解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Substantial global effort has been devoted to curtailing the tobacco epidemic over the past two decades, especially after the adoption of the Framework Convention on Tobacco Control1 by the World Health Organization in 2003. In 2015, in recognition of the burden resulting from tobacco use, strengthened tobacco control...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-020-01210-8
更新日期:2021-01-21 00:00:00
abstract::The impact of single-agent antibodies against programmed death-ligand 1 (PD-L1) as maintenance therapy is unknown in patients with metastatic breast cancer. The SAFIR02-BREAST IMMUNO substudy included patients with human epidermal growth factor receptor type 2 (Her2)-negative metastatic breast cancer whose disease did...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-020-01189-2
更新日期:2021-01-18 00:00:00
abstract::White fat stores excess energy, whereas brown and beige fat are thermogenic and dissipate energy as heat. Thermogenic adipose tissues markedly improve glucose and lipid homeostasis in mouse models, although the extent to which brown adipose tissue (BAT) influences metabolic and cardiovascular disease in humans is uncl...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-020-1126-7
更新日期:2021-01-01 00:00:00
abstract::Most of what we know about adaptive immunity has come from inbred mouse studies, using methods that are often difficult or impossible to confirm in humans. In addition, vaccine responses in mice are often poorly predictive of responses to those same vaccines in humans. Here we use human tonsils, readily available lymp...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-020-01145-0
更新日期:2021-01-01 00:00:00
abstract::Traditional screening for COVID-19 typically includes survey questions about symptoms and travel history, as well as temperature measurements. Here, we explore whether personal sensor data collected over time may help identify subtle changes indicating an infection, such as in patients with COVID-19. We have developed...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-020-1123-x
更新日期:2021-01-01 00:00:00
abstract::A Correction to this paper has been published: https://doi.org/10.1038/s41591-020-01176-7. ...
journal_title:Nature medicine
pub_type: 已发布勘误
doi:10.1038/s41591-020-01176-7
更新日期:2020-12-01 00:00:00
abstract::Preoperative immunotherapy with anti-PD1 plus anti-CTLA4 antibodies has shown remarkable pathological responses in melanoma1 and colorectal cancer2. In NABUCCO (ClinicalTrials.gov: NCT03387761 ), a single-arm feasibility trial, 24 patients with stage III urothelial cancer (UC) received two doses of ipilimumab and two ...
journal_title:Nature medicine
pub_type: 杂志文章,多中心研究
doi:10.1038/s41591-020-1085-z
更新日期:2020-12-01 00:00:00
abstract::The Zero Childhood Cancer Program is a precision medicine program to benefit children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline whole genome sequencing (WGS) and RNA sequencing (RNAseq) across 252 tumors from high-risk pediatric patients with cancer, we identified 968 reportable ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-020-1072-4
更新日期:2020-11-01 00:00:00
abstract::Drug-induced liver injury (DILI) is a leading cause of termination in drug development programs and removal of drugs from the market; this is partially due to the inability to identify patients who are at risk1. In this study, we developed a polygenic risk score (PRS) for DILI by aggregating effects of numerous genome...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-020-1023-0
更新日期:2020-10-01 00:00:00
abstract::Understanding the pathophysiology of SARS-CoV-2 infection is critical for therapeutic and public health strategies. Viral-host interactions can guide discovery of disease regulators, and protein structure function analysis points to several immune pathways, including complement and coagulation, as targets of coronavir...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-020-1021-2
更新日期:2020-10-01 00:00:00
abstract::Disruption of systemic homeostasis by either chronic or acute stressors, such as obesity1 or surgery2, alters cancer pathogenesis. Patients with cancer, particularly those with breast cancer, can be at increased risk of cardiovascular disease due to treatment toxicity and changes in lifestyle behaviors3-5. While eleva...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-020-0964-7
更新日期:2020-09-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature medicine
pub_type: 已发布勘误
doi:10.1038/s41591-020-1016-z
更新日期:2020-09-01 00:00:00
abstract::Use of wearable devices that monitor physical activity is projected to increase more than fivefold per half-decade1. We investigated how device-based physical activity energy expenditure (PAEE) and different intensity profiles were associated with all-cause mortality. We used a network harmonization approach to map do...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-020-1012-3
更新日期:2020-09-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature medicine
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41591-020-1057-3
更新日期:2020-09-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature medicine
pub_type: 已发布勘误
doi:10.1038/s41591-020-0924-2
更新日期:2020-07-01 00:00:00
abstract::In many areas of oncology, we lack sensitive tools to track low-burden disease. Although cell-free DNA (cfDNA) shows promise in detecting cancer mutations, we found that the combination of low tumor fraction (TF) and limited number of DNA fragments restricts low-disease-burden monitoring through the prevailing deep ta...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-020-0915-3
更新日期:2020-07-01 00:00:00
abstract::Phase 3 trials are the mainstay of drug development across medicine but have often not met expectations set by preceding phase 2 studies. A systematic meta-analysis evaluated all randomized controlled, double-blind trials investigating targeted disease-modifying anti-rheumatic drugs in rheumatoid and psoriatic arthrit...
journal_title:Nature medicine
pub_type: 杂志文章,meta分析
doi:10.1038/s41591-020-0833-4
更新日期:2020-06-01 00:00:00
abstract::Recent efforts toward an HIV vaccine focus on inducing broadly neutralizing antibodies, but eliciting both neutralizing antibodies (nAbs) and cellular responses may be superior. Here, we immunized macaques with an HIV envelope trimer, either alone to induce nAbs, or together with a heterologous viral vector regimen to...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-020-0858-8
更新日期:2020-06-01 00:00:00
abstract::Recurrent medulloblastoma and ependymoma are universally lethal, with no approved targeted therapies and few candidates presently under clinical evaluation. Nearly all recurrent medulloblastomas and posterior fossa group A (PFA) ependymomas are located adjacent to and bathed by the cerebrospinal fluid, presenting an o...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-020-0827-2
更新日期:2020-05-01 00:00:00
abstract::The ongoing substance misuse epidemic in the United States is complex and dynamic and should be approached as such in the development and evaluation of policy1. Drug overdose deaths (largely attributable to opioid misuse) in the United States have grown exponentially for almost four decades, but the mechanisms of this...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-020-0855-y
更新日期:2020-05-01 00:00:00
abstract::Our understanding of Alzheimer's disease (AD) pathophysiology remains incomplete. Here we used quantitative mass spectrometry and coexpression network analysis to conduct the largest proteomic study thus far on AD. A protein network module linked to sugar metabolism emerged as one of the modules most significantly ass...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-020-0815-6
更新日期:2020-05-01 00:00:00
abstract::Single-cell genomics is essential to chart tumor ecosystems. Although single-cell RNA-Seq (scRNA-Seq) profiles RNA from cells dissociated from fresh tumors, single-nucleus RNA-Seq (snRNA-Seq) is needed to profile frozen or hard-to-dissociate tumors. Each requires customization to different tissue and tumor types, posi...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-020-0844-1
更新日期:2020-05-01 00:00:00
abstract::Direct evidence in humans for the impact of the microbiome on nutrient absorption is lacking. We conducted an extended inpatient study using two interventions that we hypothesized would alter the gut microbiome and nutrient absorption. In each, stool calorie loss, a direct proxy of nutrient absorption, was measured. T...
journal_title:Nature medicine
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41591-020-0801-z
更新日期:2020-04-01 00:00:00
abstract::PD-1 plus CTLA-4 blockade is highly effective in advanced-stage, mismatch repair (MMR)-deficient (dMMR) colorectal cancers, yet not in MMR-proficient (pMMR) tumors. We postulated a higher efficacy of neoadjuvant immunotherapy in early-stage colon cancers. In the exploratory NICHE study (ClinicalTrials.gov: NCT03026140...
journal_title:Nature medicine
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41591-020-0805-8
更新日期:2020-04-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature medicine
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41591-020-0816-5
更新日期:2020-03-01 00:00:00
abstract::Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DiHS/DRESS) is a potentially fatal multiorgan inflammatory disease associated with herpesvirus reactivation and subsequent onset of autoimmune diseases1-4. Pathophysiology remains elusive and therapeutic options are limited. ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-019-0733-7
更新日期:2020-02-01 00:00:00
abstract::Temperatures that deviate from the long-term local norm affect human health, and are projected to become more frequent as the global climate changes1. There are limited data on how such anomalies affect deaths from injuries. In the present study, we used data on mortality and temperature over 38 years (1980-2017) in t...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-019-0721-y
更新日期:2020-01-01 00:00:00
abstract::De novo mutations arising on the paternal chromosome make the largest known contribution to autism risk, and correlate with paternal age at the time of conception. The recurrence risk for autism spectrum disorders is substantial, leading many families to decline future pregnancies, but the potential impact of assessin...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-019-0711-0
更新日期:2020-01-01 00:00:00
abstract::Intraoperative diagnosis is essential for providing safe and effective care during cancer surgery1. The existing workflow for intraoperative diagnosis based on hematoxylin and eosin staining of processed tissue is time, resource and labor intensive2,3. Moreover, interpretation of intraoperative histologic images is de...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-019-0715-9
更新日期:2020-01-01 00:00:00
abstract::Immune-checkpoint blockade (ICB) has demonstrated efficacy in many tumor types, but predictors of responsiveness to anti-PD1 ICB are incompletely characterized. In this study, we analyzed a clinically annotated cohort of patients with melanoma (n = 144) treated with anti-PD1 ICB, with whole-exome and whole-transcripto...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-019-0654-5
更新日期:2019-12-01 00:00:00
abstract::Late-onset sepsis (LOS) is thought to result from systemic spread of commensal microbes from the intestines of premature infants. Clinical use of probiotics for LOS prophylaxis has varied owing to limited efficacy, reflecting an incomplete understanding of relationships between development of the intestinal microbiome...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-019-0640-y
更新日期:2019-11-01 00:00:00
abstract::Stimulating an immune response against cancer through adoptive transfer of tumor-targeting lymphocytes has shown great promise in hematological malignancies, but clinical efficacy against many common solid epithelial cancers remains low. Targeting 'neoantigens'-the somatic mutations expressed only by tumor cells-might...
journal_title:Nature medicine
pub_type: 杂志文章,评审
doi:10.1038/s41591-019-0596-y
更新日期:2019-10-01 00:00:00
abstract::Conventional leg prostheses do not convey sensory information about motion or interaction with the ground to above-knee amputees, thereby reducing confidence and walking speed in the users that is associated with high mental and physical fatigue1-4. The lack of physiological feedback from the remaining extremity to th...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-019-0567-3
更新日期:2019-09-01 00:00:00
abstract::Natalizumab (NZM), a humanized monoclonal IgG4 antibody to α4 integrins, is used to treat patients with relapsing-remitting multiple sclerosis (MS)1,2, but in about 6% of the cases persistent neutralizing anti-drug antibodies (ADAs) are induced leading to therapy discontinuation3,4. To understand the basis of the ADA ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-019-0568-2
更新日期:2019-09-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature medicine
pub_type: 已发布勘误
doi:10.1038/s41591-019-0562-8
更新日期:2019-09-01 00:00:00
abstract::TRK fusions are found in a variety of cancer types, lead to oncogenic addiction, and strongly predict tumor-agnostic efficacy of TRK inhibition1-8. With the recent approval of the first selective TRK inhibitor, larotrectinib, for patients with any TRK-fusion-positive adult or pediatric solid tumor, to identify mechani...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-019-0542-z
更新日期:2019-09-01 00:00:00
abstract::Checkpoint inhibitors produce durable responses in numerous metastatic cancers, but immune-related adverse events (irAEs) complicate and limit their benefit. IrAEs can affect organ systems idiosyncratically; presentations range from mild and self-limited to fulminant and fatal. The molecular mechanisms underlying irAE...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-019-0523-2
更新日期:2019-08-01 00:00:00
abstract::The microbiome of the female reproductive tract has implications for women's reproductive health. We examined the vaginal microbiome in two cohorts of women who experienced normal term births: a cross-sectionally sampled cohort of 613 pregnant and 1,969 non-pregnant women, focusing on 300 pregnant and 300 non-pregnant...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-019-0465-8
更新日期:2019-06-01 00:00:00
abstract::It is estimated that 350 million individuals worldwide suffer from rare diseases, which are predominantly caused by mutation in a single gene1. The current molecular diagnostic rate is estimated at 50%, with whole-exome sequencing (WES) among the most successful approaches2-5. For patients in whom WES is uninformative...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-019-0457-8
更新日期:2019-06-01 00:00:00
abstract::In most cases of sporadic colorectal cancers, tumorigenesis is a multistep process, involving genomic alterations in parallel with morphologic changes. In addition, accumulating evidence suggests that the human gut microbiome is linked to the development of colorectal cancer. Here we performed fecal metagenomic and me...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-019-0458-7
更新日期:2019-06-01 00:00:00