Abstract:
:In the version of this article originally published, there was an error in Fig. 2b. RECIST ORR and pCR were both listed as 25%. RECIST ORR was actually 73%, and pCR was 45%. Also, an author's name was incorrect in the author list. Danny K. Wells should have been listed as Daniel K. Wells. The errors have been corrected in the print, HTML and PDF versions of this article.
journal_name
Nat Medjournal_title
Nature medicineauthors
Amaria RN,Reddy SM,Tawbi HA,Davies MA,Ross MI,Glitza IC,Cormier JN,Lewis C,Hwu WJ,Hanna E,Diab A,Wong MK,Royal R,Gross N,Weber R,Lai SY,Ehlers R,Blando J,Milton DR,Woodman S,Kageyama R,Wells DK,Hwu P,Patel Sdoi
10.1038/s41591-018-0251-zsubject
Has Abstractpub_date
2018-12-01 00:00:00pages
1941issue
12eissn
1078-8956issn
1546-170Xpii
10.1038/s41591-018-0251-zjournal_volume
24pub_type
已发布勘误相关文献
NATURE MEDICINE文献大全abstract::The severe disease atypical measles occurred when individuals immunized with a poorly protective inactivated vaccine contracted measles, and was postulated to be due to a lack of fusion-inhibiting antibodies. Here, rhesus macaques immunized with formalin-inactivated measles vaccine developed transient neutralizing and...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/9473
更新日期:1999-06-01 00:00:00
abstract::Matrix-producing osteoblasts and bone-resorbing osteoclasts maintain bone homeostasis. Osteoclasts are multinucleated, giant cells of hematopoietic origin formed by the fusion of mononuclear pre-osteoclasts derived from myeloid cells. Fusion-mediated giant cell formation is critical for osteoclast maturation; without ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1514
更新日期:2006-12-01 00:00:00
abstract::Natural inhibitors of angiogenesis are able to block pathological neovascularization without harming the preexisting vasculature. Here we show that two such inhibitors, thrombospondin-1 and pigment epithelium-derived factor, derive specificity for remodeling vessels from their dependence on Fas/Fas ligand (FasL)-media...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0402-349
更新日期:2002-04-01 00:00:00
abstract::The immune-modulating cytokine interleukin-6 (IL-6) is expressed both in adipose tissue and centrally in hypothalamic nuclei that regulate body composition. We investigated the impact of loss of IL-6 on body composition in mice lacking the gene encoding IL-6 (Il6-/- mice) and found that they developed mature-onset obe...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0102-75
更新日期:2002-01-01 00:00:00
abstract::The cardiac response to increased work includes a reactivation of fetal genes. The response to a decrease in cardiac work is not known. Such information is of clinical interest, because mechanical unloading can improve the functional capacity of the failing heart. We compared here the patterns of gene expression in un...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/3253
更新日期:1998-11-01 00:00:00
abstract::Exercise has numerous health-promoting effects in humans; however, individual responsiveness to exercise with regard to endurance or metabolic health differs markedly. This 'exercise resistance' is considered to be congenital, with no evident acquired causative factors. Here we show that the anti-oxidative hepatokine ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.4295
更新日期:2017-04-01 00:00:00
abstract::The live tuberculosis vaccines Mycobacterium bovis BCG (bacille Calmette-Guérin) and Mycobacterium microti both lack the potent, secreted T-cell antigens ESAT-6 (6-kDa early secretory antigenic target) and CFP-10 (10-kDa culture filtrate protein). This is a result of independent deletions in the region of deletion-1 (...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm859
更新日期:2003-05-01 00:00:00
abstract::In many areas of oncology, we lack sensitive tools to track low-burden disease. Although cell-free DNA (cfDNA) shows promise in detecting cancer mutations, we found that the combination of low tumor fraction (TF) and limited number of DNA fragments restricts low-disease-burden monitoring through the prevailing deep ta...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-020-0915-3
更新日期:2020-07-01 00:00:00
abstract::Platelet-activating factor (PAF) induces pulmonary edema and has a key role in acute lung injury (ALI). Here we show that PAF induces pulmonary edema through two mechanisms: acid sphingomyelinase (ASM)-dependent production of ceramide, and activation of the cyclooxygenase pathway. Agents that interfere with PAF-induce...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm977
更新日期:2004-02-01 00:00:00
abstract::The impact of single-agent antibodies against programmed death-ligand 1 (PD-L1) as maintenance therapy is unknown in patients with metastatic breast cancer. The SAFIR02-BREAST IMMUNO substudy included patients with human epidermal growth factor receptor type 2 (Her2)-negative metastatic breast cancer whose disease did...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-020-01189-2
更新日期:2021-01-18 00:00:00
abstract::We have designed short peptides composed of two functional domains, one a tumor blood vessel 'homing' motif and the other a programmed cell death-inducing sequence, and synthesized them by simple peptide chemistry. The 'homing' domain was designed to guide the peptide to targeted cells and allow its internalization. T...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/12469
更新日期:1999-09-01 00:00:00
abstract::Endogenous mechanisms leading to host protection and resolution of infections without immunosuppression are of wide interest. Here we elucidate the structures of four new host-protective molecules produced in neutrophil-endothelial cocultures and present in human and mouse tissues after sterile inflammation or infecti...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.3911
更新日期:2015-09-01 00:00:00
abstract::The TAM receptors Tyro3, Axl and Mertk are receptor tyrosine kinases that dampen host innate immune responses following engagement with their ligands Gas6 and Protein S, which recognize phosphatidylserine on apoptotic cells. In a form of apoptotic mimicry, many enveloped viruses display phosphatidylserine on the outer...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.3974
更新日期:2015-12-01 00:00:00
abstract::The rate of expansion of primary prostatic carcinoma is comparatively slow, with tumours frequently taking years or decades to reach clinically relevant size. We now report the presence of an endogenous inhibitor, derived from aqueous extracts of human prostate tissue, which blocks prostatic carcinoma cell proliferati...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1095-1040
更新日期:1995-10-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature medicine
pub_type: 已发布勘误
doi:10.1038/s41591-019-0562-8
更新日期:2019-09-01 00:00:00
abstract::Congenital disorder of glycosylation-Ia (CDG-Ia, also known as PMM2-CDG) is caused by mutations in the gene that encodes phosphomannomutase 2 (PMM2, EC 5.4.2.8) leading to a multisystemic disease with severe psychomotor and mental retardation. In a hypomorphic Pmm2 mouse model, we were able to overcome embryonic letha...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.2548
更新日期:2011-12-11 00:00:00
abstract::Synovial tissue affected by rheumatoid arthritis is characterized by proliferation, which leads to irreversible cartilage and bone destruction. Current and experimental treatments have been aimed mainly at correcting the underlying immune abnormalities, but these treatments often prove ineffective in preventing the in...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/10480
更新日期:1999-07-01 00:00:00
abstract::Proliferation of smooth muscle cells of the arterial wall in response to local injury is an important aetiologic factor of vascular proliferative disorders such as atherosclerosis and restenosis after angioplasty. Ras proteins are key transducers of mitogenic signals from membrane to nucleus in many cell types. We inv...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0695-541
更新日期:1995-06-01 00:00:00
abstract::Targeting EGFR is a validated approach in the treatment of squamous-cell cancers (SCCs), although there are no established biomarkers for predicting response. We have identified a synonymous mutation in EGFR, c.2361G>A (encoding p.Gln787Gln), in two patients with head and neck SCC (HNSCC) who were exceptional responde...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.4401
更新日期:2017-10-01 00:00:00
abstract::Treatment for schistosomiasis, which is responsible for more than 280,000 deaths annually, depends almost exclusively on praziquantel. Millions of people are treated annually with praziquantel, and drug-resistant parasites thus are likely to evolve. Phosphinic amides and oxadiazole 2-oxides, identified from a quantita...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1737
更新日期:2008-04-01 00:00:00
abstract::GLUT4, the insulin-responsive glucose transporter, plays an important role in postprandial glucose disposal. Altered GLUT4 activity is suggested to be one of the factors responsible for decreased glucose uptake in muscle and adipose tissue in obesity and diabetes. To assess the effect of GLUT4 expression on whole-body...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1097-1096
更新日期:1997-10-01 00:00:00
abstract::Neutrophil extracellular traps (NETs) are released as neutrophils die in vitro in a process requiring hours, leaving a temporal gap that invasive microbes may exploit. Neutrophils capable of migration and phagocytosis while undergoing NETosis have not been documented. During Gram-positive skin infections, we directly ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.2847
更新日期:2012-09-01 00:00:00
abstract::Hematopoietic stem and progenitor cells (HSPC) are endowed with the role of generating and maintaining lifelong the extremely diverse pool of blood cells1. Clinically, transplantation of human HSPC from an allogeneic healthy donor or infusion of autologous gene-corrected HSPC can effectively replenish defective blood ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-018-0195-3
更新日期:2018-11-01 00:00:00
abstract::Cough accompanied by an increased sensitivity of the cough reflex is the most common symptom of inflammatory airway disease. This symptom is also frequently reported in patients receiving angiotensin-converting enzyme (ACE) inhibitors as therapy for heart failure or hypertension, although the underlying mechanism is u...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0796-814
更新日期:1996-07-01 00:00:00
abstract::Hypertension is one of the most frequent pathologies in the industrialized world. Although recognized to be dependent on a combination of genetic and environmental factors, its molecular basis remains elusive. Increased activity of the monomeric G protein RhoA in arteries is a common feature of hypertension. However, ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.2079
更新日期:2010-02-01 00:00:00
abstract::Recent years have seen an explosion in the rate of discovery of genetic defects linked to Parkinson's disease. These breakthroughs have not provided a direct explanation for the disease process. Nevertheless, they have helped transform Parkinson's disease research by providing tangible clues to the neurobiology of the...
journal_title:Nature medicine
pub_type: 杂志文章,评审
doi:10.1038/nm1068
更新日期:2004-07-01 00:00:00
abstract::It has long been assumed that p53 suppresses tumor development through induction of apoptosis, possibly with contributions by cell cycle arrest and cell senescence1,2. However, combined deficiency in these three processes does not result in spontaneous tumor formation as observed upon loss of p53, suggesting the exist...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-018-0043-5
更新日期:2018-07-01 00:00:00
abstract::Resistance to cancer therapies presents a significant clinical challenge. Recent studies have revealed intratumoral heterogeneity as a source of therapeutic resistance. However, it is unclear whether resistance is driven predominantly by pre-existing or de novo alterations, in part because of the resolution limits of ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.3841
更新日期:2015-05-01 00:00:00
abstract::The Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) is expressed in all KSHV-associated tumors, including Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL). We found that beta-catenin is overexpressed in both PEL cells and KS tissue. Introduction of anti-LANA small inte...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm829
更新日期:2003-03-01 00:00:00
abstract::Sepsis, a leading cause of death worldwide, involves proinflammatory responses and inefficient bacterial clearance. Phagocytic cells play a crucial part in the prevention of sepsis by clearing bacteria through host innate receptors. Here we show that the FcRgamma adaptor, an immunoreceptor tyrosine-based activation mo...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1665
更新日期:2007-11-01 00:00:00