Serum insulin-like growth factor I regulates brain amyloid-beta levels.

abstract：:Hemizygous deletion of chromosome 22q11 (del22q11) causes thymic, parathyroid, craniofacial and life-threatening cardiovascular birth defects in 1 in 4,000 infants. The del22q11 syndrome is likely caused by haploinsufficiency of TBX1, but its variable expressivity indicates the involvement of additional modifiers. Her...

journal_title：Nature medicine

authors： Stalmans I,Lambrechts D,De Smet F,Jansen S,Wang J,Maity S,Kneer P,von der Ohe M,Swillen A,Maes C,Gewillig M,Molin DG,Hellings P,Boetel T,Haardt M,Compernolle V,Dewerchin M,Plaisance S,Vlietinck R,Emanuel B,Gittenb

更新日期：2003-02-01 00:00:00

abstract：:Observational clinical and ex vivo studies have established a strong association between atrial fibrillation and inflammation. However, whether inflammation is the cause or the consequence of atrial fibrillation and which specific inflammatory mediators may increase the atria's susceptibility to fibrillation remain el...

journal_title：Nature medicine

authors： Rudolph V,Andrié RP,Rudolph TK,Friedrichs K,Klinke A,Hirsch-Hoffmann B,Schwoerer AP,Lau D,Fu X,Klingel K,Sydow K,Didié M,Seniuk A,von Leitner EC,Szoecs K,Schrickel JW,Treede H,Wenzel U,Lewalter T,Nickenig G,Zimmer

更新日期：2010-04-01 00:00:00

abstract：:Activation of the zinc-finger transcription factor early growth response (Egr)-1, initially linked to developmental processes, is shown here to function as a master switch activated by ischemia to trigger expression of pivotal regulators of inflammation, coagulation and vascular hyperpermeability. Chemokine, adhesion ...

journal_title：Nature medicine

authors： Yan SF,Fujita T,Lu J,Okada K,Shan Zou Y,Mackman N,Pinsky DJ,Stern DM

更新日期：2000-12-01 00:00:00

abstract：:Movement towards or away from a given stimulus guides the directional migration of prokaryotes, simple eukaryotes and neurons. As bi-directional cues may influence entry and exit of immune effector cells from tissue sites, we evaluated the migratory responses of T-cell subsets to varying concentrations of the chemokin...

journal_title：Nature medicine

authors： Poznansky MC,Olszak IT,Foxall R,Evans RH,Luster AD,Scadden DT

更新日期：2000-05-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature medicine

authors： Qi X,Yun C,Sun L,Xia J,Wu Q,Wang Y,Wang L,Zhang Y,Liang X,Wang L,Gonzalez FJ,Patterson AD,Liu H,Mu L,Zhou Z,Zhao Y,Li R,Liu P,Zhong C,Pang Y,Jiang C,Qiao J

更新日期：2019-09-01 00:00:00

abstract：:In the version of this article originally published, there was an error in the legend for Extended Data Fig. 7. The legend for panel f was originally: "f, FACS analysis of IL7R-, CD62L- and CD45RA- expression on TRAC-1928ζ and TRAC-1XX CAR T cells at day 63 post CAR infusion (representative for at least n = 3 mice per...

journal_title：Nature medicine

authors： Feucht J,Sun J,Eyquem J,Ho YJ,Zhao Z,Leibold J,Dobrin A,Cabriolu A,Hamieh M,Sadelain M

更新日期：2019-03-01 00:00:00

abstract：:Hepatic insulin resistance is a driving force in the pathogenesis of type 2 diabetes mellitus (T2DM) and is tightly coupled with excessive storage of fat and the ensuing inflammation within the liver. There is compelling evidence that activation of the transcription factor nuclear factor-κB (NF-κB) and downstream infl...

journal_title：Nature medicine

authors： Kiechl S,Wittmann J,Giaccari A,Knoflach M,Willeit P,Bozec A,Moschen AR,Muscogiuri G,Sorice GP,Kireva T,Summerer M,Wirtz S,Luther J,Mielenz D,Billmeier U,Egger G,Mayr A,Oberhollenzer F,Kronenberg F,Orthofer M,Penni

更新日期：2013-03-01 00:00:00

abstract：:TRK fusions are found in a variety of cancer types, lead to oncogenic addiction, and strongly predict tumor-agnostic efficacy of TRK inhibition1-8. With the recent approval of the first selective TRK inhibitor, larotrectinib, for patients with any TRK-fusion-positive adult or pediatric solid tumor, to identify mechani...

journal_title：Nature medicine

authors： Cocco E,Schram AM,Kulick A,Misale S,Won HH,Yaeger R,Razavi P,Ptashkin R,Hechtman JF,Toska E,Cownie J,Somwar R,Shifman S,Mattar M,Selçuklu SD,Samoila A,Guzman S,Tuch BB,Ebata K,de Stanchina E,Nagy RJ,Lanman RB,

更新日期：2019-09-01 00:00:00

abstract：:Members of the suppressor of cytokine signaling (SOCS) family are involved in the pathogenesis of many inflammatory diseases. SOCS-3 is predominantly expressed in T-helper type 2 (T(H)2) cells, but its role in T(H)2-related allergic diseases remains to be investigated. In this study we provide a strong correlation bet...

journal_title：Nature medicine

authors： Seki Y,Inoue H,Nagata N,Hayashi K,Fukuyama S,Matsumoto K,Komine O,Hamano S,Himeno K,Inagaki-Ohara K,Cacalano N,O'Garra A,Oshida T,Saito H,Johnston JA,Yoshimura A,Kubo M

更新日期：2003-08-01 00:00:00

abstract：:Misfolding of Cu/Zn-superoxide dismutase (SOD1) is emerging as a mechanism underlying motor neuron degeneration in individuals with amyotrophic lateral sclerosis (ALS) who carry a mutant SOD1 gene (SOD1 ALS). Here we describe a structure-guided approach to developing an antibody that specifically recognizes monomer-mi...

journal_title：Nature medicine

authors： Rakhit R,Robertson J,Vande Velde C,Horne P,Ruth DM,Griffin J,Cleveland DW,Cashman NR,Chakrabartty A

更新日期：2007-06-01 00:00:00

abstract：:Endothelial dysfunction is a critical factor in many cardiovascular diseases, including hypertension. Although lipid signaling has been implicated in endothelial dysfunction and cardiovascular disease, specific molecular mechanisms are poorly understood. Here we report that Nogo-B, a membrane protein of the endoplasmi...

journal_title：Nature medicine

authors： Cantalupo A,Zhang Y,Kothiya M,Galvani S,Obinata H,Bucci M,Giordano FJ,Jiang XC,Hla T,Di Lorenzo A

更新日期：2015-09-01 00:00:00

abstract：:Recent studies suggest that statins can function to protect the vasculature in a manner that is independent of their lipid-lowering activity. We show here that statins rapidly activate the protein kinase Akt/PKB in endothelial cells. Accordingly, simvastatin enhanced phosphorylation of the endogenous Akt substrate end...

journal_title：Nature medicine

authors： Kureishi Y,Luo Z,Shiojima I,Bialik A,Fulton D,Lefer DJ,Sessa WC,Walsh K

更新日期：2000-09-01 00:00:00

abstract：:Mesenchymal stem cells can give rise to several cell types, but varying results depending on isolation methods and tissue source have led to controversies about their usefulness in clinical medicine. Here we show that vascular endothelial cells can transform into multipotent stem-like cells by an activin-like kinase-2...

journal_title：Nature medicine

authors： Medici D,Shore EM,Lounev VY,Kaplan FS,Kalluri R,Olsen BR

更新日期：2010-12-01 00:00:00

abstract：:The mechanism by which angiogenic factors recruit bone marrow (BM)-derived quiescent endothelial and hematopoietic stem cells (HSCs) is not known. Here, we report that functional vascular endothelial growth factor receptor-1 (VEGFR1) is expressed on human CD34(+) and mouse Lin(-)Sca-1(+)c-Kit(+) BM-repopulating stem c...

journal_title：Nature medicine

authors： Hattori K,Heissig B,Wu Y,Dias S,Tejada R,Ferris B,Hicklin DJ,Zhu Z,Bohlen P,Witte L,Hendrikx J,Hackett NR,Crystal RG,Moore MA,Werb Z,Lyden D,Rafii S

更新日期：2002-08-01 00:00:00

abstract：:Improved techniques to noninvasively image protein-protein interactions (PPIs) are essential. We molecularly engineered a positron emission tomography (PET)-based split reporter (herpes simplex virus type 1 thymidine kinase), cleaved between Thr265 and Ala266, and used this in a protein-fragment complementation assay ...

journal_title：Nature medicine

authors： Massoud TF,Paulmurugan R,Gambhir SS

更新日期：2010-08-01 00:00:00

abstract：:Hutchinson-Gilford progeria syndrome (HGPS) is a rare lethal genetic disorder characterized by symptoms reminiscent of accelerated aging. The major underlying genetic cause is a substitution mutation in the gene coding for lamin A, causing the production of a toxic isoform called progerin. Here we show that reduction ...

journal_title：Nature medicine

authors： Beyret E,Liao HK,Yamamoto M,Hernandez-Benitez R,Fu Y,Erikson G,Reddy P,Izpisua Belmonte JC

更新日期：2019-03-01 00:00:00

abstract：:The impact of single-agent antibodies against programmed death-ligand 1 (PD-L1) as maintenance therapy is unknown in patients with metastatic breast cancer. The SAFIR02-BREAST IMMUNO substudy included patients with human epidermal growth factor receptor type 2 (Her2)-negative metastatic breast cancer whose disease did...

journal_title：Nature medicine

authors： Bachelot T,Filleron T,Bieche I,Arnedos M,Campone M,Dalenc F,Coussy F,Sablin MP,Debled M,Lefeuvre-Plesse C,Goncalves A,Reynier MM,Jacot W,You B,Barthelemy P,Verret B,Isambert N,Tchiknavorian X,Levy C,Thery JC,L'Har

更新日期：2021-01-18 00:00:00

abstract：:Physical function declines in old age, portending disability, increased health expenditures, and mortality. Cellular senescence, leading to tissue dysfunction, may contribute to these consequences of aging, but whether senescence can directly drive age-related pathology and be therapeutically targeted is still unclear...

journal_title：Nature medicine

authors： Xu M,Pirtskhalava T,Farr JN,Weigand BM,Palmer AK,Weivoda MM,Inman CL,Ogrodnik MB,Hachfeld CM,Fraser DG,Onken JL,Johnson KO,Verzosa GC,Langhi LGP,Weigl M,Giorgadze N,LeBrasseur NK,Miller JD,Jurk D,Singh RJ,Allison

更新日期：2018-08-01 00:00:00

abstract：:The occurrence of multiple tumors in an organ heralds a rapidly fatal course. Although intravascular administration may deliver oncolytic viruses/vectors to each of these tumors, its efficiency is impeded by an antiviral activity present in complement-depleted plasma of rodents and humans. Here, this activity was show...

journal_title：Nature medicine

authors： Ikeda K,Ichikawa T,Wakimoto H,Silver JS,Deisboeck TS,Finkelstein D,Harsh GR 4th,Louis DN,Bartus RT,Hochberg FH,Chiocca EA

更新日期：1999-08-01 00:00:00

abstract：:Hearing impairment is the most common sensory disorder, with congenital hearing impairment present in approximately 1 in 1,000 newborns. Hereditary deafness is often mediated by the improper development or degeneration of cochlear hair cells. Until now, it was not known whether such congenital failures could be mitiga...

journal_title：Nature medicine

authors： Lentz JJ,Jodelka FM,Hinrich AJ,McCaffrey KE,Farris HE,Spalitta MJ,Bazan NG,Duelli DM,Rigo F,Hastings ML

更新日期：2013-03-01 00:00:00

abstract：:Modest clinical outcomes of dendritic-cell (DC) vaccine trials call for the refinement of DC vaccine design. Although many potential antigens have been identified, development of methods to enhance antigen presentation by DCs has lagged. We have engineered a potent, drug-inducible CD40 (iCD40) receptor that permits te...

journal_title：Nature medicine

authors： Hanks BA,Jiang J,Singh RA,Song W,Barry M,Huls MH,Slawin KM,Spencer DM

更新日期：2005-02-01 00:00:00

abstract：:Huntington's disease (HD) is a fatal dominantly inherited neurodegenerative disorder caused by a CAG repeat expansion leading to an elongated polyglutamine stretch in huntingtin. Mutant huntingtin (mHTT) is ubiquitously expressed in all cells but elicits selective cortical and striatal neurodegeneration in HD. The mec...

journal_title：Nature medicine

authors： Wang N,Gray M,Lu XH,Cantle JP,Holley SM,Greiner E,Gu X,Shirasaki D,Cepeda C,Li Y,Dong H,Levine MS,Yang XW

更新日期：2014-05-01 00:00:00

abstract：:Infiltration of human cancers by T cells is generally interpreted as a sign of immune recognition, and there is a growing effort to reactivate dysfunctional T cells at such tumor sites1. However, these efforts only have value if the intratumoral T cell receptor (TCR) repertoire of such cells is intrinsically tumor rea...

journal_title：Nature medicine

authors： Scheper W,Kelderman S,Fanchi LF,Linnemann C,Bendle G,de Rooij MAJ,Hirt C,Mezzadra R,Slagter M,Dijkstra K,Kluin RJC,Snaebjornsson P,Milne K,Nelson BH,Zijlmans H,Kenter G,Voest EE,Haanen JBAG,Schumacher TN

更新日期：2019-01-01 00:00:00

abstract：:Kidney transplantation has been one of the major medical advances of the past 30 years. However, tissue availability remains a major obstacle. This can potentially be overcome by the use of undifferentiated or partially developed kidney precursor cells derived from early embryos and fetal tissue. Here, transplantation...

journal_title：Nature medicine

authors： Dekel B,Burakova T,Arditti FD,Reich-Zeliger S,Milstein O,Aviel-Ronen S,Rechavi G,Friedman N,Kaminski N,Passwell JH,Reisner Y

更新日期：2003-01-01 00:00:00

abstract：:We have studied the effects of amyloid beta-peptide analogues on the activity of tissue-type plasminogen activator (t-PA) in vitro. We have found that these peptides have a marked stimulatory effect upon plasminogen activation by t-PA, comparable to that of known stimulators of t-PA. This stimulatory activity appears ...

journal_title：Nature medicine

authors： Kingston IB,Castro MJ,Anderson S

更新日期：1995-02-01 00:00:00

abstract：:The vaccines developed over the first two hundred years since Jenner's lifetime have accomplished striking reductions of infection and disease wherever applied. Pasteur's early approaches to vaccine development, attenuation and inactivation, are even now the two poles of vaccine technology. Today, purification of micr...

journal_title：Nature medicine

authors： Plotkin SA

更新日期：2005-04-01 00:00:00

abstract：:The recent development of tissue microarrays-composed of hundreds of tissue sections from different tumors arrayed on a single glass slide-facilitates rapid evaluation of large-scale outcome studies. Realization of this potential depends on the ability to rapidly and precisely quantify the protein expression within ea...

journal_title：Nature medicine

authors： Camp RL,Chung GG,Rimm DL

更新日期：2002-11-01 00:00:00

abstract：:It begins as a slowly expanding spot of light or similar visual disturbance, often accompanied by phantom noises and other sensory distortions. People who experience such 'auras' know all too well that these early warning signs will culminate in a head-splitting migraine, yet scientists have little idea what causes th...

journal_title：Nature medicine

authors： Dolgin E

更新日期：2013-09-01 00:00:00

abstract：:One function of the glucocorticoid receptor (GR) in corticotroph cells is to suppress the transcription of the gene encoding proopiomelanocortin (POMC), the precursor of the stress hormone adrenocorticotropin (ACTH). Cushing disease is a neuroendocrine condition caused by partially glucocorticoid-resistant corticotrop...

journal_title：Nature medicine

authors： Riebold M,Kozany C,Freiburger L,Sattler M,Buchfelder M,Hausch F,Stalla GK,Paez-Pereda M

更新日期：2015-03-01 00:00:00

abstract：:Attachment to the plasma membrane by linkage to a glycosylphosphatidylinositol (GPI) anchor is a mode of protein expression highly conserved from protozoa to mammals. As a clinical entity, deficiency of GPI has been recognized as paroxysmal nocturnal hemoglobinuria, an acquired clonal disorder associated with somatic ...

journal_title：Nature medicine

authors： Almeida AM,Murakami Y,Layton DM,Hillmen P,Sellick GS,Maeda Y,Richards S,Patterson S,Kotsianidis I,Mollica L,Crawford DH,Baker A,Ferguson M,Roberts I,Houlston R,Kinoshita T,Karadimitris A

更新日期：2006-07-01 00:00:00