Abstract:
:Azoospermia or oligozoospermia due to disruption of spermatogenesis are common causes of human male infertility. We used the technique of spermatogonial transplantation in two infertile mouse strains, Steel (Sl) and dominant white spotting (W), to determine if stem cells from an infertile male were capable of generating spermatogenesis. Transplantation of germ cells from infertile Sl/Sld mutant male mice to infertile W/Wv or Wv/W54 mutant male mice restored fertility to the recipient mice. Thus, transplantation of spermatogonial stem cells from an infertile donor to a permissive testicular environment can restore fertility and result in progeny with the genetic makeup of the infertile donor male.
journal_name
Nat Medjournal_title
Nature medicineauthors
Ogawa T,Dobrinski I,Avarbock MR,Brinster RLdoi
10.1038/71496keywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
29-34issue
1eissn
1078-8956issn
1546-170Xjournal_volume
6pub_type
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