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α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria.

Abstract：

:Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and are often poorly tolerated. We report that the nutritional supplement α-lipoic acid inhibits cystine stone formation in the Slc3a1-/- mouse model of cystinuria by increasing the solubility of urinary cystine. These findings identify a novel therapeutic strategy for the clinical treatment of cystinuria.

journal_name

Nat Med

journal_title

Nature medicine

authors

Zee T,Bose N,Zee J,Beck JN,Yang S,Parihar J,Yang M,Damodar S,Hall D,O'Leary MN,Ramanathan A,Gerona RR,Killilea DW,Chi T,Tischfield J,Sahota A,Kahn A,Stoller ML,Kapahi P

doi

10.1038/nm.4280

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

288-290

issue

3

eissn

1078-8956

issn

1546-170X

pii

nm.4280

journal_volume

23

pub_type

杂志文章

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