Translational value of mouse models in oncology drug development.

abstract：:Most of what we know about adaptive immunity has come from inbred mouse studies, using methods that are often difficult or impossible to confirm in humans. In addition, vaccine responses in mice are often poorly predictive of responses to those same vaccines in humans. Here we use human tonsils, readily available lymp...

journal_title：Nature medicine

authors： Wagar LE,Salahudeen A,Constantz CM,Wendel BS,Lyons MM,Mallajosyula V,Jatt LP,Adamska JZ,Blum LK,Gupta N,Jackson KJL,Yang F,Röltgen K,Roskin KM,Blaine KM,Meister KD,Ahmad IN,Cortese M,Dora EG,Tucker SN,Sperling AI

更新日期：2021-01-01 00:00:00

abstract：:Delayed T cell recovery and restricted T cell receptor (TCR) diversity after allogeneic hematopoietic stem cell transplantation (allo-HSCT) are associated with increased risks of infection and cancer relapse. Technical challenges have limited faithful measurement of TCR diversity after allo-HSCT. Here we combined 5' r...

journal_title：Nature medicine

authors： van Heijst JW,Ceberio I,Lipuma LB,Samilo DW,Wasilewski GD,Gonzales AM,Nieves JL,van den Brink MR,Perales MA,Pamer EG

更新日期：2013-03-01 00:00:00

abstract：:A signaling cascade is activated in podocytes to induce survival and cope with stress during advanced glomerular disease, a new study shows. The findings may also explain why the immunosuppressor sirolimus, an inhibitor of this pathway, can cause proteinuria in a subset of patients with chronic kidney disease (pages 1...

journal_title：Nature medicine

authors： Reiser J

更新日期：2013-10-01 00:00:00

abstract：:Notch receptor signaling is implicated in controlling smooth muscle cell proliferation and in maintaining smooth muscle cells in an undifferentiated state. Pulmonary arterial hypertension is characterized by excessive vascular resistance, smooth muscle cell proliferation in small pulmonary arteries, leading to elevati...

journal_title：Nature medicine

authors： Li X,Zhang X,Leathers R,Makino A,Huang C,Parsa P,Macias J,Yuan JX,Jamieson SW,Thistlethwaite PA

更新日期：2009-11-01 00:00:00

abstract：:We have studied the effects of amyloid beta-peptide analogues on the activity of tissue-type plasminogen activator (t-PA) in vitro. We have found that these peptides have a marked stimulatory effect upon plasminogen activation by t-PA, comparable to that of known stimulators of t-PA. This stimulatory activity appears ...

journal_title：Nature medicine

authors： Kingston IB,Castro MJ,Anderson S

更新日期：1995-02-01 00:00:00

abstract：:In the version of this article originally published, there was an error in Fig. 2b. RECIST ORR and pCR were both listed as 25%. RECIST ORR was actually 73%, and pCR was 45%. Also, an author's name was incorrect in the author list. Danny K. Wells should have been listed as Daniel K. Wells. The errors have been correcte...

journal_title：Nature medicine

authors： Amaria RN,Reddy SM,Tawbi HA,Davies MA,Ross MI,Glitza IC,Cormier JN,Lewis C,Hwu WJ,Hanna E,Diab A,Wong MK,Royal R,Gross N,Weber R,Lai SY,Ehlers R,Blando J,Milton DR,Woodman S,Kageyama R,Wells DK,Hwu P,Patel S

更新日期：2018-12-01 00:00:00

abstract：:The dorsomedial hypothalamic nucleus harbors leptin sensitive neurons and is intrinsically connected to hypothalamic nuclei involved in feeding behavior. However, it also receives ascending input from the visceroceptive neurons of the brainstem. We have identified a unique glucagon-like-peptide-2 containing neuronal p...

journal_title：Nature medicine

authors： Tang-Christensen M,Larsen PJ,Thulesen J,Rømer J,Vrang N

更新日期：2000-07-01 00:00:00

abstract：:Telomerase is a ribonucleoprotein enzyme that maintains the protective structures at the ends of eukaryotic chromosomes, called telomeres. In most human somatic cells, telomerase expression is repressed, and telomeres shorten progressively with each cell division. In contrast, most human tumors express telomerase, res...

journal_title：Nature medicine

authors： Hahn WC,Stewart SA,Brooks MW,York SG,Eaton E,Kurachi A,Beijersbergen RL,Knoll JH,Meyerson M,Weinberg RA

更新日期：1999-10-01 00:00:00

abstract：:Colon cancer is a clinically diverse disease. This heterogeneity makes it difficult to determine which patients will benefit most from adjuvant therapy and impedes the development of new targeted agents. More insight into the biological diversity of colon cancers, especially in relation to clinical features, is theref...

journal_title：Nature medicine

authors： De Sousa E Melo F,Wang X,Jansen M,Fessler E,Trinh A,de Rooij LP,de Jong JH,de Boer OJ,van Leersum R,Bijlsma MF,Rodermond H,van der Heijden M,van Noesel CJ,Tuynman JB,Dekker E,Markowetz F,Medema JP,Vermeulen L

更新日期：2013-05-01 00:00:00

abstract：:Bone homeostasis is maintained by the balance between osteoblastic bone formation and osteoclastic bone resorption. Osteoclasts are multinucleated cells that are formed by mononuclear preosteoclast fusion. Fat-soluble vitamins such as vitamin D are pivotal in maintaining skeletal integrity. However, the role of vitami...

journal_title：Nature medicine

authors： Fujita K,Iwasaki M,Ochi H,Fukuda T,Ma C,Miyamoto T,Takitani K,Negishi-Koga T,Sunamura S,Kodama T,Takayanagi H,Tamai H,Kato S,Arai H,Shinomiya K,Itoh H,Okawa A,Takeda S

更新日期：2012-03-04 00:00:00

abstract：:Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 °C) increased peripheral insulin sensitivity by ∼43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, wit...

journal_title：Nature medicine

authors： Hanssen MJ,Hoeks J,Brans B,van der Lans AA,Schaart G,van den Driessche JJ,Jörgensen JA,Boekschoten MV,Hesselink MK,Havekes B,Kersten S,Mottaghy FM,van Marken Lichtenbelt WD,Schrauwen P

更新日期：2015-08-01 00:00:00

abstract：:Reactive oxygen species (ROS) induce chemokines responsible for the recruitment of inflammatory cells to sites of injury or infection. Here we show that the plasma membrane Ca(2+)-permeable channel TRPM2 controls ROS-induced chemokine production in monocytes. In human U937 monocytes, hydrogen peroxide (H(2)O(2)) evoke...

journal_title：Nature medicine

authors： Yamamoto S,Shimizu S,Kiyonaka S,Takahashi N,Wajima T,Hara Y,Negoro T,Hiroi T,Kiuchi Y,Okada T,Kaneko S,Lange I,Fleig A,Penner R,Nishi M,Takeshima H,Mori Y

更新日期：2008-07-01 00:00:00

abstract：:HIV infection can cause extensive neuronal loss and clinically a severe dementia. The cause of the neurotoxicity remains unclear as neurons are not infected, but disturbance of glutamate-linked calcium entry has been implicated. In this study, we have shown a decrease in HIV-infected brain of the expression of mRNA an...

journal_title：Nature medicine

authors： Everall IP,Hudson L,al-Sarraj S,Honavar M,Lantos P,Kerwin R

更新日期：1995-11-01 00:00:00

abstract：:Transplantation of xenogeneic hepatocytes would provide a novel therapy for liver disease and would help to solve the problem of an insufficient supply of donor organs. We have tested whether xenogeneic cells infused into the liver could correct the metabolic defect in the Watanable heritable hyperlipidemic (WHHL) rab...

journal_title：Nature medicine

authors： Gunsalus JR,Brady DA,Coulter SM,Gray BM,Edge AS

更新日期：1997-01-01 00:00:00

abstract：:Migration inhibitory factor (MIF) is known to exert significant pro-inflammatory effects and has the potential to override the anti-inflammatory action of glucocorticoids. In this study we have identified significant quantities of MIF in the alveolar airspaces of patients with acute respiratory distress syndrome (ARDS...

journal_title：Nature medicine

authors： Donnelly SC,Haslett C,Reid PT,Grant IS,Wallace WA,Metz CN,Bruce LJ,Bucala R

更新日期：1997-03-01 00:00:00

abstract：:Severe malaria is a major cause of childhood mortality in sub-Saharan Africa but the factors predisposing children to severe forms of malaria have not been fully elucidated. In a case-control study of over 1,200 Gambian children hepatitis B virus carriage was significantly increased amongst cases of severe malaria com...

journal_title：Nature medicine

authors： Thursz MR,Kwiatkowski D,Torok ME,Allsopp CE,Greenwood BM,Whittle HC,Thomas HC,Hill AV

更新日期：1995-04-01 00:00:00

abstract：:Infections are thought to be important in the pathogenesis of many heart diseases. Coxsackievirus B3 (CVB3) has been linked to chronic dilated cardiomyopathy, a common cause of progressive heart disease, heart failure and sudden death. We show here that the sarcoma (Src) family kinase Lck (p56lck) is required for effi...

journal_title：Nature medicine

authors： Liu P,Aitken K,Kong YY,Opavsky MA,Martino T,Dawood F,Wen WH,Kozieradzki I,Bachmaier K,Straus D,Mak TW,Penninger JM

更新日期：2000-04-01 00:00:00

abstract：:Mice carrying mutations in both the dystrophin and utrophin genes die prematurely as a consequence of severe muscular dystrophy. Here, we show that intravascular administration of recombinant adeno-associated viral (rAAV) vectors carrying a microdystrophin gene restores expression of dystrophin in the respiratory, car...

journal_title：Nature medicine

authors： Gregorevic P,Allen JM,Minami E,Blankinship MJ,Haraguchi M,Meuse L,Finn E,Adams ME,Froehner SC,Murry CE,Chamberlain JS

更新日期：2006-07-01 00:00:00

abstract：:Noninvasive methods are needed to study the kinetic properties of viruses in living organisms. Oncolytic viruses are used increasingly for cancer therapy but there is currently no satisfactory way to measure efficiency of tumor transduction, changing levels of viral gene expression or the timing of virus elimination. ...

journal_title：Nature medicine

authors： Peng KW,Facteau S,Wegman T,O'Kane D,Russell SJ

更新日期：2002-05-01 00:00:00

abstract：:The concentration of human immunodeficiency virus type 1 (HIV-1) particles in blood plasma is very predictive of the subsequent disease course in an infected individual; its measurement has become one of the most important parameters for monitoring clinical status. Steady-state virus levels in plasma reflect a balance...

journal_title：Nature medicine

authors： Igarashi T,Brown C,Azadegan A,Haigwood N,Dimitrov D,Martin MA,Shibata R

更新日期：1999-02-01 00:00:00

abstract：:Unlike normal melanocytes, primary and metastatic human melanomas express high levels of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 (FGFR-1) messenger RNA, and expression of these genes is essential in sustaining the proliferation of malignant melanomas in vitro. To determine whether...

journal_title：Nature medicine

authors： Wang Y,Becker D

更新日期：1997-08-01 00:00:00

abstract：:Observational clinical and ex vivo studies have established a strong association between atrial fibrillation and inflammation. However, whether inflammation is the cause or the consequence of atrial fibrillation and which specific inflammatory mediators may increase the atria's susceptibility to fibrillation remain el...

journal_title：Nature medicine

authors： Rudolph V,Andrié RP,Rudolph TK,Friedrichs K,Klinke A,Hirsch-Hoffmann B,Schwoerer AP,Lau D,Fu X,Klingel K,Sydow K,Didié M,Seniuk A,von Leitner EC,Szoecs K,Schrickel JW,Treede H,Wenzel U,Lewalter T,Nickenig G,Zimmer

更新日期：2010-04-01 00:00:00

abstract：:Mutations in genes encoding splicing factors (which we refer to as spliceosomal genes) are commonly found in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). These mutations recurrently affect specific amino acid residues, leading to perturbed normal splice site and exon recognition. Spl...

journal_title：Nature medicine

authors： Lee SC,Dvinge H,Kim E,Cho H,Micol JB,Chung YR,Durham BH,Yoshimi A,Kim YJ,Thomas M,Lobry C,Chen CW,Pastore A,Taylor J,Wang X,Krivtsov A,Armstrong SA,Palacino J,Buonamici S,Smith PG,Bradley RK,Abdel-Wahab O

更新日期：2016-06-01 00:00:00

abstract：:The Zero Childhood Cancer Program is a precision medicine program to benefit children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline whole genome sequencing (WGS) and RNA sequencing (RNAseq) across 252 tumors from high-risk pediatric patients with cancer, we identified 968 reportable ...

journal_title：Nature medicine

authors： Wong M,Mayoh C,Lau LMS,Khuong-Quang DA,Pinese M,Kumar A,Barahona P,Wilkie EE,Sullivan P,Bowen-James R,Syed M,Martincorena I,Abascal F,Sherstyuk A,Bolanos NA,Baber J,Priestley P,Dolman MEM,Fleuren EDG,Gauthier ME,M

更新日期：2020-11-01 00:00:00

abstract：:High blood pressure, or hypertension, is a very common disorder with a substantial impact on public health because of its associated complications. Despite the high prevalence of essential hypertension and years of research, the basic causes remain obscure. Here I review recent advances in understanding the pathophysi...

journal_title：Nature medicine

authors： Coffman TM

更新日期：2011-11-07 00:00:00

abstract：:The skin protects mammals from insults, infection and dehydration and enables thermoregulation and sensory perception. Various skin-resident cells carry out these diverse functions. Constant turnover of cells and healing upon injury necessitate multiple reservoirs of stem cells. Thus, the skin provides a model for stu...

journal_title：Nature medicine

authors： Hsu YC,Li L,Fuchs E

更新日期：2014-08-01 00:00:00

abstract：:Mice transgenic for antisense Notch and normal mice treated with inhibitors of the Notch-activating enzyme gamma-secretase showed reduced damage to brain cells and improved functional outcome in a model of focal ischemic stroke. Notch endangers neurons by modulating pathways that increase their vulnerability to apopto...

journal_title：Nature medicine

authors： Arumugam TV,Chan SL,Jo DG,Yilmaz G,Tang SC,Cheng A,Gleichmann M,Okun E,Dixit VD,Chigurupati S,Mughal MR,Ouyang X,Miele L,Magnus T,Poosala S,Granger DN,Mattson MP

更新日期：2006-06-01 00:00:00

abstract：:Copy number variants are a recently discovered source of large-scale genomic diversity present in all individuals. We capitalize on these inherent genomic differences, focusing on deletion polymorphisms, to develop informative fluorescence in situ hybridization probes with the ability to unequivocally distinguish betw...

journal_title：Nature medicine

authors： Wu D,Vu Q,Nguyen A,Stone JR,Stubbs H,Kuhlmann G,Sholl LM,Iafrate AJ

更新日期：2009-02-01 00:00:00

abstract：:We and others have postulated that a constant number of T lymphocytes is normally maintained without regard to CD4+ or CD8+ phenotype ('blind' T-cell homeostasis). Here we confirm essentially constant T-cell levels (despite marked decline in CD4+ T cells and increase in CD8+ T cells) in homosexual men with incident hu...

journal_title：Nature medicine

authors： Margolick JB,Muñoz A,Donnenberg AD,Park LP,Galai N,Giorgi JV,O'Gorman MR,Ferbas J

更新日期：1995-07-01 00:00:00

abstract：:The use of genetically manipulated mouse models, gene and protein discovery and the cataloguing of genetic mutations have each allowed us to obtain new insights into skeletal morphogenesis and remodeling. These techniques have made it possible to identify molecules that are obligatory for specific cellular functions, ...

journal_title：Nature medicine

authors： Zaidi M

更新日期：2007-07-01 00:00:00