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Identification of a hormonal basis for gallbladder filling.

Abstract：

:The cycle of gallbladder filling and emptying controls the flow of bile into the intestine for digestion. Here we show that fibroblast growth factor-15, a hormone made by the distal small intestine in response to bile acids, is required for gallbladder filling. These studies demonstrate that gallbladder filling is actively regulated by an endocrine pathway and suggest a postprandial timing mechanism that controls gallbladder motility.

journal_name

Nat Med

journal_title

Nature medicine

authors

Choi M,Moschetta A,Bookout AL,Peng L,Umetani M,Holmstrom SR,Suino-Powell K,Xu HE,Richardson JA,Gerard RD,Mangelsdorf DJ,Kliewer SA

doi

10.1038/nm1501

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

1253-5

issue

11

eissn

1078-8956

issn

1546-170X

pii

nm1501

journal_volume

12

pub_type

杂志文章

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