Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposure.

Abstract:

:Some individuals remain uninfected with human immunodeficiency virus type-1 (HIV-1) despite multiple high-risk sexual exposures. We studied a cohort of 25 subjects with histories of multiple high-risk sexual exposures to HIV-1 and found that their CD8+ lymphocytes had greater anti-HIV-1 activity than did CD8+ lymphocytes from nonexposed controls. Further studies indicated that their purified CD4+ lymphocytes were less susceptible to infection with multiple primary isolates of HIV-1 than were CD4+ lymphocytes from the nonexposed controls. This relative resistance to HIV-1 infection did not extend to T-cell line-adapted strains, was restricted by the envelope glycoprotein, was not explained by the cell surface density of CD4 molecules, but was associated with the activity of the C-C chemokines RANTES, MIP-1alpha, and MIP-1beta. This relative resistance of CD4+ lymphocytes may contribute to protection from HIV-1 in multiply exposed persons.

journal_name

Nat Med

journal_title

Nature medicine

authors

Paxton WA,Martin SR,Tse D,O'Brien TR,Skurnick J,VanDevanter NL,Padian N,Braun JF,Kotler DP,Wolinsky SM,Koup RA

doi

10.1038/nm0496-412

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

412-7

issue

4

eissn

1078-8956

issn

1546-170X

journal_volume

2

pub_type

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