Environmental shaping of the microbiome.

abstract：:We describe results from IMmotion150, a randomized phase 2 study of atezolizumab (anti-PD-L1) alone or combined with bevacizumab (anti-VEGF) versus sunitinib in 305 patients with treatment-naive metastatic renal cell carcinoma. Co-primary endpoints were progression-free survival (PFS) in intent-to-treat and PD-L1+ pop...

journal_title：Nature medicine

authors： McDermott DF,Huseni MA,Atkins MB,Motzer RJ,Rini BI,Escudier B,Fong L,Joseph RW,Pal SK,Reeves JA,Sznol M,Hainsworth J,Rathmell WK,Stadler WM,Hutson T,Gore ME,Ravaud A,Bracarda S,Suárez C,Danielli R,Gruenwald V,Ch

更新日期：2018-06-01 00:00:00

abstract：:Cells that are deficient in homologous recombination, such as those that lack functional breast cancer-associated 1 (BRCA1) or BRCA2, are hypersensitive to inhibition of poly(ADP-ribose) polymerase (PARP). However, BRCA-deficient tumors represent only a small fraction of adult cancers, which might restrict the therape...

journal_title：Nature medicine

authors： Johnson N,Li YC,Walton ZE,Cheng KA,Li D,Rodig SJ,Moreau LA,Unitt C,Bronson RT,Thomas HD,Newell DR,D'Andrea AD,Curtin NJ,Wong KK,Shapiro GI

更新日期：2011-06-26 00:00:00

abstract：:Notch receptor signaling is implicated in controlling smooth muscle cell proliferation and in maintaining smooth muscle cells in an undifferentiated state. Pulmonary arterial hypertension is characterized by excessive vascular resistance, smooth muscle cell proliferation in small pulmonary arteries, leading to elevati...

journal_title：Nature medicine

authors： Li X,Zhang X,Leathers R,Makino A,Huang C,Parsa P,Macias J,Yuan JX,Jamieson SW,Thistlethwaite PA

更新日期：2009-11-01 00:00:00

abstract：:Telomerase is a ribonucleoprotein enzyme that maintains the protective structures at the ends of eukaryotic chromosomes, called telomeres. In most human somatic cells, telomerase expression is repressed, and telomeres shorten progressively with each cell division. In contrast, most human tumors express telomerase, res...

journal_title：Nature medicine

authors： Hahn WC,Stewart SA,Brooks MW,York SG,Eaton E,Kurachi A,Beijersbergen RL,Knoll JH,Meyerson M,Weinberg RA

更新日期：1999-10-01 00:00:00

abstract：:Autoimmune T-helper cells drive pathogenic autoantibody production in systemic lupus erythematosus (SLE), but the mechanisms maintaining those T cells are unknown. Autoreactive T cells are normally eliminated by functional inactivation (anergy) and activation-induced cell death (AICD) or apoptosis through death recept...

journal_title：Nature medicine

authors： Xu L,Zhang L,Yi Y,Kang HK,Datta SK

更新日期：2004-04-01 00:00:00

abstract：:A new regulatory pathway established last year allows drugs with dramatic early clinical promise to be expedited to the market quicker than ever before. To date, most of these 'breakthrough' designations have gone to cancer agents, raising the prospect of faster access to the latest lifesaving therapies for the estima...

journal_title：Nature medicine

authors： Dolgin E

更新日期：2013-06-01 00:00:00

abstract：:Alzheimer's disease is a progressive and incurable disease whose prevalence increases dramatically with age. A biochemical marker for monitoring the onset and progression of the disease would be a valuable tool for disease management. In addition, such a marker might be used as an end point in clinical intervention pr...

journal_title：Nature medicine

authors： Kennard ML,Feldman H,Yamada T,Jefferies WA

更新日期：1996-11-01 00:00:00

abstract：:The TAM receptors Tyro3, Axl and Mertk are receptor tyrosine kinases that dampen host innate immune responses following engagement with their ligands Gas6 and Protein S, which recognize phosphatidylserine on apoptotic cells. In a form of apoptotic mimicry, many enveloped viruses display phosphatidylserine on the outer...

journal_title：Nature medicine

authors： Miner JJ,Daniels BP,Shrestha B,Proenca-Modena JL,Lew ED,Lazear HM,Gorman MJ,Lemke G,Klein RS,Diamond MS

更新日期：2015-12-01 00:00:00

abstract：:The ubiquitin-proteasome pathway is the central mediator of regulated proteolysis in cells, and defects in this pathway are associated with cancer and neurodegenerative diseases. To assess 26S proteasome function in living animals, we developed a ubiquitin-luciferase reporter for bioluminescence imaging. The reporter ...

journal_title：Nature medicine

authors： Luker GD,Pica CM,Song J,Luker KE,Piwnica-Worms D

更新日期：2003-07-01 00:00:00

abstract：:Altered metabolism has been implicated in the pathogenesis of inflammatory diseases. NADPH oxidase 4 (NOX4), a source of cellular superoxide anions, has multiple biological functions that may be of importance in inflammation and in the pathogenesis of human metabolic diseases, including diabetes. However, the mechanis...

journal_title：Nature medicine

authors： Moon JS,Nakahira K,Chung KP,DeNicola GM,Koo MJ,Pabón MA,Rooney KT,Yoon JH,Ryter SW,Stout-Delgado H,Choi AM

更新日期：2016-09-01 00:00:00

abstract：:Some individuals remain uninfected with human immunodeficiency virus type-1 (HIV-1) despite multiple high-risk sexual exposures. We studied a cohort of 25 subjects with histories of multiple high-risk sexual exposures to HIV-1 and found that their CD8+ lymphocytes had greater anti-HIV-1 activity than did CD8+ lymphocy...

journal_title：Nature medicine

authors： Paxton WA,Martin SR,Tse D,O'Brien TR,Skurnick J,VanDevanter NL,Padian N,Braun JF,Kotler DP,Wolinsky SM,Koup RA

更新日期：1996-04-01 00:00:00

abstract：:The molecular alterations that occur in cells before cancer is manifest are largely uncharted. Lung carcinoma in situ (CIS) lesions are the pre-invasive precursor to squamous cell carcinoma. Although microscopically identical, their future is in equipoise, with half progressing to invasive cancer and half regressing o...

journal_title：Nature medicine

authors： Teixeira VH,Pipinikas CP,Pennycuick A,Lee-Six H,Chandrasekharan D,Beane J,Morris TJ,Karpathakis A,Feber A,Breeze CE,Ntolios P,Hynds RE,Falzon M,Capitanio A,Carroll B,Durrenberger PF,Hardavella G,Brown JM,Lynch AG,Fa

更新日期：2019-03-01 00:00:00

abstract：:Idiopathic voiding disorders affect up to 10-15% of men and women. We describe bladder abnormalities in mice with targeted deletion of the gene for neuronal nitric oxide synthase which model the clinical disorders. The mice possess hypertrophic dilated bladders and dysfunctional urinary outlets which do not relax in r...

journal_title：Nature medicine

authors： Burnett AL,Calvin DC,Chamness SL,Liu JX,Nelson RJ,Klein SL,Dawson VL,Dawson TM,Snyder SH

更新日期：1997-05-01 00:00:00

abstract：:Hematopoietic stem and progenitor cells (HSPC) are endowed with the role of generating and maintaining lifelong the extremely diverse pool of blood cells1. Clinically, transplantation of human HSPC from an allogeneic healthy donor or infusion of autologous gene-corrected HSPC can effectively replenish defective blood ...

journal_title：Nature medicine

authors： Scala S,Basso-Ricci L,Dionisio F,Pellin D,Giannelli S,Salerio FA,Leonardelli L,Cicalese MP,Ferrua F,Aiuti A,Biasco L

更新日期：2018-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder involving the florid deposition of vascular and cerebral plaques composed chiefly of amyloid beta-peptide (A beta) derived from cleavage of the amyloid precursor protein (APP). Varying in length from 39 to 43 amino acids, A beta, particularly the longer A beta(4...

journal_title：Nature medicine

authors： Cook DG,Forman MS,Sung JC,Leight S,Kolson DL,Iwatsubo T,Lee VM,Doms RW

更新日期：1997-09-01 00:00:00

abstract：:Approximately 1-5% of breast cancers are attributed to inherited mutations in BRCA1 or BRCA2 and are selectively sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. In other cancer types, germline and/or somatic mutations in BRCA1 and/or BRCA2 (BRCA1/BRCA2) also confer selective sensitivity to PARP inhibitors....

journal_title：Nature medicine

authors： Davies H,Glodzik D,Morganella S,Yates LR,Staaf J,Zou X,Ramakrishna M,Martin S,Boyault S,Sieuwerts AM,Simpson PT,King TA,Raine K,Eyfjord JE,Kong G,Borg Å,Birney E,Stunnenberg HG,van de Vijver MJ,Børresen-Dale AL,Ma

更新日期：2017-04-01 00:00:00

abstract：:Metastasis of breast cancer occurs primarily through the lymphatic system, and the extent of lymph node involvement is a key prognostic factor for the disease. Whereas the significance of angiogenesis for tumor progression has been well documented, the ability of tumor cells to induce the growth of lymphatic vessels (...

journal_title：Nature medicine

authors： Skobe M,Hawighorst T,Jackson DG,Prevo R,Janes L,Velasco P,Riccardi L,Alitalo K,Claffey K,Detmar M

更新日期：2001-02-01 00:00:00

abstract：:Owing to recent medical and technological advances in neonatal care, infants born extremely premature have increased survival rates1,2. After birth, these infants are at high risk of hypoxic episodes because of lung immaturity, hypotension and lack of cerebral-flow regulation, and can develop a severe condition called...

journal_title：Nature medicine

authors： Pașca AM,Park JY,Shin HW,Qi Q,Revah O,Krasnoff R,O'Hara R,Willsey AJ,Palmer TD,Pașca SP

更新日期：2019-05-01 00:00:00

abstract：:Treating KRAS-mutant lung adenocarcinoma (LUAD) remains a major challenge in cancer treatment given the difficulties associated with directly inhibiting the KRAS oncoprotein. One approach to addressing this challenge is to define mutations that frequently co-occur with those in KRAS, which themselves may lead to thera...

journal_title：Nature medicine

authors： Romero R,Sayin VI,Davidson SM,Bauer MR,Singh SX,LeBoeuf SE,Karakousi TR,Ellis DC,Bhutkar A,Sánchez-Rivera FJ,Subbaraj L,Martinez B,Bronson RT,Prigge JR,Schmidt EE,Thomas CJ,Goparaju C,Davies A,Dolgalev I,Heguy A,A

更新日期：2017-11-01 00:00:00

abstract：:Temporal lobe epilepsy is the most prevalent seizure disorder in adults. Compromised inhibitory neurotransmitter function in the hippocampus contributes to the hyperexcitability generating this condition, but the underlying molecular mechanisms are unknown. Combining patch-clamp recording and single-cell mRNA amplific...

journal_title：Nature medicine

authors： Brooks-Kayal AR,Shumate MD,Jin H,Rikhter TY,Coulter DA

更新日期：1998-10-01 00:00:00

abstract：: ...

journal_title：Nature medicine

authors： Stower H

更新日期：2019-02-01 00:00:00

abstract：:To better understand genetic alterations in oral premalignant lesions, we examined 84 oral leukoplakia samples from 37 patients who had been enrolled in a chemoprevention trial. The samples were analyzed for two microsatellite markers located at chromosomes 9p21 and 3p14. Loss of heterozygosity (LOH) at either or both...

journal_title：Nature medicine

authors： Mao L,Lee JS,Fan YH,Ro JY,Batsakis JG,Lippman S,Hittelman W,Hong WK

更新日期：1996-06-01 00:00:00

abstract：:This corrects the article DOI: 10.1038/nm.4439. ...

journal_title：Nature medicine

authors： Bolouri H,Farrar JE,Triche T Jr,Ries RE,Lim EL,Alonzo TA,Ma Y,Moore R,Mungall AJ,Marra MA,Zhang J,Ma X,Liu Y,Liu Y,Auvil JMG,Davidsen TM,Gesuwan P,Hermida LC,Salhia B,Capone S,Ramsingh G,Zwaan CM,Noort S,Pic

更新日期：2018-04-10 00:00:00

abstract：:The cycle of gallbladder filling and emptying controls the flow of bile into the intestine for digestion. Here we show that fibroblast growth factor-15, a hormone made by the distal small intestine in response to bile acids, is required for gallbladder filling. These studies demonstrate that gallbladder filling is act...

journal_title：Nature medicine

authors： Choi M,Moschetta A,Bookout AL,Peng L,Umetani M,Holmstrom SR,Suino-Powell K,Xu HE,Richardson JA,Gerard RD,Mangelsdorf DJ,Kliewer SA

更新日期：2006-11-01 00:00:00

abstract：:Ethylmalonic encephalopathy is caused by mutations in ETHE1, a mitochondrial matrix sulfur dioxygenase, leading to failure to detoxify sulfide, a product of intestinal anaerobes and, in trace amounts, tissues. Metronidazole, a bactericide, or N-acetylcysteine, a precursor of sulfide-buffering glutathione, substantiall...

journal_title：Nature medicine

authors： Viscomi C,Burlina AB,Dweikat I,Savoiardo M,Lamperti C,Hildebrandt T,Tiranti V,Zeviani M

更新日期：2010-08-01 00:00:00

abstract：:CD4-unhelped CD8(+) T cells are functionally defective T cells primed in the absence of CD4(+) T cell help. Given the co-stimulatory role of natural-killer group 2, member D protein (NKG2D) on CD8(+) T cells, we investigated its ability to rescue these immunologically impotent cells. We demonstrate that augmented co-s...

journal_title：Nature medicine

authors： Zloza A,Kohlhapp FJ,Lyons GE,Schenkel JM,Moore TV,Lacek AT,O'Sullivan JA,Varanasi V,Williams JW,Jagoda MC,Bellavance EC,Marzo AL,Thomas PG,Zafirova B,Polić B,Al-Harthi L,Sperling AI,Guevara-Patiño JA

更新日期：2012-02-26 00:00:00

abstract：:The N-terminal fragment of prolactin (16K PRL) inhibits tumor growth by impairing angiogenesis, but the underlying mechanisms are unknown. Here, we found that 16K PRL binds the fibrinolytic inhibitor plasminogen activator inhibitor-1 (PAI-1), which is known to contextually promote tumor angiogenesis and growth. Loss o...

journal_title：Nature medicine

authors： Bajou K,Herkenne S,Thijssen VL,D'Amico S,Nguyen NQ,Bouché A,Tabruyn S,Srahna M,Carabin JY,Nivelles O,Paques C,Cornelissen I,Lion M,Noel A,Gils A,Vinckier S,Declerck PJ,Griffioen AW,Dewerchin M,Martial JA,Carmeliet

更新日期：2014-07-01 00:00:00

abstract：:How high salt intake increases blood pressure is a key question in the study of hypertension. Salt intake induces increased renal sympathetic activity resulting in sodium retention. However, the mechanisms underlying the sympathetic control of renal sodium excretion remain unclear. In this study, we found that β(2)-ad...

journal_title：Nature medicine

authors： Mu S,Shimosawa T,Ogura S,Wang H,Uetake Y,Kawakami-Mori F,Marumo T,Yatomi Y,Geller DS,Tanaka H,Fujita T

更新日期：2011-05-01 00:00:00

abstract：:Alternative splicing ensures the expression of functionally diverse proteins from individual genes; however, aberrant mRNA splicing is associated with various conditions, including heart disease. A recent study provides new mechanistic insights into heart failure by showing that a human cardiomyopathy-linked mutation ...

journal_title：Nature medicine

authors： Linke WA,Bücker S

更新日期：2012-05-04 00:00:00

abstract：:CD4(+) T cells that express the forkhead box P3 (FOXP3) transcription factor function as regulatory T (Treg) cells and hinder effective immune responses against cancer cells. Abundant Treg cell infiltration into tumors is associated with poor clinical outcomes in various types of cancers. However, the role of Treg cel...

journal_title：Nature medicine

authors： Saito T,Nishikawa H,Wada H,Nagano Y,Sugiyama D,Atarashi K,Maeda Y,Hamaguchi M,Ohkura N,Sato E,Nagase H,Nishimura J,Yamamoto H,Takiguchi S,Tanoue T,Suda W,Morita H,Hattori M,Honda K,Mori M,Doki Y,Sakaguchi S

更新日期：2016-06-01 00:00:00