Induction of specific transplantation tolerance across xenogeneic barriers in the T-independent immune compartment.

Abstract:

:After transplantation of primarily vascularized xenografts (Xgs), T-independent mechanisms may lead to Xg rejection before T-cell activation even takes place. The possibility of achieving T-independent xenotolerance was evaluated in nude rats that normally reject hamster cardiac Xgs within 4 days by non-T cell-mediated mechanisms. After donor antigen infusion, temporary NK-cell depletion and a 4-week administration of Leflunomide, hamster heart grafts survived even after withdrawal of immunosuppression. Tolerant rats accepted second hamster hearts, but promptly rejected mouse heart Xgs. In vivo immunization and in vitro cytotoxicity assays indicated that this species-specific tolerance was based on B-lymphocyte and NK-cell tolerance respectively.

journal_name

Nat Med

journal_title

Nature medicine

authors

Lin Y,Goebels J,Xia G,Ji P,Vandeputte M,Waer M

doi

10.1038/nm0298-173

subject

Has Abstract

pub_date

1998-02-01 00:00:00

pages

173-80

issue

2

eissn

1078-8956

issn

1546-170X

journal_volume

4

pub_type

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