听力与言语-语言病理学

行为科学

医学伦理学

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  • The effects of tobacco control policies on global smoking prevalence.

    abstract::Substantial global effort has been devoted to curtailing the tobacco epidemic over the past two decades, especially after the adoption of the Framework Convention on Tobacco Control1 by the World Health Organization in 2003. In 2015, in recognition of the burden resulting from tobacco use, strengthened tobacco control...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-020-01210-8

    authors: Flor LS,Reitsma MB,Gupta V,Ng M,Gakidou E

    更新日期:2021-01-21 00:00:00

  • Durvalumab compared to maintenance chemotherapy in metastatic breast cancer: the randomized phase II SAFIR02-BREAST IMMUNO trial.

    abstract::The impact of single-agent antibodies against programmed death-ligand 1 (PD-L1) as maintenance therapy is unknown in patients with metastatic breast cancer. The SAFIR02-BREAST IMMUNO substudy included patients with human epidermal growth factor receptor type 2 (Her2)-negative metastatic breast cancer whose disease did...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-020-01189-2

    authors: Bachelot T,Filleron T,Bieche I,Arnedos M,Campone M,Dalenc F,Coussy F,Sablin MP,Debled M,Lefeuvre-Plesse C,Goncalves A,Reynier MM,Jacot W,You B,Barthelemy P,Verret B,Isambert N,Tchiknavorian X,Levy C,Thery JC,L'Har

    更新日期:2021-01-18 00:00:00

  • Brown adipose tissue is associated with cardiometabolic health.

    abstract::White fat stores excess energy, whereas brown and beige fat are thermogenic and dissipate energy as heat. Thermogenic adipose tissues markedly improve glucose and lipid homeostasis in mouse models, although the extent to which brown adipose tissue (BAT) influences metabolic and cardiovascular disease in humans is uncl...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-020-1126-7

    authors: Becher T,Palanisamy S,Kramer DJ,Eljalby M,Marx SJ,Wibmer AG,Butler SD,Jiang CS,Vaughan R,Schöder H,Mark A,Cohen P

    更新日期:2021-01-01 00:00:00

  • Modeling human adaptive immune responses with tonsil organoids.

    abstract::Most of what we know about adaptive immunity has come from inbred mouse studies, using methods that are often difficult or impossible to confirm in humans. In addition, vaccine responses in mice are often poorly predictive of responses to those same vaccines in humans. Here we use human tonsils, readily available lymp...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-020-01145-0

    authors: Wagar LE,Salahudeen A,Constantz CM,Wendel BS,Lyons MM,Mallajosyula V,Jatt LP,Adamska JZ,Blum LK,Gupta N,Jackson KJL,Yang F,Röltgen K,Roskin KM,Blaine KM,Meister KD,Ahmad IN,Cortese M,Dora EG,Tucker SN,Sperling AI

    更新日期:2021-01-01 00:00:00

  • Wearable sensor data and self-reported symptoms for COVID-19 detection.

    abstract::Traditional screening for COVID-19 typically includes survey questions about symptoms and travel history, as well as temperature measurements. Here, we explore whether personal sensor data collected over time may help identify subtle changes indicating an infection, such as in patients with COVID-19. We have developed...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-020-1123-x

    authors: Quer G,Radin JM,Gadaleta M,Baca-Motes K,Ariniello L,Ramos E,Kheterpal V,Topol EJ,Steinhubl SR

    更新日期:2021-01-01 00:00:00

  • Publisher Correction: Responding to the hidden pandemic for healthcare workers: stress.

    abstract::A Correction to this paper has been published: https://doi.org/10.1038/s41591-020-01176-7. ...

    journal_title:Nature medicine

    pub_type: 已发布勘误

    doi:10.1038/s41591-020-01176-7

    authors: Krystal JH

    更新日期:2020-12-01 00:00:00

  • Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial.

    abstract::Preoperative immunotherapy with anti-PD1 plus anti-CTLA4 antibodies has shown remarkable pathological responses in melanoma1 and colorectal cancer2. In NABUCCO (ClinicalTrials.gov: NCT03387761 ), a single-arm feasibility trial, 24 patients with stage III urothelial cancer (UC) received two doses of ipilimumab and two ...

    journal_title:Nature medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1038/s41591-020-1085-z

    authors: van Dijk N,Gil-Jimenez A,Silina K,Hendricksen K,Smit LA,de Feijter JM,van Montfoort ML,van Rooijen C,Peters D,Broeks A,van der Poel HG,Bruining A,Lubeck Y,Sikorska K,Boellaard TN,Kvistborg P,Vis DJ,Hooijberg E,Schumac

    更新日期:2020-12-01 00:00:00

  • Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer.

    abstract::The Zero Childhood Cancer Program is a precision medicine program to benefit children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline whole genome sequencing (WGS) and RNA sequencing (RNAseq) across 252 tumors from high-risk pediatric patients with cancer, we identified 968 reportable ...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-020-1072-4

    authors: Wong M,Mayoh C,Lau LMS,Khuong-Quang DA,Pinese M,Kumar A,Barahona P,Wilkie EE,Sullivan P,Bowen-James R,Syed M,Martincorena I,Abascal F,Sherstyuk A,Bolanos NA,Baber J,Priestley P,Dolman MEM,Fleuren EDG,Gauthier ME,M

    更新日期:2020-11-01 00:00:00

  • Polygenic architecture informs potential vulnerability to drug-induced liver injury.

    abstract::Drug-induced liver injury (DILI) is a leading cause of termination in drug development programs and removal of drugs from the market; this is partially due to the inability to identify patients who are at risk1. In this study, we developed a polygenic risk score (PRS) for DILI by aggregating effects of numerous genome...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-020-1023-0

    authors: Koido M,Kawakami E,Fukumura J,Noguchi Y,Ohori M,Nio Y,Nicoletti P,Aithal GP,Daly AK,Watkins PB,Anayama H,Dragan Y,Shinozawa T,Takebe T

    更新日期:2020-10-01 00:00:00

  • Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection.

    abstract::Understanding the pathophysiology of SARS-CoV-2 infection is critical for therapeutic and public health strategies. Viral-host interactions can guide discovery of disease regulators, and protein structure function analysis points to several immune pathways, including complement and coagulation, as targets of coronavir...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-020-1021-2

    authors: Ramlall V,Thangaraj PM,Meydan C,Foox J,Butler D,Kim J,May B,De Freitas JK,Glicksberg BS,Mason CE,Tatonetti NP,Shapira SD

    更新日期:2020-10-01 00:00:00

  • Myocardial infarction accelerates breast cancer via innate immune reprogramming.

    abstract::Disruption of systemic homeostasis by either chronic or acute stressors, such as obesity1 or surgery2, alters cancer pathogenesis. Patients with cancer, particularly those with breast cancer, can be at increased risk of cardiovascular disease due to treatment toxicity and changes in lifestyle behaviors3-5. While eleva...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-020-0964-7

    authors: Koelwyn GJ,Newman AAC,Afonso MS,van Solingen C,Corr EM,Brown EJ,Albers KB,Yamaguchi N,Narke D,Schlegel M,Sharma M,Shanley LC,Barrett TJ,Rahman K,Mezzano V,Fisher EA,Park DS,Newman JD,Quail DF,Nelson ER,Caan BJ,J

    更新日期:2020-09-01 00:00:00

  • Author Correction: Temporal dynamics in viral shedding and transmissibility of COVID-19.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature medicine

    pub_type: 已发布勘误

    doi:10.1038/s41591-020-1016-z

    authors: He X,Lau EHY,Wu P,Deng X,Wang J,Hao X,Lau YC,Wong JY,Guan Y,Tan X,Mo X,Chen Y,Liao B,Chen W,Hu F,Zhang Q,Zhong M,Wu Y,Zhao L,Zhang F,Cowling BJ,Li F,Leung GM

    更新日期:2020-09-01 00:00:00

  • Wearable-device-measured physical activity and future health risk.

    abstract::Use of wearable devices that monitor physical activity is projected to increase more than fivefold per half-decade1. We investigated how device-based physical activity energy expenditure (PAEE) and different intensity profiles were associated with all-cause mortality. We used a network harmonization approach to map do...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-020-1012-3

    authors: Strain T,Wijndaele K,Dempsey PC,Sharp SJ,Pearce M,Jeon J,Lindsay T,Wareham N,Brage S

    更新日期:2020-09-01 00:00:00

  • Author Correction: Sampling the host response to SARS-CoV-2 in hospitals under siege.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature medicine

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/s41591-020-1057-3

    authors: Charney AW,Simons NW,Mouskas K,Lepow L,Cheng E,Le Berichel J,Chang C,Marvin R,Del Valle DM,Calorossi S,Lansky A,Walker L,Patel M,Xie H,Yi N,Yu A,Kang G,Liharska LE,Moya E,Hartnett M,Hatem S,Wilkins L,Eaton M,

    更新日期:2020-09-01 00:00:00

  • Author Correction: A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature medicine

    pub_type: 已发布勘误

    doi:10.1038/s41591-020-0924-2

    authors: Menachery VD,Yount BL Jr,Debbink K,Agnihothram S,Gralinski LE,Plante JA,Graham RL,Scobey T,Ge XY,Donaldson EF,Randell SH,Lanzavecchia A,Marasco WA,Shi ZL,Baric RS

    更新日期:2020-07-01 00:00:00

  • Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring.

    abstract::In many areas of oncology, we lack sensitive tools to track low-burden disease. Although cell-free DNA (cfDNA) shows promise in detecting cancer mutations, we found that the combination of low tumor fraction (TF) and limited number of DNA fragments restricts low-disease-burden monitoring through the prevailing deep ta...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-020-0915-3

    authors: Zviran A,Schulman RC,Shah M,Hill STK,Deochand S,Khamnei CC,Maloney D,Patel K,Liao W,Widman AJ,Wong P,Callahan MK,Ha G,Reed S,Rotem D,Frederick D,Sharova T,Miao B,Kim T,Gydush G,Rhoades J,Huang KY,Omans ND,Bo

    更新日期:2020-07-01 00:00:00

  • Efficacy outcomes in phase 2 and phase 3 randomized controlled trials in rheumatology.

    abstract::Phase 3 trials are the mainstay of drug development across medicine but have often not met expectations set by preceding phase 2 studies. A systematic meta-analysis evaluated all randomized controlled, double-blind trials investigating targeted disease-modifying anti-rheumatic drugs in rheumatoid and psoriatic arthrit...

    journal_title:Nature medicine

    pub_type: 杂志文章,meta分析

    doi:10.1038/s41591-020-0833-4

    authors: Kerschbaumer A,Smolen JS,Herkner H,Stefanova T,Chwala E,Aletaha D

    更新日期:2020-06-01 00:00:00

  • T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers.

    abstract::Recent efforts toward an HIV vaccine focus on inducing broadly neutralizing antibodies, but eliciting both neutralizing antibodies (nAbs) and cellular responses may be superior. Here, we immunized macaques with an HIV envelope trimer, either alone to induce nAbs, or together with a heterologous viral vector regimen to...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-020-0858-8

    authors: Arunachalam PS,Charles TP,Joag V,Bollimpelli VS,Scott MKD,Wimmers F,Burton SL,Labranche CC,Petitdemange C,Gangadhara S,Styles TM,Quarnstrom CF,Walter KA,Ketas TJ,Legere T,Jagadeesh Reddy PB,Kasturi SP,Tsai A,Yeung BZ

    更新日期:2020-06-01 00:00:00

  • Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma.

    abstract::Recurrent medulloblastoma and ependymoma are universally lethal, with no approved targeted therapies and few candidates presently under clinical evaluation. Nearly all recurrent medulloblastomas and posterior fossa group A (PFA) ependymomas are located adjacent to and bathed by the cerebrospinal fluid, presenting an o...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-020-0827-2

    authors: Donovan LK,Delaidelli A,Joseph SK,Bielamowicz K,Fousek K,Holgado BL,Manno A,Srikanthan D,Gad AZ,Van Ommeren R,Przelicki D,Richman C,Ramaswamy V,Daniels C,Pallota JG,Douglas T,Joynt ACM,Haapasalo J,Nor C,Vladoiu MC,

    更新日期:2020-05-01 00:00:00

  • Age and generational patterns of overdose death risk from opioids and other drugs.

    abstract::The ongoing substance misuse epidemic in the United States is complex and dynamic and should be approached as such in the development and evaluation of policy1. Drug overdose deaths (largely attributable to opioid misuse) in the United States have grown exponentially for almost four decades, but the mechanisms of this...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-020-0855-y

    authors: Jalal H,Buchanich JM,Sinclair DR,Roberts MS,Burke DS

    更新日期:2020-05-01 00:00:00

  • Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation.

    abstract::Our understanding of Alzheimer's disease (AD) pathophysiology remains incomplete. Here we used quantitative mass spectrometry and coexpression network analysis to conduct the largest proteomic study thus far on AD. A protein network module linked to sugar metabolism emerged as one of the modules most significantly ass...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-020-0815-6

    authors: Johnson ECB,Dammer EB,Duong DM,Ping L,Zhou M,Yin L,Higginbotham LA,Guajardo A,White B,Troncoso JC,Thambisetty M,Montine TJ,Lee EB,Trojanowski JQ,Beach TG,Reiman EM,Haroutunian V,Wang M,Schadt E,Zhang B,Dickson DW

    更新日期:2020-05-01 00:00:00

  • A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors.

    abstract::Single-cell genomics is essential to chart tumor ecosystems. Although single-cell RNA-Seq (scRNA-Seq) profiles RNA from cells dissociated from fresh tumors, single-nucleus RNA-Seq (snRNA-Seq) is needed to profile frozen or hard-to-dissociate tumors. Each requires customization to different tissue and tumor types, posi...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-020-0844-1

    authors: Slyper M,Porter CBM,Ashenberg O,Waldman J,Drokhlyansky E,Wakiro I,Smillie C,Smith-Rosario G,Wu J,Dionne D,Vigneau S,Jané-Valbuena J,Tickle TL,Napolitano S,Su MJ,Patel AG,Karlstrom A,Gritsch S,Nomura M,Waghray A,Go

    更新日期:2020-05-01 00:00:00

  • Effects of underfeeding and oral vancomycin on gut microbiome and nutrient absorption in humans.

    abstract::Direct evidence in humans for the impact of the microbiome on nutrient absorption is lacking. We conducted an extended inpatient study using two interventions that we hypothesized would alter the gut microbiome and nutrient absorption. In each, stool calorie loss, a direct proxy of nutrient absorption, was measured. T...

    journal_title:Nature medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/s41591-020-0801-z

    authors: Basolo A,Hohenadel M,Ang QY,Piaggi P,Heinitz S,Walter M,Walter P,Parrington S,Trinidad DD,von Schwartzenberg RJ,Turnbaugh PJ,Krakoff J

    更新日期:2020-04-01 00:00:00

  • Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers.

    abstract::PD-1 plus CTLA-4 blockade is highly effective in advanced-stage, mismatch repair (MMR)-deficient (dMMR) colorectal cancers, yet not in MMR-proficient (pMMR) tumors. We postulated a higher efficacy of neoadjuvant immunotherapy in early-stage colon cancers. In the exploratory NICHE study (ClinicalTrials.gov: NCT03026140...

    journal_title:Nature medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/s41591-020-0805-8

    authors: Chalabi M,Fanchi LF,Dijkstra KK,Van den Berg JG,Aalbers AG,Sikorska K,Lopez-Yurda M,Grootscholten C,Beets GL,Snaebjornsson P,Maas M,Mertz M,Veninga V,Bounova G,Broeks A,Beets-Tan RG,de Wijkerslooth TR,van Lent AU,Mars

    更新日期:2020-04-01 00:00:00

  • Author Correction: China's response to a novel coronavirus stands in stark contrast to the 2002 SARS outbreak response.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature medicine

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/s41591-020-0816-5

    authors: Nkengasong J

    更新日期:2020-03-01 00:00:00

  • Targeted therapy guided by single-cell transcriptomic analysis in drug-induced hypersensitivity syndrome: a case report.

    abstract::Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DiHS/DRESS) is a potentially fatal multiorgan inflammatory disease associated with herpesvirus reactivation and subsequent onset of autoimmune diseases1-4. Pathophysiology remains elusive and therapeutic options are limited. ...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-019-0733-7

    authors: Kim D,Kobayashi T,Voisin B,Jo JH,Sakamoto K,Jin SP,Kelly M,Pasieka HB,Naff JL,Meyerle JH,Ikpeama ID,Fahle GA,Davis FP,Rosenzweig SD,Alejo JC,Pittaluga S,Kong HH,Freeman AF,Nagao K

    更新日期:2020-02-01 00:00:00

  • Anomalously warm temperatures are associated with increased injury deaths.

    abstract::Temperatures that deviate from the long-term local norm affect human health, and are projected to become more frequent as the global climate changes1. There are limited data on how such anomalies affect deaths from injuries. In the present study, we used data on mortality and temperature over 38 years (1980-2017) in t...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-019-0721-y

    authors: Parks RM,Bennett JE,Tamura-Wicks H,Kontis V,Toumi R,Danaei G,Ezzati M

    更新日期:2020-01-01 00:00:00

  • Autism risk in offspring can be assessed through quantification of male sperm mosaicism.

    abstract::De novo mutations arising on the paternal chromosome make the largest known contribution to autism risk, and correlate with paternal age at the time of conception. The recurrence risk for autism spectrum disorders is substantial, leading many families to decline future pregnancies, but the potential impact of assessin...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-019-0711-0

    authors: Breuss MW,Antaki D,George RD,Kleiber M,James KN,Ball LL,Hong O,Mitra I,Yang X,Wirth SA,Gu J,Garcia CAB,Gujral M,Brandler WM,Musaev D,Nguyen A,McEvoy-Venneri J,Knox R,Sticca E,Botello MCC,Uribe Fenner J,Pérez MC

    更新日期:2020-01-01 00:00:00

  • Near real-time intraoperative brain tumor diagnosis using stimulated Raman histology and deep neural networks.

    abstract::Intraoperative diagnosis is essential for providing safe and effective care during cancer surgery1. The existing workflow for intraoperative diagnosis based on hematoxylin and eosin staining of processed tissue is time, resource and labor intensive2,3. Moreover, interpretation of intraoperative histologic images is de...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-019-0715-9

    authors: Hollon TC,Pandian B,Adapa AR,Urias E,Save AV,Khalsa SSS,Eichberg DG,D'Amico RS,Farooq ZU,Lewis S,Petridis PD,Marie T,Shah AH,Garton HJL,Maher CO,Heth JA,McKean EL,Sullivan SE,Hervey-Jumper SL,Patil PG,Thompson BG

    更新日期:2020-01-01 00:00:00

  • Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma.

    abstract::Immune-checkpoint blockade (ICB) has demonstrated efficacy in many tumor types, but predictors of responsiveness to anti-PD1 ICB are incompletely characterized. In this study, we analyzed a clinically annotated cohort of patients with melanoma (n = 144) treated with anti-PD1 ICB, with whole-exome and whole-transcripto...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-019-0654-5

    authors: Liu D,Schilling B,Liu D,Sucker A,Livingstone E,Jerby-Arnon L,Zimmer L,Gutzmer R,Satzger I,Loquai C,Grabbe S,Vokes N,Margolis CA,Conway J,He MX,Elmarakeby H,Dietlein F,Miao D,Tracy A,Gogas H,Goldinger SM,Utikal J

    更新日期:2019-12-01 00:00:00

  • Preventing dysbiosis of the neonatal mouse intestinal microbiome protects against late-onset sepsis.

    abstract::Late-onset sepsis (LOS) is thought to result from systemic spread of commensal microbes from the intestines of premature infants. Clinical use of probiotics for LOS prophylaxis has varied owing to limited efficacy, reflecting an incomplete understanding of relationships between development of the intestinal microbiome...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-019-0640-y

    authors: Singer JR,Blosser EG,Zindl CL,Silberger DJ,Conlan S,Laufer VA,DiToro D,Deming C,Kumar R,Morrow CD,Segre JA,Gray MJ,Randolph DA,Weaver CT

    更新日期:2019-11-01 00:00:00

  • Developing neoantigen-targeted T cell-based treatments for solid tumors.

    abstract::Stimulating an immune response against cancer through adoptive transfer of tumor-targeting lymphocytes has shown great promise in hematological malignancies, but clinical efficacy against many common solid epithelial cancers remains low. Targeting 'neoantigens'-the somatic mutations expressed only by tumor cells-might...

    journal_title:Nature medicine

    pub_type: 杂志文章,评审

    doi:10.1038/s41591-019-0596-y

    authors: Yamamoto TN,Kishton RJ,Restifo NP

    更新日期:2019-10-01 00:00:00

  • Sensory feedback restoration in leg amputees improves walking speed, metabolic cost and phantom pain.

    abstract::Conventional leg prostheses do not convey sensory information about motion or interaction with the ground to above-knee amputees, thereby reducing confidence and walking speed in the users that is associated with high mental and physical fatigue1-4. The lack of physiological feedback from the remaining extremity to th...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-019-0567-3

    authors: Petrini FM,Bumbasirevic M,Valle G,Ilic V,Mijović P,Čvančara P,Barberi F,Katic N,Bortolotti D,Andreu D,Lechler K,Lesic A,Mazic S,Mijović B,Guiraud D,Stieglitz T,Alexandersson A,Micera S,Raspopovic S

    更新日期:2019-09-01 00:00:00

  • A single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients.

    abstract::Natalizumab (NZM), a humanized monoclonal IgG4 antibody to α4 integrins, is used to treat patients with relapsing-remitting multiple sclerosis (MS)1,2, but in about 6% of the cases persistent neutralizing anti-drug antibodies (ADAs) are induced leading to therapy discontinuation3,4. To understand the basis of the ADA ...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-019-0568-2

    authors: Cassotta A,Mikol V,Bertrand T,Pouzieux S,Le Parc J,Ferrari P,Dumas J,Auer M,Deisenhammer F,Gastaldi M,Franciotta D,Silacci-Fregni C,Fernandez Rodriguez B,Giacchetto-Sasselli I,Foglierini M,Jarrossay D,Geiger R,Sallusto

    更新日期:2019-09-01 00:00:00

  • Publisher Correction: Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature medicine

    pub_type: 已发布勘误

    doi:10.1038/s41591-019-0562-8

    authors: Qi X,Yun C,Sun L,Xia J,Wu Q,Wang Y,Wang L,Zhang Y,Liang X,Wang L,Gonzalez FJ,Patterson AD,Liu H,Mu L,Zhou Z,Zhao Y,Li R,Liu P,Zhong C,Pang Y,Jiang C,Qiao J

    更新日期:2019-09-01 00:00:00

  • Resistance to TRK inhibition mediated by convergent MAPK pathway activation.

    abstract::TRK fusions are found in a variety of cancer types, lead to oncogenic addiction, and strongly predict tumor-agnostic efficacy of TRK inhibition1-8. With the recent approval of the first selective TRK inhibitor, larotrectinib, for patients with any TRK-fusion-positive adult or pediatric solid tumor, to identify mechani...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-019-0542-z

    authors: Cocco E,Schram AM,Kulick A,Misale S,Won HH,Yaeger R,Razavi P,Ptashkin R,Hechtman JF,Toska E,Cownie J,Somwar R,Shifman S,Mattar M,Selçuklu SD,Samoila A,Guzman S,Tuch BB,Ebata K,de Stanchina E,Nagy RJ,Lanman RB,

    更新日期:2019-09-01 00:00:00

  • A case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor-induced encephalitis.

    abstract::Checkpoint inhibitors produce durable responses in numerous metastatic cancers, but immune-related adverse events (irAEs) complicate and limit their benefit. IrAEs can affect organ systems idiosyncratically; presentations range from mild and self-limited to fulminant and fatal. The molecular mechanisms underlying irAE...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-019-0523-2

    authors: Johnson DB,McDonnell WJ,Gonzalez-Ericsson PI,Al-Rohil RN,Mobley BC,Salem JE,Wang DY,Sanchez V,Wang Y,Chastain CA,Barker K,Liang Y,Warren S,Beechem JM,Menzies AM,Tio M,Long GV,Cohen JV,Guidon AC,O'Hare M,Chandra S

    更新日期:2019-08-01 00:00:00

  • Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy.

    abstract::The microbiome of the female reproductive tract has implications for women's reproductive health. We examined the vaginal microbiome in two cohorts of women who experienced normal term births: a cross-sectionally sampled cohort of 613 pregnant and 1,969 non-pregnant women, focusing on 300 pregnant and 300 non-pregnant...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-019-0465-8

    authors: Serrano MG,Parikh HI,Brooks JP,Edwards DJ,Arodz TJ,Edupuganti L,Huang B,Girerd PH,Bokhari YA,Bradley SP,Brooks JL,Dickinson MR,Drake JI,Duckworth RA 3rd,Fong SS,Glascock AL,Jean S,Jimenez NR,Khoury J,Koparde VN,La

    更新日期:2019-06-01 00:00:00

  • Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts.

    abstract::It is estimated that 350 million individuals worldwide suffer from rare diseases, which are predominantly caused by mutation in a single gene1. The current molecular diagnostic rate is estimated at 50%, with whole-exome sequencing (WES) among the most successful approaches2-5. For patients in whom WES is uninformative...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-019-0457-8

    authors: Frésard L,Smail C,Ferraro NM,Teran NA,Li X,Smith KS,Bonner D,Kernohan KD,Marwaha S,Zappala Z,Balliu B,Davis JR,Liu B,Prybol CJ,Kohler JN,Zastrow DB,Reuter CM,Fisk DG,Grove ME,Davidson JM,Hartley T,Joshi R,Stro

    更新日期:2019-06-01 00:00:00

  • Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer.

    abstract::In most cases of sporadic colorectal cancers, tumorigenesis is a multistep process, involving genomic alterations in parallel with morphologic changes. In addition, accumulating evidence suggests that the human gut microbiome is linked to the development of colorectal cancer. Here we performed fecal metagenomic and me...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-019-0458-7

    authors: Yachida S,Mizutani S,Shiroma H,Shiba S,Nakajima T,Sakamoto T,Watanabe H,Masuda K,Nishimoto Y,Kubo M,Hosoda F,Rokutan H,Matsumoto M,Takamaru H,Yamada M,Matsuda T,Iwasaki M,Yamaji T,Yachida T,Soga T,Kurokawa K,Toy

    更新日期:2019-06-01 00:00:00

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