Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.

abstract：:Our understanding of Alzheimer's disease (AD) pathophysiology remains incomplete. Here we used quantitative mass spectrometry and coexpression network analysis to conduct the largest proteomic study thus far on AD. A protein network module linked to sugar metabolism emerged as one of the modules most significantly ass...

journal_title：Nature medicine

authors： Johnson ECB,Dammer EB,Duong DM,Ping L,Zhou M,Yin L,Higginbotham LA,Guajardo A,White B,Troncoso JC,Thambisetty M,Montine TJ,Lee EB,Trojanowski JQ,Beach TG,Reiman EM,Haroutunian V,Wang M,Schadt E,Zhang B,Dickson DW

更新日期：2020-05-01 00:00:00

abstract：:Cancer-specific cell-surface antigens are ideal targets for monoclonal antibody (mAb)-based immunotherapy but are likely to have previously been identified in transcriptome or proteome analyses. Here, we show that the active conformer of an integrin can serve as a specific therapeutic target for multiple myeloma (MM)....

journal_title：Nature medicine

authors： Hosen N,Matsunaga Y,Hasegawa K,Matsuno H,Nakamura Y,Makita M,Watanabe K,Yoshida M,Satoh K,Morimoto S,Fujiki F,Nakajima H,Nakata J,Nishida S,Tsuboi A,Oka Y,Manabe M,Ichihara H,Aoyama Y,Mugitani A,Nakao T,Hino M,

更新日期：2017-12-01 00:00:00

abstract：:Intraoperative diagnosis is essential for providing safe and effective care during cancer surgery1. The existing workflow for intraoperative diagnosis based on hematoxylin and eosin staining of processed tissue is time, resource and labor intensive2,3. Moreover, interpretation of intraoperative histologic images is de...

journal_title：Nature medicine

authors： Hollon TC,Pandian B,Adapa AR,Urias E,Save AV,Khalsa SSS,Eichberg DG,D'Amico RS,Farooq ZU,Lewis S,Petridis PD,Marie T,Shah AH,Garton HJL,Maher CO,Heth JA,McKean EL,Sullivan SE,Hervey-Jumper SL,Patil PG,Thompson BG

更新日期：2020-01-01 00:00:00

abstract：:Low oxygen tension influences tumor progression by enhancing angiogenesis; and histone deacetylases (HDAC) are implicated in alteration of chromatin assembly and tumorigenesis. Here we show induction of HDAC under hypoxia and elucidate a role for HDAC in the regulation of hypoxia-induced angiogenesis. Overexpressed wi...

journal_title：Nature medicine

authors： Kim MS,Kwon HJ,Lee YM,Baek JH,Jang JE,Lee SW,Moon EJ,Kim HS,Lee SK,Chung HY,Kim CW,Kim KW

更新日期：2001-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder involving the florid deposition of vascular and cerebral plaques composed chiefly of amyloid beta-peptide (A beta) derived from cleavage of the amyloid precursor protein (APP). Varying in length from 39 to 43 amino acids, A beta, particularly the longer A beta(4...

journal_title：Nature medicine

authors： Cook DG,Forman MS,Sung JC,Leight S,Kolson DL,Iwatsubo T,Lee VM,Doms RW

更新日期：1997-09-01 00:00:00

abstract：:Hedgehog signaling drives oncogenesis in several cancers, and strategies targeting this pathway have been developed, most notably through inhibition of Smoothened (SMO). However, resistance to Smoothened inhibitors occurs by genetic changes of Smoothened or other downstream Hedgehog components. Here we overcome these ...

journal_title：Nature medicine

authors： Tang Y,Gholamin S,Schubert S,Willardson MI,Lee A,Bandopadhayay P,Bergthold G,Masoud S,Nguyen B,Vue N,Balansay B,Yu F,Oh S,Woo P,Chen S,Ponnuswami A,Monje M,Atwood SX,Whitson RJ,Mitra S,Cheshier SH,Qi J,Beroukh

更新日期：2014-07-01 00:00:00

abstract：:Members of the suppressor of cytokine signaling (SOCS) family are involved in the pathogenesis of many inflammatory diseases. SOCS-3 is predominantly expressed in T-helper type 2 (T(H)2) cells, but its role in T(H)2-related allergic diseases remains to be investigated. In this study we provide a strong correlation bet...

journal_title：Nature medicine

authors： Seki Y,Inoue H,Nagata N,Hayashi K,Fukuyama S,Matsumoto K,Komine O,Hamano S,Himeno K,Inagaki-Ohara K,Cacalano N,O'Garra A,Oshida T,Saito H,Johnston JA,Yoshimura A,Kubo M

更新日期：2003-08-01 00:00:00

abstract：:Relapse is the leading cause of mortality in children with acute lymphoblastic leukemia (ALL). Among chemotherapeutics, thiopurines are key drugs in ALL combination therapy. Using whole-exome sequencing, we identified relapse-specific mutations in the phosphoribosyl pyrophosphate synthetase 1 gene (PRPS1), which encod...

journal_title：Nature medicine

authors： Li B,Li H,Bai Y,Kirschner-Schwabe R,Yang JJ,Chen Y,Lu G,Tzoneva G,Ma X,Wu T,Li W,Lu H,Ding L,Liang H,Huang X,Yang M,Jin L,Kang H,Chen S,Du A,Shen S,Ding J,Chen H,Chen J,von Stackelberg A,Gu L,Zhang J,

更新日期：2015-06-01 00:00:00

abstract：:The gene encoding the lysine-specific histone methyltransferase KMT2D has emerged as one of the most frequently mutated genes in follicular lymphoma and diffuse large B cell lymphoma; however, the biological consequences of KMT2D mutations on lymphoma development are not known. Here we show that KMT2D functions as a b...

journal_title：Nature medicine

authors： Ortega-Molina A,Boss IW,Canela A,Pan H,Jiang Y,Zhao C,Jiang M,Hu D,Agirre X,Niesvizky I,Lee JE,Chen HT,Ennishi D,Scott DW,Mottok A,Hother C,Liu S,Cao XJ,Tam W,Shaknovich R,Garcia BA,Gascoyne RD,Ge K,Shilatif

更新日期：2015-10-01 00:00:00

abstract：:Advances in imaging are transforming our understanding of angiogenesis and the evaluation of drugs that stimulate or inhibit angiogenesis in preclinical models and human disease. Vascular imaging makes it possible to quantify the number and spacing of blood vessels, measure blood flow and vascular permeability, and an...

journal_title：Nature medicine

authors： McDonald DM,Choyke PL

更新日期：2003-06-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature medicine

authors： Charney AW,Simons NW,Mouskas K,Lepow L,Cheng E,Le Berichel J,Chang C,Marvin R,Del Valle DM,Calorossi S,Lansky A,Walker L,Patel M,Xie H,Yi N,Yu A,Kang G,Liharska LE,Moya E,Hartnett M,Hatem S,Wilkins L,Eaton M,

更新日期：2020-09-01 00:00:00

abstract：:With an ever increasing number of people taking numerous medications, the need to safely administer drugs and limit unintended side effects has never been greater. Antidote control remains the most direct means to counteract acute side effects of drugs, but, unfortunately, it has been challenging and cost prohibitive ...

journal_title：Nature medicine

authors： Oney S,Lam RT,Bompiani KM,Blake CM,Quick G,Heidel JD,Liu JY,Mack BC,Davis ME,Leong KW,Sullenger BA

更新日期：2009-10-01 00:00:00

abstract：:A new investigation into Duchenne muscular dystrophy (DMD) pathogenesis suggests that at least part of the muscle degeneration observed in DMD patients may result from the reduced production of muscle membrane-associated neuronal nitric oxide synthase. This reduction may lead to impaired regulation of the vasoconstric...

journal_title：Nature medicine

authors： Crosbie RH

更新日期：2001-01-01 00:00:00

abstract：:The immune-modulating cytokine interleukin-6 (IL-6) is expressed both in adipose tissue and centrally in hypothalamic nuclei that regulate body composition. We investigated the impact of loss of IL-6 on body composition in mice lacking the gene encoding IL-6 (Il6-/- mice) and found that they developed mature-onset obe...

journal_title：Nature medicine

authors： Wallenius V,Wallenius K,Ahrén B,Rudling M,Carlsten H,Dickson SL,Ohlsson C,Jansson JO

更新日期：2002-01-01 00:00:00

abstract：:Hematopoietic stem and progenitor cells (HSPC) are endowed with the role of generating and maintaining lifelong the extremely diverse pool of blood cells1. Clinically, transplantation of human HSPC from an allogeneic healthy donor or infusion of autologous gene-corrected HSPC can effectively replenish defective blood ...

journal_title：Nature medicine

authors： Scala S,Basso-Ricci L,Dionisio F,Pellin D,Giannelli S,Salerio FA,Leonardelli L,Cicalese MP,Ferrua F,Aiuti A,Biasco L

更新日期：2018-11-01 00:00:00

abstract：:Despite years of fully suppressive antiretroviral therapy (ART), HIV persists in its hosts and is never eradicated. One major barrier to eradication is that the virus infects multiple cell types that may individually contribute to HIV persistence. Tissue macrophages are critical contributors to HIV pathogenesis; howev...

journal_title：Nature medicine

authors： Honeycutt JB,Thayer WO,Baker CE,Ribeiro RM,Lada SM,Cao Y,Cleary RA,Hudgens MG,Richman DD,Garcia JV

更新日期：2017-05-01 00:00:00

abstract：:Levels of insulin-like growth factor I (IGF-I), a neuroprotective hormone, decrease in serum during aging, whereas amyloid-beta (Abeta), which is involved in the pathogenesis of Alzheimer disease, accumulates in the brain. High brain Abeta levels are found at an early age in mutant mice with low circulating IGF-I, and...

journal_title：Nature medicine

authors： Carro E,Trejo JL,Gomez-Isla T,LeRoith D,Torres-Aleman I

更新日期：2002-12-01 00:00:00

abstract：:Targeted gene transduction to specific tissues and organs through intravenous injection would be the ultimate preferred method of gene delivery. Here, we report successful targeting in a living animal through intravenous injection of a lentiviral vector pseudotyped with a modified chimeric Sindbis virus envelope (term...

journal_title：Nature medicine

authors： Morizono K,Xie Y,Ringpis GE,Johnson M,Nassanian H,Lee B,Wu L,Chen IS

更新日期：2005-03-01 00:00:00

abstract：:We determine here the functional integrity of auxiliary livers in containers fashioned from the small intestine. Liver microfragments from dipeptidyl peptidase 4 (DPP4)-deficient rats were transplanted into syngeneic normal animals with isolated intestinal segments characterized by mucosal denudation but intact vascul...

journal_title：Nature medicine

authors： Joseph B,Berishvili E,Benten D,Kumaran V,Liponava E,Bhargava K,Palestro C,Kakabadze Z,Gupta S

更新日期：2004-07-01 00:00:00

abstract：:The vaccines developed over the first two hundred years since Jenner's lifetime have accomplished striking reductions of infection and disease wherever applied. Pasteur's early approaches to vaccine development, attenuation and inactivation, are even now the two poles of vaccine technology. Today, purification of micr...

journal_title：Nature medicine

authors： Plotkin SA

更新日期：2005-04-01 00:00:00

abstract：:Unlike normal melanocytes, primary and metastatic human melanomas express high levels of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 (FGFR-1) messenger RNA, and expression of these genes is essential in sustaining the proliferation of malignant melanomas in vitro. To determine whether...

journal_title：Nature medicine

authors： Wang Y,Becker D

更新日期：1997-08-01 00:00:00

abstract：:The ongoing substance misuse epidemic in the United States is complex and dynamic and should be approached as such in the development and evaluation of policy1. Drug overdose deaths (largely attributable to opioid misuse) in the United States have grown exponentially for almost four decades, but the mechanisms of this...

journal_title：Nature medicine

authors： Jalal H,Buchanich JM,Sinclair DR,Roberts MS,Burke DS

更新日期：2020-05-01 00:00:00

abstract：:TRK fusions are found in a variety of cancer types, lead to oncogenic addiction, and strongly predict tumor-agnostic efficacy of TRK inhibition1-8. With the recent approval of the first selective TRK inhibitor, larotrectinib, for patients with any TRK-fusion-positive adult or pediatric solid tumor, to identify mechani...

journal_title：Nature medicine

authors： Cocco E,Schram AM,Kulick A,Misale S,Won HH,Yaeger R,Razavi P,Ptashkin R,Hechtman JF,Toska E,Cownie J,Somwar R,Shifman S,Mattar M,Selçuklu SD,Samoila A,Guzman S,Tuch BB,Ebata K,de Stanchina E,Nagy RJ,Lanman RB,

更新日期：2019-09-01 00:00:00

abstract：:The balance between detrimental, pro-aging, often stochastic processes and counteracting homeostatic mechanisms largely determines the progression of aging. There is substantial evidence suggesting that the endocannabinoid system (ECS) is part of the latter system because it modulates the physiological processes under...

journal_title：Nature medicine

authors： Bilkei-Gorzo A,Albayram O,Draffehn A,Michel K,Piyanova A,Oppenheimer H,Dvir-Ginzberg M,Rácz I,Ulas T,Imbeault S,Bab I,Schultze JL,Zimmer A

更新日期：2017-06-01 00:00:00

abstract：:Activation of the zinc-finger transcription factor early growth response (Egr)-1, initially linked to developmental processes, is shown here to function as a master switch activated by ischemia to trigger expression of pivotal regulators of inflammation, coagulation and vascular hyperpermeability. Chemokine, adhesion ...

journal_title：Nature medicine

authors： Yan SF,Fujita T,Lu J,Okada K,Shan Zou Y,Mackman N,Pinsky DJ,Stern DM

更新日期：2000-12-01 00:00:00

abstract：: ...

journal_title：Nature medicine

authors： Stower H

更新日期：2018-12-01 00:00:00

abstract：:Infiltration of human cancers by T cells is generally interpreted as a sign of immune recognition, and there is a growing effort to reactivate dysfunctional T cells at such tumor sites1. However, these efforts only have value if the intratumoral T cell receptor (TCR) repertoire of such cells is intrinsically tumor rea...

journal_title：Nature medicine

authors： Scheper W,Kelderman S,Fanchi LF,Linnemann C,Bendle G,de Rooij MAJ,Hirt C,Mezzadra R,Slagter M,Dijkstra K,Kluin RJC,Snaebjornsson P,Milne K,Nelson BH,Zijlmans H,Kenter G,Voest EE,Haanen JBAG,Schumacher TN

更新日期：2019-01-01 00:00:00

abstract：:A characteristic feature of Creutzfeldt-Jakob disease (CJD) is the accumulation in the brain of the amyloid protease-resistant protein PrPres. PrPres derives from a host-encoded, protease-sensitive isoform, PrPsen. Mutations of this protein are linked to familial variants of the disease, and the presence of a methioni...

journal_title：Nature medicine

authors： Silvestrini MC,Cardone F,Maras B,Pucci P,Barra D,Brunori M,Pocchiari M

更新日期：1997-05-01 00:00:00

abstract：:Disruption of systemic homeostasis by either chronic or acute stressors, such as obesity1 or surgery2, alters cancer pathogenesis. Patients with cancer, particularly those with breast cancer, can be at increased risk of cardiovascular disease due to treatment toxicity and changes in lifestyle behaviors3-5. While eleva...

journal_title：Nature medicine

authors： Koelwyn GJ,Newman AAC,Afonso MS,van Solingen C,Corr EM,Brown EJ,Albers KB,Yamaguchi N,Narke D,Schlegel M,Sharma M,Shanley LC,Barrett TJ,Rahman K,Mezzano V,Fisher EA,Park DS,Newman JD,Quail DF,Nelson ER,Caan BJ,J

更新日期：2020-09-01 00:00:00

abstract：:We and others have postulated that a constant number of T lymphocytes is normally maintained without regard to CD4+ or CD8+ phenotype ('blind' T-cell homeostasis). Here we confirm essentially constant T-cell levels (despite marked decline in CD4+ T cells and increase in CD8+ T cells) in homosexual men with incident hu...

journal_title：Nature medicine

authors： Margolick JB,Muñoz A,Donnenberg AD,Park LP,Galai N,Giorgi JV,O'Gorman MR,Ferbas J

更新日期：1995-07-01 00:00:00