Abstract:
:An amendment to this paper has been published and can be accessed via a link at the top of the paper.
journal_name
Nat Medjournal_title
Nature medicineauthors
Menachery VD,Yount BL Jr,Debbink K,Agnihothram S,Gralinski LE,Plante JA,Graham RL,Scobey T,Ge XY,Donaldson EF,Randell SH,Lanzavecchia A,Marasco WA,Shi ZL,Baric RSdoi
10.1038/s41591-020-0924-2subject
Has Abstractpub_date
2020-07-01 00:00:00pages
1146issue
7eissn
1078-8956issn
1546-170Xpii
10.1038/s41591-020-0924-2journal_volume
26pub_type
已发布勘误相关文献
NATURE MEDICINE文献大全abstract::The BTB/POZ transcriptional repressor and candidate oncogene BCL6 is frequently misregulated in B-cell lymphomas. The interface through which the BCL6 BTB domain mediates recruitment of the SMRT, NCoR and BCoR corepressors was recently identified. To determine the contribution of this interface to BCL6 transcriptional...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1134
更新日期:2004-12-01 00:00:00
abstract::Temporal lobe epilepsy is the most prevalent seizure disorder in adults. Compromised inhibitory neurotransmitter function in the hippocampus contributes to the hyperexcitability generating this condition, but the underlying molecular mechanisms are unknown. Combining patch-clamp recording and single-cell mRNA amplific...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/2661
更新日期:1998-10-01 00:00:00
abstract::Atherosclerosis is an immunoinflammatory disease elicited by accumulation of lipids in the artery wall and leads to myocardial infarction and stroke. Here, we show that naturally arising CD4(+)CD25(+) regulatory T cells, which actively maintain immunological tolerance to self and nonself antigens, are powerful inhibit...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1343
更新日期:2006-02-01 00:00:00
abstract::TRK fusions are found in a variety of cancer types, lead to oncogenic addiction, and strongly predict tumor-agnostic efficacy of TRK inhibition1-8. With the recent approval of the first selective TRK inhibitor, larotrectinib, for patients with any TRK-fusion-positive adult or pediatric solid tumor, to identify mechani...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-019-0542-z
更新日期:2019-09-01 00:00:00
abstract::Recurrent medulloblastoma and ependymoma are universally lethal, with no approved targeted therapies and few candidates presently under clinical evaluation. Nearly all recurrent medulloblastomas and posterior fossa group A (PFA) ependymomas are located adjacent to and bathed by the cerebrospinal fluid, presenting an o...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-020-0827-2
更新日期:2020-05-01 00:00:00
abstract::In most cases of sporadic colorectal cancers, tumorigenesis is a multistep process, involving genomic alterations in parallel with morphologic changes. In addition, accumulating evidence suggests that the human gut microbiome is linked to the development of colorectal cancer. Here we performed fecal metagenomic and me...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-019-0458-7
更新日期:2019-06-01 00:00:00
abstract::Glioblastoma is the most common primary central nervous system malignancy and has a poor prognosis. Standard first-line treatment, which includes surgery followed by adjuvant radio-chemotherapy, produces only modest benefits to survival1,2. Here, to explore the feasibility, safety and immunobiological effects of PD-1 ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-018-0339-5
更新日期:2019-03-01 00:00:00
abstract::How should clinical trials be improved? Ken Getz, a senior fellow at the Tufts Center for the Study of Drug Development, has been thinking up answers to this question for two decades. In 2003, Getz took on a new challenge when he launched the Center for Information & Study on Clinical Research, a nonprofit focused on ...
journal_title:Nature medicine
pub_type: 面试
doi:10.1038/nm0210-154
更新日期:2010-02-01 00:00:00
abstract::Finding new treatment-shortening antibiotics to improve cure rates and curb the alarming emergence of drug resistance is the major objective of tuberculosis (TB) drug development. Using a matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging suite in a biosafety containment facility, we show th...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.3937
更新日期:2015-10-01 00:00:00
abstract::Conventional leg prostheses do not convey sensory information about motion or interaction with the ground to above-knee amputees, thereby reducing confidence and walking speed in the users that is associated with high mental and physical fatigue1-4. The lack of physiological feedback from the remaining extremity to th...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-019-0567-3
更新日期:2019-09-01 00:00:00
abstract::Hemizygous deletion of chromosome 22q11 (del22q11) causes thymic, parathyroid, craniofacial and life-threatening cardiovascular birth defects in 1 in 4,000 infants. The del22q11 syndrome is likely caused by haploinsufficiency of TBX1, but its variable expressivity indicates the involvement of additional modifiers. Her...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm819
更新日期:2003-02-01 00:00:00
abstract::Proliferation of smooth muscle cells of the arterial wall in response to local injury is an important aetiologic factor of vascular proliferative disorders such as atherosclerosis and restenosis after angioplasty. Ras proteins are key transducers of mitogenic signals from membrane to nucleus in many cell types. We inv...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0695-541
更新日期:1995-06-01 00:00:00
abstract::Levels of insulin-like growth factor I (IGF-I), a neuroprotective hormone, decrease in serum during aging, whereas amyloid-beta (Abeta), which is involved in the pathogenesis of Alzheimer disease, accumulates in the brain. High brain Abeta levels are found at an early age in mutant mice with low circulating IGF-I, and...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1202-793
更新日期:2002-12-01 00:00:00
abstract::Huntington's disease is caused by an expanded polyglutamine repeat in the huntingtin protein (HTT), but the pathophysiological sequence of events that trigger synaptic failure and neuronal loss are not fully understood. Alterations in N-methyl-D-aspartate (NMDA)-type glutamate receptors (NMDARs) have been implicated. ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.3246
更新日期:2013-08-01 00:00:00
abstract::Platelet-activating factor (PAF) induces pulmonary edema and has a key role in acute lung injury (ALI). Here we show that PAF induces pulmonary edema through two mechanisms: acid sphingomyelinase (ASM)-dependent production of ceramide, and activation of the cyclooxygenase pathway. Agents that interfere with PAF-induce...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm977
更新日期:2004-02-01 00:00:00
abstract::Systemic inflammation induces various adaptive responses including tachycardia. Although inflammation-associated tachycardia has been thought to result from increased sympathetic discharge caused by inflammatory signals of the immune system, definitive proof has been lacking. Prostanoids, including prostaglandin (PG) ...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1231
更新日期:2005-05-01 00:00:00
abstract::Insulin receptor substrate (IRS)-1 and IRS-2 have dominant roles in the action of insulin, but other substrates of the insulin receptor kinase, such as Gab1, c-Cbl, SH2-B and APS, are also of physiological relevance. Although the protein downstream of tyrosine kinases-1 (Dok1) is known to function as a multisite adapt...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm1706
更新日期:2008-02-01 00:00:00
abstract::Bypass of stenotic coronary arteries with autologous saphenous vein is an established treatment for ischemic heart disease. However, its long-term clinical success is limited. Late vein graft failure is the result of medial and intimal thickening consequent upon medial vascular smooth muscle cell migration, proliferat...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0298-235
更新日期:1998-02-01 00:00:00
abstract::To explore the mechanism by which herpes simplex virus (HSV)-2 infection is related to HIV-1 acquisition, we conducted in situ analysis of the cellular infiltrate from sequential biopsies of HSV-2 lesions from patients on and off antiviral therapy. CD4(+) and CD8(+) T cells and a mixed population of plasmacytoid and m...
journal_title:Nature medicine
pub_type: 临床试验,杂志文章
doi:10.1038/nm.2006
更新日期:2009-08-01 00:00:00
abstract::In the version of this article originally published, a grant was omitted from the Acknowledgements section. The following sentence should have been included: "R.B.M. was supported by a Department of Veterans Affairs Merit Award (5I01BX003272)." The error has been corrected in the HTML and PDF versions of this article....
journal_title:Nature medicine
pub_type: 已发布勘误
doi:10.1038/s41591-018-0170-z
更新日期:2018-10-01 00:00:00
abstract::Although prognostic gene expression signatures for survival in early-stage lung cancer have been proposed, for clinical application, it is critical to establish their performance across different subject populations and in different laboratories. Here we report a large, training-testing, multi-site, blinded validation...
journal_title:Nature medicine
pub_type: 杂志文章,多中心研究
doi:10.1038/nm.1790
更新日期:2008-08-01 00:00:00
abstract::Activating mutations in genes encoding G protein α (Gα) subunits occur in 4-5% of all human cancers, but oncogenic alterations in Gβ subunits have not been defined. Here we demonstrate that recurrent mutations in the Gβ proteins GNB1 and GNB2 confer cytokine-independent growth and activate canonical G protein signalin...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.3751
更新日期:2015-01-01 00:00:00
abstract::The ability of the human immune system to respond to vaccination declines with age. We identified an age-associated defect in T cell receptor (TCR)-induced extracellular signal-regulated kinase (ERK) phosphorylation in naive CD4(+) T cells, whereas other signals, such as ζ chain-associated protein kinase 70 (ZAP70) an...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.2963
更新日期:2012-10-01 00:00:00
abstract::Immunodeficiency is a barrier to successful vaccination in individuals with cancer and chronic infection. We performed a randomized phase 1/2 study in lymphopenic individuals after high-dose chemotherapy and autologous hematopoietic stem cell transplantation for myeloma. Combination immunotherapy consisting of a singl...
journal_title:Nature medicine
pub_type: 杂志文章,随机对照试验
doi:10.1038/nm1310
更新日期:2005-11-01 00:00:00
abstract::Traditional screening for COVID-19 typically includes survey questions about symptoms and travel history, as well as temperature measurements. Here, we explore whether personal sensor data collected over time may help identify subtle changes indicating an infection, such as in patients with COVID-19. We have developed...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-020-1123-x
更新日期:2021-01-01 00:00:00
abstract::Immune-checkpoint blockade (ICB) has demonstrated efficacy in many tumor types, but predictors of responsiveness to anti-PD1 ICB are incompletely characterized. In this study, we analyzed a clinically annotated cohort of patients with melanoma (n = 144) treated with anti-PD1 ICB, with whole-exome and whole-transcripto...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/s41591-019-0654-5
更新日期:2019-12-01 00:00:00
abstract::Low oxygen tension influences tumor progression by enhancing angiogenesis; and histone deacetylases (HDAC) are implicated in alteration of chromatin assembly and tumorigenesis. Here we show induction of HDAC under hypoxia and elucidate a role for HDAC in the regulation of hypoxia-induced angiogenesis. Overexpressed wi...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/86507
更新日期:2001-04-01 00:00:00
abstract::The balance between detrimental, pro-aging, often stochastic processes and counteracting homeostatic mechanisms largely determines the progression of aging. There is substantial evidence suggesting that the endocannabinoid system (ECS) is part of the latter system because it modulates the physiological processes under...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm.4311
更新日期:2017-06-01 00:00:00
abstract::The glycosylation of the circulating immunoglobulin-gamma (IgG) antibody molecules changes in rheumatoid arthritis. The extent of the changes correlates with the disease severity and reverses in remission. We demonstrate here that the alteration in glycosylation associated with rheumatoid arthritis can create a new mo...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0395-237
更新日期:1995-03-01 00:00:00
abstract::We and others have postulated that a constant number of T lymphocytes is normally maintained without regard to CD4+ or CD8+ phenotype ('blind' T-cell homeostasis). Here we confirm essentially constant T-cell levels (despite marked decline in CD4+ T cells and increase in CD8+ T cells) in homosexual men with incident hu...
journal_title:Nature medicine
pub_type: 杂志文章
doi:10.1038/nm0795-674
更新日期:1995-07-01 00:00:00