Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays.

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature medicine

authors： Menachery VD,Yount BL Jr,Debbink K,Agnihothram S,Gralinski LE,Plante JA,Graham RL,Scobey T,Ge XY,Donaldson EF,Randell SH,Lanzavecchia A,Marasco WA,Shi ZL,Baric RS

更新日期：2020-07-01 00:00:00

abstract：:Proper function of the endoplasmic reticulum (ER) and mitochondria is crucial for cellular homeostasis, and dysfunction at either site has been linked to pathophysiological states, including metabolic diseases. Although the ER and mitochondria play distinct cellular roles, these organelles also form physical interacti...

journal_title：Nature medicine

authors： Arruda AP,Pers BM,Parlakgül G,Güney E,Inouye K,Hotamisligil GS

更新日期：2014-12-01 00:00:00

abstract：:After transplantation of primarily vascularized xenografts (Xgs), T-independent mechanisms may lead to Xg rejection before T-cell activation even takes place. The possibility of achieving T-independent xenotolerance was evaluated in nude rats that normally reject hamster cardiac Xgs within 4 days by non-T cell-mediate...

journal_title：Nature medicine

authors： Lin Y,Goebels J,Xia G,Ji P,Vandeputte M,Waer M

更新日期：1998-02-01 00:00:00

abstract：:Period (Per) genes are involved in regulation of the circadian clock and are thought to modulate several brain functions. We demonstrate that Per2(Brdm1) mutant mice, which have a deletion in the PAS domain of the Per2 protein, show alterations in the glutamatergic system. Lowered expression of the glutamate transport...

journal_title：Nature medicine

authors： Spanagel R,Pendyala G,Abarca C,Zghoul T,Sanchis-Segura C,Magnone MC,Lascorz J,Depner M,Holzberg D,Soyka M,Schreiber S,Matsuda F,Lathrop M,Schumann G,Albrecht U

更新日期：2005-01-01 00:00:00

abstract：:Angiopoietin-related growth factor (AGF), a member of the angiopoietin-like protein (Angptl) family, is secreted predominantly from the liver into the systemic circulation. Here, we show that most (>80%) of the AGF-deficient mice die at about embryonic day 13, whereas the surviving AGF-deficient mice develop marked ob...

journal_title：Nature medicine

authors： Oike Y,Akao M,Yasunaga K,Yamauchi T,Morisada T,Ito Y,Urano T,Kimura Y,Kubota Y,Maekawa H,Miyamoto T,Miyata K,Matsumoto S,Sakai J,Nakagata N,Takeya M,Koseki H,Ogawa Y,Kadowaki T,Suda T

更新日期：2005-04-01 00:00:00

abstract：:Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that exhibits specific tumoricidal activity against a variety of tumors. It is expressed on different cells of the immune system and plays a role in natural killer cell-mediated tumor surveillance. In allogeneic he...

journal_title：Nature medicine

authors： Schmaltz C,Alpdogan O,Kappel BJ,Muriglan SJ,Rotolo JA,Ongchin J,Willis LM,Greenberg AS,Eng JM,Crawford JM,Murphy GF,Yagita H,Walczak H,Peschon JJ,van den Brink MR

更新日期：2002-12-01 00:00:00

abstract：:We report the development of a new combinatorial approach that allows for peptide-mediated selective tissue targeting of nuclear hormone pharmacology while eliminating adverse effects in other tissues. Specifically, we report the development of a glucagon-like peptide-1 (GLP-1)-estrogen conjugate that has superior sex...

journal_title：Nature medicine

authors： Finan B,Yang B,Ottaway N,Stemmer K,Müller TD,Yi CX,Habegger K,Schriever SC,García-Cáceres C,Kabra DG,Hembree J,Holland J,Raver C,Seeley RJ,Hans W,Irmler M,Beckers J,de Angelis MH,Tiano JP,Mauvais-Jarvis F,Perez-Ti

更新日期：2012-12-01 00:00:00

abstract：:The optimism of the early period of antimicrobial discovery has been tempered by the emergence of bacterial strains with resistance to these therapeutics. Today, clinically important bacteria are characterized not only by single drug resistance but also by multiple antibiotic resistance--the legacy of past decades of ...

journal_title：Nature medicine

authors： Levy SB,Marshall B

更新日期：2004-12-01 00:00:00

abstract：:Systemic inflammation induces various adaptive responses including tachycardia. Although inflammation-associated tachycardia has been thought to result from increased sympathetic discharge caused by inflammatory signals of the immune system, definitive proof has been lacking. Prostanoids, including prostaglandin (PG) ...

journal_title：Nature medicine

authors： Takayama K,Yuhki K,Ono K,Fujino T,Hara A,Yamada T,Kuriyama S,Karibe H,Okada Y,Takahata O,Taniguchi T,Iijima T,Iwasaki H,Narumiya S,Ushikubi F

更新日期：2005-05-01 00:00:00

abstract：:LIGHT was recently described as a member of the tumor necrosis factor (TNF) 'superfamily'. We have isolated a mouse homolog of human LIGHT and investigated its immunoregulatory functions in vitro and in vivo. LIGHT has potent, CD28-independent co-stimulatory activity leading to T-cell growth and secretion of gamma int...

journal_title：Nature medicine

authors： Tamada K,Shimozaki K,Chapoval AI,Zhu G,Sica G,Flies D,Boone T,Hsu H,Fu YX,Nagata S,Ni J,Chen L

更新日期：2000-03-01 00:00:00

abstract：:Late-onset sepsis (LOS) is thought to result from systemic spread of commensal microbes from the intestines of premature infants. Clinical use of probiotics for LOS prophylaxis has varied owing to limited efficacy, reflecting an incomplete understanding of relationships between development of the intestinal microbiome...

journal_title：Nature medicine

authors： Singer JR,Blosser EG,Zindl CL,Silberger DJ,Conlan S,Laufer VA,DiToro D,Deming C,Kumar R,Morrow CD,Segre JA,Gray MJ,Randolph DA,Weaver CT

更新日期：2019-11-01 00:00:00

abstract：:Cells that are deficient in homologous recombination, such as those that lack functional breast cancer-associated 1 (BRCA1) or BRCA2, are hypersensitive to inhibition of poly(ADP-ribose) polymerase (PARP). However, BRCA-deficient tumors represent only a small fraction of adult cancers, which might restrict the therape...

journal_title：Nature medicine

authors： Johnson N,Li YC,Walton ZE,Cheng KA,Li D,Rodig SJ,Moreau LA,Unitt C,Bronson RT,Thomas HD,Newell DR,D'Andrea AD,Curtin NJ,Wong KK,Shapiro GI

更新日期：2011-06-26 00:00:00

abstract：:Autoimmune T-helper cells drive pathogenic autoantibody production in systemic lupus erythematosus (SLE), but the mechanisms maintaining those T cells are unknown. Autoreactive T cells are normally eliminated by functional inactivation (anergy) and activation-induced cell death (AICD) or apoptosis through death recept...

journal_title：Nature medicine

authors： Xu L,Zhang L,Yi Y,Kang HK,Datta SK

更新日期：2004-04-01 00:00:00

abstract：:Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are key regulators of the apoptotic process. This family comprises proapoptotic and prosurvival proteins, and shifting the balance toward the latter is an established mechanism whereby cancer cells evade apoptosis. The therapeutic potential of directly inhibiting pr...

journal_title：Nature medicine

authors： Souers AJ,Leverson JD,Boghaert ER,Ackler SL,Catron ND,Chen J,Dayton BD,Ding H,Enschede SH,Fairbrother WJ,Huang DC,Hymowitz SG,Jin S,Khaw SL,Kovar PJ,Lam LT,Lee J,Maecker HL,Marsh KC,Mason KD,Mitten MJ,Nimmer PM

更新日期：2013-02-01 00:00:00

abstract：:Atherosclerosis is an immunoinflammatory disease elicited by accumulation of lipids in the artery wall and leads to myocardial infarction and stroke. Here, we show that naturally arising CD4(+)CD25(+) regulatory T cells, which actively maintain immunological tolerance to self and nonself antigens, are powerful inhibit...

journal_title：Nature medicine

authors： Ait-Oufella H,Salomon BL,Potteaux S,Robertson AK,Gourdy P,Zoll J,Merval R,Esposito B,Cohen JL,Fisson S,Flavell RA,Hansson GK,Klatzmann D,Tedgui A,Mallat Z

更新日期：2006-02-01 00:00:00

abstract：:The structure and function of blood vessels adapt to environmental changes such as physical development and exercise. This phenomenon is based on the ability of the endothelial cells to sense and respond to blood flow; however, the underlying mechanisms remain unclear. Here we show that the ATP-gated P2X4 ion channel,...

journal_title：Nature medicine

authors： Yamamoto K,Sokabe T,Matsumoto T,Yoshimura K,Shibata M,Ohura N,Fukuda T,Sato T,Sekine K,Kato S,Isshiki M,Fujita T,Kobayashi M,Kawamura K,Masuda H,Kamiya A,Ando J

更新日期：2006-01-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA) is an important neurotransmitter that, through the subtype A GABA receptor (GABAAR), induces inhibition in the adult brain. Here we show that an excitatory, rather than inhibitory, GABAergic system exists in airway epithelial cells. Both GABAARs and the GABA synthetic enzyme glutamic aci...

journal_title：Nature medicine

authors： Xiang YY,Wang S,Liu M,Hirota JA,Li J,Ju W,Fan Y,Kelly MM,Ye B,Orser B,O'Byrne PM,Inman MD,Yang X,Lu WY

更新日期：2007-07-01 00:00:00

abstract：:T-helper type 17 cells (T(H)17) are implicated in rodent models of immune-mediated diseases. Here we report their involvement in human uveitis and scleritis, and validate our findings in experimental autoimmune uveoretinitis (EAU), a model of uveitis. T(H)17 cells were present in human peripheral blood mononuclear cel...

journal_title：Nature medicine

authors： Amadi-Obi A,Yu CR,Liu X,Mahdi RM,Clarke GL,Nussenblatt RB,Gery I,Lee YS,Egwuagu CE

更新日期：2007-06-01 00:00:00

abstract：: ...

journal_title：Nature medicine

authors： Stower H

更新日期：2019-03-01 00:00:00

abstract：:Because of their abundance, resistance to proteolysis, rapid aggregation and neurotoxicity, N-terminally truncated and, in particular, pyroglutamate (pE)-modified Abeta peptides have been suggested as being important in the initiation of pathological cascades resulting in the development of Alzheimer's disease. We fou...

journal_title：Nature medicine

authors： Schilling S,Zeitschel U,Hoffmann T,Heiser U,Francke M,Kehlen A,Holzer M,Hutter-Paier B,Prokesch M,Windisch M,Jagla W,Schlenzig D,Lindner C,Rudolph T,Reuter G,Cynis H,Montag D,Demuth HU,Rossner S

更新日期：2008-10-01 00:00:00

abstract：:Immune-checkpoint blockade (ICB) has demonstrated efficacy in many tumor types, but predictors of responsiveness to anti-PD1 ICB are incompletely characterized. In this study, we analyzed a clinically annotated cohort of patients with melanoma (n = 144) treated with anti-PD1 ICB, with whole-exome and whole-transcripto...

journal_title：Nature medicine

authors： Liu D,Schilling B,Liu D,Sucker A,Livingstone E,Jerby-Arnon L,Zimmer L,Gutzmer R,Satzger I,Loquai C,Grabbe S,Vokes N,Margolis CA,Conway J,He MX,Elmarakeby H,Dietlein F,Miao D,Tracy A,Gogas H,Goldinger SM,Utikal J

更新日期：2019-12-01 00:00:00

abstract：:Animal allergens are an important cause of asthma and allergic rhinitis. We designed and tested a chimeric human-cat fusion protein composed of a truncated human IgG Fcgamma1 and the major cat allergen Fel d1, as a proof of concept for a new approach to allergy immunotherapy. This Fcgamma-Fel d1 protein induced dose-d...

journal_title：Nature medicine

authors： Zhu D,Kepley CL,Zhang K,Terada T,Yamada T,Saxon A

更新日期：2005-04-01 00:00:00

abstract：:Neutrophils have key roles in modulating the immune response. We present a robust methodology for rapidly isolating neutrophils directly from whole blood with 'on-chip' processing for mRNA and protein isolation for genomics and proteomics. We validate this device with an ex vivo stimulation experiment and by compariso...

journal_title：Nature medicine

authors： Kotz KT,Xiao W,Miller-Graziano C,Qian WJ,Russom A,Warner EA,Moldawer LL,De A,Bankey PE,Petritis BO,Camp DG 2nd,Rosenbach AE,Goverman J,Fagan SP,Brownstein BH,Irimia D,Xu W,Wilhelmy J,Mindrinos MN,Smith RD,Davis RW

更新日期：2010-09-01 00:00:00

abstract：:We have previously shown that a single portal vein infusion of a recombinant adeno-associated viral vector (rAAV) expressing canine Factor IX (F.IX) resulted in long-term expression of therapeutic levels of F.IX in dogs with severe hemophilia B. We carried out a phase 1/2 dose-escalation clinical study to extend this ...

journal_title：Nature medicine

authors： Manno CS,Pierce GF,Arruda VR,Glader B,Ragni M,Rasko JJ,Ozelo MC,Hoots K,Blatt P,Konkle B,Dake M,Kaye R,Razavi M,Zajko A,Zehnder J,Rustagi PK,Nakai H,Chew A,Leonard D,Wright JF,Lessard RR,Sommer JM,Tigges M,S

更新日期：2006-03-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapy for hematological malignancies. However, graft-versus-host disease (GVHD) and relapse after allo-HSCT remain major impediments to the success of allo-HSCT. Chimeric antigen receptors (CARs) direct tumor cell recognition of...

journal_title：Nature medicine

authors： Ghosh A,Smith M,James SE,Davila ML,Velardi E,Argyropoulos KV,Gunset G,Perna F,Kreines FM,Levy ER,Lieberman S,Jay HV,Tuckett AZ,Zakrzewski JL,Tan L,Young LF,Takvorian K,Dudakov JA,Jenq RR,Hanash AM,Motta AC,Murph

更新日期：2017-02-01 00:00:00

abstract：:The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) is of global concern: the virus has caused severe respiratory illness, with 111 confirmed cases and 52 deaths at the time of this article's publication. Therapeutic interventions have not been evaluated in vivo; thus, patient management relies ex...

journal_title：Nature medicine

authors： Falzarano D,de Wit E,Rasmussen AL,Feldmann F,Okumura A,Scott DP,Brining D,Bushmaker T,Martellaro C,Baseler L,Benecke AG,Katze MG,Munster VJ,Feldmann H

更新日期：2013-10-01 00:00:00

abstract：:Synthetic vascular prostheses are foreign bodies, so that blood coagulation can occur on their luminal surfaces, causing graft occlusion very frequently in prostheses of small diameter. A vascular prosthesis needs angiogenesis for endothelialization of the luminal surface, as endothelial cells have natural and permane...

journal_title：Nature medicine

authors： Noishiki Y,Tomizawa Y,Yamane Y,Matsumoto A

更新日期：1996-01-01 00:00:00

abstract：:The use of genetically manipulated mouse models, gene and protein discovery and the cataloguing of genetic mutations have each allowed us to obtain new insights into skeletal morphogenesis and remodeling. These techniques have made it possible to identify molecules that are obligatory for specific cellular functions, ...

journal_title：Nature medicine

authors： Zaidi M

更新日期：2007-07-01 00:00:00

abstract：:Recent years have seen an explosion in the rate of discovery of genetic defects linked to Parkinson's disease. These breakthroughs have not provided a direct explanation for the disease process. Nevertheless, they have helped transform Parkinson's disease research by providing tangible clues to the neurobiology of the...

journal_title：Nature medicine

authors： Vila M,Przedborski S

更新日期：2004-07-01 00:00:00

abstract：:Hemizygous deletion of chromosome 22q11 (del22q11) causes thymic, parathyroid, craniofacial and life-threatening cardiovascular birth defects in 1 in 4,000 infants. The del22q11 syndrome is likely caused by haploinsufficiency of TBX1, but its variable expressivity indicates the involvement of additional modifiers. Her...

journal_title：Nature medicine

authors： Stalmans I,Lambrechts D,De Smet F,Jansen S,Wang J,Maity S,Kneer P,von der Ohe M,Swillen A,Maes C,Gewillig M,Molin DG,Hellings P,Boetel T,Haardt M,Compernolle V,Dewerchin M,Plaisance S,Vlietinck R,Emanuel B,Gittenb

更新日期：2003-02-01 00:00:00