform BRDT-that largely function as transcriptional coactivators and play critical roles in various cellular processes, including the cell cycle, apoptosis, migration and invasion. BET proteins ...

journal_title：Nature medicine

authors： Dai X,Gan W,Li X,Wang S,Zhang W,Huang L,Liu S,Zhong Q,Guo J,Zhang J,Chen T,Shimizu K,Beca F,Blattner M,Vasudevan D,Buckley DL,Qi J,Buser L,Liu P,Inuzuka H,Beck AH,Wang L,Wild PJ,Garraway LA,Rubin MA,Barb

更新日期：2017-09-01 00:00:00

abstract：:Hereditary hemochromatosis and transfusional iron overload are frequent clinical conditions associated with progressive iron accumulation in parenchymal tissues, leading to eventual organ failure. We have discovered a new mechanism to reverse iron overload-pharmacological modulation of the divalent metal transporter-1...

journal_title：Nature medicine

authors： Ludwiczek S,Theurl I,Muckenthaler MU,Jakab M,Mair SM,Theurl M,Kiss J,Paulmichl M,Hentze MW,Ritter M,Weiss G

更新日期：2007-04-01 00:00:00

abstract：:Levels of insulin-like growth factor I (IGF-I), a neuroprotective hormone, decrease in serum during aging, whereas amyloid-beta (Abeta), which is involved in the pathogenesis of Alzheimer disease, accumulates in the brain. High brain Abeta levels are found at an early age in mutant mice with low circulating IGF-I, and...

journal_title：Nature medicine

authors： Carro E,Trejo JL,Gomez-Isla T,LeRoith D,Torres-Aleman I

更新日期：2002-12-01 00:00:00

abstract：:The World Health Organization estimates that tobacco will become the largest single health problem by 2020, causing an estimated 8.4 million deaths annually. But the smoking burden will not be distributed evenly across the globe; deaths in developed nations are set to rise 50% to 2.4 million while those in Asia will s...

journal_title：Nature medicine

authors： Raw M

更新日期：2001-01-01 00:00:00