Abstract:
:Together with recent advances in the processing and culture of human tissue, bioengineering, xenotransplantation and genome editing, Induced pluripotent stem cells (iPSCs) present a range of new opportunities for the study of human cancer. Here we discuss the main advantages and limitations of iPSC modeling, and how the method intersects with other patient-derived models of cancer, such as organoids, organs-on-chips and patient-derived xenografts (PDXs). We highlight the opportunities that iPSC models can provide beyond those offered by existing systems and animal models and present current challenges and crucial areas for future improvements toward wider adoption of this technology.
journal_name
Nat Medjournal_title
Nature medicineauthors
Papapetrou EPdoi
10.1038/nm.4238subject
Has Abstractpub_date
2016-12-06 00:00:00pages
1392-1401issue
12eissn
1078-8956issn
1546-170Xpii
nm.4238journal_volume
22pub_type
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