Emerging cytopathic and antigenic simian immunodeficiency virus variants influence AIDS progression.

abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapy for hematological malignancies. However, graft-versus-host disease (GVHD) and relapse after allo-HSCT remain major impediments to the success of allo-HSCT. Chimeric antigen receptors (CARs) direct tumor cell recognition of...

journal_title：Nature medicine

authors： Ghosh A,Smith M,James SE,Davila ML,Velardi E,Argyropoulos KV,Gunset G,Perna F,Kreines FM,Levy ER,Lieberman S,Jay HV,Tuckett AZ,Zakrzewski JL,Tan L,Young LF,Takvorian K,Dudakov JA,Jenq RR,Hanash AM,Motta AC,Murph

更新日期：2017-02-01 00:00:00

abstract：:Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DiHS/DRESS) is a potentially fatal multiorgan inflammatory disease associated with herpesvirus reactivation and subsequent onset of autoimmune diseases1-4. Pathophysiology remains elusive and therapeutic options are limited. ...

journal_title：Nature medicine

authors： Kim D,Kobayashi T,Voisin B,Jo JH,Sakamoto K,Jin SP,Kelly M,Pasieka HB,Naff JL,Meyerle JH,Ikpeama ID,Fahle GA,Davis FP,Rosenzweig SD,Alejo JC,Pittaluga S,Kong HH,Freeman AF,Nagao K

更新日期：2020-02-01 00:00:00

abstract：:Naturally occurring mutations in HIV-1-infected patients have important implications for therapy and the outcome of clinical studies. However, little is known about the prevalence of mutations that confer resistance to HIV-1 protease inhibitors in isolates derived from patients naive for such inhibitors. In the first ...

journal_title：Nature medicine

authors： Kozal MJ,Shah N,Shen N,Yang R,Fucini R,Merigan TC,Richman DD,Morris D,Hubbell E,Chee M,Gingeras TR

更新日期：1996-07-01 00:00:00

abstract：:During fasting, induction of hepatic gluconeogenesis is crucial to ensure proper energy homeostasis. Such induction is dysregulated in type 2 diabetes, resulting in the development of fasting hyperglycemia. Hormonal and nutrient regulation of metabolic adaptation during fasting is mediated predominantly by the transcr...

journal_title：Nature medicine

authors： Sakai M,Matsumoto M,Tujimura T,Yongheng C,Noguchi T,Inagaki K,Inoue H,Hosooka T,Takazawa K,Kido Y,Yasuda K,Hiramatsu R,Matsuki Y,Kasuga M

更新日期：2012-03-18 00:00:00

abstract：:Hypothalamic brain-derived neurotrophic factor (BDNF) is a key element in the regulation of energy balance. Here we investigated the therapeutic efficacy of BDNF by gene transfer in mouse models of obesity and diabetes. Gene transfer of BDNF led to marked weight loss and alleviation of obesity-associated insulin resis...

journal_title：Nature medicine

authors： Cao L,Lin EJ,Cahill MC,Wang C,Liu X,During MJ

更新日期：2009-04-01 00:00:00

abstract：:Traditional screening for COVID-19 typically includes survey questions about symptoms and travel history, as well as temperature measurements. Here, we explore whether personal sensor data collected over time may help identify subtle changes indicating an infection, such as in patients with COVID-19. We have developed...

journal_title：Nature medicine

authors： Quer G,Radin JM,Gadaleta M,Baca-Motes K,Ariniello L,Ramos E,Kheterpal V,Topol EJ,Steinhubl SR

更新日期：2021-01-01 00:00:00

abstract：:Misfolding of Cu/Zn-superoxide dismutase (SOD1) is emerging as a mechanism underlying motor neuron degeneration in individuals with amyotrophic lateral sclerosis (ALS) who carry a mutant SOD1 gene (SOD1 ALS). Here we describe a structure-guided approach to developing an antibody that specifically recognizes monomer-mi...

journal_title：Nature medicine

authors： Rakhit R,Robertson J,Vande Velde C,Horne P,Ruth DM,Griffin J,Cleveland DW,Cashman NR,Chakrabartty A

更新日期：2007-06-01 00:00:00

abstract：:Treatment of cocaine addiction is hampered by high rates of relapse even after prolonged drug abstinence. This relapse to compulsive cocaine use can be triggered by re-exposure to cocaine, by re-exposure to stimuli previously associated with cocaine or by exposure to stress. In laboratory rats, similar events reinstat...

journal_title：Nature medicine

authors： De Vries TJ,Shaham Y,Homberg JR,Crombag H,Schuurman K,Dieben J,Vanderschuren LJ,Schoffelmeer AN

更新日期：2001-10-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature medicine

authors： Menachery VD,Yount BL Jr,Debbink K,Agnihothram S,Gralinski LE,Plante JA,Graham RL,Scobey T,Ge XY,Donaldson EF,Randell SH,Lanzavecchia A,Marasco WA,Shi ZL,Baric RS

更新日期：2020-07-01 00:00:00

abstract：:Approximately 1-5% of breast cancers are attributed to inherited mutations in BRCA1 or BRCA2 and are selectively sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. In other cancer types, germline and/or somatic mutations in BRCA1 and/or BRCA2 (BRCA1/BRCA2) also confer selective sensitivity to PARP inhibitors....

journal_title：Nature medicine

authors： Davies H,Glodzik D,Morganella S,Yates LR,Staaf J,Zou X,Ramakrishna M,Martin S,Boyault S,Sieuwerts AM,Simpson PT,King TA,Raine K,Eyfjord JE,Kong G,Borg Å,Birney E,Stunnenberg HG,van de Vijver MJ,Børresen-Dale AL,Ma

更新日期：2017-04-01 00:00:00

abstract：:Cancer-specific cell-surface antigens are ideal targets for monoclonal antibody (mAb)-based immunotherapy but are likely to have previously been identified in transcriptome or proteome analyses. Here, we show that the active conformer of an integrin can serve as a specific therapeutic target for multiple myeloma (MM)....

journal_title：Nature medicine

authors： Hosen N,Matsunaga Y,Hasegawa K,Matsuno H,Nakamura Y,Makita M,Watanabe K,Yoshida M,Satoh K,Morimoto S,Fujiki F,Nakajima H,Nakata J,Nishida S,Tsuboi A,Oka Y,Manabe M,Ichihara H,Aoyama Y,Mugitani A,Nakao T,Hino M,

更新日期：2017-12-01 00:00:00

abstract：:In chronic kidney disease (CKD), loss of functional nephrons results in metabolic and mechanical stress in the remaining ones, resulting in further nephron loss. Here we show that Akt2 activation has an essential role in podocyte protection after nephron reduction. Glomerulosclerosis and albuminuria were substantially...

journal_title：Nature medicine

authors： Canaud G,Bienaimé F,Viau A,Treins C,Baron W,Nguyen C,Burtin M,Berissi S,Giannakakis K,Muda AO,Zschiedrich S,Huber TB,Friedlander G,Legendre C,Pontoglio M,Pende M,Terzi F

更新日期：2013-10-01 00:00:00

abstract：:Natural inhibitors of angiogenesis are able to block pathological neovascularization without harming the preexisting vasculature. Here we show that two such inhibitors, thrombospondin-1 and pigment epithelium-derived factor, derive specificity for remodeling vessels from their dependence on Fas/Fas ligand (FasL)-media...

journal_title：Nature medicine

authors： Volpert OV,Zaichuk T,Zhou W,Reiher F,Ferguson TA,Stuart PM,Amin M,Bouck NP

更新日期：2002-04-01 00:00:00

abstract：:Adequate lipid secretion by mammary glands during lactation is essential for the survival of mammalian offspring. However, the mechanism governing this process is poorly understood. Here we show that Cidea is expressed at high levels in lactating mammary glands and its deficiency leads to premature pup death as a resu...

journal_title：Nature medicine

authors： Wang W,Lv N,Zhang S,Shui G,Qian H,Zhang J,Chen Y,Ye J,Xie Y,Shen Y,Wenk MR,Li P

更新日期：2012-01-15 00:00:00

abstract：:Transcription factor FoxO1 promotes hepatic glucose production. Genetic inhibition of FoxO1 function prevents diabetes in experimental animal models, providing impetus to identify pharmacological approaches to modulate this function. Altered Notch signaling is evident in tumorigenesis, and Notch antagonists are in cli...

journal_title：Nature medicine

authors： Pajvani UB,Shawber CJ,Samuel VT,Birkenfeld AL,Shulman GI,Kitajewski J,Accili D

更新日期：2011-07-31 00:00:00

abstract：:Because of their abundance, resistance to proteolysis, rapid aggregation and neurotoxicity, N-terminally truncated and, in particular, pyroglutamate (pE)-modified Abeta peptides have been suggested as being important in the initiation of pathological cascades resulting in the development of Alzheimer's disease. We fou...

journal_title：Nature medicine

authors： Schilling S,Zeitschel U,Hoffmann T,Heiser U,Francke M,Kehlen A,Holzer M,Hutter-Paier B,Prokesch M,Windisch M,Jagla W,Schlenzig D,Lindner C,Rudolph T,Reuter G,Cynis H,Montag D,Demuth HU,Rossner S

更新日期：2008-10-01 00:00:00

abstract：:Finding new treatment-shortening antibiotics to improve cure rates and curb the alarming emergence of drug resistance is the major objective of tuberculosis (TB) drug development. Using a matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging suite in a biosafety containment facility, we show th...

journal_title：Nature medicine

authors： Prideaux B,Via LE,Zimmerman MD,Eum S,Sarathy J,O'Brien P,Chen C,Kaya F,Weiner DM,Chen PY,Song T,Lee M,Shim TS,Cho JS,Kim W,Cho SN,Olivier KN,Barry CE 3rd,Dartois V

更新日期：2015-10-01 00:00:00

abstract：:Preventing the immune escape of tumor cells by blocking inhibitory checkpoints, such as the interaction between programmed death ligand-1 (PD-L1) and programmed death-1 (PD-1) receptor, is a powerful anticancer approach. However, many patients do not respond to checkpoint blockade. Tumor PD-L1 expression is a potentia...

journal_title：Nature medicine

authors： Cerezo M,Guemiri R,Druillennec S,Girault I,Malka-Mahieu H,Shen S,Allard D,Martineau S,Welsch C,Agoussi S,Estrada C,Adam J,Libenciuc C,Routier E,Roy S,Désaubry L,Eggermont AM,Sonenberg N,Scoazec JY,Eychène A,Vagner

更新日期：2018-12-01 00:00:00

abstract：:Pulmonary hypertension (PH) is characterized by increased proliferation and apoptosis resistance of pulmonary artery smooth muscle cells (PASMCs). Forkhead box O (FoxO) transcription factors are key regulators of cellular proliferation. Here we show that in pulmonary vessels and PASMCs of human and experimental PH lun...

journal_title：Nature medicine

authors： Savai R,Al-Tamari HM,Sedding D,Kojonazarov B,Muecke C,Teske R,Capecchi MR,Weissmann N,Grimminger F,Seeger W,Schermuly RT,Pullamsetti SS

更新日期：2014-11-01 00:00:00

abstract：:Parkinson's disease symptoms can be improved by transplanting fetal dopamine cells into the putamen of parkinsonian patients. Because the supply of human donor tissue is limited and variable, an alternative and genetically modifiable non-human source of tissue would be valuable. We have generated cloned transgenic bov...

journal_title：Nature medicine

authors： Zawada WM,Cibelli JB,Choi PK,Clarkson ED,Golueke PJ,Witta SE,Bell KP,Kane J,Ponce de Leon FA,Jerry DJ,Robl JM,Freed CR,Stice SL

更新日期：1998-05-01 00:00:00

abstract：:Despite the central role of the liver in the regulation of glucose and lipid metabolism, there are currently no methods to directly assess hepatic oxidative metabolism in humans in vivo. By using a new (13)C-labeling strategy in combination with (13)C magnetic resonance spectroscopy, we show that rates of mitochondria...

journal_title：Nature medicine

authors： Befroy DE,Perry RJ,Jain N,Dufour S,Cline GW,Trimmer JK,Brosnan J,Rothman DL,Petersen KF,Shulman GI

更新日期：2014-01-01 00:00:00

abstract：:Both the risk and the rate of development of atherosclerosis are increased in diabetics, but the mechanisms involved are unknown. Here we report a glucose-mediated increase in CD36 mRNA translation efficiency that results in increased expression of the macrophage scavenger receptor CD36. Expression of CD36 was increas...

journal_title：Nature medicine

authors： Griffin E,Re A,Hamel N,Fu C,Bush H,McCaffrey T,Asch AS

更新日期：2001-07-01 00:00:00

abstract：:Treating KRAS-mutant lung adenocarcinoma (LUAD) remains a major challenge in cancer treatment given the difficulties associated with directly inhibiting the KRAS oncoprotein. One approach to addressing this challenge is to define mutations that frequently co-occur with those in KRAS, which themselves may lead to thera...

journal_title：Nature medicine

authors： Romero R,Sayin VI,Davidson SM,Bauer MR,Singh SX,LeBoeuf SE,Karakousi TR,Ellis DC,Bhutkar A,Sánchez-Rivera FJ,Subbaraj L,Martinez B,Bronson RT,Prigge JR,Schmidt EE,Thomas CJ,Goparaju C,Davies A,Dolgalev I,Heguy A,A

更新日期：2017-11-01 00:00:00

abstract：:Solid organ transplants contain small numbers of leukocytes that can migrate into the host and establish long-lasting microchimerism. Although such microchimerism is often associated with graft acceptance and tolerance, it has been difficult to demonstrate a true causal link. Using skin from mutant mice deficient for ...

journal_title：Nature medicine

authors： Anderson CC,Matzinger P

更新日期：2001-01-01 00:00:00

abstract：:Bone homeostasis is maintained by the balance between osteoblastic bone formation and osteoclastic bone resorption. Osteoclasts are multinucleated cells that are formed by mononuclear preosteoclast fusion. Fat-soluble vitamins such as vitamin D are pivotal in maintaining skeletal integrity. However, the role of vitami...

journal_title：Nature medicine

authors： Fujita K,Iwasaki M,Ochi H,Fukuda T,Ma C,Miyamoto T,Takitani K,Negishi-Koga T,Sunamura S,Kodama T,Takayanagi H,Tamai H,Kato S,Arai H,Shinomiya K,Itoh H,Okawa A,Takeda S

更新日期：2012-03-04 00:00:00

abstract：:The intestine is densely populated by anaerobic commensal bacteria. These microorganisms shape immune system development, but understanding of host-commensal interactions is hampered by a lack of tools for studying the anaerobic intestinal environment. We applied metabolic oligosaccharide engineering and bioorthogonal...

journal_title：Nature medicine

authors： Geva-Zatorsky N,Alvarez D,Hudak JE,Reading NC,Erturk-Hasdemir D,Dasgupta S,von Andrian UH,Kasper DL

更新日期：2015-09-01 00:00:00

abstract：:Surgery or radiation therapy of metastatic cancer often damages lymph nodes, leading to secondary lymphedema. Here we show, using a newly established mouse model, that collecting lymphatic vessels can be regenerated and fused to lymph node transplants after lymph node removal. Treatment of lymph node-excised mice with...

journal_title：Nature medicine

authors： Tammela T,Saaristo A,Holopainen T,Lyytikkä J,Kotronen A,Pitkonen M,Abo-Ramadan U,Ylä-Herttuala S,Petrova TV,Alitalo K

更新日期：2007-12-01 00:00:00

abstract：:In many areas of oncology, we lack sensitive tools to track low-burden disease. Although cell-free DNA (cfDNA) shows promise in detecting cancer mutations, we found that the combination of low tumor fraction (TF) and limited number of DNA fragments restricts low-disease-burden monitoring through the prevailing deep ta...

journal_title：Nature medicine

authors： Zviran A,Schulman RC,Shah M,Hill STK,Deochand S,Khamnei CC,Maloney D,Patel K,Liao W,Widman AJ,Wong P,Callahan MK,Ha G,Reed S,Rotem D,Frederick D,Sharova T,Miao B,Kim T,Gydush G,Rhoades J,Huang KY,Omans ND,Bo

更新日期：2020-07-01 00:00:00

abstract：:Retinal neovascularization is a major cause of blindness in such disorders as retinopathy of prematurity, proliferative diabetic retinopathy and senile macular degeneration. Because ligation of vitronectin receptor-type integrins appears to be required for the survival and maturation of newly formed but not quiescent ...

journal_title：Nature medicine

authors： Hammes HP,Brownlee M,Jonczyk A,Sutter A,Preissner KT

更新日期：1996-05-01 00:00:00

abstract：:With the goal of modeling human disease of the large intestine, we sought to develop an effective protocol for deriving colonic organoids (COs) from differentiated human embryonic stem cells (hESCs) or induced pluripotent stem cells (iPSCs). Extensive gene and immunohistochemical profiling confirmed that the derived C...

journal_title：Nature medicine

authors： Crespo M,Vilar E,Tsai SY,Chang K,Amin S,Srinivasan T,Zhang T,Pipalia NH,Chen HJ,Witherspoon M,Gordillo M,Xiang JZ,Maxfield FR,Lipkin S,Evans T,Chen S

更新日期：2017-07-01 00:00:00