Abstract:
:Migration inhibitory factor (MIF) is known to exert significant pro-inflammatory effects and has the potential to override the anti-inflammatory action of glucocorticoids. In this study we have identified significant quantities of MIF in the alveolar airspaces of patients with acute respiratory distress syndrome (ARDS). We show in alveolar cells from patients with ARDS that MIF augments pro-inflammatory cytokine secretion (TNF alpha and IL-8), anti-MIF significantly attenuates TNF alpha and IL-8 secretion and MIF overrides, in a concentration-related fashion, the anti-inflammatory effects of glucocorticoids. These findings suggest that MIF may act as a mediator sustaining the pulmonary inflammatory response in ARDS and that an anti-MIF strategy may represent a novel therapeutic approach in inflammatory diseases such as ARDS.
journal_name
Nat Medjournal_title
Nature medicineauthors
Donnelly SC,Haslett C,Reid PT,Grant IS,Wallace WA,Metz CN,Bruce LJ,Bucala Rdoi
10.1038/nm0397-320subject
Has Abstractpub_date
1997-03-01 00:00:00pages
320-3issue
3eissn
1078-8956issn
1546-170Xjournal_volume
3pub_type
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