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Induction of the p16INK4a senescence gene as a new therapeutic strategy for the treatment of rheumatoid arthritis.

Abstract：

:Synovial tissue affected by rheumatoid arthritis is characterized by proliferation, which leads to irreversible cartilage and bone destruction. Current and experimental treatments have been aimed mainly at correcting the underlying immune abnormalities, but these treatments often prove ineffective in preventing the invasive destruction. We studied the expression of cyclin-dependent kinase inhibitors in rheumatoid synovial cells as a means of suppressing synovial cell proliferation. Synovial cells derived from hypertrophic synovial tissue readily expressed p16INK4a when they were growth-inhibited. This was not seen in other fibroblasts, including those derived from normal and osteoarthritis-affected synovial tissues. In vivo adenoviral gene therapy with the p16INK4a gene efficiently inhibited the pathology in an animal model of rheumatoid arthritis. Thus, the induction of p16INK4a may provide a new approach to the effective treatment of rheumatoid arthritis.

journal_name

Nat Med

journal_title

Nature medicine

authors

Taniguchi K,Kohsaka H,Inoue N,Terada Y,Ito H,Hirokawa K,Miyasaka N

doi

10.1038/10480

keywords:

subject

Has Abstract

pub_date

1999-07-01 00:00:00

pages

760-7

issue

7

eissn

1078-8956

issn

1546-170X

journal_volume

5

pub_type

杂志文章

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