Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor-type integrins inhibits retinal neovascularization.


:Retinal neovascularization is a major cause of blindness in such disorders as retinopathy of prematurity, proliferative diabetic retinopathy and senile macular degeneration. Because ligation of vitronectin receptor-type integrins appears to be required for the survival and maturation of newly formed but not quiescent blood vessels in several vascular beds including the retina, blockade of this downstream adhesion receptor system was investigated. In a mouse model of hypoxia-induced retinal neovascularization twice daily administration of 1 to 20 mg cyclic alpha v-integrin antagonist peptide per kilogram of body weight reduced capillary proliferation in a dose-dependent fashion--maximum 76%--without obvious side effects. A cyclic control peptide displayed no inhibitory effect on neovascularization. These findings indicate that systemic application of vitronectin receptor antagonists appears to be clinically feasible and is efficient in preventing retinal neovascularization and superior to cytokine-blocking strategies.


Nat Med


Nature medicine


Hammes HP,Brownlee M,Jonczyk A,Sutter A,Preissner KT




Has Abstract


1996-05-01 00:00:00












  • HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders.

    abstract::Given the variation in the HIV-1 viral load (VL) set point across subjects, as opposed to a fairly stable VL over time within an infected individual, it is important to identify the characteristics of the host and virus that affect VL set point. Although recently infected individuals with multiple phylogenetically lin...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Janes H,Herbeck JT,Tovanabutra S,Thomas R,Frahm N,Duerr A,Hural J,Corey L,Self SG,Buchbinder SP,McElrath MJ,O'Connell RJ,Paris RM,Rerks-Ngarm S,Nitayaphan S,Pitisuttihum P,Kaewkungwal J,Robb ML,Michael NL,Mullins JI

    更新日期:2015-10-01 00:00:00

  • Getting biological about the genetics of diabetes.

    abstract::New technology has provided methods for collecting large amounts of data reflecting gene expression, metabolite and protein abundance, and post-translational modification of proteins. Integration of these various data sets enable the genetic mapping of many new phenotypes and facilitates the creation of network models...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Newgard CB,Attie AD

    更新日期:2010-04-01 00:00:00

  • Inducible nitric oxide synthase gene expression in the brain during systemic inflammation.

    abstract::Inducible nitric oxide synthase (iNOS) is a transcriptionally regulated enzyme that synthesizes nitric oxide from L-arginine that has a key role in the pathophysiology of systemic inflammation and sepsis. Transgenic animals with a null mutation for the iNOS gene are resistant to hypotension and death caused by Escheri...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Wong ML,Rettori V,al-Shekhlee A,Bongiorno PB,Canteros G,McCann SM,Gold PW,Licinio J

    更新日期:1996-05-01 00:00:00

  • Genetic clues to the pathogenesis of Parkinson's disease.

    abstract::Recent years have seen an explosion in the rate of discovery of genetic defects linked to Parkinson's disease. These breakthroughs have not provided a direct explanation for the disease process. Nevertheless, they have helped transform Parkinson's disease research by providing tangible clues to the neurobiology of the...

    journal_title:Nature medicine

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    authors: Vila M,Przedborski S

    更新日期:2004-07-01 00:00:00

  • Bradykinin-evoked sensitization of airway sensory nerves: a mechanism for ACE-inhibitor cough.

    abstract::Cough accompanied by an increased sensitivity of the cough reflex is the most common symptom of inflammatory airway disease. This symptom is also frequently reported in patients receiving angiotensin-converting enzyme (ACE) inhibitors as therapy for heart failure or hypertension, although the underlying mechanism is u...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Fox AJ,Lalloo UG,Belvisi MG,Bernareggi M,Chung KF,Barnes PJ

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    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Nakai A,Yamaguchi O,Takeda T,Higuchi Y,Hikoso S,Taniike M,Omiya S,Mizote I,Matsumura Y,Asahi M,Nishida K,Hori M,Mizushima N,Otsu K

    更新日期:2007-05-01 00:00:00

  • 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen.

    abstract::The cardioprotective effects of estrogen are mediated by receptors expressed in vascular cells. Here we show that 27-hydroxycholesterol (27HC), an abundant cholesterol metabolite that is elevated with hypercholesterolemia and found in atherosclerotic lesions, is a competitive antagonist of estrogen receptor action in ...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Umetani M,Domoto H,Gormley AK,Yuhanna IS,Cummins CL,Javitt NB,Korach KS,Shaul PW,Mangelsdorf DJ

    更新日期:2007-10-01 00:00:00

  • CCL27-CCR10 interactions regulate T cell-mediated skin inflammation.

    abstract::The skin-associated chemokine CCL27 (also called CTACK, ALP and ESkine) and its receptor CCR10 (GPR-2) mediate chemotactic responses of skin-homing T cells in vitro. Here we report that most skin-infiltrating lymphocytes in patients suffering from psoriasis, atopic or allergic-contact dermatitis express CCR10. Epiderm...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Homey B,Alenius H,Müller A,Soto H,Bowman EP,Yuan W,McEvoy L,Lauerma AI,Assmann T,Bünemann E,Lehto M,Wolff H,Yen D,Marxhausen H,To W,Sedgwick J,Ruzicka T,Lehmann P,Zlotnik A

    更新日期:2002-02-01 00:00:00

  • Inducible cyclooxygenase may have anti-inflammatory properties.

    abstract::Cyclooxygenase (COX) has two isoforms. Generally, COX 1 is constitutively expressed in most tissues, where it maintains physiological processes; inducible COX 2 is considered a pro-inflammatory enzyme and a chief target for the treatment of inflammatory diseases. Here we present evidence that COX 2 may have anti-infla...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Gilroy DW,Colville-Nash PR,Willis D,Chivers J,Paul-Clark MJ,Willoughby DA

    更新日期:1999-06-01 00:00:00

  • Decreased expression of AMPA receptor messenger RNA and protein in AIDS: a model for HIV-associated neurotoxicity.

    abstract::HIV infection can cause extensive neuronal loss and clinically a severe dementia. The cause of the neurotoxicity remains unclear as neurons are not infected, but disturbance of glutamate-linked calcium entry has been implicated. In this study, we have shown a decrease in HIV-infected brain of the expression of mRNA an...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Everall IP,Hudson L,al-Sarraj S,Honavar M,Lantos P,Kerwin R

    更新日期:1995-11-01 00:00:00

  • Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection.

    abstract::Targeted gene transduction to specific tissues and organs through intravenous injection would be the ultimate preferred method of gene delivery. Here, we report successful targeting in a living animal through intravenous injection of a lentiviral vector pseudotyped with a modified chimeric Sindbis virus envelope (term...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Morizono K,Xie Y,Ringpis GE,Johnson M,Nassanian H,Lee B,Wu L,Chen IS

    更新日期:2005-03-01 00:00:00

  • Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease.

    abstract::Huntington's disease (HD) is a fatal dominantly inherited neurodegenerative disorder caused by a CAG repeat expansion leading to an elongated polyglutamine stretch in huntingtin. Mutant huntingtin (mHTT) is ubiquitously expressed in all cells but elicits selective cortical and striatal neurodegeneration in HD. The mec...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Wang N,Gray M,Lu XH,Cantle JP,Holley SM,Greiner E,Gu X,Shirasaki D,Cepeda C,Li Y,Dong H,Levine MS,Yang XW

    更新日期:2014-05-01 00:00:00

  • Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1.

    abstract::The inwardly rectifying K(+) channel Kir6.1 forms K(+) channels by coupling with a sulfonylurea receptor in reconstituted systems, but the physiological roles of Kir6.1-containing K(+) channels have not been determined. We report here that mice lacking the gene encoding Kir6.1 (known as Kcnj8) have a high rate of sudd...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Miki T,Suzuki M,Shibasaki T,Uemura H,Sato T,Yamaguchi K,Koseki H,Iwanaga T,Nakaya H,Seino S

    更新日期:2002-05-01 00:00:00

  • Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer.

    abstract::Immunodeficiency is a barrier to successful vaccination in individuals with cancer and chronic infection. We performed a randomized phase 1/2 study in lymphopenic individuals after high-dose chemotherapy and autologous hematopoietic stem cell transplantation for myeloma. Combination immunotherapy consisting of a singl...

    journal_title:Nature medicine

    pub_type: 杂志文章,随机对照试验


    authors: Rapoport AP,Stadtmauer EA,Aqui N,Badros A,Cotte J,Chrisley L,Veloso E,Zheng Z,Westphal S,Mair R,Chi N,Ratterree B,Pochran MF,Natt S,Hinkle J,Sickles C,Sohal A,Ruehle K,Lynch C,Zhang L,Porter DL,Luger S,Guo C,

    更新日期:2005-11-01 00:00:00

  • Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain.

    abstract::Post-ischemic inflammation is an essential step in the progression of brain ischemia-reperfusion injury. However, the mechanism that activates infiltrating macrophages in the ischemic brain remains to be clarified. Here we demonstrate that peroxiredoxin (Prx) family proteins released extracellularly from necrotic brai...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Shichita T,Hasegawa E,Kimura A,Morita R,Sakaguchi R,Takada I,Sekiya T,Ooboshi H,Kitazono T,Yanagawa T,Ishii T,Takahashi H,Mori S,Nishibori M,Kuroda K,Akira S,Miyake K,Yoshimura A

    更新日期:2012-06-01 00:00:00

  • Association of hepatitis B surface antigen carriage with severe malaria in Gambian children.

    abstract::Severe malaria is a major cause of childhood mortality in sub-Saharan Africa but the factors predisposing children to severe forms of malaria have not been fully elucidated. In a case-control study of over 1,200 Gambian children hepatitis B virus carriage was significantly increased amongst cases of severe malaria com...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Thursz MR,Kwiatkowski D,Torok ME,Allsopp CE,Greenwood BM,Whittle HC,Thomas HC,Hill AV

    更新日期:1995-04-01 00:00:00

  • A victory for genes.

    abstract::The ability to patent human genes has been costly to researchers and patients, and has restricted competition in the biotech marketplace. The recent US Supreme Court decision making isolated human genes unpatentable will bring freedom of choice to the patient, and level the playing field for research and development. ...

    journal_title:Nature medicine

    pub_type: 社论



    更新日期:2013-07-01 00:00:00

  • ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents.

    abstract::The 55-kilodalton (kDa) protein from the E1B-region of adenovirus binds to and inactivates the p53 gene, which is mutated in half of human cancers. We have previously shown that the replication and cytopathogenicity of an E1B, 55-kDa gene-attenuated adenovirus, ONYX-015, is blocked by functional p53 in RKO and U20S ca...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Heise C,Sampson-Johannes A,Williams A,McCormick F,Von Hoff DD,Kirn DH

    更新日期:1997-06-01 00:00:00

  • Author Correction: Sampling the host response to SARS-CoV-2 in hospitals under siege.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature medicine

    pub_type: 杂志文章,已发布勘误


    authors: Charney AW,Simons NW,Mouskas K,Lepow L,Cheng E,Le Berichel J,Chang C,Marvin R,Del Valle DM,Calorossi S,Lansky A,Walker L,Patel M,Xie H,Yi N,Yu A,Kang G,Liharska LE,Moya E,Hartnett M,Hatem S,Wilkins L,Eaton M,

    更新日期:2020-09-01 00:00:00

  • Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.

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    journal_title:Nature medicine

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    authors: Polo JM,Dell'Oso T,Ranuncolo SM,Cerchietti L,Beck D,Da Silva GF,Prive GG,Licht JD,Melnick A

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  • Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer.

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    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Wong M,Mayoh C,Lau LMS,Khuong-Quang DA,Pinese M,Kumar A,Barahona P,Wilkie EE,Sullivan P,Bowen-James R,Syed M,Martincorena I,Abascal F,Sherstyuk A,Bolanos NA,Baber J,Priestley P,Dolman MEM,Fleuren EDG,Gauthier ME,M

    更新日期:2020-11-01 00:00:00

  • gammadelta T cells provide a breath of fresh air for asthma research.

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    journal_title:Nature medicine

    pub_type: 评论,新闻


    authors: Holt PG,Sly PD

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  • Simultaneous PET-MRI: a new approach for functional and morphological imaging.

    abstract::Noninvasive imaging at the molecular level is an emerging field in biomedical research. This paper introduces a new technology synergizing two leading imaging methodologies: positron emission tomography (PET) and magnetic resonance imaging (MRI). Although the value of PET lies in its high-sensitivity tracking of bioma...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Judenhofer MS,Wehrl HF,Newport DF,Catana C,Siegel SB,Becker M,Thielscher A,Kneilling M,Lichy MP,Eichner M,Klingel K,Reischl G,Widmaier S,Röcken M,Nutt RE,Machulla HJ,Uludag K,Cherry SR,Claussen CD,Pichler BJ

    更新日期:2008-04-01 00:00:00

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    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Xu M,Pirtskhalava T,Farr JN,Weigand BM,Palmer AK,Weivoda MM,Inman CL,Ogrodnik MB,Hachfeld CM,Fraser DG,Onken JL,Johnson KO,Verzosa GC,Langhi LGP,Weigl M,Giorgadze N,LeBrasseur NK,Miller JD,Jurk D,Singh RJ,Allison

    更新日期:2018-08-01 00:00:00

  • Successful prenatal mannose treatment for congenital disorder of glycosylation-Ia in mice.

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    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Schneider A,Thiel C,Rindermann J,DeRossi C,Popovici D,Hoffmann GF,Gröne HJ,Körner C

    更新日期:2011-12-11 00:00:00

  • Hypomorphic promoter mutation in PIGM causes inherited glycosylphosphatidylinositol deficiency.

    abstract::Attachment to the plasma membrane by linkage to a glycosylphosphatidylinositol (GPI) anchor is a mode of protein expression highly conserved from protozoa to mammals. As a clinical entity, deficiency of GPI has been recognized as paroxysmal nocturnal hemoglobinuria, an acquired clonal disorder associated with somatic ...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Almeida AM,Murakami Y,Layton DM,Hillmen P,Sellick GS,Maeda Y,Richards S,Patterson S,Kotsianidis I,Mollica L,Crawford DH,Baker A,Ferguson M,Roberts I,Houlston R,Kinoshita T,Karadimitris A

    更新日期:2006-07-01 00:00:00

  • RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain.

    abstract::Amyloid-beta peptide (Abeta) interacts with the vasculature to influence Abeta levels in the brain and cerebral blood flow, providing a means of amplifying the Abeta-induced cellular stress underlying neuronal dysfunction and dementia. Systemic Abeta infusion and studies in genetically manipulated mice show that Abeta...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Deane R,Du Yan S,Submamaryan RK,LaRue B,Jovanovic S,Hogg E,Welch D,Manness L,Lin C,Yu J,Zhu H,Ghiso J,Frangione B,Stern A,Schmidt AM,Armstrong DL,Arnold B,Liliensiek B,Nawroth P,Hofman F,Kindy M,Stern D,Zlokov

    更新日期:2003-07-01 00:00:00

  • Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer.

    abstract::In most cases of sporadic colorectal cancers, tumorigenesis is a multistep process, involving genomic alterations in parallel with morphologic changes. In addition, accumulating evidence suggests that the human gut microbiome is linked to the development of colorectal cancer. Here we performed fecal metagenomic and me...

    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Yachida S,Mizutani S,Shiroma H,Shiba S,Nakajima T,Sakamoto T,Watanabe H,Masuda K,Nishimoto Y,Kubo M,Hosoda F,Rokutan H,Matsumoto M,Takamaru H,Yamada M,Matsuda T,Iwasaki M,Yamaji T,Yachida T,Soga T,Kurokawa K,Toy

    更新日期:2019-06-01 00:00:00

  • NO vascular control in Duchenne muscular dystrophy.

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    journal_title:Nature medicine

    pub_type: 杂志文章


    authors: Crosbie RH

    更新日期:2001-01-01 00:00:00

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    abstract::Alternative splicing ensures the expression of functionally diverse proteins from individual genes; however, aberrant mRNA splicing is associated with various conditions, including heart disease. A recent study provides new mechanistic insights into heart failure by showing that a human cardiomyopathy-linked mutation ...

    journal_title:Nature medicine

    pub_type: 评论,杂志文章


    authors: Linke WA,Bücker S

    更新日期:2012-05-04 00:00:00