Abstract:
:Molecular targeted therapy has the potential to dramatically improve survival in patients with cancer. However, complete and durable responses to targeted therapy are rare in individuals with advanced-stage solid cancers. Even the most effective targeted therapies generally do not induce a complete tumor response, resulting in residual disease and tumor progression that limits patient survival. We discuss the emerging need to more fully understand the molecular basis of residual disease as a prelude to designing therapeutic strategies to minimize or eliminate residual disease so that we can move from temporary to chronic control of disease, or a cure, for patients with advanced-stage solid cancers. Ultimately, we propose a shift from the current reactive paradigm of analyzing and treating acquired drug resistance to a pre-emptive paradigm of defining the mechanisms that result in residual disease, to target and limit this disease reservoir.
journal_name
Nat Medjournal_title
Nature medicineauthors
Bivona TG,Doebele RCdoi
10.1038/nm.4091subject
Has Abstractpub_date
2016-05-05 00:00:00pages
472-8issue
5eissn
1078-8956issn
1546-170Xpii
nm.4091journal_volume
22pub_type
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