当前位置： SCI文献检索 > NATURE MEDICINE期刊下所有文献 > Natural regulatory T cells control the development of atherosclerosis in mice.

Natural regulatory T cells control the development of atherosclerosis in mice.

Abstract：

:Atherosclerosis is an immunoinflammatory disease elicited by accumulation of lipids in the artery wall and leads to myocardial infarction and stroke. Here, we show that naturally arising CD4(+)CD25(+) regulatory T cells, which actively maintain immunological tolerance to self and nonself antigens, are powerful inhibitors of atherosclerosis in several mouse models. These results provide new insights into the immunopathogenesis of atherosclerosis and could lead to new therapeutic approaches that involve immune modulation using regulatory T cells.

journal_name

Nat Med

journal_title

Nature medicine

authors

Ait-Oufella H,Salomon BL,Potteaux S,Robertson AK,Gourdy P,Zoll J,Merval R,Esposito B,Cohen JL,Fisson S,Flavell RA,Hansson GK,Klatzmann D,Tedgui A,Mallat Z

doi

10.1038/nm1343

keywords:

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

178-80

issue

2

eissn

1078-8956

issn

1546-170X

pii

nm1343

journal_volume

12

pub_type

杂志文章

相关文献

NATURE MEDICINE文献大全
  • v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation.

    abstract：:Matrix-producing osteoblasts and bone-resorbing osteoclasts maintain bone homeostasis. Osteoclasts are multinucleated, giant cells of hematopoietic origin formed by the fusion of mononuclear pre-osteoclasts derived from myeloid cells. Fusion-mediated giant cell formation is critical for osteoclast maturation; without ...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1514

    authors： Lee SH,Rho J,Jeong D,Sul JY,Kim T,Kim N,Kang JS,Miyamoto T,Suda T,Lee SK,Pignolo RJ,Koczon-Jaremko B,Lorenzo J,Choi Y

    更新日期：2006-12-01 00:00:00

  • Senolytics improve physical function and increase lifespan in old age.

    abstract：:Physical function declines in old age, portending disability, increased health expenditures, and mortality. Cellular senescence, leading to tissue dysfunction, may contribute to these consequences of aging, but whether senescence can directly drive age-related pathology and be therapeutically targeted is still unclear...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/s41591-018-0092-9

    authors： Xu M,Pirtskhalava T,Farr JN,Weigand BM,Palmer AK,Weivoda MM,Inman CL,Ogrodnik MB,Hachfeld CM,Fraser DG,Onken JL,Johnson KO,Verzosa GC,Langhi LGP,Weigl M,Giorgadze N,LeBrasseur NK,Miller JD,Jurk D,Singh RJ,Allison

    更新日期：2018-08-01 00:00:00

  • Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer.

    abstract：:Expression of the oncogenic transcription factor MYC is disproportionately elevated in triple-negative breast cancer (TNBC), as compared to estrogen receptor-, progesterone receptor- or human epidermal growth factor 2 receptor-positive (RP) breast cancer. We and others have shown that MYC alters metabolism during tumo...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.4055

    authors： Camarda R,Zhou AY,Kohnz RA,Balakrishnan S,Mahieu C,Anderton B,Eyob H,Kajimura S,Tward A,Krings G,Nomura DK,Goga A

    更新日期：2016-04-01 00:00:00

  • Sensory feedback restoration in leg amputees improves walking speed, metabolic cost and phantom pain.

    abstract：:Conventional leg prostheses do not convey sensory information about motion or interaction with the ground to above-knee amputees, thereby reducing confidence and walking speed in the users that is associated with high mental and physical fatigue1-4. The lack of physiological feedback from the remaining extremity to th...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/s41591-019-0567-3

    authors： Petrini FM,Bumbasirevic M,Valle G,Ilic V,Mijović P,Čvančara P,Barberi F,Katic N,Bortolotti D,Andreu D,Lechler K,Lesic A,Mazic S,Mijović B,Guiraud D,Stieglitz T,Alexandersson A,Micera S,Raspopovic S

    更新日期：2019-09-01 00:00:00

  • Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice.

    abstract：:The structure and function of blood vessels adapt to environmental changes such as physical development and exercise. This phenomenon is based on the ability of the endothelial cells to sense and respond to blood flow; however, the underlying mechanisms remain unclear. Here we show that the ATP-gated P2X4 ion channel,...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1338

    authors： Yamamoto K,Sokabe T,Matsumoto T,Yoshimura K,Shibata M,Ohura N,Fukuda T,Sato T,Sekine K,Kato S,Isshiki M,Fujita T,Kobayashi M,Kawamura K,Masuda H,Kamiya A,Ando J

    更新日期：2006-01-01 00:00:00

  • Anomalously warm temperatures are associated with increased injury deaths.

    abstract：:Temperatures that deviate from the long-term local norm affect human health, and are projected to become more frequent as the global climate changes1. There are limited data on how such anomalies affect deaths from injuries. In the present study, we used data on mortality and temperature over 38 years (1980-2017) in t...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/s41591-019-0721-y

    authors： Parks RM,Bennett JE,Tamura-Wicks H,Kontis V,Toumi R,Danaei G,Ezzati M

    更新日期：2020-01-01 00:00:00

  • Developing neoantigen-targeted T cell-based treatments for solid tumors.

    abstract：:Stimulating an immune response against cancer through adoptive transfer of tumor-targeting lymphocytes has shown great promise in hematological malignancies, but clinical efficacy against many common solid epithelial cancers remains low. Targeting 'neoantigens'-the somatic mutations expressed only by tumor cells-might...

    journal_title：Nature medicine

    pub_type： 杂志文章,评审

    doi：10.1038/s41591-019-0596-y

    authors： Yamamoto TN,Kishton RJ,Restifo NP

    更新日期：2019-10-01 00:00:00

  • Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers.

    abstract：:Infiltration of human cancers by T cells is generally interpreted as a sign of immune recognition, and there is a growing effort to reactivate dysfunctional T cells at such tumor sites1. However, these efforts only have value if the intratumoral T cell receptor (TCR) repertoire of such cells is intrinsically tumor rea...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/s41591-018-0266-5

    authors： Scheper W,Kelderman S,Fanchi LF,Linnemann C,Bendle G,de Rooij MAJ,Hirt C,Mezzadra R,Slagter M,Dijkstra K,Kluin RJC,Snaebjornsson P,Milne K,Nelson BH,Zijlmans H,Kenter G,Voest EE,Haanen JBAG,Schumacher TN

    更新日期：2019-01-01 00:00:00

  • Efficacy outcomes in phase 2 and phase 3 randomized controlled trials in rheumatology.

    abstract：:Phase 3 trials are the mainstay of drug development across medicine but have often not met expectations set by preceding phase 2 studies. A systematic meta-analysis evaluated all randomized controlled, double-blind trials investigating targeted disease-modifying anti-rheumatic drugs in rheumatoid and psoriatic arthrit...

    journal_title：Nature medicine

    pub_type： 杂志文章,meta分析

    doi：10.1038/s41591-020-0833-4

    authors： Kerschbaumer A,Smolen JS,Herkner H,Stefanova T,Chwala E,Aletaha D

    更新日期：2020-06-01 00:00:00

  • A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis.

    abstract：:We report the involvement of an evolutionarily conserved set of mycobacterial genes, the esx-3 region, in evasion of bacterial killing by innate immunity. Whereas high-dose intravenous infections of mice with the rapidly growing mycobacterial species Mycobacterium smegmatis bearing an intact esx-3 locus were rapidly l...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.2420

    authors： Sweeney KA,Dao DN,Goldberg MF,Hsu T,Venkataswamy MM,Henao-Tamayo M,Ordway D,Sellers RS,Jain P,Chen B,Chen M,Kim J,Lukose R,Chan J,Orme IM,Porcelli SA,Jacobs WR Jr

    更新日期：2011-09-04 00:00:00

  • Identification of the prion protein allotypes which accumulate in the brain of sporadic and familial Creutzfeldt-Jakob disease patients.

    abstract：:A characteristic feature of Creutzfeldt-Jakob disease (CJD) is the accumulation in the brain of the amyloid protease-resistant protein PrPres. PrPres derives from a host-encoded, protease-sensitive isoform, PrPsen. Mutations of this protein are linked to familial variants of the disease, and the presence of a methioni...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0597-521

    authors： Silvestrini MC,Cardone F,Maras B,Pucci P,Barra D,Brunori M,Pocchiari M

    更新日期：1997-05-01 00:00:00

  • Age and generational patterns of overdose death risk from opioids and other drugs.

    abstract：:The ongoing substance misuse epidemic in the United States is complex and dynamic and should be approached as such in the development and evaluation of policy1. Drug overdose deaths (largely attributable to opioid misuse) in the United States have grown exponentially for almost four decades, but the mechanisms of this...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/s41591-020-0855-y

    authors： Jalal H,Buchanich JM,Sinclair DR,Roberts MS,Burke DS

    更新日期：2020-05-01 00:00:00

  • Autocrine angiogenic vascular prosthesis with bone marrow transplantation.

    abstract：:Synthetic vascular prostheses are foreign bodies, so that blood coagulation can occur on their luminal surfaces, causing graft occlusion very frequently in prostheses of small diameter. A vascular prosthesis needs angiogenesis for endothelialization of the luminal surface, as endothelial cells have natural and permane...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm0196-90

    authors： Noishiki Y,Tomizawa Y,Yamane Y,Matsumoto A

    更新日期：1996-01-01 00:00:00

  • Inhibition of gastric inhibitory polypeptide signaling prevents obesity.

    abstract：:Secretion of gastric inhibitory polypeptide (GIP), a duodenal hormone, is primarily induced by absorption of ingested fat. Here we describe a novel pathway of obesity promotion via GIP. Wild-type mice fed a high-fat diet exhibited both hypersecretion of GIP and extreme visceral and subcutaneous fat deposition with ins...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm727

    authors： Miyawaki K,Yamada Y,Ban N,Ihara Y,Tsukiyama K,Zhou H,Fujimoto S,Oku A,Tsuda K,Toyokuni S,Hiai H,Mizunoya W,Fushiki T,Holst JJ,Makino M,Tashita A,Kobara Y,Tsubamoto Y,Jinnouchi T,Jomori T,Seino Y

    更新日期：2002-07-01 00:00:00

  • Molecular foundations of cancer: new targets for intervention.

    abstract：:Conceptual and practical advances in molecular medicine are changing our understanding of cancer pathogenesis. In time this should provide the opportunity to alter the natural history of many cancers. ...

    journal_title：Nature medicine

    pub_type： 杂志文章,评审

    doi：10.1038/nm0495-309

    authors： Karp JE,Broder S

    更新日期：1995-04-01 00:00:00

  • Serum insulin-like growth factor I regulates brain amyloid-beta levels.

    abstract：:Levels of insulin-like growth factor I (IGF-I), a neuroprotective hormone, decrease in serum during aging, whereas amyloid-beta (Abeta), which is involved in the pathogenesis of Alzheimer disease, accumulates in the brain. High brain Abeta levels are found at an early age in mutant mice with low circulating IGF-I, and...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm1202-793

    authors： Carro E,Trejo JL,Gomez-Isla T,LeRoith D,Torres-Aleman I

    更新日期：2002-12-01 00:00:00

  • Activators of the nuclear receptor PPARgamma enhance colon polyp formation.

    abstract：:A high-fat diet increases the risk of colon, breast and prostate cancer. The molecular mechanism by which dietary lipids promote tumorigenesis is unknown. Their effects may be mediated at least in part by the peroxisome proliferator-activated receptors (PPARs). These ligand-activated nuclear receptors modulate gene ex...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/2042

    authors： Saez E,Tontonoz P,Nelson MC,Alvarez JG,Ming UT,Baird SM,Thomazy VA,Evans RM

    更新日期：1998-09-01 00:00:00

  • Translational value of mouse models in oncology drug development.

    abstract：:Much has been written about the advantages and disadvantages of various oncology model systems, with the overall finding that these models lack the predictive power required to translate preclinical efficacy into clinical activity. Despite assertions that some preclinical model systems are superior to others, no singl...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.3853

    authors： Gould SE,Junttila MR,de Sauvage FJ

    更新日期：2015-05-01 00:00:00

  • Epigenetic modulation of the renal β-adrenergic-WNK4 pathway in salt-sensitive hypertension.

    abstract：:How high salt intake increases blood pressure is a key question in the study of hypertension. Salt intake induces increased renal sympathetic activity resulting in sodium retention. However, the mechanisms underlying the sympathetic control of renal sodium excretion remain unclear. In this study, we found that β(2)-ad...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.2337

    authors： Mu S,Shimosawa T,Ogura S,Wang H,Uetake Y,Kawakami-Mori F,Marumo T,Yatomi Y,Geller DS,Tanaka H,Fujita T

    更新日期：2011-05-01 00:00:00

  • Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity.

    abstract：:Proper function of the endoplasmic reticulum (ER) and mitochondria is crucial for cellular homeostasis, and dysfunction at either site has been linked to pathophysiological states, including metabolic diseases. Although the ER and mitochondria play distinct cellular roles, these organelles also form physical interacti...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.3735

    authors： Arruda AP,Pers BM,Parlakgül G,Güney E,Inouye K,Hotamisligil GS

    更新日期：2014-12-01 00:00:00

  • Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma.

    abstract：:Targeting EGFR is a validated approach in the treatment of squamous-cell cancers (SCCs), although there are no established biomarkers for predicting response. We have identified a synonymous mutation in EGFR, c.2361G>A (encoding p.Gln787Gln), in two patients with head and neck SCC (HNSCC) who were exceptional responde...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.4401

    authors： Tan DSW,Chong FT,Leong HS,Toh SY,Lau DP,Kwang XL,Zhang X,Sundaram GM,Tan GS,Chang MM,Chua BT,Lim WT,Tan EH,Ang MK,Lim TKH,Sampath P,Chowbay B,Skanderup AJ,DasGupta R,Iyer NG

    更新日期：2017-10-01 00:00:00

  • Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3.

    abstract：:The neural tube defects (NTDs) spina bifida and anencephaly are widely prevalent severe birth defects. The mouse mutant curly tail (ct/ct) has served as a model of NTDs for 50 years, even though the responsible genetic defect remained unrecognized. Here we show by gene targeting, mapping and genetic complementation st...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm961

    authors： Ting SB,Wilanowski T,Auden A,Hall M,Voss AK,Thomas T,Parekh V,Cunningham JM,Jane SM

    更新日期：2003-12-01 00:00:00

  • A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome.

    abstract：:The identification of the genes associated with chromosomal translocation breakpoints has fundamentally changed understanding of the molecular basis of hematological malignancies. By contrast, the study of chromosomal deletions has been hampered by the large number of genes deleted and the complexity of their analysis...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.2063

    authors： Barlow JL,Drynan LF,Hewett DR,Holmes LR,Lorenzo-Abalde S,Lane AL,Jolin HE,Pannell R,Middleton AJ,Wong SH,Warren AJ,Wainscoat JS,Boultwood J,McKenzie AN

    更新日期：2010-01-01 00:00:00

  • Microbiota depletion promotes browning of white adipose tissue and reduces obesity.

    abstract：:Brown adipose tissue (BAT) promotes a lean and healthy phenotype and improves insulin sensitivity. In response to cold or exercise, brown fat cells also emerge in the white adipose tissue (WAT; also known as beige cells), a process known as browning. Here we show that the development of functional beige fat in the ing...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.3994

    authors： Suárez-Zamorano N,Fabbiano S,Chevalier C,Stojanović O,Colin DJ,Stevanović A,Veyrat-Durebex C,Tarallo V,Rigo D,Germain S,Ilievska M,Montet X,Seimbille Y,Hapfelmeier S,Trajkovski M

    更新日期：2015-12-01 00:00:00

  • Spontaneous combined hyperlipidemia, coronary heart disease and decreased survival in Dahl salt-sensitive hypertensive rats transgenic for human cholesteryl ester transfer protein.

    abstract：:The acceleration of atherosclerosis by polygenic (essential) hypertension is well-characterized in humans; however, the lack of an animal model that simulates human disease hinders the elucidation of pathogenic mechanisms. We report here a transgenic atherosclerosis-polygenic hypertension model in Dahl salt-sensitive ...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/70956

    authors： Herrera VL,Makrides SC,Xie HX,Adari H,Krauss RM,Ryan US,Ruiz-Opazo N

    更新日期：1999-12-01 00:00:00

  • Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models.

    abstract：:Huntington's disease is caused by an expanded polyglutamine repeat in the huntingtin protein (HTT), but the pathophysiological sequence of events that trigger synaptic failure and neuronal loss are not fully understood. Alterations in N-methyl-D-aspartate (NMDA)-type glutamate receptors (NMDARs) have been implicated. ...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.3246

    authors： Marco S,Giralt A,Petrovic MM,Pouladi MA,Martínez-Turrillas R,Martínez-Hernández J,Kaltenbach LS,Torres-Peraza J,Graham RK,Watanabe M,Luján R,Nakanishi N,Lipton SA,Lo DC,Hayden MR,Alberch J,Wesseling JF,Pérez-Otaño I

    更新日期：2013-08-01 00:00:00

  • gammadelta T cells provide a breath of fresh air for asthma research.

    abstract：:gammadelta T cells downregulate airways responsiveness to allergen challenge, possibly by controlling the 'repair' response of the airway epithelium to alphabeta T cell-mediated damage (pages 1150-1156). ...

    journal_title：Nature medicine

    pub_type： 评论,新闻

    doi：10.1038/13447

    authors： Holt PG,Sly PD

    更新日期：1999-10-01 00:00:00

  • Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.

    abstract：:Neurofibrillary tangles (NFTs), composed of truncated and hyperphosphorylated tau, are a common feature of numerous aging-related neurodegenerative diseases, including Alzheimer's disease (AD). However, the molecular mechanisms mediating tau truncation and aggregation during aging remain elusive. Here we show that asp...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/nm.3700

    authors： Zhang Z,Song M,Liu X,Kang SS,Kwon IS,Duong DM,Seyfried NT,Hu WT,Liu Z,Wang JZ,Cheng L,Sun YE,Yu SP,Levey AI,Ye K

    更新日期：2014-11-01 00:00:00

  • The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux.

    abstract：:Cytochrome P450 3A4 is an important mediator of drug catabolism that can be regulated by the steroid and xenobiotic receptor (SXR). We show here that SXR also regulates drug efflux by activating expression of the gene MDR1, which encodes the protein P-glycoprotein (ABCB1). Paclitaxel (Taxol), a commonly used chemother...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/87912

    authors： Synold TW,Dussault I,Forman BM

    更新日期：2001-05-01 00:00:00

  • Autism risk in offspring can be assessed through quantification of male sperm mosaicism.

    abstract：:De novo mutations arising on the paternal chromosome make the largest known contribution to autism risk, and correlate with paternal age at the time of conception. The recurrence risk for autism spectrum disorders is substantial, leading many families to decline future pregnancies, but the potential impact of assessin...

    journal_title：Nature medicine

    pub_type： 杂志文章

    doi：10.1038/s41591-019-0711-0

    authors： Breuss MW,Antaki D,George RD,Kleiber M,James KN,Ball LL,Hong O,Mitra I,Yang X,Wirth SA,Gu J,Garcia CAB,Gujral M,Brandler WM,Musaev D,Nguyen A,McEvoy-Venneri J,Knox R,Sticca E,Botello MCC,Uribe Fenner J,Pérez MC

    更新日期：2020-01-01 00:00:00