NO vascular control in Duchenne muscular dystrophy.

Abstract:

:A new investigation into Duchenne muscular dystrophy (DMD) pathogenesis suggests that at least part of the muscle degeneration observed in DMD patients may result from the reduced production of muscle membrane-associated neuronal nitric oxide synthase. This reduction may lead to impaired regulation of the vasoconstrictor response and eventual muscle damage.

journal_name

Nat Med

journal_title

Nature medicine

authors

Crosbie RH

doi

10.1038/83309

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

27-9

issue

1

eissn

1078-8956

issn

1546-170X

journal_volume

7

pub_type

杂志文章
  • A GABAergic system in airway epithelium is essential for mucus overproduction in asthma.

    abstract::Gamma-aminobutyric acid (GABA) is an important neurotransmitter that, through the subtype A GABA receptor (GABAAR), induces inhibition in the adult brain. Here we show that an excitatory, rather than inhibitory, GABAergic system exists in airway epithelial cells. Both GABAARs and the GABA synthetic enzyme glutamic aci...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm1604

    authors: Xiang YY,Wang S,Liu M,Hirota JA,Li J,Ju W,Fan Y,Kelly MM,Ye B,Orser B,O'Byrne PM,Inman MD,Yang X,Lu WY

    更新日期:2007-07-01 00:00:00

  • Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure.

    abstract::Endothelial dysfunction is a critical factor in many cardiovascular diseases, including hypertension. Although lipid signaling has been implicated in endothelial dysfunction and cardiovascular disease, specific molecular mechanisms are poorly understood. Here we report that Nogo-B, a membrane protein of the endoplasmi...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm.3934

    authors: Cantalupo A,Zhang Y,Kothiya M,Galvani S,Obinata H,Bucci M,Giordano FJ,Jiang XC,Hla T,Di Lorenzo A

    更新日期:2015-09-01 00:00:00

  • Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity.

    abstract::Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapy for hematological malignancies. However, graft-versus-host disease (GVHD) and relapse after allo-HSCT remain major impediments to the success of allo-HSCT. Chimeric antigen receptors (CARs) direct tumor cell recognition of...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm.4258

    authors: Ghosh A,Smith M,James SE,Davila ML,Velardi E,Argyropoulos KV,Gunset G,Perna F,Kreines FM,Levy ER,Lieberman S,Jay HV,Tuckett AZ,Zakrzewski JL,Tan L,Young LF,Takvorian K,Dudakov JA,Jenq RR,Hanash AM,Motta AC,Murph

    更新日期:2017-02-01 00:00:00

  • Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury.

    abstract::Traumatic spinal cord injury often results in complete loss of voluntary motor and sensory function below the site of injury. The long-term neurological deficits after spinal cord trauma may be due in part to widespread apoptosis of neurons and oligodendroglia in regions distant from and relatively unaffected by the i...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/11387

    authors: Springer JE,Azbill RD,Knapp PE

    更新日期:1999-08-01 00:00:00

  • Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques.

    abstract::The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) is of global concern: the virus has caused severe respiratory illness, with 111 confirmed cases and 52 deaths at the time of this article's publication. Therapeutic interventions have not been evaluated in vivo; thus, patient management relies ex...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm.3362

    authors: Falzarano D,de Wit E,Rasmussen AL,Feldmann F,Okumura A,Scott DP,Brining D,Bushmaker T,Martellaro C,Baseler L,Benecke AG,Katze MG,Munster VJ,Feldmann H

    更新日期:2013-10-01 00:00:00

  • Restoration of cytomegalovirus-specific CD4+ T-lymphocyte responses after ganciclovir and highly active antiretroviral therapy in individuals infected with HIV-1.

    abstract::Recent studies of subjects infected with human immunodeficiency virus (HIV-1) have produced conflicting results about the extent of reconstitution possible in the CD4+ lymphocyte repertoire after highly active antiretroviral therapy (HAART). The effect of HAART on the incidence of opportunistic infections will probabl...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm0898-953

    authors: Komanduri KV,Viswanathan MN,Wieder ED,Schmidt DK,Bredt BM,Jacobson MA,McCune JM

    更新日期:1998-08-01 00:00:00

  • Somatic cell cloned transgenic bovine neurons for transplantation in parkinsonian rats.

    abstract::Parkinson's disease symptoms can be improved by transplanting fetal dopamine cells into the putamen of parkinsonian patients. Because the supply of human donor tissue is limited and variable, an alternative and genetically modifiable non-human source of tissue would be valuable. We have generated cloned transgenic bov...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm0598-569

    authors: Zawada WM,Cibelli JB,Choi PK,Clarkson ED,Golueke PJ,Witta SE,Bell KP,Kane J,Ponce de Leon FA,Jerry DJ,Robl JM,Freed CR,Stice SL

    更新日期:1998-05-01 00:00:00

  • rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice.

    abstract::Mice carrying mutations in both the dystrophin and utrophin genes die prematurely as a consequence of severe muscular dystrophy. Here, we show that intravascular administration of recombinant adeno-associated viral (rAAV) vectors carrying a microdystrophin gene restores expression of dystrophin in the respiratory, car...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm1439

    authors: Gregorevic P,Allen JM,Minami E,Blankinship MJ,Haraguchi M,Meuse L,Finn E,Adams ME,Froehner SC,Murry CE,Chamberlain JS

    更新日期:2006-07-01 00:00:00

  • Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity.

    abstract::Immune sensing of a microbe occurs via multiple receptors. How signals from different receptors are coordinated to yield a specific immune response is poorly understood. We show that two pathogen recognition receptors, Toll-like receptor 2 (TLR2) and dectin-1, recognizing the same microbial stimulus, stimulate distinc...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm.1925

    authors: Manicassamy S,Ravindran R,Deng J,Oluoch H,Denning TL,Kasturi SP,Rosenthal KM,Evavold BD,Pulendran B

    更新日期:2009-04-01 00:00:00

  • Aminoglycoside antibiotics restore CFTR function by overcoming premature stop mutations.

    abstract::Cystic fibrosis (CF) is caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR). A single recessive mutation, the deletion of phenylalanine 508 (deltaF508), causes severe CF and resides on 70% of mutant chromosomes. Severe CF is also caused by premature stop mutations, which are foun...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm0496-467

    authors: Howard M,Frizzell RA,Bedwell DM

    更新日期:1996-04-01 00:00:00

  • ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents.

    abstract::The 55-kilodalton (kDa) protein from the E1B-region of adenovirus binds to and inactivates the p53 gene, which is mutated in half of human cancers. We have previously shown that the replication and cytopathogenicity of an E1B, 55-kDa gene-attenuated adenovirus, ONYX-015, is blocked by functional p53 in RKO and U20S ca...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm0697-639

    authors: Heise C,Sampson-Johannes A,Williams A,McCormick F,Von Hoff DD,Kirn DH

    更新日期:1997-06-01 00:00:00

  • Up against the wall.

    abstract::The notoriously drug-resistant bug MRSA has made headlines for years, but a whole other class of bacteria may prove even more troublesome. These microbes, Gram-negative bacteria, are increasingly a threat--and yet not a single late-stage drug in development specifically targets them. Christian Torres follows one man's...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm0610-628

    authors: Torres C

    更新日期:2010-06-01 00:00:00

  • Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia.

    abstract::Spinal sensorimotor networks that are functionally disconnected from the brain because of spinal cord injury (SCI) can be facilitated via epidural electrical stimulation (EES) to restore robust, coordinated motor activity in humans with paralysis1-3. Previously, we reported a clinical case of complete sensorimotor par...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-018-0175-7

    authors: Gill ML,Grahn PJ,Calvert JS,Linde MB,Lavrov IA,Strommen JA,Beck LA,Sayenko DG,Van Straaten MG,Drubach DI,Veith DD,Thoreson AR,Lopez C,Gerasimenko YP,Edgerton VR,Lee KH,Zhao KD

    更新日期:2018-11-01 00:00:00

  • Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy.

    abstract::Peripheral nerve injuries represent a significant problem in public health, constituting 2-5% of all trauma cases1. For severe nerve injuries, even advanced forms of clinical intervention often lead to incomplete and unsatisfactory motor and/or sensory function2. Numerous studies report the potential of pharmacologica...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-018-0196-2

    authors: Koo J,MacEwan MR,Kang SK,Won SM,Stephen M,Gamble P,Xie Z,Yan Y,Chen YY,Shin J,Birenbaum N,Chung S,Kim SB,Khalifeh J,Harburg DV,Bean K,Paskett M,Kim J,Zohny ZS,Lee SM,Zhang R,Luo K,Ji B,Banks A,Lee HM,Hua

    更新日期:2018-12-01 00:00:00

  • Resistance to TRK inhibition mediated by convergent MAPK pathway activation.

    abstract::TRK fusions are found in a variety of cancer types, lead to oncogenic addiction, and strongly predict tumor-agnostic efficacy of TRK inhibition1-8. With the recent approval of the first selective TRK inhibitor, larotrectinib, for patients with any TRK-fusion-positive adult or pediatric solid tumor, to identify mechani...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-019-0542-z

    authors: Cocco E,Schram AM,Kulick A,Misale S,Won HH,Yaeger R,Razavi P,Ptashkin R,Hechtman JF,Toska E,Cownie J,Somwar R,Shifman S,Mattar M,Selçuklu SD,Samoila A,Guzman S,Tuch BB,Ebata K,de Stanchina E,Nagy RJ,Lanman RB,

    更新日期:2019-09-01 00:00:00

  • Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis.

    abstract::Osteoarthritis is a highly prevalent and debilitating joint disorder. There is no effective medical therapy for the condition because of limited understanding of its pathogenesis. We show that transforming growth factor β1 (TGF-β1) is activated in subchondral bone in response to altered mechanical loading in an anteri...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm.3143

    authors: Zhen G,Wen C,Jia X,Li Y,Crane JL,Mears SC,Askin FB,Frassica FJ,Chang W,Yao J,Carrino JA,Cosgarea A,Artemov D,Chen Q,Zhao Z,Zhou X,Riley L,Sponseller P,Wan M,Lu WW,Cao X

    更新日期:2013-06-01 00:00:00

  • Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection.

    abstract::Understanding the pathophysiology of SARS-CoV-2 infection is critical for therapeutic and public health strategies. Viral-host interactions can guide discovery of disease regulators, and protein structure function analysis points to several immune pathways, including complement and coagulation, as targets of coronavir...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-020-1021-2

    authors: Ramlall V,Thangaraj PM,Meydan C,Foox J,Butler D,Kim J,May B,De Freitas JK,Glicksberg BS,Mason CE,Tatonetti NP,Shapira SD

    更新日期:2020-10-01 00:00:00

  • Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.

    abstract::Immunization of transgenic mouse models of Alzheimer disease using amyloid-beta peptide (Abeta) reduces both the Alzheimer disease-like neuropathology and the spatial memory impairments of these mice. However, a therapeutic trial of immunization with Abeta42 in humans was discontinued because a few patients developed ...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm790

    authors: McLaurin J,Cecal R,Kierstead ME,Tian X,Phinney AL,Manea M,French JE,Lambermon MH,Darabie AA,Brown ME,Janus C,Chishti MA,Horne P,Westaway D,Fraser PE,Mount HT,Przybylski M,St George-Hyslop P

    更新日期:2002-11-01 00:00:00

  • Elimination of Ehrlich tumours by ATP-induced growth inhibition, glutathione depletion and X-rays.

    abstract::ATP-induced tumour growth inhibition is accompanied by a selective decrease in the content of the tripeptide glutathione (GSH) within the cancer cells in vivo. Depletion of cellular GSH sensitizes tumours to chemotherapy and radiation, but the usefulness of this depletion depends on whether the levels of GSH can be re...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm0195-84

    authors: Estrela JM,Obrador E,Navarro J,Lasso De la Vega MC,Pellicer JA

    更新日期:1995-01-01 00:00:00

  • Akt2 relaxes podocytes in chronic kidney disease.

    abstract::A signaling cascade is activated in podocytes to induce survival and cope with stress during advanced glomerular disease, a new study shows. The findings may also explain why the immunosuppressor sirolimus, an inhibitor of this pathway, can cause proteinuria in a subset of patients with chronic kidney disease (pages 1...

    journal_title:Nature medicine

    pub_type: 评论,新闻

    doi:10.1038/nm.3357

    authors: Reiser J

    更新日期:2013-10-01 00:00:00

  • Reduction of serum cholesterol in Watanabe rabbits by xenogeneic hepatocellular transplantation.

    abstract::Transplantation of xenogeneic hepatocytes would provide a novel therapy for liver disease and would help to solve the problem of an insufficient supply of donor organs. We have tested whether xenogeneic cells infused into the liver could correct the metabolic defect in the Watanable heritable hyperlipidemic (WHHL) rab...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm0197-48

    authors: Gunsalus JR,Brady DA,Coulter SM,Gray BM,Edge AS

    更新日期:1997-01-01 00:00:00

  • Re-engineered CD40 receptor enables potent pharmacological activation of dendritic-cell cancer vaccines in vivo.

    abstract::Modest clinical outcomes of dendritic-cell (DC) vaccine trials call for the refinement of DC vaccine design. Although many potential antigens have been identified, development of methods to enhance antigen presentation by DCs has lagged. We have engineered a potent, drug-inducible CD40 (iCD40) receptor that permits te...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm1183

    authors: Hanks BA,Jiang J,Singh RA,Song W,Barry M,Huls MH,Slawin KM,Spencer DM

    更新日期:2005-02-01 00:00:00

  • Translational control of tumor immune escape via the eIF4F-STAT1-PD-L1 axis in melanoma.

    abstract::Preventing the immune escape of tumor cells by blocking inhibitory checkpoints, such as the interaction between programmed death ligand-1 (PD-L1) and programmed death-1 (PD-1) receptor, is a powerful anticancer approach. However, many patients do not respond to checkpoint blockade. Tumor PD-L1 expression is a potentia...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/s41591-018-0217-1

    authors: Cerezo M,Guemiri R,Druillennec S,Girault I,Malka-Mahieu H,Shen S,Allard D,Martineau S,Welsch C,Agoussi S,Estrada C,Adam J,Libenciuc C,Routier E,Roy S,Désaubry L,Eggermont AM,Sonenberg N,Scoazec JY,Eychène A,Vagner

    更新日期:2018-12-01 00:00:00

  • Antisense targeting of basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanomas blocks intratumoral angiogenesis and tumor growth.

    abstract::Unlike normal melanocytes, primary and metastatic human melanomas express high levels of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 (FGFR-1) messenger RNA, and expression of these genes is essential in sustaining the proliferation of malignant melanomas in vitro. To determine whether...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm0897-887

    authors: Wang Y,Becker D

    更新日期:1997-08-01 00:00:00

  • A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice.

    abstract::The balance between detrimental, pro-aging, often stochastic processes and counteracting homeostatic mechanisms largely determines the progression of aging. There is substantial evidence suggesting that the endocannabinoid system (ECS) is part of the latter system because it modulates the physiological processes under...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm.4311

    authors: Bilkei-Gorzo A,Albayram O,Draffehn A,Michel K,Piyanova A,Oppenheimer H,Dvir-Ginzberg M,Rácz I,Ulas T,Imbeault S,Bab I,Schultze JL,Zimmer A

    更新日期:2017-06-01 00:00:00

  • Bimoclomol: a nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects.

    abstract::Preservation of the chemical architecture of a cell or of an organism under changing and perhaps stressful conditions is termed homeostasis. An integral feature of homeostasis is the rapid expression of genes whose products are specifically dedicated to protect cellular functions against stress. One of the best known ...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm1097-1150

    authors: Vígh L,Literáti PN,Horváth I,Török Z,Balogh G,Glatz A,Kovács E,Boros I,Ferdinándy P,Farkas B,Jaszlits L,Jednákovits A,Korányi L,Maresca B

    更新日期:1997-10-01 00:00:00

  • Publisher Correction: Responding to the hidden pandemic for healthcare workers: stress.

    abstract::A Correction to this paper has been published: https://doi.org/10.1038/s41591-020-01176-7. ...

    journal_title:Nature medicine

    pub_type: 已发布勘误

    doi:10.1038/s41591-020-01176-7

    authors: Krystal JH

    更新日期:2020-12-01 00:00:00

  • Studying clonal dynamics in response to cancer therapy using high-complexity barcoding.

    abstract::Resistance to cancer therapies presents a significant clinical challenge. Recent studies have revealed intratumoral heterogeneity as a source of therapeutic resistance. However, it is unclear whether resistance is driven predominantly by pre-existing or de novo alterations, in part because of the resolution limits of ...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm.3841

    authors: Bhang HE,Ruddy DA,Krishnamurthy Radhakrishna V,Caushi JX,Zhao R,Hims MM,Singh AP,Kao I,Rakiec D,Shaw P,Balak M,Raza A,Ackley E,Keen N,Schlabach MR,Palmer M,Leary RJ,Chiang DY,Sellers WR,Michor F,Cooke VG,Korn JM

    更新日期:2015-05-01 00:00:00

  • GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes.

    abstract::GLUT4, the insulin-responsive glucose transporter, plays an important role in postprandial glucose disposal. Altered GLUT4 activity is suggested to be one of the factors responsible for decreased glucose uptake in muscle and adipose tissue in obesity and diabetes. To assess the effect of GLUT4 expression on whole-body...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm1097-1096

    authors: Stenbit AE,Tsao TS,Li J,Burcelin R,Geenen DL,Factor SM,Houseknecht K,Katz EB,Charron MJ

    更新日期:1997-10-01 00:00:00

  • Novel role of human CD4 molecule identified in neurodegeneration.

    abstract::The human CD4 molecule (hCD4) is expressed on T lymphocytes and macrophages and acts as a key component of the cellular receptor for HIV. At baseline, hCD4 transgenic mice expressed hCD4 on microglia, the resident mononuclear phagocytes of the brain, and showed no neuronal damage. Activation of brain microglia by peri...

    journal_title:Nature medicine

    pub_type: 杂志文章

    doi:10.1038/nm0498-441

    authors: Buttini M,Westland CE,Masliah E,Yafeh AM,Wyss-Coray T,Mucke L

    更新日期:1998-04-01 00:00:00