Vaccines: past, present and future.

abstract：:The cycle of gallbladder filling and emptying controls the flow of bile into the intestine for digestion. Here we show that fibroblast growth factor-15, a hormone made by the distal small intestine in response to bile acids, is required for gallbladder filling. These studies demonstrate that gallbladder filling is act...

journal_title：Nature medicine

authors： Choi M,Moschetta A,Bookout AL,Peng L,Umetani M,Holmstrom SR,Suino-Powell K,Xu HE,Richardson JA,Gerard RD,Mangelsdorf DJ,Kliewer SA

更新日期：2006-11-01 00:00:00

abstract：:The skin-associated chemokine CCL27 (also called CTACK, ALP and ESkine) and its receptor CCR10 (GPR-2) mediate chemotactic responses of skin-homing T cells in vitro. Here we report that most skin-infiltrating lymphocytes in patients suffering from psoriasis, atopic or allergic-contact dermatitis express CCR10. Epiderm...

journal_title：Nature medicine

authors： Homey B,Alenius H,Müller A,Soto H,Bowman EP,Yuan W,McEvoy L,Lauerma AI,Assmann T,Bünemann E,Lehto M,Wolff H,Yen D,Marxhausen H,To W,Sedgwick J,Ruzicka T,Lehmann P,Zlotnik A

更新日期：2002-02-01 00:00:00

abstract：:Spinal sensorimotor networks that are functionally disconnected from the brain because of spinal cord injury (SCI) can be facilitated via epidural electrical stimulation (EES) to restore robust, coordinated motor activity in humans with paralysis1-3. Previously, we reported a clinical case of complete sensorimotor par...

journal_title：Nature medicine

authors： Gill ML,Grahn PJ,Calvert JS,Linde MB,Lavrov IA,Strommen JA,Beck LA,Sayenko DG,Van Straaten MG,Drubach DI,Veith DD,Thoreson AR,Lopez C,Gerasimenko YP,Edgerton VR,Lee KH,Zhao KD

更新日期：2018-11-01 00:00:00

abstract：:Immune sensing of a microbe occurs via multiple receptors. How signals from different receptors are coordinated to yield a specific immune response is poorly understood. We show that two pathogen recognition receptors, Toll-like receptor 2 (TLR2) and dectin-1, recognizing the same microbial stimulus, stimulate distinc...

journal_title：Nature medicine

authors： Manicassamy S,Ravindran R,Deng J,Oluoch H,Denning TL,Kasturi SP,Rosenthal KM,Evavold BD,Pulendran B

更新日期：2009-04-01 00:00:00

abstract：:Approximately 1-5% of breast cancers are attributed to inherited mutations in BRCA1 or BRCA2 and are selectively sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. In other cancer types, germline and/or somatic mutations in BRCA1 and/or BRCA2 (BRCA1/BRCA2) also confer selective sensitivity to PARP inhibitors....

journal_title：Nature medicine

authors： Davies H,Glodzik D,Morganella S,Yates LR,Staaf J,Zou X,Ramakrishna M,Martin S,Boyault S,Sieuwerts AM,Simpson PT,King TA,Raine K,Eyfjord JE,Kong G,Borg Å,Birney E,Stunnenberg HG,van de Vijver MJ,Børresen-Dale AL,Ma

更新日期：2017-04-01 00:00:00

abstract：:Preservation of the chemical architecture of a cell or of an organism under changing and perhaps stressful conditions is termed homeostasis. An integral feature of homeostasis is the rapid expression of genes whose products are specifically dedicated to protect cellular functions against stress. One of the best known ...

journal_title：Nature medicine

authors： Vígh L,Literáti PN,Horváth I,Török Z,Balogh G,Glatz A,Kovács E,Boros I,Ferdinándy P,Farkas B,Jaszlits L,Jednákovits A,Korányi L,Maresca B

更新日期：1997-10-01 00:00:00

abstract：:Cellular immunity has an inherent high level of functional heterogeneity. Capturing the full spectrum of these functions requires analysis of large numbers of effector molecules from single cells. We report a microfluidic platform designed for highly multiplexed (more than ten proteins), reliable, sample-efficient (∼1...

journal_title：Nature medicine

authors： Ma C,Fan R,Ahmad H,Shi Q,Comin-Anduix B,Chodon T,Koya RC,Liu CC,Kwong GA,Radu CG,Ribas A,Heath JR

更新日期：2011-06-01 00:00:00

abstract：:Mutations in genes encoding splicing factors (which we refer to as spliceosomal genes) are commonly found in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). These mutations recurrently affect specific amino acid residues, leading to perturbed normal splice site and exon recognition. Spl...

journal_title：Nature medicine

authors： Lee SC,Dvinge H,Kim E,Cho H,Micol JB,Chung YR,Durham BH,Yoshimi A,Kim YJ,Thomas M,Lobry C,Chen CW,Pastore A,Taylor J,Wang X,Krivtsov A,Armstrong SA,Palacino J,Buonamici S,Smith PG,Bradley RK,Abdel-Wahab O

更新日期：2016-06-01 00:00:00

abstract：:Osteoarthritis is a highly prevalent and debilitating joint disorder. There is no effective medical therapy for the condition because of limited understanding of its pathogenesis. We show that transforming growth factor β1 (TGF-β1) is activated in subchondral bone in response to altered mechanical loading in an anteri...

journal_title：Nature medicine

authors： Zhen G,Wen C,Jia X,Li Y,Crane JL,Mears SC,Askin FB,Frassica FJ,Chang W,Yao J,Carrino JA,Cosgarea A,Artemov D,Chen Q,Zhao Z,Zhou X,Riley L,Sponseller P,Wan M,Lu WW,Cao X

更新日期：2013-06-01 00:00:00

abstract：:Recent studies of subjects infected with human immunodeficiency virus (HIV-1) have produced conflicting results about the extent of reconstitution possible in the CD4+ lymphocyte repertoire after highly active antiretroviral therapy (HAART). The effect of HAART on the incidence of opportunistic infections will probabl...

journal_title：Nature medicine

authors： Komanduri KV,Viswanathan MN,Wieder ED,Schmidt DK,Bredt BM,Jacobson MA,McCune JM

更新日期：1998-08-01 00:00:00

abstract：:Networks of interstitial cells of Cajal embedded in the musculature of the gastrointestinal tract are involved in the generation of electrical pacemaker activity for gastrointestinal motility. This pacemaker activity manifests itself as rhythmic slow waves in membrane potential, and controls the frequency and propagat...

journal_title：Nature medicine

authors： Thomsen L,Robinson TL,Lee JC,Farraway LA,Hughes MJ,Andrews DW,Huizinga JD

更新日期：1998-07-01 00:00:00

abstract：:Immunization of transgenic mouse models of Alzheimer disease using amyloid-beta peptide (Abeta) reduces both the Alzheimer disease-like neuropathology and the spatial memory impairments of these mice. However, a therapeutic trial of immunization with Abeta42 in humans was discontinued because a few patients developed ...

journal_title：Nature medicine

authors： McLaurin J,Cecal R,Kierstead ME,Tian X,Phinney AL,Manea M,French JE,Lambermon MH,Darabie AA,Brown ME,Janus C,Chishti MA,Horne P,Westaway D,Fraser PE,Mount HT,Przybylski M,St George-Hyslop P

更新日期：2002-11-01 00:00:00

abstract：:A high-fat diet increases the risk of colon, breast and prostate cancer. The molecular mechanism by which dietary lipids promote tumorigenesis is unknown. Their effects may be mediated at least in part by the peroxisome proliferator-activated receptors (PPARs). These ligand-activated nuclear receptors modulate gene ex...

journal_title：Nature medicine

authors： Saez E,Tontonoz P,Nelson MC,Alvarez JG,Ming UT,Baird SM,Thomazy VA,Evans RM

更新日期：1998-09-01 00:00:00

abstract：:To better understand genetic alterations in oral premalignant lesions, we examined 84 oral leukoplakia samples from 37 patients who had been enrolled in a chemoprevention trial. The samples were analyzed for two microsatellite markers located at chromosomes 9p21 and 3p14. Loss of heterozygosity (LOH) at either or both...

journal_title：Nature medicine

authors： Mao L,Lee JS,Fan YH,Ro JY,Batsakis JG,Lippman S,Hittelman W,Hong WK

更新日期：1996-06-01 00:00:00

abstract：:A new investigation into Duchenne muscular dystrophy (DMD) pathogenesis suggests that at least part of the muscle degeneration observed in DMD patients may result from the reduced production of muscle membrane-associated neuronal nitric oxide synthase. This reduction may lead to impaired regulation of the vasoconstric...

journal_title：Nature medicine

authors： Crosbie RH

更新日期：2001-01-01 00:00:00

abstract：:Glioblastoma is the most common primary central nervous system malignancy and has a poor prognosis. Standard first-line treatment, which includes surgery followed by adjuvant radio-chemotherapy, produces only modest benefits to survival1,2. Here, to explore the feasibility, safety and immunobiological effects of PD-1 ...

journal_title：Nature medicine

authors： Schalper KA,Rodriguez-Ruiz ME,Diez-Valle R,López-Janeiro A,Porciuncula A,Idoate MA,Inogés S,de Andrea C,López-Diaz de Cerio A,Tejada S,Berraondo P,Villarroel-Espindola F,Choi J,Gúrpide A,Giraldez M,Goicoechea I,Gallego Pe

更新日期：2019-03-01 00:00:00

abstract：:We show that the fraction of proliferating CD4+ lymphocytes is similar in HIV-infected subjects in the early stage of disease and in HIV-negative subjects, whereas the fraction of proliferating CD8+ lymphocytes is increased 6.8-fold in HIV-infected subjects. After initiation of antiviral therapy, there is a late incre...

journal_title：Nature medicine

authors： Fleury S,de Boer RJ,Rizzardi GP,Wolthers KC,Otto SA,Welbon CC,Graziosi C,Knabenhans C,Soudeyns H,Bart PA,Gallant S,Corpataux JM,Gillet M,Meylan P,Schnyder P,Meuwly JY,Spreen W,Glauser MP,Miedema F,Pantaleo G

更新日期：1998-07-01 00:00:00

abstract：:Preoperative immunotherapy with anti-PD1 plus anti-CTLA4 antibodies has shown remarkable pathological responses in melanoma1 and colorectal cancer2. In NABUCCO (ClinicalTrials.gov: NCT03387761 ), a single-arm feasibility trial, 24 patients with stage III urothelial cancer (UC) received two doses of ipilimumab and two ...

journal_title：Nature medicine

authors： van Dijk N,Gil-Jimenez A,Silina K,Hendricksen K,Smit LA,de Feijter JM,van Montfoort ML,van Rooijen C,Peters D,Broeks A,van der Poel HG,Bruining A,Lubeck Y,Sikorska K,Boellaard TN,Kvistborg P,Vis DJ,Hooijberg E,Schumac

更新日期：2020-12-01 00:00:00

abstract：:Regulatory T cells (T(reg) cells) suppress autoreactive immune responses and limit the efficacy of tumor vaccines; however, it remains a challenge to selectively eliminate or inhibit T(reg) cells. In this study, the zinc-finger A20, a negative regulator of the Toll-like receptor and tumor necrosis factor receptor sign...

journal_title：Nature medicine

authors： Song XT,Evel-Kabler K,Shen L,Rollins L,Huang XF,Chen SY

更新日期：2008-03-01 00:00:00

abstract：:It is estimated that 350 million individuals worldwide suffer from rare diseases, which are predominantly caused by mutation in a single gene1. The current molecular diagnostic rate is estimated at 50%, with whole-exome sequencing (WES) among the most successful approaches2-5. For patients in whom WES is uninformative...

journal_title：Nature medicine

authors： Frésard L,Smail C,Ferraro NM,Teran NA,Li X,Smith KS,Bonner D,Kernohan KD,Marwaha S,Zappala Z,Balliu B,Davis JR,Liu B,Prybol CJ,Kohler JN,Zastrow DB,Reuter CM,Fisk DG,Grove ME,Davidson JM,Hartley T,Joshi R,Stro

更新日期：2019-06-01 00:00:00

abstract：:Adequate lipid secretion by mammary glands during lactation is essential for the survival of mammalian offspring. However, the mechanism governing this process is poorly understood. Here we show that Cidea is expressed at high levels in lactating mammary glands and its deficiency leads to premature pup death as a resu...

journal_title：Nature medicine

authors： Wang W,Lv N,Zhang S,Shui G,Qian H,Zhang J,Chen Y,Ye J,Xie Y,Shen Y,Wenk MR,Li P

更新日期：2012-01-15 00:00:00

abstract：:Autoimmune T-helper cells drive pathogenic autoantibody production in systemic lupus erythematosus (SLE), but the mechanisms maintaining those T cells are unknown. Autoreactive T cells are normally eliminated by functional inactivation (anergy) and activation-induced cell death (AICD) or apoptosis through death recept...

journal_title：Nature medicine

authors： Xu L,Zhang L,Yi Y,Kang HK,Datta SK

更新日期：2004-04-01 00:00:00

abstract：:Noninvasive imaging at the molecular level is an emerging field in biomedical research. This paper introduces a new technology synergizing two leading imaging methodologies: positron emission tomography (PET) and magnetic resonance imaging (MRI). Although the value of PET lies in its high-sensitivity tracking of bioma...

journal_title：Nature medicine

authors： Judenhofer MS,Wehrl HF,Newport DF,Catana C,Siegel SB,Becker M,Thielscher A,Kneilling M,Lichy MP,Eichner M,Klingel K,Reischl G,Widmaier S,Röcken M,Nutt RE,Machulla HJ,Uludag K,Cherry SR,Claussen CD,Pichler BJ

更新日期：2008-04-01 00:00:00

abstract：:We determine here the functional integrity of auxiliary livers in containers fashioned from the small intestine. Liver microfragments from dipeptidyl peptidase 4 (DPP4)-deficient rats were transplanted into syngeneic normal animals with isolated intestinal segments characterized by mucosal denudation but intact vascul...

journal_title：Nature medicine

authors： Joseph B,Berishvili E,Benten D,Kumaran V,Liponava E,Bhargava K,Palestro C,Kakabadze Z,Gupta S

更新日期：2004-07-01 00:00:00

abstract：:GLUT4, the insulin-responsive glucose transporter, plays an important role in postprandial glucose disposal. Altered GLUT4 activity is suggested to be one of the factors responsible for decreased glucose uptake in muscle and adipose tissue in obesity and diabetes. To assess the effect of GLUT4 expression on whole-body...

journal_title：Nature medicine

authors： Stenbit AE,Tsao TS,Li J,Burcelin R,Geenen DL,Factor SM,Houseknecht K,Katz EB,Charron MJ

更新日期：1997-10-01 00:00:00

abstract：:After transplantation of primarily vascularized xenografts (Xgs), T-independent mechanisms may lead to Xg rejection before T-cell activation even takes place. The possibility of achieving T-independent xenotolerance was evaluated in nude rats that normally reject hamster cardiac Xgs within 4 days by non-T cell-mediate...

journal_title：Nature medicine

authors： Lin Y,Goebels J,Xia G,Ji P,Vandeputte M,Waer M

更新日期：1998-02-01 00:00:00

abstract：:Our understanding of Alzheimer's disease (AD) pathophysiology remains incomplete. Here we used quantitative mass spectrometry and coexpression network analysis to conduct the largest proteomic study thus far on AD. A protein network module linked to sugar metabolism emerged as one of the modules most significantly ass...

journal_title：Nature medicine

authors： Johnson ECB,Dammer EB,Duong DM,Ping L,Zhou M,Yin L,Higginbotham LA,Guajardo A,White B,Troncoso JC,Thambisetty M,Montine TJ,Lee EB,Trojanowski JQ,Beach TG,Reiman EM,Haroutunian V,Wang M,Schadt E,Zhang B,Dickson DW

更新日期：2020-05-01 00:00:00

abstract：:Liver disease is one of the leading causes of death worldwide. Patients with cirrhosis display an increased predisposition to and mortality from infection due to multimodal defects in the innate immune system; however, the causative mechanism has remained elusive. We present evidence that the cyclooxygenase (COX)-deri...

journal_title：Nature medicine

authors： O'Brien AJ,Fullerton JN,Massey KA,Auld G,Sewell G,James S,Newson J,Karra E,Winstanley A,Alazawi W,Garcia-Martinez R,Cordoba J,Nicolaou A,Gilroy DW

更新日期：2014-05-01 00:00:00

abstract：:A new study provides mechanistic insights into how live attenuated simian immunodeficiency virus (SIV) vaccines (LAVs) can protect monkeys from infection with pathogenic SIV. The authors show that replicating LAVs stimulate a protective immune response from a safe haven in the germinal centers of lymph nodes (pages 16...

journal_title：Nature medicine

authors： Robinson HL,Amara RR

更新日期：2012-11-01 00:00:00

abstract：:Breast cancers are either primarily resistant to chemotherapy (intrinsic resistance), or respond to chemotherapy but later recur with a multidrug-resistant phenotype because of overexpression of the multidrug transporter P-glycoprotein. The MDR1 gene encoding P-glycoprotein may be transcriptionally regulated by a Y-bo...

journal_title：Nature medicine

authors： Bargou RC,Jürchott K,Wagener C,Bergmann S,Metzner S,Bommert K,Mapara MY,Winzer KJ,Dietel M,Dörken B,Royer HD

更新日期：1997-04-01 00:00:00