Fighting tobacco dependence in Europe.

abstract：:De novo mutations arising on the paternal chromosome make the largest known contribution to autism risk, and correlate with paternal age at the time of conception. The recurrence risk for autism spectrum disorders is substantial, leading many families to decline future pregnancies, but the potential impact of assessin...

journal_title：Nature medicine

authors： Breuss MW,Antaki D,George RD,Kleiber M,James KN,Ball LL,Hong O,Mitra I,Yang X,Wirth SA,Gu J,Garcia CAB,Gujral M,Brandler WM,Musaev D,Nguyen A,McEvoy-Venneri J,Knox R,Sticca E,Botello MCC,Uribe Fenner J,Pérez MC

更新日期：2020-01-01 00:00:00

abstract：:Insulin receptor substrate (IRS)-1 and IRS-2 have dominant roles in the action of insulin, but other substrates of the insulin receptor kinase, such as Gab1, c-Cbl, SH2-B and APS, are also of physiological relevance. Although the protein downstream of tyrosine kinases-1 (Dok1) is known to function as a multisite adapt...

journal_title：Nature medicine

authors： Hosooka T,Noguchi T,Kotani K,Nakamura T,Sakaue H,Inoue H,Ogawa W,Tobimatsu K,Takazawa K,Sakai M,Matsuki Y,Hiramatsu R,Yasuda T,Lazar MA,Yamanashi Y,Kasuga M

更新日期：2008-02-01 00:00:00

abstract：:Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 °C) increased peripheral insulin sensitivity by ∼43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, wit...

journal_title：Nature medicine

authors： Hanssen MJ,Hoeks J,Brans B,van der Lans AA,Schaart G,van den Driessche JJ,Jörgensen JA,Boekschoten MV,Hesselink MK,Havekes B,Kersten S,Mottaghy FM,van Marken Lichtenbelt WD,Schrauwen P

更新日期：2015-08-01 00:00:00

abstract：:Diabetes, a disease in which the body does not produce or use insulin properly, is a serious global health problem. Gut polypeptides secreted in response to food intake, such as glucagon-like peptide-1 (GLP-1), are potent incretin hormones that enhance the glucose-dependent secretion of insulin from pancreatic beta ce...

journal_title：Nature medicine

authors： Hirasawa A,Tsumaya K,Awaji T,Katsuma S,Adachi T,Yamada M,Sugimoto Y,Miyazaki S,Tsujimoto G

更新日期：2005-01-01 00:00:00

abstract：:Multiple sclerosis is an autoimmune disease of the central nervous system (CNS) that is initiated when self-reactive T cells enter the brain and become locally activated after encountering their specific nervous antigens. When and where the disease-relevant antigen encounters occur is unclear. Here we combined fluores...

journal_title：Nature medicine

authors： Lodygin D,Odoardi F,Schläger C,Körner H,Kitz A,Nosov M,van den Brandt J,Reichardt HM,Haberl M,Flügel A

更新日期：2013-06-01 00:00:00

abstract：:Attachment to the plasma membrane by linkage to a glycosylphosphatidylinositol (GPI) anchor is a mode of protein expression highly conserved from protozoa to mammals. As a clinical entity, deficiency of GPI has been recognized as paroxysmal nocturnal hemoglobinuria, an acquired clonal disorder associated with somatic ...

journal_title：Nature medicine

authors： Almeida AM,Murakami Y,Layton DM,Hillmen P,Sellick GS,Maeda Y,Richards S,Patterson S,Kotsianidis I,Mollica L,Crawford DH,Baker A,Ferguson M,Roberts I,Houlston R,Kinoshita T,Karadimitris A

更新日期：2006-07-01 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) signaling influences bone metabolism, but its therapeutic potential in bone disorders has remained unexplored. We show that raising S1P levels in adult mice through conditionally deleting or pharmacologically inhibiting S1P lyase, the sole enzyme responsible for irreversibly degrading S1P...

journal_title：Nature medicine

authors： Weske S,Vaidya M,Reese A,von Wnuck Lipinski K,Keul P,Bayer JK,Fischer JW,Flögel U,Nelsen J,Epple M,Scatena M,Schwedhelm E,Dörr M,Völzke H,Moritz E,Hannemann A,Rauch BH,Gräler MH,Heusch G,Levkau B

更新日期：2018-05-01 00:00:00

abstract：:The lifetime prevalence (∼16%) and the economic burden ($100 billion annually) associated with major depressive disorder (MDD) make it one of the most common and debilitating neurobiological illnesses. To date, the exact cellular and molecular mechanisms underlying the pathophysiology of MDD have not been identified. ...

journal_title：Nature medicine

authors： Duric V,Banasr M,Licznerski P,Schmidt HD,Stockmeier CA,Simen AA,Newton SS,Duman RS

更新日期：2010-11-01 00:00:00

abstract：:Animal allergens are an important cause of asthma and allergic rhinitis. We designed and tested a chimeric human-cat fusion protein composed of a truncated human IgG Fcgamma1 and the major cat allergen Fel d1, as a proof of concept for a new approach to allergy immunotherapy. This Fcgamma-Fel d1 protein induced dose-d...

journal_title：Nature medicine

authors： Zhu D,Kepley CL,Zhang K,Terada T,Yamada T,Saxon A

更新日期：2005-04-01 00:00:00

abstract：:Much has been written about the advantages and disadvantages of various oncology model systems, with the overall finding that these models lack the predictive power required to translate preclinical efficacy into clinical activity. Despite assertions that some preclinical model systems are superior to others, no singl...

journal_title：Nature medicine

authors： Gould SE,Junttila MR,de Sauvage FJ

更新日期：2015-05-01 00:00:00

abstract：:How should clinical trials be improved? Ken Getz, a senior fellow at the Tufts Center for the Study of Drug Development, has been thinking up answers to this question for two decades. In 2003, Getz took on a new challenge when he launched the Center for Information & Study on Clinical Research, a nonprofit focused on ...

journal_title：Nature medicine

authors： Getz K

更新日期：2010-02-01 00:00:00

abstract：:Hepatic injury is associated with a defective intestinal barrier and increased hepatic exposure to bacterial products. Here we report that the intestinal bacterial microflora and a functional Toll-like receptor 4 (TLR4), but not TLR2, are required for hepatic fibrogenesis. Using Tlr4-chimeric mice and in vivo lipopoly...

journal_title：Nature medicine

authors： Seki E,De Minicis S,Osterreicher CH,Kluwe J,Osawa Y,Brenner DA,Schwabe RF

更新日期：2007-11-01 00:00:00

abstract：:Immune sensing of a microbe occurs via multiple receptors. How signals from different receptors are coordinated to yield a specific immune response is poorly understood. We show that two pathogen recognition receptors, Toll-like receptor 2 (TLR2) and dectin-1, recognizing the same microbial stimulus, stimulate distinc...

journal_title：Nature medicine

authors： Manicassamy S,Ravindran R,Deng J,Oluoch H,Denning TL,Kasturi SP,Rosenthal KM,Evavold BD,Pulendran B

更新日期：2009-04-01 00:00:00

abstract：:Treatment for schistosomiasis, which is responsible for more than 280,000 deaths annually, depends almost exclusively on praziquantel. Millions of people are treated annually with praziquantel, and drug-resistant parasites thus are likely to evolve. Phosphinic amides and oxadiazole 2-oxides, identified from a quantita...

journal_title：Nature medicine

authors： Sayed AA,Simeonov A,Thomas CJ,Inglese J,Austin CP,Williams DL

更新日期：2008-04-01 00:00:00

abstract：:The structure and function of blood vessels adapt to environmental changes such as physical development and exercise. This phenomenon is based on the ability of the endothelial cells to sense and respond to blood flow; however, the underlying mechanisms remain unclear. Here we show that the ATP-gated P2X4 ion channel,...

journal_title：Nature medicine

authors： Yamamoto K,Sokabe T,Matsumoto T,Yoshimura K,Shibata M,Ohura N,Fukuda T,Sato T,Sekine K,Kato S,Isshiki M,Fujita T,Kobayashi M,Kawamura K,Masuda H,Kamiya A,Ando J

更新日期：2006-01-01 00:00:00

abstract：:Phase 3 trials are the mainstay of drug development across medicine but have often not met expectations set by preceding phase 2 studies. A systematic meta-analysis evaluated all randomized controlled, double-blind trials investigating targeted disease-modifying anti-rheumatic drugs in rheumatoid and psoriatic arthrit...

journal_title：Nature medicine

authors： Kerschbaumer A,Smolen JS,Herkner H,Stefanova T,Chwala E,Aletaha D

更新日期：2020-06-01 00:00:00

abstract：:Oxidative damage from elevated production of reactive oxygen species (ROS) contributes to ischemia-reperfusion injury in myocardial infarction and stroke. The mechanism by which the increase in ROS occurs is not known, and it is unclear how this increase can be prevented. A wide variety of nitric oxide donors and S-ni...

journal_title：Nature medicine

authors： Chouchani ET,Methner C,Nadtochiy SM,Logan A,Pell VR,Ding S,James AM,Cochemé HM,Reinhold J,Lilley KS,Partridge L,Fearnley IM,Robinson AJ,Hartley RC,Smith RA,Krieg T,Brookes PS,Murphy MP

更新日期：2013-06-01 00:00:00

abstract：:Hutchinson-Gilford progeria syndrome (HGPS) is a childhood premature aging disease caused by a spontaneous point mutation in lamin A (encoded by LMNA), one of the major architectural elements of the mammalian cell nucleus. The HGPS mutation activates an aberrant cryptic splice site in LMNA pre-mRNA, leading to synthes...

journal_title：Nature medicine

authors： Scaffidi P,Misteli T

更新日期：2005-04-01 00:00:00

abstract：:Systemic inflammation induces various adaptive responses including tachycardia. Although inflammation-associated tachycardia has been thought to result from increased sympathetic discharge caused by inflammatory signals of the immune system, definitive proof has been lacking. Prostanoids, including prostaglandin (PG) ...

journal_title：Nature medicine

authors： Takayama K,Yuhki K,Ono K,Fujino T,Hara A,Yamada T,Kuriyama S,Karibe H,Okada Y,Takahata O,Taniguchi T,Iijima T,Iwasaki H,Narumiya S,Ushikubi F

更新日期：2005-05-01 00:00:00

abstract：:Hemophilia B is a severe X-linked bleeding diathesis caused by the absence of functional blood coagulation factor IX, and is an excellent candidate for treatment of a genetic disease by gene therapy. Using an adeno-associated viral vector, we demonstrate sustained expression (>17 months) of factor IX in a large-animal...

journal_title：Nature medicine

authors： Herzog RW,Yang EY,Couto LB,Hagstrom JN,Elwell D,Fields PA,Burton M,Bellinger DA,Read MS,Brinkhous KM,Podsakoff GM,Nichols TC,Kurtzman GJ,High KA

更新日期：1999-01-01 00:00:00

abstract：:In the Supplementary Information originally published with this article, a lane was missing in the β-actin blot in Supplementary Fig. 2. The lane has been added. The error has been corrected in the Supplementary Information associated with this article. ...

journal_title：Nature medicine

authors： Wong GS,Zhou J,Bin Liu J,Wu Z,Xu X,Li T,Xu D,Schumacher SE,Puschhof J,McFarland J,Zou C,Dulak A,Henderson L,Xu P,O'Day E,Rendak R,Liao WL,Cecchi F,Hembrough T,Schwartz S,Szeto C,Rustgi AK,Wong KK,Diehl JA,

更新日期：2018-10-01 00:00:00

abstract：:We have previously shown that a single portal vein infusion of a recombinant adeno-associated viral vector (rAAV) expressing canine Factor IX (F.IX) resulted in long-term expression of therapeutic levels of F.IX in dogs with severe hemophilia B. We carried out a phase 1/2 dose-escalation clinical study to extend this ...

journal_title：Nature medicine

authors： Manno CS,Pierce GF,Arruda VR,Glader B,Ragni M,Rasko JJ,Ozelo MC,Hoots K,Blatt P,Konkle B,Dake M,Kaye R,Razavi M,Zajko A,Zehnder J,Rustagi PK,Nakai H,Chew A,Leonard D,Wright JF,Lessard RR,Sommer JM,Tigges M,S

更新日期：2006-03-01 00:00:00

abstract：:Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DiHS/DRESS) is a potentially fatal multiorgan inflammatory disease associated with herpesvirus reactivation and subsequent onset of autoimmune diseases1-4. Pathophysiology remains elusive and therapeutic options are limited. ...

journal_title：Nature medicine

authors： Kim D,Kobayashi T,Voisin B,Jo JH,Sakamoto K,Jin SP,Kelly M,Pasieka HB,Naff JL,Meyerle JH,Ikpeama ID,Fahle GA,Davis FP,Rosenzweig SD,Alejo JC,Pittaluga S,Kong HH,Freeman AF,Nagao K

更新日期：2020-02-01 00:00:00

abstract：:CD4-unhelped CD8(+) T cells are functionally defective T cells primed in the absence of CD4(+) T cell help. Given the co-stimulatory role of natural-killer group 2, member D protein (NKG2D) on CD8(+) T cells, we investigated its ability to rescue these immunologically impotent cells. We demonstrate that augmented co-s...

journal_title：Nature medicine

authors： Zloza A,Kohlhapp FJ,Lyons GE,Schenkel JM,Moore TV,Lacek AT,O'Sullivan JA,Varanasi V,Williams JW,Jagoda MC,Bellavance EC,Marzo AL,Thomas PG,Zafirova B,Polić B,Al-Harthi L,Sperling AI,Guevara-Patiño JA

更新日期：2012-02-26 00:00:00

abstract：:Although the treatment of acute myeloid leukemia (AML) has improved substantially in the past three decades, more than half of all patients develop disease that is refractory to intensive chemotherapy. Functional genomics approaches offer a means to discover specific molecules mediating the aberrant growth and surviva...

journal_title：Nature medicine

authors： Kentsis A,Reed C,Rice KL,Sanda T,Rodig SJ,Tholouli E,Christie A,Valk PJ,Delwel R,Ngo V,Kutok JL,Dahlberg SE,Moreau LA,Byers RJ,Christensen JG,Vande Woude G,Licht JD,Kung AL,Staudt LM,Look AT

更新日期：2012-07-01 00:00:00

abstract：:Sexual transmission is the most frequent (86%) route of adult HIV-1 transmission worldwide. In the absence of a prophylactic anti-HIV vaccine, other methods of preventing infection should be implemented. Virucidal spermicides have been considered for this purpose, but their application is contraindicated by adverse ef...

journal_title：Nature medicine

authors： Neurath AR,Jiang S,Strick N,Lin K,Li YY,Debnath AK

更新日期：1996-02-01 00:00:00

abstract：:The molecular alterations that occur in cells before cancer is manifest are largely uncharted. Lung carcinoma in situ (CIS) lesions are the pre-invasive precursor to squamous cell carcinoma. Although microscopically identical, their future is in equipoise, with half progressing to invasive cancer and half regressing o...

journal_title：Nature medicine

authors： Teixeira VH,Pipinikas CP,Pennycuick A,Lee-Six H,Chandrasekharan D,Beane J,Morris TJ,Karpathakis A,Feber A,Breeze CE,Ntolios P,Hynds RE,Falzon M,Capitanio A,Carroll B,Durrenberger PF,Hardavella G,Brown JM,Lynch AG,Fa

更新日期：2019-03-01 00:00:00

abstract：:In the version of this article originally published, a grant was omitted from the Acknowledgements section. The following sentence should have been included: "R.B.M. was supported by a Department of Veterans Affairs Merit Award (5I01BX003272)." The error has been corrected in the HTML and PDF versions of this article....

journal_title：Nature medicine

authors： Rangarajan S,Bone NB,Zmijewska AA,Jiang S,Park DW,Bernard K,Locy ML,Ravi S,Deshane J,Mannon RB,Abraham E,Darley-Usmar V,Thannickal VJ,Zmijewski JW

更新日期：2018-10-01 00:00:00

abstract：:Monogenic deficiency diseases provide unique opportunities to define the contributions of individual molecules to human physiology and to identify pathologies arising from their dysfunction. Here we describe a deficiency disease in two human siblings that presented with severe bleeding, frequent infections and osteope...

journal_title：Nature medicine

authors： Malinin NL,Zhang L,Choi J,Ciocea A,Razorenova O,Ma YQ,Podrez EA,Tosi M,Lennon DP,Caplan AI,Shurin SB,Plow EF,Byzova TV

更新日期：2009-03-01 00:00:00

abstract：:The ability to patent human genes has been costly to researchers and patients, and has restricted competition in the biotech marketplace. The recent US Supreme Court decision making isolated human genes unpatentable will bring freedom of choice to the patient, and level the playing field for research and development. ...

journal_title：Nature medicine

authors：

更新日期：2013-07-01 00:00:00