Cancer's true breakthroughs.

abstract：:Traditional screening for COVID-19 typically includes survey questions about symptoms and travel history, as well as temperature measurements. Here, we explore whether personal sensor data collected over time may help identify subtle changes indicating an infection, such as in patients with COVID-19. We have developed...

journal_title：Nature medicine

authors： Quer G,Radin JM,Gadaleta M,Baca-Motes K,Ariniello L,Ramos E,Kheterpal V,Topol EJ,Steinhubl SR

更新日期：2021-01-01 00:00:00

abstract：:Preoperative immunotherapy with anti-PD1 plus anti-CTLA4 antibodies has shown remarkable pathological responses in melanoma1 and colorectal cancer2. In NABUCCO (ClinicalTrials.gov: NCT03387761 ), a single-arm feasibility trial, 24 patients with stage III urothelial cancer (UC) received two doses of ipilimumab and two ...

journal_title：Nature medicine

authors： van Dijk N,Gil-Jimenez A,Silina K,Hendricksen K,Smit LA,de Feijter JM,van Montfoort ML,van Rooijen C,Peters D,Broeks A,van der Poel HG,Bruining A,Lubeck Y,Sikorska K,Boellaard TN,Kvistborg P,Vis DJ,Hooijberg E,Schumac

更新日期：2020-12-01 00:00:00

abstract：:Cells from the telomerase knockout mouse immortalize with an approximately ten million-fold greater frequency than human cells. In this commentary, Wright and Shay discuss the implications of this difference between mice and men and its relationship to cancer. ...

journal_title：Nature medicine

authors： Wright WE,Shay JW

更新日期：2000-08-01 00:00:00

abstract：:Transforming growth factor beta 1 (TGF-beta 1) is a platelet-derived cytokine involved in both normal wound healing and scarring. We show that human platelets contain two pools of latent TGF-beta 1, which constitute more than 95% of the total TGF-beta assayed in whole platelets. During clotting, one pool, the large la...

journal_title：Nature medicine

authors： Grainger DJ,Wakefield L,Bethell HW,Farndale RW,Metcalfe JC

更新日期：1995-09-01 00:00:00

abstract：:GLUT4, the insulin-responsive glucose transporter, plays an important role in postprandial glucose disposal. Altered GLUT4 activity is suggested to be one of the factors responsible for decreased glucose uptake in muscle and adipose tissue in obesity and diabetes. To assess the effect of GLUT4 expression on whole-body...

journal_title：Nature medicine

authors： Stenbit AE,Tsao TS,Li J,Burcelin R,Geenen DL,Factor SM,Houseknecht K,Katz EB,Charron MJ

更新日期：1997-10-01 00:00:00

abstract：:Given the variation in the HIV-1 viral load (VL) set point across subjects, as opposed to a fairly stable VL over time within an infected individual, it is important to identify the characteristics of the host and virus that affect VL set point. Although recently infected individuals with multiple phylogenetically lin...

journal_title：Nature medicine

authors： Janes H,Herbeck JT,Tovanabutra S,Thomas R,Frahm N,Duerr A,Hural J,Corey L,Self SG,Buchbinder SP,McElrath MJ,O'Connell RJ,Paris RM,Rerks-Ngarm S,Nitayaphan S,Pitisuttihum P,Kaewkungwal J,Robb ML,Michael NL,Mullins JI

更新日期：2015-10-01 00:00:00

abstract：:Immune sensing of a microbe occurs via multiple receptors. How signals from different receptors are coordinated to yield a specific immune response is poorly understood. We show that two pathogen recognition receptors, Toll-like receptor 2 (TLR2) and dectin-1, recognizing the same microbial stimulus, stimulate distinc...

journal_title：Nature medicine

authors： Manicassamy S,Ravindran R,Deng J,Oluoch H,Denning TL,Kasturi SP,Rosenthal KM,Evavold BD,Pulendran B

更新日期：2009-04-01 00:00:00

abstract：:The immune-modulating cytokine interleukin-6 (IL-6) is expressed both in adipose tissue and centrally in hypothalamic nuclei that regulate body composition. We investigated the impact of loss of IL-6 on body composition in mice lacking the gene encoding IL-6 (Il6-/- mice) and found that they developed mature-onset obe...

journal_title：Nature medicine

authors： Wallenius V,Wallenius K,Ahrén B,Rudling M,Carlsten H,Dickson SL,Ohlsson C,Jansson JO

更新日期：2002-01-01 00:00:00

abstract：:Human liver cancer research currently lacks in vitro models that can faithfully recapitulate the pathophysiology of the original tumor. We recently described a novel, near-physiological organoid culture system, wherein primary human healthy liver cells form long-term expanding organoids that retain liver tissue functi...

journal_title：Nature medicine

authors： Broutier L,Mastrogiovanni G,Verstegen MM,Francies HE,Gavarró LM,Bradshaw CR,Allen GE,Arnes-Benito R,Sidorova O,Gaspersz MP,Georgakopoulos N,Koo BK,Dietmann S,Davies SE,Praseedom RK,Lieshout R,IJzermans JNM,Wigmore SJ,

更新日期：2017-12-01 00:00:00

abstract：:Platelet-activating factor (PAF) induces pulmonary edema and has a key role in acute lung injury (ALI). Here we show that PAF induces pulmonary edema through two mechanisms: acid sphingomyelinase (ASM)-dependent production of ceramide, and activation of the cyclooxygenase pathway. Agents that interfere with PAF-induce...

journal_title：Nature medicine

authors： Göggel R,Winoto-Morbach S,Vielhaber G,Imai Y,Lindner K,Brade L,Brade H,Ehlers S,Slutsky AS,Schütze S,Gulbins E,Uhlig S

更新日期：2004-02-01 00:00:00

abstract：:The notoriously drug-resistant bug MRSA has made headlines for years, but a whole other class of bacteria may prove even more troublesome. These microbes, Gram-negative bacteria, are increasingly a threat--and yet not a single late-stage drug in development specifically targets them. Christian Torres follows one man's...

journal_title：Nature medicine

authors： Torres C

更新日期：2010-06-01 00:00:00

abstract：:Parkinson's disease symptoms can be improved by transplanting fetal dopamine cells into the putamen of parkinsonian patients. Because the supply of human donor tissue is limited and variable, an alternative and genetically modifiable non-human source of tissue would be valuable. We have generated cloned transgenic bov...

journal_title：Nature medicine

authors： Zawada WM,Cibelli JB,Choi PK,Clarkson ED,Golueke PJ,Witta SE,Bell KP,Kane J,Ponce de Leon FA,Jerry DJ,Robl JM,Freed CR,Stice SL

更新日期：1998-05-01 00:00:00

abstract：:Temperatures that deviate from the long-term local norm affect human health, and are projected to become more frequent as the global climate changes1. There are limited data on how such anomalies affect deaths from injuries. In the present study, we used data on mortality and temperature over 38 years (1980-2017) in t...

journal_title：Nature medicine

authors： Parks RM,Bennett JE,Tamura-Wicks H,Kontis V,Toumi R,Danaei G,Ezzati M

更新日期：2020-01-01 00:00:00

abstract：:Smallpox was eradicated without an adequate understanding of how vaccination induced protection. In response to possible bioterrorism with smallpox, the UK government vaccinated approximately 300 health care workers with vaccinia virus (VACV) strain Lister. Antibody responses were analyzed using ELISA for multiple sur...

journal_title：Nature medicine

authors： Pütz MM,Midgley CM,Law M,Smith GL

更新日期：2006-11-01 00:00:00

abstract：:Although subtypes of pancreatic ductal adenocarcinoma (PDAC) have been described, this malignancy is clinically still treated as a single disease. Here we present patient-derived models representing the full spectrum of previously identified quasi-mesenchymal (QM-PDA), classical and exocrine-like PDAC subtypes, and id...

journal_title：Nature medicine

authors： Noll EM,Eisen C,Stenzinger A,Espinet E,Muckenhuber A,Klein C,Vogel V,Klaus B,Nadler W,Rösli C,Lutz C,Kulke M,Engelhardt J,Zickgraf FM,Espinosa O,Schlesner M,Jiang X,Kopp-Schneider A,Neuhaus P,Bahra M,Sinn BV,Eil

更新日期：2016-03-01 00:00:00

abstract：:Networks of interstitial cells of Cajal embedded in the musculature of the gastrointestinal tract are involved in the generation of electrical pacemaker activity for gastrointestinal motility. This pacemaker activity manifests itself as rhythmic slow waves in membrane potential, and controls the frequency and propagat...

journal_title：Nature medicine

authors： Thomsen L,Robinson TL,Lee JC,Farraway LA,Hughes MJ,Andrews DW,Huizinga JD

更新日期：1998-07-01 00:00:00

abstract：:The search for immunosuppressant drugs to increase the success of organ transplantation led to the discovery of the immunophilins, proteins that interface with a range of signal transduction systems inside cells, especially in the nervous and immune systems. Here we review how these interesting molecules work and cons...

journal_title：Nature medicine

authors： Snyder SH,Sabatini DM

更新日期：1995-01-01 00:00:00

abstract：: ...

journal_title：Nature medicine

authors： Stower H

更新日期：2019-01-01 00:00:00

abstract：:Because of their abundance, resistance to proteolysis, rapid aggregation and neurotoxicity, N-terminally truncated and, in particular, pyroglutamate (pE)-modified Abeta peptides have been suggested as being important in the initiation of pathological cascades resulting in the development of Alzheimer's disease. We fou...

journal_title：Nature medicine

authors： Schilling S,Zeitschel U,Hoffmann T,Heiser U,Francke M,Kehlen A,Holzer M,Hutter-Paier B,Prokesch M,Windisch M,Jagla W,Schlenzig D,Lindner C,Rudolph T,Reuter G,Cynis H,Montag D,Demuth HU,Rossner S

更新日期：2008-10-01 00:00:00

abstract：:The pathogenic bacterium Neisseria meningitidis is an important cause of septicemia and meningitis, especially in childhood. The establishment and maintenance of bacteremic infection is a pre-requisite for all the pathological sequelae of meningococcal infection. To further understand the genetic basis of this essenti...

journal_title：Nature medicine

authors： Sun YH,Bakshi S,Chalmers R,Tang CM

更新日期：2000-11-01 00:00:00

abstract：:Cytochrome P450 3A4 is an important mediator of drug catabolism that can be regulated by the steroid and xenobiotic receptor (SXR). We show here that SXR also regulates drug efflux by activating expression of the gene MDR1, which encodes the protein P-glycoprotein (ABCB1). Paclitaxel (Taxol), a commonly used chemother...

journal_title：Nature medicine

authors： Synold TW,Dussault I,Forman BM

更新日期：2001-05-01 00:00:00

abstract：:Infections are thought to be important in the pathogenesis of many heart diseases. Coxsackievirus B3 (CVB3) has been linked to chronic dilated cardiomyopathy, a common cause of progressive heart disease, heart failure and sudden death. We show here that the sarcoma (Src) family kinase Lck (p56lck) is required for effi...

journal_title：Nature medicine

authors： Liu P,Aitken K,Kong YY,Opavsky MA,Martino T,Dawood F,Wen WH,Kozieradzki I,Bachmaier K,Straus D,Mak TW,Penninger JM

更新日期：2000-04-01 00:00:00

abstract：: ...

journal_title：Nature medicine

authors： Stower H

更新日期：2019-02-01 00:00:00

abstract：:The ubiquitin-proteasome pathway is the central mediator of regulated proteolysis in cells, and defects in this pathway are associated with cancer and neurodegenerative diseases. To assess 26S proteasome function in living animals, we developed a ubiquitin-luciferase reporter for bioluminescence imaging. The reporter ...

journal_title：Nature medicine

authors： Luker GD,Pica CM,Song J,Luker KE,Piwnica-Worms D

更新日期：2003-07-01 00:00:00

abstract：:Angiopoietin-related growth factor (AGF), a member of the angiopoietin-like protein (Angptl) family, is secreted predominantly from the liver into the systemic circulation. Here, we show that most (>80%) of the AGF-deficient mice die at about embryonic day 13, whereas the surviving AGF-deficient mice develop marked ob...

journal_title：Nature medicine

authors： Oike Y,Akao M,Yasunaga K,Yamauchi T,Morisada T,Ito Y,Urano T,Kimura Y,Kubota Y,Maekawa H,Miyamoto T,Miyata K,Matsumoto S,Sakai J,Nakagata N,Takeya M,Koseki H,Ogawa Y,Kadowaki T,Suda T

更新日期：2005-04-01 00:00:00

abstract：:Approximately 1-5% of breast cancers are attributed to inherited mutations in BRCA1 or BRCA2 and are selectively sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. In other cancer types, germline and/or somatic mutations in BRCA1 and/or BRCA2 (BRCA1/BRCA2) also confer selective sensitivity to PARP inhibitors....

journal_title：Nature medicine

authors： Davies H,Glodzik D,Morganella S,Yates LR,Staaf J,Zou X,Ramakrishna M,Martin S,Boyault S,Sieuwerts AM,Simpson PT,King TA,Raine K,Eyfjord JE,Kong G,Borg Å,Birney E,Stunnenberg HG,van de Vijver MJ,Børresen-Dale AL,Ma

更新日期：2017-04-01 00:00:00

abstract：:The live tuberculosis vaccines Mycobacterium bovis BCG (bacille Calmette-Guérin) and Mycobacterium microti both lack the potent, secreted T-cell antigens ESAT-6 (6-kDa early secretory antigenic target) and CFP-10 (10-kDa culture filtrate protein). This is a result of independent deletions in the region of deletion-1 (...

journal_title：Nature medicine

authors： Pym AS,Brodin P,Majlessi L,Brosch R,Demangel C,Williams A,Griffiths KE,Marchal G,Leclerc C,Cole ST

更新日期：2003-05-01 00:00:00

abstract：:Conventional leg prostheses do not convey sensory information about motion or interaction with the ground to above-knee amputees, thereby reducing confidence and walking speed in the users that is associated with high mental and physical fatigue1-4. The lack of physiological feedback from the remaining extremity to th...

journal_title：Nature medicine

authors： Petrini FM,Bumbasirevic M,Valle G,Ilic V,Mijović P,Čvančara P,Barberi F,Katic N,Bortolotti D,Andreu D,Lechler K,Lesic A,Mazic S,Mijović B,Guiraud D,Stieglitz T,Alexandersson A,Micera S,Raspopovic S

更新日期：2019-09-01 00:00:00

abstract：:Notch receptor signaling is implicated in controlling smooth muscle cell proliferation and in maintaining smooth muscle cells in an undifferentiated state. Pulmonary arterial hypertension is characterized by excessive vascular resistance, smooth muscle cell proliferation in small pulmonary arteries, leading to elevati...

journal_title：Nature medicine

authors： Li X,Zhang X,Leathers R,Makino A,Huang C,Parsa P,Macias J,Yuan JX,Jamieson SW,Thistlethwaite PA

更新日期：2009-11-01 00:00:00

abstract：:High blood pressure, or hypertension, is a very common disorder with a substantial impact on public health because of its associated complications. Despite the high prevalence of essential hypertension and years of research, the basic causes remain obscure. Here I review recent advances in understanding the pathophysi...

journal_title：Nature medicine

authors： Coffman TM

更新日期：2011-11-07 00:00:00