Limited CD4+ T-cell renewal in early HIV-1 infection: effect of highly active antiretroviral therapy.

abstract：:HIV-specific mucosal and cellular immunity was analyzed in heterosexual couples discordant for HIV status in serum and in HIV-unexposed controls. HIV-specific IgA but not IgG was present in urine and vaginal wash samples from HIV-exposed seronegative individuals (ESN), whereas both IgA and IgG were observed in their H...

journal_title：Nature medicine

authors： Mazzoli S,Trabattoni D,Lo Caputo S,Piconi S,Blé C,Meacci F,Ruzzante S,Salvi A,Semplici F,Longhi R,Fusi ML,Tofani N,Biasin M,Villa ML,Mazzotta F,Clerici M

更新日期：1997-11-01 00:00:00

abstract：:Regulatory T cells (T(reg) cells) suppress autoreactive immune responses and limit the efficacy of tumor vaccines; however, it remains a challenge to selectively eliminate or inhibit T(reg) cells. In this study, the zinc-finger A20, a negative regulator of the Toll-like receptor and tumor necrosis factor receptor sign...

journal_title：Nature medicine

authors： Song XT,Evel-Kabler K,Shen L,Rollins L,Huang XF,Chen SY

更新日期：2008-03-01 00:00:00

abstract：:Chondrocyte hypertrophy followed by cartilage matrix degradation and vascular invasion, characterized by expression of type X collagen (COL10A1), matrix metalloproteinase-13 (MMP-13) and vascular endothelial growth factor (VEGF), respectively, are central steps of endochondral ossification during normal skeletal growt...

journal_title：Nature medicine

authors： Saito T,Fukai A,Mabuchi A,Ikeda T,Yano F,Ohba S,Nishida N,Akune T,Yoshimura N,Nakagawa T,Nakamura K,Tokunaga K,Chung UI,Kawaguchi H

更新日期：2010-06-01 00:00:00

abstract：:Cells from the telomerase knockout mouse immortalize with an approximately ten million-fold greater frequency than human cells. In this commentary, Wright and Shay discuss the implications of this difference between mice and men and its relationship to cancer. ...

journal_title：Nature medicine

authors： Wright WE,Shay JW

更新日期：2000-08-01 00:00:00

abstract：:Animal allergens are an important cause of asthma and allergic rhinitis. We designed and tested a chimeric human-cat fusion protein composed of a truncated human IgG Fcgamma1 and the major cat allergen Fel d1, as a proof of concept for a new approach to allergy immunotherapy. This Fcgamma-Fel d1 protein induced dose-d...

journal_title：Nature medicine

authors： Zhu D,Kepley CL,Zhang K,Terada T,Yamada T,Saxon A

更新日期：2005-04-01 00:00:00

abstract：: ...

journal_title：Nature medicine

authors： Stower H

更新日期：2018-12-01 00:00:00

abstract：:Much has been written about the advantages and disadvantages of various oncology model systems, with the overall finding that these models lack the predictive power required to translate preclinical efficacy into clinical activity. Despite assertions that some preclinical model systems are superior to others, no singl...

journal_title：Nature medicine

authors： Gould SE,Junttila MR,de Sauvage FJ

更新日期：2015-05-01 00:00:00

abstract：:Because of their abundance, resistance to proteolysis, rapid aggregation and neurotoxicity, N-terminally truncated and, in particular, pyroglutamate (pE)-modified Abeta peptides have been suggested as being important in the initiation of pathological cascades resulting in the development of Alzheimer's disease. We fou...

journal_title：Nature medicine

authors： Schilling S,Zeitschel U,Hoffmann T,Heiser U,Francke M,Kehlen A,Holzer M,Hutter-Paier B,Prokesch M,Windisch M,Jagla W,Schlenzig D,Lindner C,Rudolph T,Reuter G,Cynis H,Montag D,Demuth HU,Rossner S

更新日期：2008-10-01 00:00:00

abstract：:Targeting the mammalian target of rapamycin (mTOR) protein is a promising strategy for cancer therapy. The mTOR kinase functions in two complexes, TORC1 (target of rapamycin complex-1) and TORC2 (target of rapamycin complex-2); however, neither of these complexes is fully inhibited by the allosteric inhibitor rapamyci...

journal_title：Nature medicine

authors： Janes MR,Limon JJ,So L,Chen J,Lim RJ,Chavez MA,Vu C,Lilly MB,Mallya S,Ong ST,Konopleva M,Martin MB,Ren P,Liu Y,Rommel C,Fruman DA

更新日期：2010-02-01 00:00:00

abstract：:Oxygen-regulated protein 150 kD (ORP150) is a novel endoplasmic-reticulum-associated chaperone induced by hypoxia/ischemia. Although ORP150 was sparingly upregulated in neurons from human brain undergoing ischemic stress, there was robust induction in astrocytes. Cultured neurons overexpressing ORP150 were resistant t...

journal_title：Nature medicine

authors： Tamatani M,Matsuyama T,Yamaguchi A,Mitsuda N,Tsukamoto Y,Taniguchi M,Che YH,Ozawa K,Hori O,Nishimura H,Yamashita A,Okabe M,Yanagi H,Stern DM,Ogawa S,Tohyama M

更新日期：2001-03-01 00:00:00

abstract：:Although subtypes of pancreatic ductal adenocarcinoma (PDAC) have been described, this malignancy is clinically still treated as a single disease. Here we present patient-derived models representing the full spectrum of previously identified quasi-mesenchymal (QM-PDA), classical and exocrine-like PDAC subtypes, and id...

journal_title：Nature medicine

authors： Noll EM,Eisen C,Stenzinger A,Espinet E,Muckenhuber A,Klein C,Vogel V,Klaus B,Nadler W,Rösli C,Lutz C,Kulke M,Engelhardt J,Zickgraf FM,Espinosa O,Schlesner M,Jiang X,Kopp-Schneider A,Neuhaus P,Bahra M,Sinn BV,Eil

更新日期：2016-03-01 00:00:00

abstract：:Exercise has numerous health-promoting effects in humans; however, individual responsiveness to exercise with regard to endurance or metabolic health differs markedly. This 'exercise resistance' is considered to be congenital, with no evident acquired causative factors. Here we show that the anti-oxidative hepatokine ...

journal_title：Nature medicine

authors： Misu H,Takayama H,Saito Y,Mita Y,Kikuchi A,Ishii KA,Chikamoto K,Kanamori T,Tajima N,Lan F,Takeshita Y,Honda M,Tanaka M,Kato S,Matsuyama N,Yoshioka Y,Iwayama K,Tokuyama K,Akazawa N,Maeda S,Takekoshi K,Matsugo S,

更新日期：2017-04-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature medicine

authors： Charney AW,Simons NW,Mouskas K,Lepow L,Cheng E,Le Berichel J,Chang C,Marvin R,Del Valle DM,Calorossi S,Lansky A,Walker L,Patel M,Xie H,Yi N,Yu A,Kang G,Liharska LE,Moya E,Hartnett M,Hatem S,Wilkins L,Eaton M,

更新日期：2020-09-01 00:00:00

abstract：:In the version of this article originally published, Dimitry G. Sayenko's affiliations were not correct. The following affiliation for this author was missing: Department of Neurosurgery, Center for Neuroregeneration, Houston Methodist Research Institute, Houston, TX, USA. This affiliation has been added for the autho...

journal_title：Nature medicine

authors： Gill ML,Grahn PJ,Calvert JS,Linde MB,Lavrov IA,Strommen JA,Beck LA,Sayenko DG,Van Straaten MG,Drubach DI,Veith DD,Thoreson AR,Lopez C,Gerasimenko YP,Edgerton VR,Lee KH,Zhao KD

更新日期：2018-12-01 00:00:00

abstract：:The immune-modulating cytokine interleukin-6 (IL-6) is expressed both in adipose tissue and centrally in hypothalamic nuclei that regulate body composition. We investigated the impact of loss of IL-6 on body composition in mice lacking the gene encoding IL-6 (Il6-/- mice) and found that they developed mature-onset obe...

journal_title：Nature medicine

authors： Wallenius V,Wallenius K,Ahrén B,Rudling M,Carlsten H,Dickson SL,Ohlsson C,Jansson JO

更新日期：2002-01-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapy for hematological malignancies. However, graft-versus-host disease (GVHD) and relapse after allo-HSCT remain major impediments to the success of allo-HSCT. Chimeric antigen receptors (CARs) direct tumor cell recognition of...

journal_title：Nature medicine

authors： Ghosh A,Smith M,James SE,Davila ML,Velardi E,Argyropoulos KV,Gunset G,Perna F,Kreines FM,Levy ER,Lieberman S,Jay HV,Tuckett AZ,Zakrzewski JL,Tan L,Young LF,Takvorian K,Dudakov JA,Jenq RR,Hanash AM,Motta AC,Murph

更新日期：2017-02-01 00:00:00

abstract：:The TAM receptors Tyro3, Axl and Mertk are receptor tyrosine kinases that dampen host innate immune responses following engagement with their ligands Gas6 and Protein S, which recognize phosphatidylserine on apoptotic cells. In a form of apoptotic mimicry, many enveloped viruses display phosphatidylserine on the outer...

journal_title：Nature medicine

authors： Miner JJ,Daniels BP,Shrestha B,Proenca-Modena JL,Lew ED,Lazear HM,Gorman MJ,Lemke G,Klein RS,Diamond MS

更新日期：2015-12-01 00:00:00

abstract：:Retinoic acid and arsenic trioxide target the protein stability and transcriptional repression activity of the fusion oncoprotein PML-RARA, resulting in regression of acute promyelocytic leukemia (APL). Phenotypically, retinoic acid induces differentiation of APL cells. Here we show that retinoic acid also triggers gr...

journal_title：Nature medicine

authors： Nasr R,Guillemin MC,Ferhi O,Soilihi H,Peres L,Berthier C,Rousselot P,Robledo-Sarmiento M,Lallemand-Breitenbach V,Gourmel B,Vitoux D,Pandolfi PP,Rochette-Egly C,Zhu J,de Thé H

更新日期：2008-12-01 00:00:00

abstract：:The World Health Organization estimates that tobacco will become the largest single health problem by 2020, causing an estimated 8.4 million deaths annually. But the smoking burden will not be distributed evenly across the globe; deaths in developed nations are set to rise 50% to 2.4 million while those in Asia will s...

journal_title：Nature medicine

authors： Raw M

更新日期：2001-01-01 00:00:00

abstract：:Viral replication and microbial translocation from the gut to the blood during HIV infection lead to hyperimmune activation, which contributes to the decline in CD4+ T cell numbers during HIV infection. Programmed death-1 (PD-1) and interleukin-10 (IL-10) are both upregulated during HIV infection. Blocking interaction...

journal_title：Nature medicine

authors： Said EA,Dupuy FP,Trautmann L,Zhang Y,Shi Y,El-Far M,Hill BJ,Noto A,Ancuta P,Peretz Y,Fonseca SG,Van Grevenynghe J,Boulassel MR,Bruneau J,Shoukry NH,Routy JP,Douek DC,Haddad EK,Sekaly RP

更新日期：2010-04-01 00:00:00

abstract：:Drug-induced liver injury (DILI) is a leading cause of termination in drug development programs and removal of drugs from the market; this is partially due to the inability to identify patients who are at risk1. In this study, we developed a polygenic risk score (PRS) for DILI by aggregating effects of numerous genome...

journal_title：Nature medicine

authors： Koido M,Kawakami E,Fukumura J,Noguchi Y,Ohori M,Nio Y,Nicoletti P,Aithal GP,Daly AK,Watkins PB,Anayama H,Dragan Y,Shinozawa T,Takebe T

更新日期：2020-10-01 00:00:00

abstract：:After transplantation of primarily vascularized xenografts (Xgs), T-independent mechanisms may lead to Xg rejection before T-cell activation even takes place. The possibility of achieving T-independent xenotolerance was evaluated in nude rats that normally reject hamster cardiac Xgs within 4 days by non-T cell-mediate...

journal_title：Nature medicine

authors： Lin Y,Goebels J,Xia G,Ji P,Vandeputte M,Waer M

更新日期：1998-02-01 00:00:00

abstract：:How high salt intake increases blood pressure is a key question in the study of hypertension. Salt intake induces increased renal sympathetic activity resulting in sodium retention. However, the mechanisms underlying the sympathetic control of renal sodium excretion remain unclear. In this study, we found that β(2)-ad...

journal_title：Nature medicine

authors： Mu S,Shimosawa T,Ogura S,Wang H,Uetake Y,Kawakami-Mori F,Marumo T,Yatomi Y,Geller DS,Tanaka H,Fujita T

更新日期：2011-05-01 00:00:00

abstract：:The use of genetically manipulated mouse models, gene and protein discovery and the cataloguing of genetic mutations have each allowed us to obtain new insights into skeletal morphogenesis and remodeling. These techniques have made it possible to identify molecules that are obligatory for specific cellular functions, ...

journal_title：Nature medicine

authors： Zaidi M

更新日期：2007-07-01 00:00:00

abstract：:TRK fusions are found in a variety of cancer types, lead to oncogenic addiction, and strongly predict tumor-agnostic efficacy of TRK inhibition1-8. With the recent approval of the first selective TRK inhibitor, larotrectinib, for patients with any TRK-fusion-positive adult or pediatric solid tumor, to identify mechani...

journal_title：Nature medicine

authors： Cocco E,Schram AM,Kulick A,Misale S,Won HH,Yaeger R,Razavi P,Ptashkin R,Hechtman JF,Toska E,Cownie J,Somwar R,Shifman S,Mattar M,Selçuklu SD,Samoila A,Guzman S,Tuch BB,Ebata K,de Stanchina E,Nagy RJ,Lanman RB,

更新日期：2019-09-01 00:00:00

abstract：:Glioblastoma is the most common primary central nervous system malignancy and has a poor prognosis. Standard first-line treatment, which includes surgery followed by adjuvant radio-chemotherapy, produces only modest benefits to survival1,2. Here, to explore the feasibility, safety and immunobiological effects of PD-1 ...

journal_title：Nature medicine

authors： Schalper KA,Rodriguez-Ruiz ME,Diez-Valle R,López-Janeiro A,Porciuncula A,Idoate MA,Inogés S,de Andrea C,López-Diaz de Cerio A,Tejada S,Berraondo P,Villarroel-Espindola F,Choi J,Gúrpide A,Giraldez M,Goicoechea I,Gallego Pe

更新日期：2019-03-01 00:00:00

abstract：:Chlamydia trachomatis is the leading cause worldwide of preventable infectious blindness (trachoma) and sexually transmitted disease, including nongonoccocal urethritis and pelvic inflammatory disease. To date, no effective vaccine against C. trachomatis infection has been identified. A monoclonal anti-idiotypic antib...

journal_title：Nature medicine

authors： Whittum-Hudson JA,An LL,Saltzman WM,Prendergast RA,MacDonald AB

更新日期：1996-10-01 00:00:00

abstract：:Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) that compromise its chloride channel activity. The most common mutation, p.Phe508del, results in the production of a misfolded CFTR protein, which has residual channel activity but is prematu...

journal_title：Nature medicine

authors： Romani L,Oikonomou V,Moretti S,Iannitti RG,D'Adamo MC,Villella VR,Pariano M,Sforna L,Borghi M,Bellet MM,Fallarino F,Pallotta MT,Servillo G,Ferrari E,Puccetti P,Kroemer G,Pessia M,Maiuri L,Goldstein AL,Garaci E

更新日期：2017-05-01 00:00:00

abstract：:With an ever increasing number of people taking numerous medications, the need to safely administer drugs and limit unintended side effects has never been greater. Antidote control remains the most direct means to counteract acute side effects of drugs, but, unfortunately, it has been challenging and cost prohibitive ...

journal_title：Nature medicine

authors： Oney S,Lam RT,Bompiani KM,Blake CM,Quick G,Heidel JD,Liu JY,Mack BC,Davis ME,Leong KW,Sullenger BA

更新日期：2009-10-01 00:00:00

abstract：:Hemophilia B is a severe X-linked bleeding diathesis caused by the absence of functional blood coagulation factor IX, and is an excellent candidate for treatment of a genetic disease by gene therapy. Using an adeno-associated viral vector, we demonstrate sustained expression (>17 months) of factor IX in a large-animal...

journal_title：Nature medicine

authors： Herzog RW,Yang EY,Couto LB,Hagstrom JN,Elwell D,Fields PA,Burton M,Bellinger DA,Read MS,Brinkhous KM,Podsakoff GM,Nichols TC,Kurtzman GJ,High KA

更新日期：1999-01-01 00:00:00