Antibacterial resistance worldwide: causes, challenges and responses.

abstract：:The cycle of gallbladder filling and emptying controls the flow of bile into the intestine for digestion. Here we show that fibroblast growth factor-15, a hormone made by the distal small intestine in response to bile acids, is required for gallbladder filling. These studies demonstrate that gallbladder filling is act...

journal_title：Nature medicine

authors： Choi M,Moschetta A,Bookout AL,Peng L,Umetani M,Holmstrom SR,Suino-Powell K,Xu HE,Richardson JA,Gerard RD,Mangelsdorf DJ,Kliewer SA

更新日期：2006-11-01 00:00:00

abstract：:Late-onset sepsis (LOS) is thought to result from systemic spread of commensal microbes from the intestines of premature infants. Clinical use of probiotics for LOS prophylaxis has varied owing to limited efficacy, reflecting an incomplete understanding of relationships between development of the intestinal microbiome...

journal_title：Nature medicine

authors： Singer JR,Blosser EG,Zindl CL,Silberger DJ,Conlan S,Laufer VA,DiToro D,Deming C,Kumar R,Morrow CD,Segre JA,Gray MJ,Randolph DA,Weaver CT

更新日期：2019-11-01 00:00:00

abstract：:Modest clinical outcomes of dendritic-cell (DC) vaccine trials call for the refinement of DC vaccine design. Although many potential antigens have been identified, development of methods to enhance antigen presentation by DCs has lagged. We have engineered a potent, drug-inducible CD40 (iCD40) receptor that permits te...

journal_title：Nature medicine

authors： Hanks BA,Jiang J,Singh RA,Song W,Barry M,Huls MH,Slawin KM,Spencer DM

更新日期：2005-02-01 00:00:00

abstract：:Angiogenesis, the formation of new blood vessels, is a requirement for malignant tumor growth and metastasis. In the absence of angiogenesis, local tumor expansion is suppressed at a few millimeters and cells lack routes for distant hematogenous spread. Clinical studies have demonstrated that the degree of angiogenesi...

journal_title：Nature medicine

authors： Sipkins DA,Cheresh DA,Kazemi MR,Nevin LM,Bednarski MD,Li KC

更新日期：1998-05-01 00:00:00

abstract：:The Dunning rat prostatic carcinoma is a model system where cell motility closely correlates with the metastatic phenotype. We have identified a novel gene, upregulated in the highly motile and metastatic Dunning cancer cell lines, that represents a new member of the thymosin-beta family, thymosin beta 15. Transfectio...

journal_title：Nature medicine

authors： Bao L,Loda M,Janmey PA,Stewart R,Anand-Apte B,Zetter BR

更新日期：1996-12-01 00:00:00

abstract：:Despite a more than 20-year experience of therapeutic benefit, the relevant molecular and cellular targets of intravenous immunoglobulin (IVIg) in autoimmune disease remain unclear. Contrary to the prevailing theories of IVIg action in autoimmunity, we show that IVIg drives signaling through activating Fc gamma recept...

journal_title：Nature medicine

authors： Siragam V,Crow AR,Brinc D,Song S,Freedman J,Lazarus AH

更新日期：2006-06-01 00:00:00

abstract：:We have studied the effects of amyloid beta-peptide analogues on the activity of tissue-type plasminogen activator (t-PA) in vitro. We have found that these peptides have a marked stimulatory effect upon plasminogen activation by t-PA, comparable to that of known stimulators of t-PA. This stimulatory activity appears ...

journal_title：Nature medicine

authors： Kingston IB,Castro MJ,Anderson S

更新日期：1995-02-01 00:00:00

abstract：:Alzheimer's disease is a progressive and incurable disease whose prevalence increases dramatically with age. A biochemical marker for monitoring the onset and progression of the disease would be a valuable tool for disease management. In addition, such a marker might be used as an end point in clinical intervention pr...

journal_title：Nature medicine

authors： Kennard ML,Feldman H,Yamada T,Jefferies WA

更新日期：1996-11-01 00:00:00

abstract：:Reactive oxygen species (ROS) induce chemokines responsible for the recruitment of inflammatory cells to sites of injury or infection. Here we show that the plasma membrane Ca(2+)-permeable channel TRPM2 controls ROS-induced chemokine production in monocytes. In human U937 monocytes, hydrogen peroxide (H(2)O(2)) evoke...

journal_title：Nature medicine

authors： Yamamoto S,Shimizu S,Kiyonaka S,Takahashi N,Wajima T,Hara Y,Negoro T,Hiroi T,Kiuchi Y,Okada T,Kaneko S,Lange I,Fleig A,Penner R,Nishi M,Takeshima H,Mori Y

更新日期：2008-07-01 00:00:00

abstract：:Hematopoietic stem and progenitor cells (HSPC) are endowed with the role of generating and maintaining lifelong the extremely diverse pool of blood cells1. Clinically, transplantation of human HSPC from an allogeneic healthy donor or infusion of autologous gene-corrected HSPC can effectively replenish defective blood ...

journal_title：Nature medicine

authors： Scala S,Basso-Ricci L,Dionisio F,Pellin D,Giannelli S,Salerio FA,Leonardelli L,Cicalese MP,Ferrua F,Aiuti A,Biasco L

更新日期：2018-11-01 00:00:00

abstract：:Epstein-Barr virus is ubiquitous and is causally implicated in lymphoid and epithelial malignancies. Virus invades oropharyngeal mucosa and establishes latency in B lymphocytes. Reactivating lymphocytes shed virus into saliva for spread to new hosts. A complex of three virus glycoproteins, gH, gL and gp42, is essentia...

journal_title：Nature medicine

authors： Borza CM,Hutt-Fletcher LM

更新日期：2002-06-01 00:00:00

abstract：:Genetic alterations in malignant tissues are potential targets for gene-based cancer therapies. Alternatively, aberrant expression of certain specific genes associated with malignant transformation may be envisioned to enhance the expression of chemosensitizing drugs. Epstein-Barr virus (EBV)-related B-cell lymphomas ...

journal_title：Nature medicine

authors： Franken M,Estabrooks A,Cavacini L,Sherburne B,Wang F,Scadden DT

更新日期：1996-12-01 00:00:00

abstract：:Obesity and metabolic syndrome are increasingly recognized as major risk factors for cardiovascular disease. Herein we show that Krüppel-like transcription factor 5 (KLF5) is a crucial regulator of energy metabolism. Klf5(+/-) mice were resistant to high fat-induced obesity, hypercholesterolemia and glucose intoleranc...

journal_title：Nature medicine

authors： Oishi Y,Manabe I,Tobe K,Ohsugi M,Kubota T,Fujiu K,Maemura K,Kubota N,Kadowaki T,Nagai R

更新日期：2008-06-01 00:00:00

abstract：:Chlamydia trachomatis is the leading cause worldwide of preventable infectious blindness (trachoma) and sexually transmitted disease, including nongonoccocal urethritis and pelvic inflammatory disease. To date, no effective vaccine against C. trachomatis infection has been identified. A monoclonal anti-idiotypic antib...

journal_title：Nature medicine

authors： Whittum-Hudson JA,An LL,Saltzman WM,Prendergast RA,MacDonald AB

更新日期：1996-10-01 00:00:00

abstract：:Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) characterized by localized areas of demyelination. Although the etiology and pathogenesis of MS remain largely unknown, it is generally assumed that immune responses to myelin antigens contribute to the disease process. The exact se...

journal_title：Nature medicine

authors： Liu J,Marino MW,Wong G,Grail D,Dunn A,Bettadapura J,Slavin AJ,Old L,Bernard CC

更新日期：1998-01-01 00:00:00

abstract：:Angiogenic tumor vessels are promising targets for the activity and the selective delivery of cancer therapeutics. The bone marrow contributes different cell types to the tumor stroma, including hematopoietic cells and, as recently suggested, vascular endothelial cells (ECs). Thus, transplantation of genetically modif...

journal_title：Nature medicine

authors： De Palma M,Venneri MA,Roca C,Naldini L

更新日期：2003-06-01 00:00:00

abstract：:Kidney transplantation has been one of the major medical advances of the past 30 years. However, tissue availability remains a major obstacle. This can potentially be overcome by the use of undifferentiated or partially developed kidney precursor cells derived from early embryos and fetal tissue. Here, transplantation...

journal_title：Nature medicine

authors： Dekel B,Burakova T,Arditti FD,Reich-Zeliger S,Milstein O,Aviel-Ronen S,Rechavi G,Friedman N,Kaminski N,Passwell JH,Reisner Y

更新日期：2003-01-01 00:00:00

abstract：:A characteristic feature of Creutzfeldt-Jakob disease (CJD) is the accumulation in the brain of the amyloid protease-resistant protein PrPres. PrPres derives from a host-encoded, protease-sensitive isoform, PrPsen. Mutations of this protein are linked to familial variants of the disease, and the presence of a methioni...

journal_title：Nature medicine

authors： Silvestrini MC,Cardone F,Maras B,Pucci P,Barra D,Brunori M,Pocchiari M

更新日期：1997-05-01 00:00:00

abstract：:Parkinson's disease symptoms can be improved by transplanting fetal dopamine cells into the putamen of parkinsonian patients. Because the supply of human donor tissue is limited and variable, an alternative and genetically modifiable non-human source of tissue would be valuable. We have generated cloned transgenic bov...

journal_title：Nature medicine

authors： Zawada WM,Cibelli JB,Choi PK,Clarkson ED,Golueke PJ,Witta SE,Bell KP,Kane J,Ponce de Leon FA,Jerry DJ,Robl JM,Freed CR,Stice SL

更新日期：1998-05-01 00:00:00

abstract：:Viral replication and microbial translocation from the gut to the blood during HIV infection lead to hyperimmune activation, which contributes to the decline in CD4+ T cell numbers during HIV infection. Programmed death-1 (PD-1) and interleukin-10 (IL-10) are both upregulated during HIV infection. Blocking interaction...

journal_title：Nature medicine

authors： Said EA,Dupuy FP,Trautmann L,Zhang Y,Shi Y,El-Far M,Hill BJ,Noto A,Ancuta P,Peretz Y,Fonseca SG,Van Grevenynghe J,Boulassel MR,Bruneau J,Shoukry NH,Routy JP,Douek DC,Haddad EK,Sekaly RP

更新日期：2010-04-01 00:00:00

abstract：:We formulate a two-phase paradigm of autoimmunity associated with systemic lupus erythematosus, the archetypal autoimmune disease. The initial Toll-like receptor (TLR)-independent phase is mediated by dendritic cell uptake of apoptotic cell debris and associated nucleic acids, whereas the subsequent TLR-dependent phas...

journal_title：Nature medicine

authors： Baccala R,Hoebe K,Kono DH,Beutler B,Theofilopoulos AN

更新日期：2007-05-01 00:00:00

abstract：:The Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) is expressed in all KSHV-associated tumors, including Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL). We found that beta-catenin is overexpressed in both PEL cells and KS tissue. Introduction of anti-LANA small inte...

journal_title：Nature medicine

authors： Fujimuro M,Wu FY,ApRhys C,Kajumbula H,Young DB,Hayward GS,Hayward SD

更新日期：2003-03-01 00:00:00

abstract：:Naturally occurring mutations in HIV-1-infected patients have important implications for therapy and the outcome of clinical studies. However, little is known about the prevalence of mutations that confer resistance to HIV-1 protease inhibitors in isolates derived from patients naive for such inhibitors. In the first ...

journal_title：Nature medicine

authors： Kozal MJ,Shah N,Shen N,Yang R,Fucini R,Merigan TC,Richman DD,Morris D,Hubbell E,Chee M,Gingeras TR

更新日期：1996-07-01 00:00:00

abstract：:Immune-checkpoint blockade (ICB) has demonstrated efficacy in many tumor types, but predictors of responsiveness to anti-PD1 ICB are incompletely characterized. In this study, we analyzed a clinically annotated cohort of patients with melanoma (n = 144) treated with anti-PD1 ICB, with whole-exome and whole-transcripto...

journal_title：Nature medicine

authors： Liu D,Schilling B,Liu D,Sucker A,Livingstone E,Jerby-Arnon L,Zimmer L,Gutzmer R,Satzger I,Loquai C,Grabbe S,Vokes N,Margolis CA,Conway J,He MX,Elmarakeby H,Dietlein F,Miao D,Tracy A,Gogas H,Goldinger SM,Utikal J

更新日期：2019-12-01 00:00:00

abstract：:Metabolic reprograming is an emerging hallmark of tumor biology and an actively pursued opportunity in discovery of oncology drugs. Extensive efforts have focused on therapeutic targeting of glycolysis, whereas drugging mitochondrial oxidative phosphorylation (OXPHOS) has remained largely unexplored, partly owing to a...

journal_title：Nature medicine

authors： Molina JR,Sun Y,Protopopova M,Gera S,Bandi M,Bristow C,McAfoos T,Morlacchi P,Ackroyd J,Agip AA,Al-Atrash G,Asara J,Bardenhagen J,Carrillo CC,Carroll C,Chang E,Ciurea S,Cross JB,Czako B,Deem A,Daver N,de Groot JF

更新日期：2018-07-01 00:00:00

abstract：:The present study describes a technique for quantitation of mRNA in a few isotypic cells obtained from an intact organ structure by combining laser-assisted cell picking and real-time PCR. The microscopically controlled lasering of selected cells in stained tissue sections was applied to lung alveolar macrophages, whi...

journal_title：Nature medicine

authors： Fink L,Seeger W,Ermert L,Hänze J,Stahl U,Grimminger F,Kummer W,Bohle RM

更新日期：1998-11-01 00:00:00

abstract：:Mesenchymal tumor subpopulations secrete pro-tumorigenic cytokines and promote treatment resistance1-4. This phenomenon has been implicated in chemorefractory small cell lung cancer and resistance to targeted therapies5-8, but remains incompletely defined. Here, we identify a subclass of endogenous retroviruses (ERVs)...

journal_title：Nature medicine

authors： Cañadas I,Thummalapalli R,Kim JW,Kitajima S,Jenkins RW,Christensen CL,Campisi M,Kuang Y,Zhang Y,Gjini E,Zhang G,Tian T,Sen DR,Miao D,Imamura Y,Thai T,Piel B,Terai H,Aref AR,Hagan T,Koyama S,Watanabe M,Baba H,

更新日期：2018-08-01 00:00:00

abstract：:Transplantation of xenogeneic hepatocytes would provide a novel therapy for liver disease and would help to solve the problem of an insufficient supply of donor organs. We have tested whether xenogeneic cells infused into the liver could correct the metabolic defect in the Watanable heritable hyperlipidemic (WHHL) rab...

journal_title：Nature medicine

authors： Gunsalus JR,Brady DA,Coulter SM,Gray BM,Edge AS

更新日期：1997-01-01 00:00:00

abstract：:Understanding the mechanisms of osteoclastogenesis is crucial for developing new drugs to treat diseases associated with bone loss, such as osteoporosis. Here we report that the C-C chemokine receptor-2 (CCR2) is crucially involved in balancing bone mass. CCR2-knockout mice have high bone mass owing to a decrease in n...

journal_title：Nature medicine

authors： Binder NB,Niederreiter B,Hoffmann O,Stange R,Pap T,Stulnig TM,Mack M,Erben RG,Smolen JS,Redlich K

更新日期：2009-04-01 00:00:00

abstract：:Period (Per) genes are involved in regulation of the circadian clock and are thought to modulate several brain functions. We demonstrate that Per2(Brdm1) mutant mice, which have a deletion in the PAS domain of the Per2 protein, show alterations in the glutamatergic system. Lowered expression of the glutamate transport...

journal_title：Nature medicine

authors： Spanagel R,Pendyala G,Abarca C,Zghoul T,Sanchis-Segura C,Magnone MC,Lascorz J,Depner M,Holzberg D,Soyka M,Schreiber S,Matsuda F,Lathrop M,Schumann G,Albrecht U

更新日期：2005-01-01 00:00:00